SYNDROME OF INTRACRANIAL HYPERTENSION AND IRON DEFICIENCY IN INFANTS WITH CEREBRAL ISCHEMIA IN THE NEONATAL PERIOD

2021 ◽  
Vol 100 (1) ◽  
pp. 36-41
Author(s):  
D.D. Gaynetdinova ◽  
◽  
D.F. Galeeva ◽  
Keyword(s):  
Cerebral Ischemia ◽  
Iron Deficiency ◽  
Intracranial Hypertension ◽  
Ferritin Level ◽  
Negative Relationship ◽  
Clinical Manifestations ◽  
Neurological Status ◽  
Blood Parameters ◽  
Latent Iron Deficiency ◽  
Analytical System

Objective of the research: to study the relationship between severity of clinical manifestations of intracranial hypertension (ICH) syndrome of perinatal genesis and red blood counts in infants who underwent cerebral ischemia (CI) at birth. Materials and methods: 94 children with ICH syndrome of perinatal posthypoxic genesis at the age of 6 months of corrected age were examined: 1st group – with normal hemoglobin (Hb) level, 32 children (34%); 2nd group – with reduced Hb level, 62 children (66%). Researchers used anamnestic, clinico-neurological (assessment of the somatic and neurological status with objectification of ICH severity using a specially developed 60-point «Assessment of intracranial hypertension severity» (AIHS) scale in children aged 1 month to 1 year), laboratory study of Hb level on an automated hematological analyzer Sysmex XE2100, Sysmex, Germany, and ferritin level on a modular analytical system Сobas8000, Roche, Denmark) and statistical methods of research. Results: 77% of children (72 children) were diagnosed with mild ICH, 22% (21 children) had moderate severity, and one child (1%) had severe ICH. A strong negative relationship was obtained between the severity of ICH syndrome (the number of points on AIHS scale) and the Hb level (R=–0,72): the lower the Hb level, the more pronounced the clinical manifestations of the ICH syndrome. The ferritin content turned out to be reduced in 83% (78 children), an average negative correlation was found between the severity of the ICH syndrome (the number of points on AIHS scale and ferritin values (R=–0,55): the lower the ferritin content in the blood, the more severe the clinical manifestations of ICH syndrome. Conclusion: in infants with ICH syndrome in the residual period of neonatal IC, a relationship was found between the severity of clinical and instrumental manifestations of ICH syndrome with red blood parameters (Hb and serum ferritin). In this regard, the participation of latent iron deficiency in the pathophysiological processes of the formation and course of ICH syndrome in infants is not excluded.

scholarly journals Evaluation of Iron Status in Diabetic CKD Stage 5 Pre- Dialysis Patients

2013 ◽  
Vol 3 (1) ◽  
pp. 5-10
Author(s):  
Wasim Md. Mohosinul Haque ◽  
Arif Mahmud ◽  
Muhammad Abdur Rahmin ◽  
Jesmin Jahan ◽  
Sarker Mohammad Sajjad ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Haemoglobin Level ◽  
Serum Ferritin ◽  
Serum Iron ◽  
Iron Status ◽  
Ferritin Level ◽  
Negative Relationship ◽  
Diabetic Patients ◽  
Number Of Patients ◽  
Ckd Stage

Objective: To evaluate the iron status among patients with diabetes mellitus and CKD stage 5, who have not started dialysis yet. Methodology: This cross-sectional study was carried on a total of 50 adult diabetic patients with stage 5 CKD, in the Department of Nephrology, BIRDEM General Hospital, Dhaka over 6 months. Results: Total number of patients was 50. Sixty two percent were male and 38% were female. Mean age was 55.22 (range 33-75) years. Mean± SD hemoglobin and ferritin levels were 7.61±2.54 mg/dl and 155.22±92.32 ng/ml respectively. Seventy percent of the study subjects had haemoglobin level d” 9 mg/dl. In 48% of the study subjects, ferritin level was less than 100ng/ml. Fourty six percent of the study subjects had TSAT level below 20%. Haemoglobin, serum ferritin and TSAT level in the study subjects had negative relationship with duration of CKD. Haemoglobin and serum ferritin levels were positively correlated with eGFR of the study population. TIBC level had negative relationship with haemoglobin level which was statistically significant. Serum iron, ferritin and TSAT level in the study subjects were positively correlated with haemoglobin level. Relationship of haemoglobin with serum iron and TSAT level was statistically significant. Statistical analysis showed relationship between eGFR with haemoglobin and serum ferritin level was significant (P<0.05). Conclusion: Most of the diabetic CKD stage 5 patients had reduced hemoglobin level and iron deficiency is one of the contributory factors and TSAT is the better indicator for iron deficiency than serum iron, TIBC and ferritin level. Birdem Med J 2013; 3(1): 5-10 DOI: http://dx.doi.org/10.3329/birdem.v3i1.17120

scholarly journals A Comparative Study of Interleukin 6, Inflammatory Markers, Ferritin, and Hematological Profile in Rheumatoid Arthritis Patients with Anemia of Chronic Disease and Iron Deficiency Anemia

Anemia ◽  
2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Eman Tariq Ali ◽  
Azza Sajed Jabbar ◽  
Ali Nazar Mohammed
Keyword(s):  
Rheumatoid Arthritis ◽  
Iron Deficiency ◽  
Serum Level ◽  
Iron Deficiency Anemia ◽  
Iron Status ◽  
Ferritin Level ◽  
Hematological Parameters ◽  
Blood Parameters ◽  
Deficiency Anemia ◽  
Anemia Of Chronic Disease

Background. Interleukin-6 (IL-6) proinflammatory cytokine is associated with the pathogenesis of rheumatoid arthritis and development of anemia in it. This is a comparative study of inflammatory and hematological parameters in RA patients with anemia of chronic disease (ACD) and iron deficiency anemia (IDA). It aimed to demonstrate the changes in serum level of IL-6, ferritin level, and hematological parameters in different groups of patients with RA and to find out the potential correlation between serum level of IL-6 and ferritin level and the relationship between serum level of IL-6 and iron status. Methods. The study included 89 patients from both sexes divided into four groups (group 1: 30 iron deficiency anemia (IDA), 59 RA; group 2: 20 RA-COMBI; group 3: 23 RA-ACD; and group 4: 16 nonanemic RA). These different groups were compared with a healthy group of 50 healthy individuals. Different blood parameters (WBC, RBC, HGB, HCT, MCV, and MCH) have been evaluated. Serum concentrations of IL-6, hsCRP, anti-CCP, and ferritin were measured in all patients and healthy individual using enzyme-linked immunosorbent assay ELISA. Results. There were significant changes in most of blood parameters between the groups, and there was a significant increase in the levels of IL-6 among RA patients. This increase was highly significant among RA-ACD patients in particular, and this elevation has been directly correlated with clinical indices of disease activity such as hsCRP, ESR, anti-CCP, and ferritin. There was an inverse relationship between ferritin and all iron status parameter, such as RBC, HGB, and haematocrit. Conclusion. IL-6 and ferritin level estimation may be workable tests to differentiate the patients with IDA and ACD in RA.

scholarly journals Increased levels of pentraxins protein and cytokines bear good association in patients with severe dengue infection

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Goutam Patra ◽  
Bibhuti Saha ◽  
Sumi Mukhopadhyay
Keyword(s):  
Dengue Infection ◽  
Clinical Manifestations ◽  
Blood Parameters ◽  
Warning Signs ◽  
Severe Dengue ◽  
Disease Manifestation ◽  
Mild Disease ◽  
Tnf Α ◽  
The Status ◽  
The Tropics

AbstractDengue is an arboviral infection with high rates of morbidity and mortality throughout the tropics and sub-tropics. This work studied the status of pentraxin (CRP/SAP) protein, ferritin, TNF-α and IL-1β levels in Dengue patients of different pathophysiological manifestations. Accordingly, clinically confirmed Dengue cases (n = 97) were enrolled and subsequently blood parameters were studied by Haematology cell counter and Biochemistry Autoanalyser. CRP, SAP, ferritin, TNF-α and IL-1β ELISA were done in all the samples by using standard ELISA kits. Statistical Analysis was done in all the experiments. The levels of CRP (p < 0.0001), SAP (p < 0.0001), ferritin (p < 0.0001), TNF-α (p < 0.0001) and IL-1β (p < 0.0001) were high in patients with Severe Dengue as compared to Dengue without warning signs. High levels of SGOT, SGPT and decreased platelet counts were found in severe patients as compared to Healthy donor. CRP/SAP as well as TNF-α/IL-1β were independently associated with both dengue severity and overall disease manifestation. Statistically significant increased CRP, SAP, ferritin, TNF-α and IL-1β titres were correlated in patients with severe clinical manifestations as compared to mild disease forms of dengue. Elevated levels of pentraxin, TNF-α/IL-1β in blood during dengue infection could act as an early predictor in Severe Dengue infection.

scholarly journals Idiopathic intracranial hypertension presenting as iron deficiency anemia: a case report

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Peng Yong Sim ◽  
Priyal Taribagil ◽  
Ione O. C. Woollacott ◽  
Safina Rashid ◽  
Desmond P. Kidd
Keyword(s):  
Case Report ◽  
Iron Deficiency ◽  
Intracranial Hypertension ◽  
Iron Deficiency Anemia ◽  
Idiopathic Intracranial Hypertension ◽  
Deficiency Anemia ◽  
Visual Deficits ◽  
Fluid Analysis ◽  
Optic Disc Swelling

Abstract Background The presentation of idiopathic intracranial hypertension (IIH) in association with iron deficiency anemia (IDA) is rare. Case presentation This case report depicts the unusual case of a 31-year-old woman of mixed Jamaican and English heritage with IIH who presented initially as IDA in the context of menorrhagia. Subsequent ophthalmic review, lumbar puncture, cerebrospinal fluid analysis and neuroimaging studies revealed severe bilateral optic disc swelling and raised intracranial pressure in keeping with IIH. Prompt treatment of IDA with blood transfusion and orally administered iron supplements, in addition to medical treatment for IIH, contributed to significant improvement of symptoms and prevented long-term visual deficits. Conclusion The possibility of IDA, albeit rare, should always be considered and investigated appropriately in all patients with IIH, as the treatment of the anemia alone may be sight-saving.

Iron Homeostasis and Disorders in Dogs and Cats: A Review

2011 ◽  
Vol 47 (3) ◽  
pp. 151-160 ◽  
Author(s):  
Jennifer L. McCown ◽  
Andrew J. Specht
Keyword(s):  
Iron Deficiency ◽  
Iron Overload ◽  
Iron Homeostasis ◽  
Diagnostic Testing ◽  
Clinical Manifestations ◽  
Essential Element ◽  
The Body ◽  
Deficiency Anemia ◽  
Enzyme Systems ◽  
Living Organisms

Iron is an essential element for nearly all living organisms and disruption of iron homeostasis can lead to a number of clinical manifestations. Iron is used in the formation of both hemoglobin and myoglobin, as well as numerous enzyme systems of the body. Disorders of iron in the body include iron deficiency anemia, anemia of inflammatory disease, and iron overload. This article reviews normal iron metabolism, disease syndromes of iron imbalance, diagnostic testing, and treatment of either iron deficiency or excess. Recent advances in diagnosing iron deficiency using reticulocyte indices are reviewed.

scholarly journals Anaplastic ependymoma

2021 ◽  
Vol 70 (2) ◽  
Author(s):  
Anatolii Litovcenco ◽  
◽  
Ala Bajurea ◽  
Maxim Sula ◽  
◽  
...  
Keyword(s):  
Intracranial Hypertension ◽  
Multimodal Treatment ◽  
Clinical Case ◽  
Brain Mri ◽  
Clinical Manifestations ◽  
Anaplastic Ependymoma

The authors present a clinical case of anaplastic ependymoma in a 6-year-old child with the clinical manifestations of intracranial hypertension syndrome with evolutionary hydrocephaly and cerebellar-atactic syndrome. CT and brain MRI investigation as well as histology were essential in establishing multimodal treatment. 11 references, 3 pictures.

scholarly journals Iron deficiency syndromes in clinical oncology and their correction with nutritive action drugs

2019 ◽  
Vol 2 (13) ◽  
pp. 20-25
Author(s):  
L. N. Kostyuchenko ◽  
G. S. Mikhailyantz ◽  
M. Y. Danilov ◽  
A. O. Atroshchenko ◽  
A. D. Kruglov ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Iron Deficiency ◽  
Nutritional Status ◽  
Clinical Oncology ◽  
Nutritional Risk ◽  
Latent Iron Deficiency ◽  
Special Matrix

Treatment of iron deficiency conditions by nutritive support media is one of the debatable areas. In the analysis of nutritional status, nutritional risk and ferrumdeficiency parameters in patients with operated colorectal cancer in different stages, the possibility of correction of prelatent and latent iron deficiency with ferrum‑containing media of nutritional alimentation is shown. With the development of anemia, the use of с intravenous correction (preferably with drugs sorbed on a special matrix that allows the gland to be isolated in portions) is shown.

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