Antihypertensive Effect of Gingerol Extract from Red Ginger (Zingiber officinale var rubrum) from Indonesia in Male Wistar Rats (Rattus norvegicus) Induced Hypertension

2017 ◽  
Vol 7 (2) ◽  
Keyword(s):  
Rattus Norvegicus ◽  
Wistar Rats ◽  
Antihypertensive Effect ◽  
Zingiber Officinale ◽  
Induced Hypertension ◽  
Male Wistar Rats ◽  
Red Ginger

scholarly journals Efek Pemberian Ekstrak Jahe (Zingiber officinale) terhadap Gambaran Histopatologik Lambung Tikus Wistar yang Diinduksi Asam Asetat

2020 ◽  
Vol 1 (2) ◽  
Author(s):  
Monica Ch. Pungus ◽  
Magdalena P. Lintong ◽  
Maria K. Sambuaga
Keyword(s):  
Acetic Acid ◽  
Rattus Norvegicus ◽  
Wistar Rats ◽  
Zingiber Officinale ◽  
Positive Control ◽  
Arachidonic Acid Metabolism ◽  
Peptic Ulcers ◽  
Mucosal Layer ◽  
Male Wistar Rats ◽  
Red Ginger

Abstract: In stomach induced by acetic acid, the gastric acidity may increase leading to irritation of the mucosal layer and imbalance of defense factors and damaging factors. This might lead to the occurrence of gastritis or peptic ulcers. Ginger is rich in flavonoids. In the inflammation process, ginger constituents such as zingerone, zingiberenes, gingerols, and shogaol may be able to inhibit the cyclooxygenation and lipookoxygenase pathways in the arachidonic acid metabolism. This study was aimed to identify the effects of ginger on the histopathological features of stomach induced by acetic acid. This was an experimental laboratory study. In this study, we used red ginger (Zingiber officinale var. rubrum) originated from Tomohon. Samples were male Wistar rats (Rattus norvegicus) divided into 5 groups; one as the positive control. The results showed that groups given ginger had intact surface mucosa, inflammation cells (eosinophils and PMN), and blood vessel dilation. Meanwhile, the positive control showed erosive surface mucosa. Worms were identified in all groups. It is concluded that in Wistar rats, administration of ginger after the stomach induced by acetic acid still showed gastritis feature but without acute erosive gastritis.Keywords: ginger, stomach, gastritis, peptic ulcers, acetic acid, vinegar Abstrak: Pada lambung yang diinduksi dengan asam asetat, kadar keasaman lambung dapat meningkat sehingga mengiritasi lapisan mukosa dan mengakibatkan ketidakseimbangan faktor pertahanan dan faktor perusak lambung. Hal ini dapat menyebabkan gastritis atau ulkus peptikum. Jahe dikenal kaya akan flavonoid. Pada proses inflamasi, konstituen dari jahe seperti zingerone, zingiberenes, gingerols, dan shogaol mampu menghambat jalur siklooksigenasi dan lipooksi-genase pada metabolisme asam arakidonat. Penelitian ini bertujuan untuk mengetahui efek pemberian jahe terhadap gambaran histopatologik lambung yang diinduksi dengan asam asetat. Jenis penelitian ialah eksperimental laboratorik. Pada penelitian ini digunakan jahe merah (Zingiber officinale var. rubrum) yang berasal dari daerah Tomohon. Sampel penelitian ialah 25 ekor tikus Wistar (Rattus norvegicus) jantan, dibagi atas 5 kelompok; satu kelompok sebagai kontrol positif. Hasil penelitian mendapatkan kelompok yang diberikan jahe memperlihatkan permukaan mukosa lambung intak, adanya sel-sel radang (eosinofil dan PMN), serta pelebaran pembuluh darah sedangkan pada kelompok kontrol positif yang hanya diberikan asam asetat tampak permukaan mukosa lambung erosif. Pada semua sampel ditemukan adanya cacing. Simpulan penelitian ini ialah pada tikus Wistar, pemberian jahe setelah lambung diinduksi dengan asam asetat masih menun-jukkan adanya gambaran histopatologik gastritis namun tidak terdapat gastritis erosif akut.Kata kunci: jahe, lambung, gastritis, ulkus peptikum, asam asetat

scholarly journals Antihypertensive effect of methanol leaf extract of Anacardium occidentale against L‐Nitro Arginine Methyl Ester (L‐NAME)‐induced hypertension in male Wistar rats

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Adebowale Benard Saba ◽  
Adedeji Kolawole Adebayo ◽  
Ademola Adetokunbo Oyagbemi ◽  
Temidayo Olutayo Omobowale ◽  
Olufunke Eunice Ola-Davies ◽  
...  
Keyword(s):  
Methyl Ester ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Antihypertensive Effect ◽  
Anacardium Occidentale ◽  
Induced Hypertension ◽  
Male Wistar Rats

scholarly journals Effect of Caffeic Acid Phenethyl Ester Provision on Fibroblast Growth Factor-2, Matrix Metalloproteinase-9 Expression, Osteoclast and Osteoblast Numbers during Experimental Tooth Movement in Wistar Rats (Rattus norvegicus)

2021 ◽  
Author(s):  
Ida Bagus Narmada ◽  
Paristyawati Dwi Putri ◽  
Lucky Lucynda ◽  
Ari Triwardhani ◽  
I Gusti Aju Wahju Ardani ◽  
...  
Keyword(s):  
Growth Factor ◽  
Matrix Metalloproteinase ◽  
Rattus Norvegicus ◽  
Wistar Rats ◽  
Tooth Movement ◽  
Caffeic Acid Phenethyl Ester ◽  
Fibroblast Growth Factor 2 ◽  
Fibroblast Growth ◽  
Male Wistar Rats ◽  
Metalloproteinase 9

Abstract Objectives To investigate the effect of caffeic acid phenethyl ester (CAPE) provision on matrix metalloproteinase-9 (MMP-9), fibroblast growth factor-2 (FGF-2) expression, osteoclast and osteoblast numbers during experimental orthodontic tooth movement (OTM) in male Wistar rats (Rattus norvegicus). Materials and Methods Forty-eight healthy male Wistar rats (R. norvegicus), 16 to 20 weeks old with 200 to 250 g body weight (bw) were divided into several groups as follows: K1: OTM for 3 days; K2: OTM for 7 days; K3: OTM for 14 days; KP1: OTM and CAPE for 3 days; KP2: OTM and CAPE for 7 days; and KP3: OTM and CAPE for 14 days. A nickel titanium closed coil spring 8.0 mm long with 10 g/mm2 was installed between the upper left first molar and upper central incisor to move molar mesially. CAPE provision with a dose of 20 mg/kg bw of animal studies was done per orally. Immunohistochemistry was done to examine MMP-9 expression and osteoclast number in compression side as well as FGF-2 expression and osteoblast number in tensile side of the OTM. Statistical Analysis One-way analysis of variance test and Tukey’s honest significant difference test were performed to determine the difference between the groups (p < 0.05). Results MMP-9 expression and osteoclast numbers in the compression side were significantly different between the groups. Similarly, FGF-2 expression and osteoclast numbers in the tensile side were significantly different between the groups. Conclusions CAPE provision during OTM increases the number of osteoblasts and the FGF-2 expression significantly in the tensile side. Osteoclast numbers and MMP-9 expression significantly decrease in the compression side.

scholarly journals Ekstrak Etanol Daun Jati Belanda (Guazuma ulmifolia Lamk) Memperbaiki Profil Lipid Tikus (Rattus norvegicus) Wistar Jantan Dislipidemia

2020 ◽  
Vol 1 (1) ◽  
pp. 25-30
Author(s):  
Melita Hidajat ◽  
I Gusti Made Aman ◽  
Hendro Sukoco ◽  
Ferbian Milas Siswanto
Keyword(s):  
Treatment Group ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Rattus Norvegicus ◽  
Wistar Rats ◽  
Control Group ◽  
Wistar Strain ◽  
Before And After ◽  
Male Wistar Rats ◽  
Guazuma Ulmifolia

The purpose of this study was to prove that the administration of Jati (Guazuma ulmifolia Lamk) leaves extract improves the lipid profile of dyslipidemic male Wistar rats. Subjects were 20 rats (Rattus norvegicus), male, Wistar strain, dyslipidemia (total cholesterol ≥ 200 mg dl-1), aged 2 months old, weighing 180-200 grams. The control group (10 rats) were given a placebo of 3 ml aquadest (P0) and the treatment group was given extracts of the Jati (Guazuma ulmifolia Lamk) leaves extract of 25 mg kg-1 BW (P1). Before and after treatment for 14 days, total cholesterol, triglyceride, LDL, and HDL levels were examined. The results showed that in the P0 group there were no changes in total cholesterol, triglyceride, LDL, and HDL levels (p>0.05), whereas the P1 group experienced a decrease in total cholesterol, triglyceride and LDL levels (p<0.05) and an increase in HDL levels (p<0.05). The results of this study indicated that the Jati leaves extract was effective to improve the lipid profile of dyslipidemic rats. It was necessary to compare the effectiveness of Jati leaves extract with synthetic dyslipidemia drugs used in the community such as statin.

Dietary linoleic acid and salt-induced hypertension

1981 ◽  
Vol 59 (8) ◽  
pp. 872-875 ◽  
Author(s):  
Murray C. Macdonald ◽  
Robert L. Kline ◽  
Gordon J. Mogenson
Keyword(s):  
Blood Pressure ◽  
Linoleic Acid ◽  
Systolic Blood Pressure ◽  
Wistar Rats ◽  
Sodium Content ◽  
Significant Elevation ◽  
Dietary Linoleic Acid ◽  
Low Level ◽  
Induced Hypertension ◽  
Male Wistar Rats

Male Wistar rats chronically fed a low level (0.41%) of linoleic acid (LA) in the diet as supplied by 5% olive oil developed a significant elevation of systolic blood pressure as compared with rats fed either a medium (4.2%) or high (9.4%) level of dietary LA. Chronic excess intake of NaCl (3.75% in the diet) was associated with a significant elevation of blood pressure on all three diets but a low level of LA in the diet exaggerated the salt-induced hypertension. The results suggest that inadequate dietary LA may result in an increase in systolic blood pressure regardless of the sodium content of the diet.

Effect of Adrenalectomy on the Development of Isolation-Induced Hypertension in Rats

1981 ◽  
Vol 61 (5) ◽  
pp. 511-519 ◽  
Author(s):  
S. M. Gardiner ◽  
K. E. Milmer ◽  
T. Bennett
Keyword(s):  
Volume Expansion ◽  
Chloride Solution ◽  
Wistar Rats ◽  
Sodium Chloride Solution ◽  
Adrenal Glands ◽  
Tap Water ◽  
Fluid Retention ◽  
Induced Hypertension ◽  
Male Wistar Rats ◽  
Adrenalectomized Rats

1. Male Wistar rats develop systolic arterial hypertension when housed in glass metabolism cages. The present experiments were designed to investigate the involvement of the adrenal glands in this form of hypertension. 2. Rats were bilaterally adrenalectomized and maintained by either salt supplementation (1% sodium chloride solution instead of tap water to drink) or steroid replacement (corticosterone solution in the drinking water). 3. Adrenalectomized rats treated as above did not develop hypertension in response to isolation, whereas sham-operated rats (drinking either 1% saline or tap water) did. 4. Hypertension in the sham-operated rats was not accompanied by a renal retention of sodium and water. 5. It is concluded that increased adrenal activity is involved in the development of isolation-induced hypertension, but not by causing a fluid retention and hence volume expansion. The relative contributions of adrenal medullary and cortical activity remain to be determined.

Chronic administration of gabapentin and a gabapentin-carbamazepine combination reversibly suppress testicular function in male Wistar rats ( Rattus norvegicus )

2017 ◽  
Vol 24 (2) ◽  
pp. 63-69 ◽  
Author(s):  
Opeyemi Samson Osuntokun ◽  
Gbola Olayiwola ◽  
Ayowole Oladele ◽  
Idowu Ola ◽  
Oludele AyokaAbiodun
Keyword(s):  
Rattus Norvegicus ◽  
Wistar Rats ◽  
Chronic Administration ◽  
Testicular Function ◽  
Male Wistar Rats
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