Safety and efficacy of mirabegron and solifenacin in elderly patient with overactive bladder

2021 ◽  
Vol 14 (1) ◽  
pp. 53-57
Author(s):  
Tomasz Wiatr ◽  
Piotr Chłosta
Keyword(s):  
Elderly People ◽  
The Elderly ◽  
Similar Efficacy ◽  
Urgency Incontinence ◽  
Bladder Training ◽  
Adrenoceptor Agonist ◽  
Urinary Tract Symptoms ◽  
M3 Receptors ◽  
Lower Urinary

Lower urinary tract symptoms, including urgency, urgency incontinence, pollakiuria and nocturia are common in the elderly people and has significant impact on quality of life. Pharmacological treatment is recommended when conservative management, such as fluid intake normalization or bladder training, does not alleviate symptoms. Antimuscarinics were often used as the I line treatment for OAB, as these drugs block the activity of the muscarinic M2/M3 receptors in the bladder and provide a significant clinical benefit for OAB symptoms in the elderly people, but their side effects are common, often leading to treatment discontinuation. Mirabegron, a β3-adrenoceptor agonist, shows similar efficacy to antimuscarinic drugs without the risk of anticholinergic effects.

scholarly journals Tai Chi for Lower Urinary Tract Symptoms and Quality of Life in Elderly Patients with Benign Prostate Hypertrophy: A Randomized Controlled Trial

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Seil Jung ◽  
Eun-Nam Lee ◽  
Sook-Ryon Lee ◽  
Mi-Sook Kim ◽  
Myeong Soo Lee
Keyword(s):  
Quality Of Life ◽  
Elderly Patients ◽  
Lower Urinary Tract ◽  
Tai Chi ◽  
The Elderly ◽  
Benign Prostate Hypertrophy ◽  
Urinary Tract Symptoms ◽  
Benign Prostate ◽  
Lower Urinary

Tai chi exercise has been recommended as suitable for the improvement of health in the elderly. The purpose of this study was to investigate the effects of tai chi on lower urinary tract symptoms (LUTSs), quality of life (QoL), and sex hormone levels in patients with benign prostate hypertrophy (BPH). The elderly patients with BPH were randomized to receive tai chi or usual care. Fifty-six participants were randomized into either the tai chi group (n=28) or the control group (n=28). After 12 weeks of treatment, the tai chi group showed significant improvement in LUTS and QoL. There was a significant effect of tai chi on testosterone but no significant effect on insulin or glucose. No serious adverse events were observed during the study period. In conclusion, our results suggest that 12 weeks of tai chi may improve LUTS and QoL in elderly patients with BPH.

1276: Lower Urinary Tract Symptoms: Local Ischemia Assessed by Sonographic Findings and Correlated to Impaired Quality of Life

2006 ◽  
Vol 175 (4S) ◽  
pp. 410-411
Author(s):  
Germar M. Pinggera ◽  
Michael Mitterberger ◽  
Leo Pallwein ◽  
Peter Rehder ◽  
Ferdinand Frauscher ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Urinary Tract ◽  
Lower Urinary Tract Symptoms ◽  
Lower Urinary Tract ◽  
Local Ischemia ◽  
Urinary Tract Symptoms ◽  
Impaired Quality ◽  
Lower Urinary

scholarly journals Predictors of urogenital distress and impaired quality of life in adult Egyptians with lower urinary tract symptoms

2021 ◽  
Vol 27 (1) ◽  
Author(s):  
Isaac Samir Wasfy ◽  
Enayat Mohamed Soltan ◽  
Hassan A. Abdelwahab ◽  
Hend Mikhail Salama
Keyword(s):  
Quality Of Life ◽  
Urinary Tract ◽  
Lower Urinary Tract Symptoms ◽  
Lower Urinary Tract ◽  
Emotional Health ◽  
Stress Symptoms ◽  
Urinary Tract Symptoms ◽  
Impaired Quality ◽  
Lower Urinary

Abstract Background This study aims to assess the severity of lower urinary tract symptoms, and to assess predictors of impaired quality of life among Egyptian adults complain of lower urinary tract symptoms. Methods An observational cross-sectional research was done using an online anonymous poll survey. The survey was implemented through sharing on different social media applications. The survey was posted from June 1, 2020, to June 10, 2020. The overall communities of the Egyptian adults who satisfied the incorporation rules and consented to take an interest in the research were incorporated using convenience and snowball collecting methods (188 adults). A semi-structured questionnaire on socio-demographic characteristics and Arabic Urogenital Distress Inventory (UDI-6) and Incontinence Impact Questionnaire (IIQ-7) short forms were used. Results Approximately 220 Egyptian adults shared in the research but only 188 fulfilled inclusion and exclusion criteria. Approximately 92% of them had at least one symptom of lower urinary tract manifestations. Irritative symptoms presented in 65 (85.5%) of males and 102 (91.1%) of females. Stress symptoms presented in 44 (57.9%) of males and 63 (56.2%) of females with higher statistically significant mean of stress symptoms. Obstruction/discomfort symptoms presented in 51 (67.1%) of males, and 77 (68.8%) of females. Seeking help and duration of the urological problem were statistically significant independent positive predictors of UDI-6-total. The Irritative score, obstruction/discomfort score, and duration of the urological problem were statistically significant independent positive predictors of IIQ-7-total. Conclusions Urological problems are common and have an impact on the quality of life in various domains of physical activity, social relationships, travel, and emotional health.

scholarly journals The impact of adding solifenacin to tamsulosin therapy for treatment of storage lower urinary tract symptoms owing to benign prostatic hyperplasia

2020 ◽  
Vol 26 (1) ◽  
Author(s):  
Mohamed Elbadry ◽  
Ahmed Issam Ali ◽  
Eman Saleh ◽  
Amal Kamal ◽  
Ahmed H. Gabr
Keyword(s):  
Quality Of Life ◽  
Lower Urinary Tract ◽  
Group Versus ◽  
Prostatic Hyperplasia ◽  
Combination Group ◽  
Urinary Tract Symptoms ◽  
Bladder Symptoms ◽  
Group 1 ◽  
Lower Urinary

Abstract Background Benign prostatic hyperplasia (BPH) is a common problem in aging males which has a potential impact on patients’ health-related quality of life. In the present prospective study, we evaluated the effect of adding solifenacin to tamsulosin, compared to tamsulosin alone on overactive bladder symptoms scores (OABSS) and patients’ quality of life (QoL) in patients with filling lower urinary tract symptoms due to BPH. Methods Patients included in our study were randomly assigned into 2 groups: group 1 included patients with BPH who received tamsulosin alone and group 2 included patients with BPH who received a combination of tamsulosin and sofinacin. Treatment period was 12 weeks in both groups. Quality of life and overactive bladder symptoms score questionnaires were obtained and compared in both groups before and after treatment. Results No significant differences were found between both groups before treatment. At the end of treatment period, The QoL score for Group 1 patients was significantly greater than the other group (mean rank was 138.98 in tamsulosin group versus 62.02 in the combination group, P-value < 0.01). Similarly, OABSS for tamsulosin only group was significantly higher than combined treatment patients (mean rank was 145.03 in tamsulin group versus 55.98 in the combination group, P-value < 0.01). Conclusion Adding solifenacin to tamsulosin was associated with an improvement of QoL and OABSS in patients with irritative urinary symptoms due to BPH when compared with tamsulosin monotherapy.

scholarly journals Pharmacological Effects and Potential Clinical Usefulness of Polyphenols in Benign Prostatic Hyperplasia

Molecules ◽  
2021 ◽  
Vol 26 (2) ◽  
pp. 450
Author(s):  
Kensuke Mitsunari ◽  
Yasuyoshi Miyata ◽  
Tomohiro Matsuo ◽  
Yuta Mukae ◽  
Asato Otsubo ◽  
...  
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Molecular Mechanisms ◽  
Prostatic Hyperplasia ◽  
Pathological Conditions ◽  
Urinary Tract Symptoms ◽  
Anti Inflammatory ◽  
Lower Urinary

Benign prostatic hyperplasia (BPH) is arguably the most common benign disease among men. This disease is often associated with lower urinary tract symptoms (LUTS) in men and significantly decreases the quality of life. Polyphenol consumption reportedly plays an important role in the prevention of many diseases, including BPH. In recent years, in addition to disease prevention, many studies have reported the efficacy and safety of polyphenol treatment against various pathological conditions in vivo and in vitro. Furthermore, numerous studies have also revealed the molecular mechanisms of the antioxidant and anti-inflammatory effects of polyphenols. We believe that an improved understanding of the detailed pharmacological roles of polyphenol-induced activities at a molecular level is important for the prevention and treatment of BPH. Polyphenols are composed of many members, and their biological roles differ. In this review, we first provide information regarding the pathological roles of oxidative stress and inflammation in BPH. Next, the antioxidant and anti-inflammatory effects of polyphenols, including those of flavonoids and non-flavonoids, are discussed. Finally, we talk about the results and limitations of previous clinical trials that have used polyphenols in BPH, with particular focus on their molecular mechanisms of action.

Information and psychological security in the development of computer literacy in the elderly

2021 ◽  
pp. 270-278
Author(s):  
Tatyana Borisovna Berestok
Keyword(s):  
Quality Of Life ◽  
Elderly People ◽  
Computer Literacy ◽  
Negative Impact ◽  
Social Institutions ◽  
The Elderly ◽  
Information Environment ◽  
Specific Information ◽  
Negative Factors

This article deals with the issue of self-preservation of elderly people when learning to work on a computer from the point of view of information and psychological security. The necessity of solving new socio-psychological problems is indicated: to develop the ability to give a correct assessment of a specific information threat, to prevent the negative impact of the information environment, to resist negative factors, and to contribute to improving the quality of life. The purpose of counseling elderly people is to develop their ability to understand the problem of the negative impact of the information environment on psychological and physiological health, to be able to apply methods to ensure information and psychological security. Consulting and educational work with the elderly and employees of social institutions engaged in professional activities directly related to the above category should be aimed at preventing cases of fraudulent activities. Consulting work with them should not only meet the general principles of building psychological contact, but also cause an understanding of the importance of compliance with security in the digital sphere. Elderly people develop the ability to assess correctly a specific information threat and prevent the negative impact of the information environment by providing adequate resistance to negative factors and contributing to improving their quality of life. It is increasingly difficult for older people to navigate threats, unmotivated anxiety increases, depressiveness appears and becomes fixed, and asocial personality traits are formed. At the present time, it is necessary to consider the formation of information and computer literacy as a mechanism to counteract the negative impact of the information environment and a necessary condition for developing an effective strategy for the social adaptation of elderly people.

Psychosocial Consequences among Elderly Living In Institutional and Non-Institutional Settings

2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Nagesh Jamwal
Keyword(s):  
Quality Of Life ◽  
Elderly People ◽  
Research Work ◽  
The Elderly ◽  
Institutional Settings ◽  
Elderly Males ◽  
Psychosocial Consequences ◽  
Age Range ◽  
Elderly Living

Background – Elderly people face many psychological, physical and socio economic morbidities due to ageing. Institutional settings have been opened for those elderly people who are neither able to take care of themselves nor is there any person to look after them. Objectives- The present research work was conducted to study the quality of life, loneliness and psychological distress of the elderly males and females living in institutions and non-institutional settings in urban Jammu district. Methods –The study was conducted using purposive sampling on 40 elderly living in institutional settings and 40 elderly living in non- institutional settings in the age range of 60-80 years. Tools used – GHQ  by Gautam, Nuhawan and Kamal ,UCLA loneliness scale(Russell, 1996)  and WHO (QOL-BREF, 1998),  was used. Results – The results revealed significant differences on loneliness and quality of life between those living in institutional settings and those living with their families.

scholarly journals Safety assessment of essential medicines for elderly people: a bibliographic survey

2014 ◽  
Vol 50 (2) ◽  
pp. 269-284 ◽  
Author(s):  
Fabiana Rossi Varallo ◽  
Fernanda Mariana de Oliveira ◽  
Patrícia de Carvalho Mastroianni
Keyword(s):  
Elderly People ◽  
Safety Assessment ◽  
Search Strategy ◽  
Adverse Drug Events ◽  
The Elderly ◽  
Essential Medicines ◽  
Age Group ◽  
Over The Counter ◽  
Manual Search

Certain medicines are considered potentially inappropriate (PIM) for elderly people as they increase the risk of adverse drug events (ADE) and because safer alternative therapies are available on the market. In this context, in order to identify the instruments that assess the quality of medical prescriptions for elderly and to determine which drugs are considered PIM, a bibliographic survey was conducted in PUBMED, LILACS and PAHO databases, in February and March/2010. The search strategy included the use of health descriptors and a manual search in the references cited by selected papers. During the period of data collection, 15 instruments were identified. In 2012, with the publication of the update of Beers criteria, this instrument was included in the study. We identified 163 PIM of 25 therapeutic classes, of which 125 (76.7%) are marketed in Brazil. Of these, 31 (24.8%) are essential medicines (RENAME 2012), of which 13 have safer therapeutic equivalents and 19 (15.2%) are over-the-counter drugs. Data suggest the need for inclusion of safer alternatives for the elderly in the national list of essential medicines and the pharmaceutical care for early detection of ADE in this age group, in order to contribute to the safe use of medicines.

Sign in / Sign up

Export Citation Format

Share Document