scholarly journals KORELASI FUNGSI HATI TERHADAP DERAJAT PENYAKIT DEMAM BERDARAH DENGUE ANAK

2016 ◽  
Vol 18 (3) ◽  
pp. 172
Author(s):  
Ani Kartini ◽  
Mutmainnah Mutmainnah ◽  
Ibrahim Abdul Samad
Keyword(s):  
Clinical Pathology ◽  
Liver Function Tests ◽  
Dengue Haemorrhagic Fever ◽  
Haemorrhagic Fever ◽  
Cross Sectional ◽  
Liver Functions ◽  
Spearman Correlation Test ◽  
Grade Ii ◽  
The Mean ◽  
Using Data

Dengue Haemorrhagic Fever (DHF) may result acute liver failure. Although these cases are rare but is more common in children, and early identification of these infections is important to reduce the morbidity as well as mortality. The aim of this study was to know the determinations and the correlation of liver functions with the grade of Dengue Haemorrhagic Fever in children. This study was conducted by cross sectional, using data from the medical records of DHF patients who had liver function tests (AST, ALT, PT, aPTT and albumin) in the Laboratory of Clinical Pathology Dr. Wahidin Sudirohusodo Hospital Makassar from the period of July 2008 to June 2010. AST, ALT and albumin were tested using Cobas Integra 400, PT and aPTT were tested using Humaclot VA, and the data were analyzed with Spearman correlation test. There were fifty-five samples: 26 (47.3%) were males and 29 (52.7%) were females. We found 15 (27.3%) grade I, 13 (23.6%) grade II, 16 (29.1%) grade III and 11 (20%) grade IV patients. In this study are found that AST and ALT increased and there is a tendency of extending aPTT value but there was no significant correlation with the grade of DHF. The mean of albumin was lower in grade IV, there was a significant correlation between albumin and the grade of DHF (r=–0.375, p<0.05). In conclusion, there was a significant correlation between albumin and the grade of DHF. It is suggested that the routine albumin examination in DHF patients should be carried on to know whether a prevention of complications is needed to reduce the possibility of mortality.

scholarly journals Clinical Profile of Dengue Fever in Children

1970 ◽  
Vol 33 (2) ◽  
pp. 55-58 ◽  
Author(s):  
ABM Shahidul Alam ◽  
S Anwar Sadat ◽  
Zakaria Swapan ◽  
Aftab U Ahmed ◽  
Md Nazmul Karim ◽  
...  
Keyword(s):  
Abdominal Pain ◽  
Dengue Fever ◽  
Dengue Infection ◽  
Cross Sectional Study ◽  
Dengue Haemorrhagic Fever ◽  
Published Data ◽  
Haemorrhagic Fever ◽  
Cross Sectional ◽  
Normal Platelet ◽  
The Mean

Background: Dengue infection has become endemic in Bangladesh since it hasbeen broken out in June 2000. Although children are the usual victim of dengueinfection, there is paucity of published data regarding dengue infection in children inour country.Objectives: This study was designed to document the presenting features and outcomeof Dengue infection in children.Materials and Methods: This cross sectional study was done among the childrenhaving Dengue infection. Fifty four consecutive patients were enrolled. Purposivesampling was done. In every patient a detailed history was taken. Clinical examinationsand relevant investigations were done. Data were collected in a predesigned structuredquestionnaire. Data were analyzed with the help of descriptive statistics and Chisquare(x2) Test.Results: The mean age of the patients was 6.5±3.5 years with equal male and femaleratio. Among 54 patients, 40.7% presented with dengue fever (DF), the rest (59.3%)presented with dengue haemorrhagic fever (DHF). Most of the patients presented withhigh grade continued type of fever (75.9%), followed by abdominal pain (59.3%),vomiting (57.4%). Itchy rash and fever were the most important characteristic signs(75.9% each). Flushed appearance observed in 68.4% and 59.3% patients showedbleeding manifestation of which sub-conjunctival haemorrage was the commonestform (33.3%). Leucopenia were present in only 9.3% of the patients. Platelet countless than 100×109/L were found in 68.5% patients. Tourniquet test was positive in31.5% of cases. All of the patients had packed cell volume (PCV) less than 45%.Raised serum alanine aminotransferase (ALT) was observed in 40.7% of children.IgM and/or IgG antibodies for dengue virus were positive in 96.29% patients. Majority(94%) of the patients completely recovered from the disease and only 6% died.Conclusion: High grade continued fever, vomiting with abdominal pain and itchy skinrash (with normal platelet count) were the presenting features. Commonest form ofbleeding manifestation was subconjunctival haemorrhage. Bleeding manifestationhad a significant association with the degree of thrombocytopenia but no corelationwas observed with tourniquet test positivity.Key words: Dengue fever (DF); dengue haemorrhagic fever (DHF); paediatric.DOI: 10.3329/bjch.v33i2.5678Bangladesh Journal of Child Health 2009; Vol.33(2): 55-58

scholarly journals Polypharmacy Increases Risk of Dyspnea Among Adults With Serious, Life-Limiting Diseases

2019 ◽  
Vol 37 (4) ◽  
pp. 278-285 ◽  
Author(s):  
Kathleen M. Akgün ◽  
Supriya Krishnan ◽  
Shelli L. Feder ◽  
Janet Tate ◽  
Jean S. Kutner ◽  
...  
Keyword(s):  
Symptom Assessment ◽  
Assessment System ◽  
Advanced Illness ◽  
Cross Sectional ◽  
Chronic Medication ◽  
Parallel Group ◽  
Increased Risk ◽  
Dyspnea Score ◽  
The Mean ◽  
Using Data

Background: Polypharmacy is associated with dyspnea in cross-sectional studies, but associations have not been determined in longitudinal analyses. Statins are commonly prescribed but their contribution to dyspnea is unknown. We determined whether polypharmacy was associated with dyspnea trajectory over time in adults with advanced illness enrolled in a statin discontinuation trial, overall, and in models stratified by statin discontinuation. Methods: Using data from a parallel-group unblinded pragmatic clinical trial (patients on statins ≥3 months with life expectancy of 1 month to 1 year, enrolled in the parent study between June 3, 2011, and May 2, 2013, n = 308/381 [81%]), we restricted analyses to patients with available baseline medication count and ≥1 dyspnea score. Polypharmacy was assessed by self-reported chronic medication count. Dyspnea trajectory group, our primary outcome, was determined over 24 weeks using the Edmonton Symptom Assessment System. Results: The mean age of the patients was 73.8 years (standard deviation [SD]: ±11.0) and the mean medication count was 11.6 (SD: ±5.0). We identified 3 dyspnea trajectory groups: none (n = 108), mild (n = 130), and moderate–severe (n = 70). Statins were discontinued in 51.8%, 48.5%, and 42.9% of patients, respectively. In multivariable models adjusting for age, sex, diagnosis, and statin discontinuation, each additional medication was associated with 8% (odds ratio [OR] = 1.08 [1.01-1.14]) and 16% (OR = 1.16 [1.08-1.25]) increased risk for mild and moderate–severe dyspnea, respectively. In stratified models, polypharmacy was associated with dyspnea in the statin continuation group only (mild OR = 1.12 [1.01-1.24], moderate–severe OR = 1.24 [1.11-1.39]) versus statin discontinuation (mild OR = 1.03 [0.95-1.12], and moderate–severe OR = 1.09 [0.98-1.22]). Conclusion: Polypharmacy was strongly associated with dyspnea. Prospective interventions to decrease polypharmacy may impact dyspnea symptoms, especially for statins.

scholarly journals Étude Des Aspects Épidémiologiques Du Choléra Dans Le District De Santé De Tcholliré (Nord- Cameroun)

2016 ◽  
Vol 12 (15) ◽  
pp. 278
Author(s):  
Justin Ndié ◽  
Isaac Bayoro ◽  
Isidore Takoukam ◽  
Paul Wina
Keyword(s):  
Sex Ratio ◽  
Diarrheal Disease ◽  
Cross Sectional Study ◽  
Health District ◽  
Ringer Lactate ◽  
Cross Sectional ◽  
Epidemiologic Surveillance ◽  
Timely Response ◽  
The Mean ◽  
Using Data

Cholera evolves in an endemo-epidemic mode in developing countries. In Cameroon, because of the weakness of our health system, mainly of the epidemiologic surveillance and inadequate timely response, many localities in our country are faced with intermittent cholera epidemics. This study was aimed at analyzing the epidemiological aspects of cholera in the Tcholliré Health District (North Region-Cameroon) in 2011. We therefore applied a retrospective cross-sectional study using data on cholera cases registered within the 27th and the 40th epidemiological weeks in the Tcholliré Health District in 2011. All patients infected with cholera were included. The demographic, clinical and therapeutic variables, as well as the origin and the evolution of cases were drawn from the cholera data base of the Tcholliré Health District. Data analysis was done using SPSS and Excel software. Between the 27th and 40th epidemiological weeks, 334 cases of cholera were notified in the Tcholliré Health District. The sex ratio was 1.27 (187M/147W), the men were most infected (56%). The mean age was 28±17 years, youths aged 16 to 34 were the age group that were most affected with 42.20%. The number of cases varied significantly based on the sex ratio and the health area (p = 0.012). The rate of relapse was 0.61 % and the mortality rate was 1.2%. All the patients had watery stools and vomiting. In addition, all patients were treated primarily with intravenous normal saline at 0.9% or Ringer Lactate and ORS for oral therapy. The antibiotic used was Doxycycline 100 mg. Cholera remains a diarrheal disease that threatens all regions in Cameroon. It comes about as a result of a deficiency in individual and collective hygienic practices, and a passive epidemiologic monitoring. Nevertheless, the institution of a monitoring system and also effective combat methods will significantly reduce the recurrence of cholera epidemics.

scholarly journals Faktor-Faktor yang Berhubungan dengan Upaya Pencegahan Demam Berdarah Dengue (DBD) Menggunakan Prinsip Menguras, Menutup, dan Memanfaatkan Kembali (3M)

2020 ◽  
Vol 3 (2) ◽  
Author(s):  
Dian Emilia Sari
Keyword(s):  
Aedes Aegypti ◽  
Dengue Haemorrhagic Fever ◽  
P Value ◽  
Haemorrhagic Fever ◽  
Chi Square ◽  
Cross Sectional

Dengue Haemorrhagic Fever (DHF) atau Demam Berdarah Dengue adalah penyakit menular yang disebabkan oleh virus dengue yang ditularkan melalui gigitan nyamuk Aedes Aegypti. Keluarga dapat berperan secara aktif dalam melakukan gerakan PSN dengan cara 3M Plus, yaitu menguras, menutup dan memanfaatkan kembali. Penilitian ini bertujuan untuk diketahuinya faktor-faktor yang berhubungan dengan upaya pencegahan DBD di Puskesmas 4 Ulu Palembang Tahun 2019. Penelitian ini menggunakan desain kuantitatif dengan pendekatan cross sectional. Sampel dalam penelitian ini adalah  pengunjung Puskesmas berjumlah 56 orang yang dipilih  menggunakan tekhnik accidental sampling. Pengumpulan data menggunakan  kuesioner. Analisis hubungan dengan menggunakan uji Chi Square (α = 0.05). Penelitian ini dilaksanakan pada tanggal 1-5 Juli 2019. Hasil analisis didapatkan nilai  pengetahuan (p value = 0.006); sikap (p value = 0.000); tingkat pendidikan (p value = 0.000). Disimpulkan adanya hubungan antara pengetahuan,sikap, dan tingkat pendidikan dengan upaya pencegahan DBD. Diharapkan terhadap masyarakat agar lebih aktif lagi bertindak dalam pencegahan DBD, seperti melakukan gerakan pemberantasan sarang nyamuk 3M Plus.

scholarly journals AO EXTERNAL FIXATOR

2016 ◽  
Vol 23 (03) ◽  
pp. 279-283
Author(s):  
Ashfaque Hussain Mirjat ◽  
Irshad Ahmed Bhutto ◽  
Shakeel Ahmed Memon
Keyword(s):  
External Fixator ◽  
Inclusion Criteria ◽  
Diabetic Mellitus ◽  
Surgical Time ◽  
Cross Sectional ◽  
Effective Administration ◽  
Diaphyseal Fractures ◽  
Grade Ii ◽  
The Mean ◽  
Motorcycle Accidents

Objectives: To appraise effectiveness of AO external fixator, a treatment methodfor open diaphseal tibial fractures (type II, IIIA). Methods: Study Design: Cross sectional study.Setting: Department of Orthopedic Surgery and Traumatology (DOST) Liaquat University ofMedical & Health Sciences Jamshoro. Period: Two year from 2009 to 2011. Total 40 cases ofopen tibia fracture had selected all the cases with fresh open diaphyseal fractures of tibia andpatient arriving within one week injury. And Grade II, IIIA had included. All the cases associatedwith head injury or abdominal injury, diabetic mellitus and liver or kidney disease had excluded.Results: Total 40 cases of open diaphyseal fracture of tibia were selected in this study basedon inclusion criteria. The mean age was 33.1 + 10.27 years. Out of 40 cases, 36(90.0%) weremale. Majority of patients of RTA were injured due to motorcycle accidents 24(60.0%). Mean ofunion time was 18.1 + 3.72 weeks. Wound became infected in 5(12.5%) cases, 5.0%, n = 40)were seen with late union, screw sites infection found in 5.0% cases, Knee stiffness was foundin 10.0% cases, six 15.0% patients developed pain during walking. Conclusion: AO fixationis very safe, insignificant intrusive, get short surgical time, following by hospital duration, lowinfection rate and can be utilized as unequivocal and effective administration of open tibialfractures.

scholarly journals The Magnitude of Hepatic Transaminase Rise and Its Correlation with the Severity of Dengue Fever

2016 ◽  
Vol 5 (2) ◽  
pp. 74-77
Author(s):  
Farhana Afroz ◽  
Hasna Fahmima Haque ◽  
Samira Rahat Afroze ◽  
Muhammad Abdur Rahim ◽  
Jamal Uddin Ahmed ◽  
...  
Keyword(s):  
Dengue Fever ◽  
Serum Bilirubin ◽  
Haemorrhagic Fever ◽  
Hepatic Enzyme ◽  
Hepatic Enzymes ◽  
Hepatic Involvement ◽  
Hepatic Transaminase ◽  
Grade Ii ◽  
The Mean ◽  
Grade Iii

Background and Objective: Biochemical evidence of hepatic enzyme rise is very common in dengue fever. This study was designed to see the levels of elevated hepatic enzymes and their correlation with severity of dengue fever (DF).\Materials and Methods: It was an observational study conducted in the Department of Internal Medicine of BIRDEM Hospital, Dhaka, over a period of six months (July to December, 2010). Fifty serologically confirmed (IgM/IgM and IgG) dengue fever patients were included in the study.Results: Of the 50 patients, 32 (64%) were male and 18 (36%) were female. The mean age was 44.2 (21-54) years. Out of 50 cases, 23 (46%) cases had classical dengue fever, 20 (40%) had dengue haemorrhagic fever (DHF) Grade I, 6 (12%) had DHF Grade II and 1 (2%) had DHF Grade III. Hepatic enzymes were raised in 47 (94%) cases. Mean aspartate aminotransferase (AST) was 98.77 U/L, mean alanine aminotransferase (ALT) was 88.09 U/L. In 46 (92%) cases AST was more than ALT. Enzyme rise was more in DHF (Grade III- mean AST 298 U/L, mean ALT 232 U/L, Grade II- mean AST 212.6 U/L, mean ALT 198.7 U/L, Grade I- mean AST 97.3 U/ L, mean ALT 86.2 U/L) than classical dengue fever (mean AST 61.7 U/L, mean ALT 54.9 U/L). Mean bilirubin was 1.82 mg/dl. No difference was observed between classical dengue fever and DHF regarding serum bilirubin level.Conclusion: The above results suggest that hepatic involvement in dengue fever is common and the amplitude of transaminase rise indicates the severity of the disease.Birdem Med J 2015; 5(2): 74-77

Syringomyelia Resolution Following Chiari Surgery: A Novel Scale for Communication and Research

Neurosurgery ◽  
2020 ◽  
Vol 88 (1) ◽  
pp. E60-E66
Author(s):  
Jacques Lara-Reyna ◽  
John Chae ◽  
Umberto Tosi ◽  
Mark M Souweidane ◽  
Rafael Uribe-Cardenas ◽  
...  
Keyword(s):  
Chiari Malformation ◽  
Cross Sectional Area ◽  
Percentage Change ◽  
Grading System ◽  
Sectional Area ◽  
Cross Sectional ◽  
Size Grade ◽  
Grade Ii ◽  
The Mean ◽  
Grade Iii

Abstract BACKGROUND The pathophysiological connection between Chiari malformation and syringomyelia is accepted. Debate remains, however, how can we best define changes in syringomyelia following surgery. OBJECTIVE To introduce a grading system focusing on syrinx reduction based on routinely and reproducible radiological information, and provide a suggestion of the application of this scale for prediction of patient's prognoses. METHODS Data from 48 patients with Chiari malformation and syringomyelia were compiled. We calculated syrinx cross-sectional area by approximating an ellipse in the largest axial plane. We compared the percentage of reduction or enlargement following surgery. The percentage change was grouped into four grades: Grade 0 = Increasing size, grade I ≤ 50% reduction, grade II = 50% to 90% reduction, grade III ≥ 90% reduction. RESULTS A total of 89.6% of patients had syrinx improvement after surgery. A total of 5 patients were grade 0, 14 were grade I, 20 patients were grade II, and 9 patients met criteria for grade III. The mean postoperative syrinx area was 24.1 mm2 (0-169 mm2) with a mean syrinx reduction of 62.7%. CONCLUSION Radiological improvement of syringomyelia can be mathematically defined and standardized to assist in communication in outcome-based trials. Radiological resolution is expected most patients.

ANGKA BANDING ALBUMIN KREATININ AIR KEMIH DAN HbA1C SERTA ESTIMASI LAJU FILTRASI GLOMERULUS PADA PASIEN DIABETES MELITUS TIPE 2

2016 ◽  
Vol 21 (3) ◽  
pp. 250
Author(s):  
Amiroh Kurniati ◽  
Tahono Tahono
Keyword(s):  
Glycemic Control ◽  
Clinical Pathology ◽  
Poor Glycemic Control ◽  
Control Group ◽  
Pathology Laboratory ◽  
Cross Sectional ◽  
Chronic Hyperglycemia ◽  
Type 2 Dm ◽  
Spearman Correlation Test

Diabetes Mellitus (DM) type 2 is a metabolic disease that prevalence increasing. A chronic hyperglycemia with poor glycemic control can stimulate oxidative stress, which will continue to occurrence of complications in the kidneys characterized by the presenceof microalbuminuria can be measured by the ratio of urinary albumin creatinine ratio (UACR) and the change in estimated glomerular filtration rate (eGFR). The aims of this study was to know the correlation between the UACR with HbA1c value and eGFR in patients with type 2 DM by finding them out. This study used cross sectional research design. Subjects were patients with type 2 DM who attend control in Endocrinology Subdivision of Internal Medicine Departement and perform blood and urine tests in Clinical Pathology Laboratory in Dr. Moewardi Hospital Surakarta in August 2013. To determine the pattern of the data distribution, the researchers used KolmogorovSmirnov test, and to analyse the result used Spearman (r) correlation with p<0.05 and confidence interval 95%. Statistical analysis using Spearman correlation test (r), significant when p<0.05 with 95% confidence intervals. From 68 samples examined the mean age is 60.9 year old, with equal participants for male and female (34 subjects each). Most subjects were in poor glycemic control group (72.1%) and in the range of microalbuminuria (44.1%). There was a significant correlation between UACR with HbA1c and eGFR in type 2 DM patient (r=0.412, p=0.000; and r= -0.270, p=0.02, respectively). Based on this study it can be concluded that increased UACR were associated with worsened glycemic control and were characterized by higher levels of HbA1c and its eGFR value would be lower. Further analysis requires further research with a larger sample size and more attention to the factors that may affect the related examination

Determining the Accuracy of the Mandibular Canal Region in 3D Biomodels Fabricated from CBCT Scanned Data: A Cadaveric Study

2019 ◽  
Vol 15 (7) ◽  
pp. 645-653 ◽  
Author(s):  
Syed Yusoff Alzawawi Syed Abd Fattah ◽  
Firdaus Hariri ◽  
Phrabhakaran Nambiar ◽  
Zulkiflee Abu Bakar ◽  
Zainal Ariff Abdul Rahman
Keyword(s):  
Computed Tomography ◽  
Gold Standard ◽  
Mandibular Canal ◽  
Mean Value ◽  
Cone Beam ◽  
Cross Sectional ◽  
Measurement Protocol ◽  
Significant Difference ◽  
The Mean ◽  
Using Data

Objective:To validate the accuracy of the mandibular canal region in 3D biomodel produced by using data obtained from Cone-Beam Computed Tomography (CBCT) of cadaveric mandibles.Methods:Six hemi-mandible samples were scanned using the i-CAT CBCT system. The scanned data was transferred to the OsiriX software for measurement protocol and subsequently into Mimics software to fabricate customized cutting jigs and 3D biomodels based on rapid prototyping technology. The hemi-mandibles were segmented into 5 dentoalveolar blocks using the customized jigs. Digital calliper was used to measure six distances surrounding the mandibular canal on each section. The same distances were measured on the corresponding cross-sectional OsiriX images and the 3D biomodels of each dentoalveolar block.Results:Statistically no significant difference was found when measurements from OsiriX images and 3D biomodels were compared to the “gold standard” -direct digital calliper measurement of the cadaveric dentoalveolar blocks. Moreover, the mean value difference of the various measurements between the different study components was also minimal.Conclusion:Various distances surrounding the mandibular canal from 3D biomodels produced from the CBCT scanned data was similar to that of direct digital calliper measurements of the cadaveric specimens.

Role of C- reactive proteins and liver function tests in assessing the severity of dengue fever

2020 ◽  
pp. 1-17
Author(s):  
Akash Khetpal ◽  
Ansab Godil ◽  
Muhammad Tanveer Alam ◽  
Inam ul Haq Muhammad Makhdoom ◽  
Arsalan Majeed Adam ◽  
...  
Keyword(s):  
Liver Function ◽  
Dengue Fever ◽  
Dengue Shock Syndrome ◽  
Liver Function Tests ◽  
Dengue Haemorrhagic Fever ◽  
Severe Dengue ◽  
Haemorrhagic Fever ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Function Tests

Abstract Objective: To determine whether C-reactive protein and liver function tests can serve as severity markers for dengue fever. Methods: The cross-sectional study was conducted in 2015-16 in Karachi and comprised patients with dengue fever visiting a tertiary care hospital. World Health Organisation classifications 1997 and 2009 were used to categorise patients according to clinical signs and symptoms. Receiver Operating Characteristics curve was used to determine discriminative ability and optimum cut-off value of biochemical markers. Comparisons were done through one-way analysis of variance using SPSS 17. Results: Of the 218 patients, 133(61%) were males and 85(39%) were females. The overall mean age was 35.07+15.96 years. Levels of C-reactive protein and total bilirubin were significantly higher for dengue haemorrhagic fever compared to dengue fever; dengue shock syndrome compared to dengue fever; dengue shock syndrome compared to dengue haemorrhagic fever; and dengue shock syndrome compared to dengue fever / dengue haemorrhagic fever (p<0.05 each). Levels of alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase were significantly higher for dengue shock syndrome compared to dengue fever; dengue shock syndrome compared to dengue haemorrhagic fever; and dengue shock syndrome compared to dengue fever / dengue haemorrhagic fever (p<0.05 each). Levels of C-reactive protein, total bilirubin, alanine aminotransferase and alkaline phosphatise in patients with severe dengue were significantly higher compared to non-severe dengue. Conclusion: C-reactive protein and liver function tests were found to be effective biochemical markers in assessing dengue fever severity.

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