scholarly journals Characterization of Inclusion Complexes between Miconazole and Different Cyclodextrin Derivatives

2018 ◽  
Vol 64 (2) ◽  
pp. 70-76 ◽  
Author(s):  
Hajnal Kelemen ◽  
Gabriel Hancu ◽  
Serban Andrei Gâz-Florea ◽  
Eniko Nemes-Nagy ◽  
Lajos Attila Papp ◽  
...  
Keyword(s):  
Inclusion Complexes ◽  
Binary Systems ◽  
Solid Phase ◽  
Pharmaceutical Formulations ◽  
Local Drug Delivery ◽  
Scanning Calorimetry ◽  
Major Drawback ◽  
Molar Ratios ◽  
Ft Ir

Abstract Objective: Miconazole, an imidazole antifungal derivative, is a very hydrophobic compound, a major drawback in obtaining topical pharmaceutical formulations with optimal bioavailability. Cyclodextrins (CDs) may increase local drug delivery by enhancing the drug release and/or permeation. The aim of the study is the characterization of inclusion complexes between miconazole and different CD derivatives. Methods: Several CD derivatives were tested in the experiments. The binary systems between miconazole and different CDs were prepared in 1:1 molar ratios by physical-mixture and kneading methods. Differential scanning calorimetry (DSC) and Fourier transformed-infrared spectroscopy (FT-IR) methods were used to characterize solid state interactions between miconazole and CDs in their binary systems. Results: The FT-IR analysis suggests the formation of a new solid phase, indicating a molecular interaction between the components. The DSC analysis sustains the hypothesis of formation of partial inclusion complexes between miconazole nitrate and CD. Conclusion: The thermic behaviour of the complexes depends both on the preparation method and the composition of the products.

scholarly journals Characterization of Inclusion Complexes Between Fluconazol and Different Cyclodextrin Derivatives

2019 ◽  
Vol 70 (8) ◽  
pp. 2737-2741
Author(s):  
Hajnal Kelemen ◽  
Gabriel Hancu ◽  
Bernadette Mentes ◽  
Ibolya Fulop ◽  
Melania Carcu Dobrin ◽  
...  
Keyword(s):  
Inclusion Complexes ◽  
Binary Systems ◽  
Solid Phase ◽  
Cyclodextrin Derivatives ◽  
Scanning Calorimetry ◽  
Molar Ratios ◽  
Fourier Transformed Infrared Spectroscopy ◽  
Kneading Method ◽  
Ft Ir

The aim of this study is to confirm the formation of inclusion complexes between fluconazoleand different cyclodextrin derivatives. Fluconazole is slightly soluble in water, but its solubility can be further increased by complexation with cyclodextrins. The binary systems between fluconazole and cyclodextrins were prepared in 1:1 molar ratios by physical-mixture method and kneading method. Differential scanning calorimetry (DSC), Fourier transformed-infrared spectroscopy (FT-IR) and molecular modeling methods were used to characterize solid state interactions between fluconazole and cyclodextrins in their binary systems. The analysis suggest the formation of a new solid phase, indicating a molecular interaction between the components. All binary systems showed superior dissolution profiles compared to pure fluconazole.

scholarly journals CHARACTERISATION OF INCLUSION COMPLEXES BETWEEN BIFONAZOLE AND DIFFERENT CYCLODEXTRINS IN SOLID AND SOLUTION STATE

2017 ◽  
Vol 36 (1) ◽  
pp. 81 ◽  
Author(s):  
Hajnal Kelemen ◽  
Angella Csillag ◽  
Gabriel Hancu ◽  
Blanka Székely-Szentmiklósi ◽  
Ibolya Fülöp ◽  
...  
Keyword(s):  
Inclusion Complexes ◽  
Binary Systems ◽  
Pharmaceutical Formulations ◽  
2D Nmr ◽  
Local Drug Delivery ◽  
Stable Complex ◽  
Resonance Spectroscopy ◽  
Scanning Calorimetry ◽  
2D Nmr Spectroscopy ◽  
Major Drawback

The aim of this study is to confirm the formation of inclusion complexes between bifonazole (BFZ) and different cyclodextrin (CD) derivatives. Bifonazole, an imidazole antifungal derivative,is a very hydrophobic compound, which is a major drawback in obtaining topical pharmaceutical formulations with optimal bioavailability. Cyclodextrins may increase local drug delivery by enhancing the drug release and/or permeation. The binary systems between bifonazole and cyclodextrins were prepared in two molar ratios by physical-mixture methods.The physicochemical properties of these complexes were studied by differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR) and nuclear magnetic resonance spectroscopy (NMR) methods. Results showed favourable molecular interaction between the components, in solid state and in solution. 1H NMR -CD titrations and molecular modelling study showed that the most stable complex was obtained when using γ-CD. The Job’s method and 2D NMR spectroscopy sustain the 2:1 stoichiometry of the BFZ:γ-CD complex.

Studies on the Preparation, Characterization and Solubility of -Cyclodextrin-Roxythromycin Inclusion Complexes

2009 ◽  
Vol 2 (2) ◽  
pp. 523-530
Author(s):  
D. Nagasamy Venkatesh ◽  
S. Karthick ◽  
M. Umesh ◽  
G. Vivek ◽  
R.M. Valliappan ◽  
...  
Keyword(s):  
Dissolution Rate ◽  
Inclusion Complexes ◽  
Phase Solubility ◽  
X Ray Diffraction ◽  
Scanning Calorimetry ◽  
X Ray ◽  
Ir Studies ◽  
Poorly Soluble ◽  
Poorly Soluble Drug

Roxythromycin/ β-cyclodextrin (Roxy/ β-CD) dispersions were prepared with a view to study the influence of β-CD on the solubility and dissolution rate of this poorly soluble drug. Phase-solubility profile indicated that the solubility of roxythromycin was significantly increased in the presence of β-cyclodextrin and was classified as AL-type, indicating the 1:1 stoichiometric inclusion complexes. Physical characterization of the prepared systems was carried out by differential scanning calorimetry (DSC), X-ray diffraction studies (XRD) and IR studies. Solid state characterization of the drug β-CD binary system using XRD, FTIR and DSC revealed distinct loss of drug crystallinity in the formulation, ostensibly accounting for enhancement of dissolution rate.

Thermal Behaviour of Candesartan Active substance and in pharmaceutical compounds

2017 ◽  
Vol 68 (8) ◽  
pp. 1895-1902
Author(s):  
Ioana Cristina Tita ◽  
Eleonora Marian ◽  
Bogdan Tita ◽  
Claudia Crina Toma ◽  
Laura Vicas
Keyword(s):  
Thermal Behaviour ◽  
Active Substance ◽  
Pharmaceutical Research ◽  
Pharmaceutical Product ◽  
Nitrogen Atmosphere ◽  
Pure Substance ◽  
Scanning Calorimetry ◽  
X Ray ◽  
Ft Ir

Thermal analysis is one of the most frequently used instrumental techniques in the pharmaceutical research, for the thermal characterization of different materials from solids to semi-solids, which are of pharmaceutical relevance. In this paper, simultaneous thermogravimetry/derivative thermogravimetry (TG/DTG) and differential scanning calorimetry (DSC) were used for characterization of the thermal behaviour of candesartan cilexetil � active substance (C-AS) under dynamic nitrogen atmosphere and nonisothermal conditions, in comparison with pharmaceutical product containing the corresponding active substance. It was observed that the commercial samples showed a different thermal profile than the standard sample, caused by the presence of excipients in the pharmaceutical product and to possible interaction of these with the active substance. The Fourier transformed infrared spectroscopy (FT-IR) and X-ray powder diffraction (XRPD) were used as complementary techniques adequately implement and assist in interpretation of the thermal results. The main conclusion of this comparative study was that the TG/DTG and DSC curves, together with the FT-IR spectra, respectively X-ray difractograms constitute believe data for the discrimination between the pure substance and pharmaceutical forms.

scholarly journals THE PHYSICOCHEMICAL CHARACTERISTICS OF RECYCLED-PLASTIC PELLETS OBTAINED FROM DISPOSABLE FACE MASK WASTES

2021 ◽  
Vol 23 (1) ◽  
pp. 16
Author(s):  
Vienna Saraswaty ◽  
Rossy Choerun Nissa ◽  
Bonita Firdiana ◽  
Akbar Hanif Dawam Abdullah
Keyword(s):  
Tensile Strength ◽  
Physicochemical Characterization ◽  
Face Mask ◽  
Physicochemical Characteristics ◽  
Scanning Calorimetry ◽  
Elongation At Break ◽  
Ft Ir ◽  
The Government ◽  
Plastic Pellets

THE PHYSICOCHEMICAL CHARACTERISTICS OF RECYCLED-PLASTIC PELLETS OBTAINED FROM DISPOSABLE FACE MASK WASTES. The government policy to wear a face mask during the COVID-19 pandemic has increased disposable face mask wastes. Thus, to reduce such wastes, it is necessary to evaluate the physicochemical characteristics of disposable face masks wastes before the recycling process and the recycled products. In this study, physicochemical characterization of the 3-ply disposable face masks and the recycled plastic pellets after disinfection using 0.5% v/v sodium hypochlorite were evaluated. A set of parameters including the characterization of surface morphology by a scanning electron microscope (SEM), functional groups properties by a fourier transform infra-red spectroscopy (FT-IR), thermal behavior by a differential scanning calorimetry (DSC), tensile strength and elongation at break were evaluated. The surface morphological of each layer 3-ply disposable face mask showed that the layers were composed of non-woven fibers. The FT-IR evaluation revealed that 3-ply disposable face mask was made from a polypropylene. At the same time, the DSC analysis found that the polypropylene was in the form of homopolymer. The SEM analysis showed that the recycled plastic pellets showed a rough and uneven surface. The FT-IR, tensile strength and elongation at break of the recycled plastic pellets showed similarity with a virgin PP type CP442XP and a recycled PP from secondary recycling PP (COPLAST COMPANY). In summary, recycling 3-ply disposable face mask wastes to become plastic pellets is recommended for handling disposable face mask wastes problem.

Preparation and characterization of oxidized starch-graft-poly(styrene-butyl acrylate) latex via emulsion polymerization

2014 ◽  
Vol 34 (7) ◽  
pp. 611-616 ◽  
Author(s):  
Shijie Cheng ◽  
Jun Xu ◽  
Yumin Wu
Keyword(s):  
Emulsion Polymerization ◽  
Butyl Acrylate ◽  
Colloidal Stability ◽  
Graft Copolymerization ◽  
Scanning Calorimetry ◽  
Oxidized Starch ◽  
Ir Transmission ◽  
Ft Ir ◽  
Synthetic Latex

Abstract Oxidized starch-graft-poly(styrene-butyl acrylate) [OS-g-P(St-BA)] latex was synthesized by the graft copolymerization of OS with St and n-butyl acrylate (BA) via emulsion polymerization. The graft copolymers were characterized by Fourier transform infrared (FT-IR), transmission electronic microscopy (TEM), dynamic light scattering, thermogravimetry (TG), and differential scanning calorimetry (DSC). The effects of the amount of OS, monomers, and initiator on graft copolymerization were investigated. Under the optimal conditions, the percentage of graft (PG), grafting efficiency (GE), and ζ potential could reach 256.5%, 41.7%, and -30.1 mV, respectively. The results indicated that the OS grafted onto particles greatly enhanced the colloidal stability of latex. The thermal stability properties of OS-g-P(St-BA) were also improved by the addition of OS. The OS-g-P(St-BA) latex may be used to partly replace the conventional synthetic latex for paper coating.

scholarly journals Formulation and Characterization of Aceclofenac-Loaded Nanofiber Based Orally Dissolving Webs

Pharmaceutics ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 417 ◽  
Author(s):  
Emese Sipos ◽  
Nóra Kósa ◽  
Adrienn Kazsoki ◽  
Zoltán-István Szabó ◽  
Romána Zelkó
Keyword(s):  
Oral Absorption ◽  
Vinyl Pyrrolidone ◽  
Drug Dissolution ◽  
In Vitro Dissolution ◽  
Drug Release Profile ◽  
Scanning Calorimetry ◽  
Ft Ir ◽  
Fast Dissolution ◽  
Poly Vinyl Pyrrolidone

Aceclofenac-loaded poly(vinyl-pyrrolidone)-based nanofiber formulations were prepared by electrospinning to obtain drug-loaded orally disintegrating webs to enhance the solubility and dissolution rate of the poorly soluble anti-inflammatory active that belongs to the BCS Class-II. Triethanolamine-containing ternary composite of aceclofenac-poly(vinyl-pyrrolidone) nanofibers were formulated to exert the synergistic effect on the drug-dissolution improvement. The composition and the electrospinning parameters were changed to select the fibrous sample of optimum fiber characteristics. To determine the morphology of the nanofibers, scanning electron microscopy was used. Fourier transform infrared spectroscopy (FT-IR), and differential scanning calorimetry (DSC) were applied for the solid-state characterization of the samples, while the drug release profile was followed by the in vitro dissolution test. The nanofibrous formulations had diameters in the range of few hundred nanometers. FT-IR spectra and DSC thermograms indicated the amorphization of aceclofenac, which resulted in a rapid release of the active substance. The characteristics of the selected ternary fiber composition (10 mg/g aceclofenac, 1% w/w triethanolamine, 15% w/w PVPK90) were found to be suitable for obtaining orally dissolving webs of fast dissolution and potential oral absorption.

Study on the Synthesis and Characterization of PANi/Nano-CeO2 Composites

2007 ◽  
Vol 124-126 ◽  
pp. 287-290 ◽  
Author(s):  
Fei Liu ◽  
Yong Jun He ◽  
Jeung Soo Huh
Keyword(s):  
In Situ Polymerization ◽  
Solid Phase ◽  
Polymerization Reaction ◽  
Solid Phase Reaction ◽  
Phase Reaction ◽  
Vis Spectroscopy ◽  
Ft Ir ◽  
Average Size

The nano-CeO2 was synthesized by two-step solid-phase reaction. The image of TEM showed that nano-CeO2 with an average size of about 70 nm. The series of polyaniline/nano-CeO2 composites with different PANi: CeO2 ratios were prepared by in-situ polymerization in the presence of hydrochloric acid (HCl) as dopant by adding nano-CeO2 into the polymerization reaction mixture of aniline. The composites obtained were characterized by FT-IR and UV-vis spectroscopy analysis. The FT-IR spectra of nanocomposites indicate different blue-shifts, attributed to C–N stretching mode for benzenoid unit. The UV-vis spectra of nanocomposites display einstein-shifts compared with PANi at 620nm. The conductivity properties of the composites are also changed compare to the pure PANi. These results suggest that the interactions between the polymer matrix and nanoparticles take place in polyaniline/nano- CeO2 composites.

Synthesis and characterization of the solid uranium(VI) dioxo-diacetohydroxamate complex

2007 ◽  
Vol 95 (8) ◽  
Author(s):  
Cynthia-May S. Gong ◽  
Frédéric Poineau ◽  
Kenneth R. Czerwinski
Keyword(s):  
Solid Phase ◽  
Uranyl Acetate ◽  
Proton Nuclear Magnetic Resonance ◽  
Acetohydroxamic Acid ◽  
Acetate Dihydrate ◽  
Reaction Conditions ◽  
X Ray ◽  
Ft Ir ◽  
X Ray Absorption

A novel dry synthesis for the uranium(VI) dioxo-diacetohydroxamate (UAHA) complex has been developed. The complex was generated in >80% yield by mechanically grinding solid uranyl acetate dihydrate (UAc) with solid acetohydroxamic acid in stoichiometric amounts. The resulting UOThe UAHA solid was extensively characterized by ultraviolet-visible (UV-vis), Fourier-transform infrared (FT-IR), and extended X-ray absorption fine structure (EXAFS) spectroscopies. The compound did not fluoresce after laser excitation. Proton nuclear magnetic resonance (NMR) spectra were obtained of the complex in DThe easy synthesis and purification of UAHA enables researchers to strictly control reaction conditions; to eliminate interfering salts and water; and to study the complex in the solid-phase.

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