Purely Cutaneous Rosai-Dorfman Disease: a True Clinical Diagnosis Challenge

Abstract Rosai-Dorfman disease (RDD) is a rare idiopathic benign disease, self-limited non-Langerhans cell histiocytosis, most frequently presented as a massive bilateral and painless lymphadenopathy, associated with fever and weight loss. Extranodal manifestations of RDD represents a true diagnosis challenge for clinicians and surgical pathologists. A 64-year-old female, known with arterial hypertension and type 2 diabetes, presented to our Surgery Clinic for a left arm painless cutaneous tumour, having its onset one year before, and rapidly enlarged in the last two months. Physical examination revealed a firm and elastic cutaneous nodular lesion of 4 x 2 cm in size, prominent to the skin, with central ulceration area of 10 x 5 mm, located on the posterior side of the left arm. Surgery was performed, with lymphoma as a differential diagnosis at intraoperative extemporaneous examination. The RDD disease diagnosis was considered at histopathological analysis and confirmed by immunohistochemistry. Herein, we describe a rare case of purely cutaneous RDD presenting as unique cutaneous ulcerative nodular lesion, surgical treated only, and without local relapse after one-year follow-up.

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Cardiovascular risk factors associated with acute myocardial infarction and stroke in the MADIABETES cohort

Scientific Reports ◽

10.1038/s41598-021-94121-8 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

M. A. Salinero-Fort ◽

F. J. San Andrés-Rebollo ◽

J. Cárdenas-Valladolid ◽

M. Méndez-Bailón ◽

R. M. Chico-Moraleja ◽

...

Keyword(s):

Atrial Fibrillation ◽

Blood Pressure ◽

Antihypertensive Drugs ◽

Hdl Cholesterol ◽

First Year ◽

Backward Elimination ◽

One Year ◽

Time Varying Covariates

AbstractWe aimed to develop two models to estimate first AMI and stroke/TIA, respectively, in type 2 diabetes mellitus patients, by applying backward elimination to the following variables: age, sex, duration of diabetes, smoking, BMI, and use of antihyperglycemic drugs, statins, and aspirin. As time-varying covariates, we analyzed blood pressure, albuminuria, lipid profile, HbA1c, retinopathy, neuropathy, and atrial fibrillation (only in stroke/TIA model). Both models were stratified by antihypertensive drugs. We evaluated 2980 patients (52.8% women; 67.3 ± 11.2 years) with 24,159 person-years of follow-up. We recorded 114 cases of AMI and 185 cases of stroke/TIA. The factors that were independently associated with first AMI were age (≥ 75 years vs. < 75 years) (p = 0.019), higher HbA1c (> 64 mmol/mol vs. < 53 mmol/mol) (p = 0.003), HDL-cholesterol (0.90–1.81 mmol/L vs. < 0.90 mmol/L) (p = 0.002), and diastolic blood pressure (65–85 mmHg vs. < 65 mmHg) (p < 0.001). The factors that were independently associated with first stroke/TIA were age (≥ 75 years vs. < 60 years) (p < 0.001), atrial fibrillation (first year after the diagnosis vs. more than one year) (p = 0.001), glomerular filtration rate (per each 15 mL/min/1.73 m2 decrease) (p < 0.001), total cholesterol (3.88–6.46 mmol/L vs. < 3.88 mmol/L) (p < 0.001), triglycerides (per each increment of 1.13 mmol/L) (p = 0.031), albuminuria (p < 0.001), neuropathy (p = 0.01), and retinopathy (p = 0.023).

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Effects of laparoscopic gastric plication (LGP) in patients with type 2 diabetes, one year follow-up

Journal of Diabetes & Metabolic Disorders ◽

10.1186/s40200-015-0188-4 ◽

2015 ◽

Vol 14 (1) ◽

Cited By ~ 8

Author(s):

Mohammad Talebpour ◽

Atieh Talebpour ◽

Gilda Barzin ◽

Reza Shariat Moharari ◽

Mohammad Reza Khajavi

Keyword(s):

Type 2 Diabetes ◽

Gastric Plication ◽

Laparoscopic Gastric Plication ◽

One Year

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Can the Onset of Type 2 Diabetes Be Delayed by a Group-Based Lifestyle Intervention in Women with Prediabetes following Gestational Diabetes Mellitus (GDM)? Findings from a Randomized Control Mixed Methods Trial

Journal of Diabetes Research ◽

10.1155/2015/798460 ◽

2015 ◽

Vol 2015 ◽

pp. 1-11 ◽

Cited By ~ 6

Author(s):

Angela O’Dea ◽

Marie Tierney ◽

Brian E. McGuire ◽

John Newell ◽

Liam G. Glynn ◽

...

Keyword(s):

Type 2 Diabetes ◽

Mixed Methods ◽

Gestational Diabetes ◽

Lifestyle Intervention ◽

Intervention Group ◽

Outcome Variable ◽

Control Group ◽

One Year

Objective. To evaluate a 12-week group-based lifestyle intervention programme for women with prediabetes following gestational diabetes (GDM).Design. A two-group, mixed methods randomized controlled trial in which 50 women with a history of GDM and abnormal glucose tolerance postpartum were randomly assigned to intervention (n=24) or wait control (n=26) and postintervention qualitative interviews with participants.Main Outcome Measures. Modifiable biochemical, anthropometric, behavioural, and psychosocial risk factors associated with the development of type 2 diabetes. The primary outcome variable was the change in fasting plasma glucose (FPG) from study entry to one-year follow-up.Results. At one-year follow-up, the intervention group showed significant improvements over the wait control group on stress, diet self-efficacy, and quality of life. There was no evidence of an effect of the intervention on measures of biochemistry or anthropometry; the effect on one health behaviour, diet adherence, was close to significance.Conclusions. Prevention programmes must tackle the barriers to participation faced by this population; home-based interventions should be investigated. Strategies for promoting long-term health self-management need to be developed and tested.

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