scholarly journals Measurement of the dimensions of personality traits in patients addicted to psychoactive substances in context of relapses

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Krzysztof Chmielowiec ◽  
Agnieszka Boroń
Keyword(s):  
Personality Traits ◽  
High Intensity ◽  
Inpatient Treatment ◽  
Treatment Center ◽  
Moderate Intensity ◽  
Low Grade ◽  
Psychoactive Substances ◽  
Personality Dimension ◽  
Addiction Therapy ◽  
Therapy Center

Abstract Introduction: Recurrent use of psychoactive substances, including alcohol, affects most patients. It is an expression of the chronicity of the disease process. Understanding the causes of this phenomenon is the key to searching for effective therapeutic strategies for this disease. The aim: Analysis of individual dimensions of personality traits in patients in the context of relapses. Material and method: The research was carried out on a group of 301 people addicted to psychoactive substances staying in an addiction therapy center in Lubuskie and Zachodniopomorskie voivodships in Poland. The subjects were divided into two groups. The first group consisted of addicts with reported one-time therapy. The second group consisted of addicts who received at least two treatments at an addiction therapy center. The personality dimension was measured using the NEO-FFI questionnaire and the STAI questionnaire. Results: The following percentages of neuroticism (NF NEUR) were marked in people addicted to psychoactive substances with a single stay in an inpatient treatment center: 8.55% with low intensity, 40.13% with moderate intensity and 51.32% with high intensity. On the other hand, in people addicted to psychoactive substances with multiple stays in an inpatient treatment center, the features of low-grade neuroticism were found to be 6.85%, 25.34% of moderate and 67.81% of high intensity (χ2 = 8.643, p = 0.013). Conclusions: A higher score on the Nervousness Scale of the Neo FFI inventory has a significant impact on the course of addiction and the occurrence of relapses.

scholarly journals Association of DRD2 (rs 1799732), ANKK1 (rs1800497), DAT (rs28363170), DRD4 (exon 3 - VNTR) gene polymorphisms in the context of relapses in therapy.

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Jolanta Chmielowiec ◽  
Agnieszka Boroń
Keyword(s):  
Dopamine Receptor ◽  
Treatment Center ◽  
Control Group ◽  
Special Role ◽  
Psychoactive Substances ◽  
Vntr Polymorphism ◽  
Genotype Frequencies ◽  
Addiction Therapy ◽  
Pcr Method ◽  
Therapy Center

Abstract Introduction: Disorders in the field of reward system neurotransmission are mentioned as one of the most important causes of addiction. Genetic variation is assigned a special role. The literature on the subject mentions primarily the genes of dopamine neurotransmission: DAT (dopamine transporter), DRD2 (dopamine receptor D2), DRD4 (dopamine receptor D4). However, so far there are few literature reports on these genes in the context of innovators in addiction therapy. The aim: Analysis of the relationship between the variability of specific polymorphisms in the DRD2 (rs1799732), ANKK1 (rs1800497), DAT (rs28363170), DRD4 (exon 3 - VNTR) genes with the occurrence of relapses in people addicted to psychoactive substances. Material and methods: The research was carried out on a group of 301 people addicted to psychoactive substances staying in an addiction therapy center in Lubuskie and Zachodniopomorskie voivodships in Poland. The control group consisted of 301 people with no diagnosed addiction to psychoactive substances nor mental disorders. The study of polymorphisms DRD2 (rs 1799732), ANKK1 (rs1800497) was performed by real-time PCR method; whereas DAT (rs28363170), DRD4 (exon 3 - VNTR) was genotyped by PCR and the amplified products were visualized using ethidium bromide stained gel electrophoresis (3% agarose) and UV photography. Results: This study showed that in addicts genotype frequencies of the VNTR polymorphism in the third exon of human DRD4 were as follow: S/L in 33.55%, S/S - 63.12% and L/L 3.32%; while in the control group S/L - 32.56%, S/S - 58.8 % and L/L -8.6% (χ2 = 7.617, p = 0.022). Significant differences in the frequency of DRD2 gene polymorphism rs1799732 were observed (frequency of alleles; χ2 = 5.48, p = 0.0192) and DRD4 VNTR polymorphism (χ2 = 7.687, p = 0.021) between the addicted to psychoactive substances who have a one-time stay in an inpatient treatment center and the control group.

scholarly journals High intensity interval training (HIIT) as a viable alternative to induce the prevention of respiratory diseases: a point of view of exercise immunology during COVID-19 outbreak

2020 ◽  
Vol 9 (10) ◽  
pp. e7069109186
Author(s):  
Carolina Cavalcante de Paula ◽  
Sergio Machado ◽  
Gustavo De Conti Teixeira Costa ◽  
Marcelo Magalhães Sales ◽  
Thiago Gottgtroy Miranda ◽  
...  
Keyword(s):  
High Intensity ◽  
Lower Cost ◽  
Adaptive Immune System ◽  
Interval Training ◽  
Moderate Intensity ◽  
Low Grade ◽  
High Intensity Interval Training ◽  
Moderate Intensity Exercise ◽  
Cost Of Time ◽  
High Intensity Interval

The immune system's response against SARS-Cov-2 seems crucial to control viral infection, since this system is homeostatic, dynamic and promotes immunoprotection of the organism through the activation of the innate and adaptive immune system via activation of cellular and chemical complexes that recognize, neutralize, metabolize and eliminate heterologous substances, with or without tissue damage. An obesogenic microenvironment can further increase the risk of disease complications, and cause a more virulent viral strain and a more lethal virus. Moreover, physical inactivity as well as poor eating habits impairs the body's energy metabolism and immune cells due to low-grade chronic inflammation. Studies suggest that light to moderate exercise, as well as mild calorie restriction, as an effective approach to relieve obesity and therefore an interesting strategy to strengthen the immune response during the outbreak of COVID-19, while a vaccine is not developed. Some studies have been shown significant findings in favor of High intensity interval training (HIIT) protocols when compared to moderate intensity exercise, showing how immunological system responds to vigorous to high intensity training. However, HIIT has a lower cost of time, reducing the time/efficiency ratio, that is, a lower cost of time with similar or even better benefits to higher volume exercise programs. Let us not forget: "time is the most precious asset we have".

A Comparison of a Moderate with Moderate-high Intensity Oral Anticoagulant Treatment in Patients with Mechanical Heart Valve Prostheses

1997 ◽  
Vol 77 (05) ◽  
pp. 0839-0844 ◽  
Author(s):  
Vittorio Pengo ◽  
Fabio Barbero ◽  
Alberto Banzato ◽  
Elisabetta Garelli ◽  
Franco Noventa ◽  
...  
Keyword(s):  
Heart Valve ◽  
High Intensity ◽  
Oral Anticoagulant ◽  
Oral Anticoagulants ◽  
Mechanical Heart Valve ◽  
Moderate Intensity ◽  
Minor Bleeding ◽  
Anticoagulant Treatment ◽  
Oral Anticoagulant Treatment ◽  
Valve Prostheses

SummaryBackground. The long-term administration of oral anticoagulants to patients with mechanical heart valve prostheses is generally accepted. However, the appropriate intensity of oral anticoagulant treatment in these patients is still controversial.Methods and Results. From March 1991 to March 1994, patients referred to the Padova Thrombosis Center who had undergone mechanical heart valve substitution at least 6 months earlier were randomly assigned to receive oral anticoagulants at moderate intensity (target INR = 3) or moderate-high intensity (target INR = 4). Principal end points were major bleeding, thromboembolism and vascular death. Minor bleeding was a secondary end-point.A total of 104 patients were assigned to the target 3 group and 101 to the target 4 group; they were followed for from 1.5 years to up 4.5 years (mean, 3 years). Principal end-points occurred in 13 patients in the target 3 group (4 per 100 patient-years) and in 20 patients in the target 4 group (6.9 per 100 patient-years). Major hemorrhagic events occurred in 15 patients, 4 in the target 3 group (1.2 per 100 patient-years) and 11 in the target 4 group (3.8 per 100 patient-years) (p = 0.019). The 12 recorded episodes of thromboembolism, 4 of which consisted of a visual deficit, were all transient ischemic attacks, 6 in the target 3 group (1.8 per 100 patient-years) and 6 in the target 4 group (2.1 per 100 patient- years). There were 3 vascular deaths in each group (0.9 and 1 per 100 patient-years for target 3 and target 4 groups, respectively). Minor bleeding episodes occurred 85 times (26 per 100 patient-years) in the target 3 group and 123 times (43 per 100 patient-years) in the target 4 group (p = 0.001).Conclusions. Mechanical heart valve patients on anticoagulant treatment who had been operated on at least 6 months earlier experienced fewer bleeding complications when maintained on a moderate intensity regimen (target INR = 3) than those on a moderate-high intensity regimen (target INR = 4). The number of thromboembolic events and vascular deaths did not differ between the two groups.

Effects of High Intensity Statin Therapy in the Treatment of Diabetic Dyslipidemia in Patients with Coronary Artery Disease

2018 ◽  
Vol 24 (4) ◽  
pp. 427-441 ◽  
Author(s):  
Marija Vavlukis ◽  
Sasko Kedev
Keyword(s):  
Statin Therapy ◽  
High Intensity ◽  
Statistical Significance ◽  
Incident Diabetes ◽  
Moderate Intensity ◽  
Protective Effects ◽  
Pcsk9 Inhibitors ◽  
Diabetic Dyslipidemia ◽  
Patients With Diabetes

Background: Diabetic dyslipidemia has specifics that differ from dyslipidemia in patients without diabetes, which contributes to accelerated atherosclerosis equally as dysglycemia. The aim of this study was to deduce the interdependence of diabetic dyslipidemia and cardiovascular diseases (CVD), therapeutic strategies and the risk of diabetes development with statin therapy. Method: We conducted a literature review of English articles through PubMed, PubMed Central and Cochrane, on the role of diabetic dyslipidemia in atherosclerosis, the antilipemic treatment with statins, and the role of statin therapy in newly developed diabetes, by using key words: atherosclerosis, diabetes mellitus, diabetic dyslipidemia, CVD, statins, nicotinic acid, fibrates, PCSK9 inhibitors. Results: hyperglycemia and dyslipidemia cannot be treated separately in patients with diabetes. It seems that dyslipidemia plays one of the key roles in the development of atherosclerosis. High levels of TG, decreased levels of HDL-C and increased levels of small dense LDL- C particles in the systemic circulation are the most specific attributes of diabetic dyslipidemia, all of which originate from an inflated flux of free fatty acids occurring due to the preceding resistance to insulin, and exacerbated by elevated levels of inflammatory adipokines. Statins are a fundamental treatment for diabetic dyslipidemia, both for dyslipidemia and for CVD prevention. The use of statin treatment with high intensity is endorsed for all diabetes-and-CVD patients, while a moderate - intensity treatment can be applied to patients with diabetes, having additional risk factors for CVD. Statins alone are thought to possess a small, although of statistical significance, risk of incident diabetes, outweighed by their benefits. Conclusion: As important as hyperglycemia and glycoregulation are in CVD development in patients with diabetes, diabetic dyslipidemia plays an even more important role. Statins remain the cornerstone of antilipemic treatment in diabetic dyslipidemia, and their protective effects in CVD progression overcome the risk of statin- associated incident diabetes.

scholarly journals Effects of Caffeine and Acute Aerobic Exercise on Working Memory and Caffeine Withdrawal

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Anisa Morava ◽  
Matthew James Fagan ◽  
Harry Prapavessis
Keyword(s):  
Working Memory ◽  
Phase I ◽  
Aerobic Exercise ◽  
Acute Exercise ◽  
Withdrawal Symptoms ◽  
Moderate Intensity ◽  
Psychoactive Substances ◽  
Caffeine Withdrawal ◽  
Single Bout ◽  
Cognitive Benefits

AbstractStudies show that a single bout of exercise confers cognitive benefits. However, many individuals use psychoactive substances such as caffeine to enhance cognitive performance. The effects of acute exercise in comparison to caffeine on cognition remain unknown. Furthermore, caffeine use is associated with withdrawal symptoms upon cessation. Whether acute exercise can reduce withdrawal symptoms also remains unknown. The objectives of this study were to compare the effects of acute moderate intensity aerobic exercise to caffeine on working memory (WM) and caffeine withdrawal symptoms (CWS). In Phase I, non-caffeine (n = 29) and caffeine consumers (n = 30) completed a WM assessment, followed by acute exercise and caffeine. In Phase II, caffeine consumers (n = 25) from Phase I underwent the WM assessment and reported CWS following a 12-hour deprivation period. Acute moderate intensity aerobic exercise and caffeine (1.2 mg/kg) significantly improved WM accuracy and reduced CWS comparably. WM performance was not reduced following caffeine deprivation.

scholarly journals Should Heartbeats/Training Session Be Considered When Comparing the Cardiovascular Benefits of High-Intensity Interval Aerobic and Moderate-Intensity Continuous Training? A Critical Appraisal

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Jhennyfer Aline Lima Rodrigues ◽  
Stella Vieira Philbois ◽  
Tábata de Paula Facioli ◽  
Ada Clarice Gastaldi ◽  
Hugo Celso Dutra de Souza
Keyword(s):  
High Intensity ◽  
Critical Appraisal ◽  
Training Session ◽  
Moderate Intensity ◽  
Continuous Training ◽  
High Intensity Interval
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