scholarly journals On the Estimation of Permeabilities and Draw Resistances of Cigarette Components

2004 ◽  
Vol 21 (1) ◽  
pp. 25-31
Author(s):  
B Eitzinger
Keyword(s):  
Flow Velocity ◽  
Linear Model ◽  
Unique Solution ◽  
Condition Number ◽  
Noise Levels ◽  
Estimation Task ◽  
Experimental Conditions ◽  
Non Linear ◽  
High Bias ◽  
Cigarette Paper

AbstractThe goal of this study is to investigate whether the permeability of the tipping/plugwrap system, the permeability of the cigarette paper and the draw resistances of the filter and tobacco rod can be calculated from measurements of the degree of filter ventilation and of the open and closed draw resistance. This issue is investigated for a linear and a non-linear model of the flow in unlit cigarettes. At first it is proven that there exist experimental conditions to which the cigarette can be exposed such that the problem has at least a unique solution. The problem is then solved by least-squares optimisation for a linear and a non-linear model of the air flow in unlit cigarettes with various noise levels on the output quantities. The error sensitivity of the optimisation problem is estimated by calculation of the condition number.From the simulation several facts can be concluded. Firstly, for the linear model varying the flow velocity at the mouth end of the cigarette does not provide enough information to uniquely determine the properties of the cigarette's components. Secondly, estimates of these properties from the linear model have low standard deviations but a high bias, which makes the linear model useless for the estimation task. Thirdly, estimates from the non-linear model are more reliable if the pressure at the cigarette tip is varied instead of the flow velocity at the mouth end. Fourthly, the measurements of the degree of filter ventilation and of the open and closed draw resistance need to be at least 10 to 20 times more accurate than the desired accuracy of the estimate. Several methods to improve this situation are proposed.

scholarly journals AKT Inhibitors: The Road Ahead to Computational Modeling-Guided Discovery

2021 ◽  
Vol 22 (8) ◽  
pp. 3944
Author(s):  
Amit Kumar Halder ◽  
M. Natália D. S. Cordeiro
Keyword(s):  
Linear Model ◽  
Inhibitory Activity ◽  
Kinase Inhibitor ◽  
External Validation ◽  
Systematic Evaluation ◽  
Gradient Boosting ◽  
Experimental Conditions ◽  
Linear Discriminant ◽  
Non Linear ◽  
Qsar Models

AKT, is a serine/threonine protein kinase comprising three isoforms—namely: AKT1, AKT2 and AKT3, whose inhibitors have been recognized as promising therapeutic targets for various human disorders, especially cancer. In this work, we report a systematic evaluation of multi-target Quantitative Structure-Activity Relationship (mt-QSAR) models to probe AKT’ inhibitory activity, based on different feature selection algorithms and machine learning tools. The best predictive linear and non-linear mt-QSAR models were found by the genetic algorithm-based linear discriminant analysis (GA-LDA) and gradient boosting (Xgboost) techniques, respectively, using a dataset containing 5523 inhibitors of the AKT isoforms assayed under various experimental conditions. The linear model highlighted the key structural attributes responsible for higher inhibitory activity whereas the non-linear model displayed an overall accuracy higher than 90%. Both these predictive models, generated through internal and external validation methods, were then used for screening the Asinex kinase inhibitor library to identify the most potential virtual hits as pan-AKT inhibitors. The virtual hits identified were then filtered by stepwise analyses based on reverse pharmacophore-mapping based prediction. Finally, results of molecular dynamics simulations were used to estimate the theoretical binding affinity of the selected virtual hits towards the three isoforms of enzyme AKT. Our computational findings thus provide important guidelines to facilitate the discovery of novel AKT inhibitors.

Flow velocity and light level drive non-linear response of seagrass Zostera noltei to ammonium enrichment

2016 ◽  
Vol 545 ◽  
pp. 109-121 ◽  
Author(s):  
B Villazán ◽  
FG Brun ◽  
V González‑Ortiz ◽  
F Moreno‑Marín ◽  
TJ Bouma ◽  
...  
Keyword(s):  
Flow Velocity ◽  
Linear Response ◽  
Light Level ◽  
Zostera Noltei ◽  
Non Linear

scholarly journals Influence of the Porosity of Polymer Foams on the Performances of Capacitive Flexible Pressure Sensors

Sensors ◽  
2019 ◽  
Vol 19 (9) ◽  
pp. 1968 ◽  
Author(s):  
Sylvie Bilent ◽  
Thi Hong Nhung Dinh ◽  
Emile Martincic ◽  
Pierre-Yves Joubert
Keyword(s):  
Experimental Data ◽  
Linear Model ◽  
Dielectric Material ◽  
Pressure Sensors ◽  
Volume Ratio ◽  
Measurement Range ◽  
Polymer Foams ◽  
First Order ◽  
Non Linear ◽  
Flexible Pressure Sensors

This paper reports on the study of microporous polydimethylsiloxane (PDMS) foams as a highly deformable dielectric material used in the composition of flexible capacitive pressure sensors dedicated to wearable use. A fabrication process allowing the porosity of the foams to be adjusted was proposed and the fabricated foams were characterized. Then, elementary capacitive pressure sensors (15 × 15 mm2 square shaped electrodes) were elaborated with fabricated foams (5 mm or 10 mm thick) and were electromechanically characterized. Since the sensor responses under load are strongly non-linear, a behavioral non-linear model (first order exponential) was proposed, adjusted to the experimental data, and used to objectively estimate the sensor performances in terms of sensitivity and measurement range. The main conclusions of this study are that the porosity of the PDMS foams can be adjusted through the sugar:PDMS volume ratio and the size of sugar crystals used to fabricate the foams. Additionally, the porosity of the foams significantly modified the sensor performances. Indeed, compared to bulk PDMS sensors of the same size, the sensitivity of porous PDMS sensors could be multiplied by a factor up to 100 (the sensitivity is 0.14 %.kPa−1 for a bulk PDMS sensor and up to 13.7 %.kPa−1 for a porous PDMS sensor of the same dimensions), while the measurement range was reduced from a factor of 2 to 3 (from 594 kPa for a bulk PDMS sensor down to between 255 and 177 kPa for a PDMS foam sensor of the same dimensions, according to the porosity). This study opens the way to the design and fabrication of wearable flexible pressure sensors with adjustable performances through the control of the porosity of the fabricated PDMS foams.

Analysis of Single Buffer Random Polling System With State-Dependent Input Process and Server/Station Breakdowns

2018 ◽  
Vol 9 (1) ◽  
pp. 22-50 ◽  
Author(s):  
Thomas Y.S. Lee
Keyword(s):  
Steady State ◽  
Linear Model ◽  
Repair Process ◽  
Polling System ◽  
Steady State Analysis ◽  
Relaxation System ◽  
Polling Model ◽  
State Dependent ◽  
Non Linear ◽  
State Analysis

Models and analytical techniques are developed to evaluate the performance of two variations of single buffers (conventional and buffer relaxation system) multiple queues system. In the conventional system, each queue can have at most one customer at any time and newly arriving customers find the buffer full are lost. In the buffer relaxation system, the queue being served may have two customers, while each of the other queues may have at most one customer. Thomas Y.S. Lee developed a state-dependent non-linear model of uncertainty for analyzing a random polling system with server breakdown/repair, multi-phase service, correlated input processes, and single buffers. The state-dependent non-linear model of uncertainty introduced in this paper allows us to incorporate correlated arrival processes where the customer arrival rate depends on the location of the server and/or the server's mode of operation into the polling model. The author allows the possibility that the server is unreliable. Specifically, when the server visits a queue, Lee assumes that the system is subject to two types of failures: queue-dependent, and general. General failures are observed upon server arrival at a queue. But there are two possibilities that a queue-dependent breakdown (if occurs) can be observed; (i) is observed immediately when it occurs and (ii) is observed only at the end of the current service. In both cases, a repair process is initiated immediately after the queue-dependent breakdown is observed. The author's model allows the possibility of the server breakdowns/repair process to be non-stationary in the number of breakdowns/repairs to reflect that breakdowns/repairs or customer processing may be progressively easier or harder, or that they follow a more general learning curve. Thomas Y.S. Lee will show that his model encompasses a variety of examples. He was able to perform both transient and steady state analysis. The steady state analysis allows us to compute several performance measures including the average customer waiting time, loss probability, throughput and mean cycle time.

Selection of models to describe the temperature-dependent development of Neoleucinodes elegantalis (Lepidoptera: Crambidae) and its application to predict the species voltinism under future climate conditions

2021 ◽  
pp. 1-9
Author(s):  
Hevellyn Talissa dos Santos ◽  
Cesar Augusto Marchioro
Keyword(s):  
Climate Change ◽  
Linear Model ◽  
Future Climate ◽  
Future Climate Change ◽  
Climate Change Scenarios ◽  
Temperature Dependent ◽  
Dependent Development ◽  
Degree Day ◽  
Non Linear ◽  
The Impact

Abstract The small tomato borer, Neoleucinodes elegantalis (Guenée, 1854) is a multivoltine pest of tomato and other cultivated solanaceous plants. The knowledge on how N. elegantalis respond to temperature may help in the development of pest management strategies, and in the understanding of the effects of climate change on its voltinism. In this context, this study aimed to select models to describe the temperature-dependent development rate of N. elegantalis and apply the best models to evaluate the impacts of climate change on pest voltinism. Voltinism was estimated with the best fit non-linear model and the degree-day approach using future climate change scenarios representing intermediary and high greenhouse gas emission rates. Two out of the six models assessed showed a good fit to the observed data and accurately estimated the thermal thresholds of N. elegantalis. The degree-day and the non-linear model estimated more generations in the warmer regions and fewer generations in the colder areas, but differences of up to 41% between models were recorded mainly in the warmer regions. In general, both models predicted an increase in the voltinism of N. elegantalis in most of the study area, and this increase was more pronounced in the scenarios with high emission of greenhouse gases. The mathematical model (74.8%) and the location (9.8%) were the factors that mostly contributed to the observed variation in pest voltinism. Our findings highlight the impact of climate change on the voltinism of N. elegantalis and indicate that an increase in its population growth is expected in most regions of the study area.

Experimental demonstration of non-linear model-based in-line control of pH

1992 ◽  
Vol 2 (3) ◽  
pp. 145-153 ◽  
Author(s):  
Suhas K. Mahuli ◽  
R. Russell Rhinehart ◽  
James B. Riggs
Keyword(s):  
Linear Model ◽  
Experimental Demonstration ◽  
Model Based ◽  
Non Linear
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