scholarly journals Progress in clinical research complicated infection with diabetes mellitus

2018 ◽  
Vol 7 (3) ◽  
pp. 101-108
Author(s):  
Jiangeng Han ◽  
Xin Wang ◽  
Zheng Chen ◽  
Ning Gao ◽  
Chen Wang
Keyword(s):  
Diabetes Mellitus ◽  
Mortality Rate ◽  
Active Treatment ◽  
Poor Prognosis ◽  
Otitis Externa ◽  
Urinary System ◽  
Concurrent Infection ◽  
Patients With Diabetes ◽  
Defense Function ◽  
Skin Mucosa

Abstract Patients with diabetes are prone to concurrent infection. The mechanism of concurrent infection is related to factors such as hyperglycemia and weakened defense function. The infections of patients with diabetes include general and special infections. General infection includes infections in the respiratory system, urinary system, hepatobiliary system, and skin mucosa. Meanwhile, special infection includes invasive otitis externa, nasal mucormycosis, necrotizing fasciitis, and emphysema infection. Patients with special infections also have a higher mortality rate than those with general ones. Complicated infection with diabetes is difficult to treat and has poor prognosis. Therefore, a patient requires active treatment once infected with this infection.

Hyperglycaemic crises in adult patients with diabetes mellitus

2011 ◽  
pp. 1874-1888 ◽  
Author(s):  
Abbas E. Kitabchi ◽  
Ebenezer Nyenwe
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Mortality Rate ◽  
Incidence Rate ◽  
Hospital Admissions ◽  
Population Based ◽  
Patients With Diabetes ◽  
The Usa ◽  
The Uk

Diabetic ketoacidosis (DKA) and hyperosmolar nonketotic state (HONK; also referred to, in the USA, as hyperglycaemic hyperosmolar state) are the two most serious, potentially fatal acute metabolic complications of diabetes mellitus. In the USA, the annual incidence rate for DKA ranges from 4.6 to 8 episodes per 1000 patients with diabetes of all ages, and 13.4 per 1000 patients in subjects younger than 30 years old (1). The incidence rate in the USA is comparable to the rates in Europe, with estimates of 13.6 per 1000 patients with type 1 diabetes in the UK (2), and 14.9 per 1000 patients with type 1 diabetes in Sweden (3). In the USA, hospitalization for DKA has risen by more than 30% in the last decade, with DKA accounting for approximately 1 35 000 hospital admissions in 2006 (4). The incidence of HONK is difficult to determine because of the lack of population–based studies and the multiple combined illnesses often found in these patients. In general, it is estimated that the rate of hospital admissions due to HONK is lower than it is for DKA and HONK accounts for less than 1% of all primary diabetic admissions (5). The mortality rate in patients with DKA has significantly decreased in experienced centres since the advent of low-dose insulin and appropriate fluid-/electrolyte-replacement protocols. Among adults with DKA in the USA, the overall mortality rate is less than 1% (4). A trend toward remarkable reduction in mortality from DKA has been reported in Europe as well, with one UK university recording no deaths among 46 patients who were admitted for DKA between 1997 and 1999 (2). The incidence and mortality of DKA remains high in developing countries, owing to socioeconomic factors. For instance, in Nairobi, Kenya, the incidence of DKA was about 80 per 1000 hospitalized diabetic patients in a study reported in 2005, and mortality rate was as high as 30% (6). The mortality rate of patients with HONK remains high even in the developed world, at approximately 11%. The prognosis of both conditions is substantially worsened with increased age, presence of coma, and hypotension (7). Despite threat to life, DKA is also expensive, with estimated annual direct and indirect cost of 2 billion US dollars (8).

scholarly journals Diabetic macroangiopathy

2019 ◽  
Vol 91 (10) ◽  
pp. 139-143
Author(s):  
A F Verbovoy ◽  
A V Pashentseva ◽  
N I Verbovaya
Keyword(s):  
Diabetes Mellitus ◽  
Health Care ◽  
Active Treatment ◽  
Social Problem ◽  
Diabetic Macroangiopathy ◽  
The World ◽  
Patients With Diabetes

Diabetes mellitus represents a significant medico - social problem for health care around the world. The main reason for an invalidism and a mortality of patients with diabetes mellitus are the lesions of heart and vessels united in the concept "diabetic macroangiopathty". This complication is often taped already at the time of diagnosis of a diabetes mellitus and demands active treatment.

scholarly journals Fungal Invasive Co-Infection Due to Aspergillus fumigatus and Rhizopus arrhizus: A Rhino-Orbital Presentation

2021 ◽  
Vol 7 (12) ◽  
pp. 1096
Author(s):  
Juan Pablo Ramírez-Hinojosa ◽  
Salvador Medrano-Ahumada ◽  
Roberto Arenas ◽  
Arturo Bravo-Escobar ◽  
Sara Paraguirre-Martínez ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Mortality Rate ◽  
Aspergillus Fumigatus ◽  
Liposomal Amphotericin ◽  
Poor Prognosis ◽  
Diabetes Mellitus Type 2 ◽  
Fungal Infections ◽  
Rhizopus Arrhizus ◽  
Immunocompromised Patients

Aspergillosis and mucormycosis are filamentous fungal infections occurring predominantly in immunocompromised patients. Fulminant process with rapid infiltration of the contiguous tissue is distinctive for both type of fungi. The rhinocerebral co-infection by Aspergillus and Mucorales is very rare and is usually associated in immunocompromised patients with a high mortality rate. This rare co-infection leads to difficulties in diagnosis, and therapeutic delays can result in a poor prognosis. Overall, the treatment of choice is surgical debridement and liposomal amphotericin B. This paper describes a combined aspergillosis and mucormycosis case in a diabetes mellitus type 2 patient with chronic ulcerations of the palatal and cheek. To our knowledge, this is the first report of an uncommon co-infection of Aspergillus fumigatus and Rhizopus arrhizus in a rhino-orbital presentation.

scholarly journals THE EFFICACY OF PLASMA EXCHANGE IN COVID-19 PATIENTS WITH COMORBID DIABETES MELLITUS

2021 ◽  
Vol 71 (5) ◽  
pp. 1732-35
Author(s):  
Komal Arshad ◽  
Zill-e-Humayun . ◽  
Sultan Mehmood Kamran ◽  
Ikram Khaliq ◽  
Muhammad Raza Asif ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Mortality Rate ◽  
Plasma Exchange ◽  
Standard Therapy ◽  
Therapeutic Plasma Exchange ◽  
Military Hospital ◽  
Microsoft Excel ◽  
Patients With Diabetes ◽  
Male Patients ◽  
Coronavirus Infection

Objective: To explore the use of therapeutic plasma exchange as adjunctive therapy in COVID-19 patients with and without diabetes mellitus. Study Design: Prospective, observational study. Place and Duration of Study: Pakistan Emirates Military Hospital Rawalpindi, from Jan to Feb 2021. Methodology: A total of 90 male patients with laboratory-confirmed coronavirus infection were selected based on our inclusion criteria and their management and outcomes were recorded. The data were analyzed using SPSS-22 and Microsoft Excel. Results: The mortality rate was lower in patients who received 1 or more sessions of plasma exchange compared to those who did not receive plasma exchange (7.5% vs 12%). A lower mortality rate was seen in patients without diabetes who received therapeutic plasma exchange in addition to standard therapy compared to patients who received standard therapy alone (0 vs 14.82%, p=0.112). In patients with diabetes, a higher mortality rate was found in the group that had received therapeutic plasma exchange in addition to standard therapy instead of standard therapy alone (20% vs 8.7%, p=0.365). Conclusion: Overall our study supports the use of therapeutic plasma exchange in COVID-19 patients. However, although statistically insignificant, there appears to be a higher mortality rate in patients with diabetes who received therapeutic plasma exchange in addition to standard therapy. As such, we recommend further investigation of this aspect.

scholarly journals The Characteristics and Mortality of Osteoporosis, Osteomyelitis, or Rheumatoid Arthritis in the Diabetes Population: A Retrospective Study

2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Jin-Feng Huang ◽  
Qi-Nan Wu ◽  
Xuan-Qi Zheng ◽  
Xiao-Lei Sun ◽  
Chen-Yu Wu ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Diabetes Mellitus ◽  
Retrospective Study ◽  
Mortality Rate ◽  
Causes Of Death ◽  
Treatment Strategies ◽  
Mortality Rates ◽  
Crude Mortality ◽  
Patients With Diabetes ◽  
Icd 10

Background. Patients with diabetes mellitus are prone to develop osteoporosis, osteomyelitis, or rheumatoid arthritis (RA). Furthermore, the presence of these complications in those with diabetes may lead to higher mortality. The aim of our study was to assess characteristics and mortality of osteoporosis, osteomyelitis, or rheumatoid arthritis in individuals with diabetes. Methods. We analyzed osteoporosis, osteomyelitis, and RA deaths associated with diabetes from 1999–2017 using the CDC WONDER system (CDC WONDER; https://wonder.cdc.gov). We used ICD-10 codes to categorize the underlying and contributing causes of death. Crude mortality rates (CMR) and age-adjusted mortality rates (AAMR) per 1,000,000 person-years were calculated. Results. The AAMR for osteoporosis in the population with diabetes was significantly higher in females (AAMR: 4.17, 95% CI: 4.10–4.24) than in males (AAMR: 1.12, 95% CI: 1.07–1.16). Deaths due to osteoporosis increased gradually from 1999, peaked in 2003 (AAMR: 3.78, 95% CI: 3.55–4.00), and reached a nadir in 2016 (AAMR: 2.32, 95% CI: 2.15–2.48). The AAMR for RA associated with diabetes was slightly higher in females (AAMR: 4.04, 95% CI: 3.98–4.11) than in males (AAMR: 2.45, 95% CI: 2.39–2.51). The mortality rate due to RA increased slightly from 1999 (AAMR: 3.18, 95% CI: 2.97–3.39) to 2017 (AAMR: 3.20, 95% CI: 3.02–3.38). The AAMR for osteomyelitis associated with diabetes was higher in males (AAMR: 4.36, 95% CI: 4.28–4.44) than in females (AAMR: 2.31, 95% CI: 2.26–2.36). From 1999 to 2017, the AAMR from osteomyelitis in this population was 2.63 (95% CI: 2.44–2.82) per 1,000,000 person-years in 1999 and 4.25 (95% CI: 4.05–4.46) per 1,000,000 person-years in 2017. Conclusions. We found an increase in the age-adjusted mortality rates of RA and osteomyelitis and a decrease of osteoporosis associated with diabetes from 1999 to 2017. We suggest that increased attention should therefore be given to these diseases in the population with diabetes, especially in efforts to develop preventative and treatment strategies.

scholarly journals Mortality Rate and Predictors of Mortality in Hospitalized COVID-19 Patients with Diabetes

Healthcare ◽  
2020 ◽  
Vol 8 (3) ◽  
pp. 338
Author(s):  
Dilaram Acharya ◽  
Kwan Lee ◽  
Dong Seok Lee ◽  
Yun Sik Lee ◽  
Seong-Su Moon
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Mortality Rate ◽  
South Korea ◽  
Multivariate Logistic Regression Analysis ◽  
High Serum ◽  
Multivariate Logistic Regression ◽  
Risk Of Mortality ◽  
Patients With Diabetes ◽  
The Mean

Studies have confirmed COVID-19 patients with diabetes are at higher risk of mortality than their non-diabetic counterparts. However, data-driven evidence of factors associated with increased mortality risk among hospitalized COVID-19 patients with diabetes is scarce in South Korea. This study was conducted to determine the mortality rate and identify risk factors of mortality among hospitalized COVID-19 patients with type 2 diabetes in Gyeongsangbuk-do province, South Korea. In this hospital-based, cross-sectional study, we enrolled a total of 324 patients with confirmed COVID-19, hospitalized at two of the tertiary level healthcare facilitates of Gyeongsangbuk-do, South Korea from 18 February to 30 June 2020. Demographic and clinical data and laboratory profiles were analyzed and multivariate logistic regression analysis was used to identify risk factors of mortality among diabetic patients with COVID-19. Of the 324 patients, 55 (16.97%) had diabetes mellitus. The mean age of all study subjects was 55 years, and the mean age of those with diabetes was greater than that of those without (69.8 years vs. 51.9 years). Remarkably, the mortality rate was much higher among those with diabetes (20.0% vs. 4.8%). Multivariate logistic regression analysis revealed that an older age (≥70 years) and a high serum lactate dehydrogenase (LDH) levels significantly predicted mortality among hospitalized COVID-19 patients with diabetes. Our study cautions more attention to be paid to patients with diabetes mellitus hospitalized for COVID-19, especially those aged ≥ 70 years and those with a high serum LDH level, to reduce the risk of mortality.

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