Alteration of secretory IgA in human breast milk and stool samples after the intake of a probiotic — report of 2 cases

AbstractOnly a few studies reveal immunological changes in breast milk after the intake of probiotic and none focus on secretory IgA (sIgA). The aim our report was to investigate the levels of sIgA in human breast milk and stools before and after 4 weeks of probiotic intake in a patient with ulcerative colitis (UC) and a control. The study included 2 lactating women: 1 with UC and 1 control. Both received daily 3.75 billion viable Lactobacillus bulgaricus for 28 days. SIgA was measured in breast milk and stools before and after the probiotic intake. The concentration of sIgA in breast milk before the probiotic intake in UC was 408.5 vs 137.4 µg/ml in contol. Fecal sIgA in UC was 420 vs 274 µg/ml in control. After 28 days of probiotic intake there was a decrease in breast milk sIgA in UC but an increase in control — 266.7 vs 914 µg/ml respectively. There was an increase in fecal sIgA both in UC and control — 674.4 vs 1033 µg/ml. It is tempting to speculate that the different sIgA secretion towards the probiotic may be a result of an altered mucosal immune response in UC.

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Excretion of Iohexol and Metrizoate in Human Breast Milk

Acta Radiologica ◽

10.1177/028418518702800505 ◽

1987 ◽

Vol 28 (5) ◽

pp. 523-526 ◽

Cited By ~ 15

Author(s):

S. T. Nielsen ◽

I. Matheson ◽

J. N. Rasmussen ◽

K. Skinnemoen ◽

E. Andrew ◽

...

Keyword(s):

Breast Milk ◽

Low Dose ◽

Decay Curve ◽

Human Breast Milk ◽

Human Breast ◽

Blood Samples ◽

Lactating Women ◽

Milk Samples ◽

Slow Decay ◽

Contrast Medium Injection

Six lactating women undergoing contrast media examination had milk and blood taken to determine the rate and extent of excretion of iohexol (Omnipaque) (four mothers) and metrizoate (Isopaque) (two mothers). Blood samples were taken up to 45 minutes and milk samples up to 48 hours after the contrast medium injection. The excretion was low, reaching a maximum at 3 to 6 hours and showing a slow decay curve (t 1/2 = 15 to 108 hours). One mother, who was weaning her baby, showed a different excretion pattern. The amount excreted during 24 hours was about 0.5 per cent of the weight adjusted maternal dose for both iohexol and metrizoate. It is not likely, that such a low dose of poorly absorbed drug would cause any adverse effects in the infant, unless it is hypersensitive to the drug already. The authors consider breast feeding to be acceptable for mothers receiving iohexol or metrizoate.

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Higher Absorption of Vitamin C from Food than from Supplements by Breastfeeding Mothers at Early Stages of Lactation

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000436 ◽

2016 ◽

Vol 86 (3-4) ◽

pp. 81-87

Author(s):

Dorota Martysiak-Żurowska ◽

Maciej Zagierski ◽

Ewa Woś-Wasilewska ◽

Agnieszka Szlagatys-Sidorkiewicz

Keyword(s):

Liquid Chromatography ◽

Breast Milk ◽

Vitamin C ◽

Daily Intake ◽

Human Breast Milk ◽

Dietary Intakes ◽

Human Breast ◽

Natural Sources ◽

Lactating Women ◽

Lactation Stage

Abstract.The aim of the present study was to determine the effect of vitamin C supply in the diet of lactating women on vitamin C concentrations in human milk (n = 97) sampled at different stages of lactation. Vitamin C levels were measured by liquid chromatography. Dietary intake of vitamin C was determined based on 3-day food dairies kept by breastfeeding mothers. Maternal dietary intakes of vitamin C from natural sources on lactation day 90 (n = 18) were significantly higher than on lactation days 15 (n = 42) and 30 (n = 37). The number of women taking vitamin C supplements decreased in successive stages of lactation. The average daily intake of vitamin C was estimated at 119 mg, but nearly 20% of mothers consumed less than 50 mg of vitamin C per day. No significant correlations were observed between lactation stage and vitamin C levels in breast milk (r = 0.110, p = 0.064). The average vitamin C concentrations in human breast milk were determined at 50.9 mg / L, and were not higher than 80.6 mg / L regardless of lactation stage and maternal intake of vitamin C. Vitamin C excretion into breast milk is regulated to prevent exceeding saturation level. The vitamin C concentration in milk was positive correlated with maternal intake of vitamin C from food, in the case of non-supplemented diet (r = 0.402, p = 0.041). Our results suggest that vitamin C occurring in food is much better absorbed and passes into breast milk than vitamin C from supplements.

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HIV-1 Concentrations in Human Breast Milk Before and After Weaning

Science Translational Medicine ◽

10.1126/scitranslmed.3005113 ◽

2013 ◽

Vol 5 (181) ◽

pp. 181ra51-181ra51 ◽

Cited By ~ 19

Author(s):

L. Kuhn ◽

H.-Y. Kim ◽

J. Walter ◽

D. M. Thea ◽

M. Sinkala ◽

...

Keyword(s):

Breast Milk ◽

Human Breast Milk ◽

Human Breast ◽

Before And After ◽

Hiv 1

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Human breast milk concentration of neopterin at various stages of lactation and during a single feeding

Pteridines ◽

10.1515/pterid-2015-0001 ◽

2015 ◽

Vol 26 (2) ◽

pp. 73-77

Author(s):

Katarzyna Plata-Nazar ◽

Ewa Woś-Wasilewska ◽

Agnieszka Szlagatys-Sidorkiewcz ◽

Grażyna Łuczak ◽

Maciej Zagierski ◽

...

Keyword(s):

Breast Milk ◽

Human Breast Milk ◽

Human Breast ◽

Physiological Level ◽

Milk Samples ◽

Stage Of Lactation ◽

Lactation Stage ◽

Neopterin Concentration ◽

Before And After ◽

Immunoenzymatic Assay

AbstractThe aim of this work was to determine the physiological level of neopterin in human breast milk, and to study its variability depending on the duration of a single feeding and the lactation stage. Breast milk samples from 74 women were collected between 2 and 4 days after delivery, and at 15, 30, and 90 days after delivery. Additionally, breast milk samples from eight women were collected before and after 7 and 15 min of breastfeeding. The concentration of neopterin in breast milk was determined by an immunoenzymatic assay. The range of breast milk neopterin concentration at various stages of lactation amounted to 15.4–19.2 nmol/L at 2–4 days after delivery, 20.2–23.0 nmol/L at day 15, 20.8–24.5 nmol/L at day 30, and 16.9–20.4 nmol/L at day 90. The level of neopterin 2–4 days after delivery was significantly lower than that at days 15 and 30; moreover, the concentration of neopterin at day 30 was significantly higher than that at day 90. No significant differences were documented between neopterin concentrations at various phases of a single feeding. While the breast milk concentration of neopterin changes depending on the stage of lactation, it remains stable throughout a single feeding.

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Salmon Consumption during Pregnancy Alters Fatty Acid Composition and Secretory IgA Concentration in Human Breast Milk

Journal of Nutrition ◽

10.3945/jn.112.160804 ◽

2012 ◽

Vol 142 (8) ◽

pp. 1603-1610 ◽

Cited By ~ 30

Author(s):

Heidi J. Urwin ◽

Elizabeth A. Miles ◽

Paul S. Noakes ◽

Lefkothea-Stella Kremmyda ◽

Maria Vlachava ◽

...

Keyword(s):

Fatty Acid Composition ◽

Fatty Acid ◽

Breast Milk ◽

Acid Composition ◽

Secretory Iga ◽

Human Breast Milk ◽

Human Breast

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Human breast milk, infant formula, and follow-up milks comparison by electronic tongue

Acta Alimentaria ◽

10.1556/066.2020.00122 ◽

2021 ◽

Vol 50 (1) ◽

pp. 33-41

Author(s):

M. Krpan ◽

N. Major ◽

Z. Šatalić ◽

M. Hruškar

Keyword(s):

Breast Milk ◽

Infant Formula ◽

Electronic Tongue ◽

Human Breast Milk ◽

Human Breast ◽

Lactating Women ◽

Future Studies ◽

Infant Formulae ◽

Breast Fed

AbstractHuman breast milk, infant formula, and follow-up milks were tested by a commercial electronic tongue (αAstree, Alpha MOS) with the aim to determine taste diversity, since it has been recently shown that infants exposed to different tastes early in life, develop different food preference at a later age. Human milk (36 samples) were obtained from 13 lactating women, while 12 samples of infant formula and 14 samples of follow-up milk were obtained from the Croatian market and opened prior to analysis. Human breast milk samples showed a much higher diversity than both infant formulae and follow-up milks. These results suggest that breast-fed infants are exposed to a broader sensory experience, while formula fed infants are exposed to less diverse taste. Future studies will probably answer how this influences later food choice, taste preferences, and consequently, risk of obesity and other chronic diseases.

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