scholarly journals Genotoxin Effect of Composite Resin

Author(s):  
Tienneke Riana Septiwidyati ◽  
Elza Ibrahim Auerkari

At this moment composite resin is the most widely used material for dental restoration. The content of the resin is a mixture of monomer bisphenol A glycidyl methacrylate (Bis-GMA), trimethylene glycol dimethylmethacrylate (TEGDMA) and urethane dimethacrylate (UDMA) and special particle fillers made of radioopaque glass. Many studies have been conducted to study the biocompatibility of composite resin, especially the cytotoxicity and genotoxicity test. Genotoxicity tests that are often carried out are comet test for DNA damage protection and micronuclei test for protection of genome damage. The monomer content of composite resins can have a genotoxic effect.

2018 ◽  
Vol 21 (3) ◽  
pp. 288
Author(s):  
Bruno Mendonça Lucena De Veras ◽  
Geórgia Pires dos Santos Menezes ◽  
Hugo Leonardo Mendes Barros ◽  
Marcelya Chrystian Moura Rocha ◽  
Aditonio De Carvalho Monteiro ◽  
...  

<p><strong>Objective: </strong>The objective of this study was to evaluate the 6-month clinical performance of class I occlusal composite resin restorations through a multicenter, randomized, double-blind, clinical trial. <strong>Material e Métodos: </strong>Two hundred and eighty class I occlusal restorations were performed in 70 patients (aged between 17 to 50 years).  The restorations were divided into four groups: G1 (Filtek P60/3M ESPE); G2 (Rok/SDI); G3 (Filtek™ P90/3M ESPE); G4 (Evolux/Dentsply). Two pre-calibrated dental practitioners performed and evaluated the restorative procedures regarding to color match, marginal discoloration, recurrent caries, wear (anatomic form) and marginal integrity according to the USPHS criteria. <strong>Resultados: </strong>In 85.8% of the evaluated restorations was observed the ideal score (A) for color match; 91.4% for marginal discoloration; 100% for recurrent caries; 87.7% for wear (anatomic form) and 99.3% for marginal integrity.<strong> Conclusion: </strong>The composite resins used in this study presented satisfactory and similar clinical performance in a 6-month clinical evaluation.</p><p><strong>Keywords</strong></p><p>Dentistry; Composite resins; Permanent dental restoration; Molar; Bicuspid.</p>


2019 ◽  
Vol 52 (1) ◽  
pp. 24
Author(s):  
Jayanti Rosha ◽  
Adioro Soetojo ◽  
Putu Dewi Purnama Sari Budha ◽  
M. Mudjiono

Background: Residual monomers are non-polymerized monomers which can cause clinical harm, for example inflammation, to oral cavity tissue while the remaining monomers can potentially be carcinogenic. The more residual monomers that remain due to an imperfect polymerization processes, the lower the compressive strength level and the higher the number of micro slits that can cause secondary caries and tooth sensitivity. Urethane dimethacrylate (UDMA) and bisphenol A glycol dimethacrylate (Bis-GMA) constitute two of the resins most frequently used in packable composites. During the short irradiaton period forming part of the polymerization process, UDMA and Bis-GMA have the potential to produce residual monomers. Purpose: This study aimed to compare the number of residual monomers in packable composite resin following irradiation lasting 1x20 seconds and 2x20 seconds. Methods: 28 samples of cylindrical packable composite with a thickness of 2 mm and a diameter of 5 mm were divided into four groups. Groups 1 and 2 were irradiated for 1x20 seconds, and groups 3 and 4 for 2x20 seconds with the composite subsequently being immersed in ethanol solution for 24 hours. The number of residual monomers using high-performance liquid chromatography (HPLC) devices was calculated and the results statistically analyzed using a Mann-Whitney Test. Results: Repeated irradiation had no effect on the amount of residual monomers in packable composite resins. However, there were differences in the number of residual monomers in the material contained in packable composite resins Bis-GMA and UDMA, while the remaining monomers in UDMA outnumbered those in Bis-GMA. Conclusion: The number of residual monomers in Bis-GMA is lower than in the remaining UDMA after 1x20 seconds irradiation, while the number of residual monomers in Bis-GMA and UDMA following 2x20 seconds irradiation was no different to that after irradiation of 1x20 seconds duration.


2020 ◽  
Vol 5 (2) ◽  
pp. 172
Author(s):  
Dewi Puspitasari ◽  
Maharani Laillyza Apriasari ◽  
Dewi Rahayu ◽  
Priyawan Rachmadi

ABSTRACTBackgrounds: The use of mouthwash daily may influence the mechanical properties of bioactive composite resin as a dental restoration, one of the mechanical properties is surface hardness. Herbal mouthwash can be used to minimize the side effect of mouthwash that contain alcohol. Mauli banana stem and basil leaf extracts can be produced into herbal mouthwash. Methods: Thirty specimens (10mm diameter x 2mm thick; n=5/group) bioactive composite resins were immersed in a mixed solution of Mauli banana and basil leaf extracts with concentration of 25%, 50%, 75 %%, 100%, the control group of chlorhexidine gluconate 0.2% and aquadest for 7 days in 37oC. Measurement of the surface hardness was using the Vickers Microhardness Tester with 100 gf load for 15 seconds. Results: One Way ANOVA and Post Hoc Bonferroni exhibited the significant differences (p <0.05) in hardness values between the specimens that immersed in the mixed solution Mauli banana and Basil leaf extracts, which in the concentration of 100% (4,49 ± 4,61 VHN) compared with 25% (38,20 ± 2,58 VHN), 50% (41,40 ± 3,84 VHN) and 75% concentration (40,40 ± 3,55 VHN). There was no siginificant difference (p >0.05) between specimens immersed in CHX, aquadest and the mixed solution of mauli banana and basil leaf extracts in all concentration. Conclusion: There is no change in bioactive composite resin surface hardness after immersed in the mixed solution of Mauli Banana stem (Musa acuminata) and Basil leaf (Ocimum basilicum) extracts.Keywords: Basil leaf extract, Bioactive resin, Mauli Banana stem extract, Surface hardness


Materials ◽  
2018 ◽  
Vol 11 (12) ◽  
pp. 2444 ◽  
Author(s):  
Shenggui Chen ◽  
Junzhong Yang ◽  
Yong-Guang Jia ◽  
Bingheng Lu ◽  
Li Ren

With the rapid application of light-curing 3D printing technology, the demand for high-performance polymer resins is increasing. Existing light-curable resins often have drawbacks limiting their clinical applications. This study aims to develop a new type of polymethyl methacrylate (PMMA) composite resins with enhanced mechanical properties, high antibacterial activities and excellent biocompatibilities. A series of reinforced composite resins were prepared by mechanically mixing PMMA with modified cellulose nanocrystals (CNCs), which were coated with polydopamine and decorated by silver nanoparticles (AgNPs) via Tollen reaction. The morphology of CNCs-Ag was observed by transmission electron microscopy and the formation of AgNPs on CNCs was confirmed by X-Ray photoelectron spectroscopy analyses. Functional groups in PMMA-CNCs-Ag composites were verified by Fourier Transform infrared spectroscopy (FTIR) spectroscopy. The mechanical assessment and scanning electron microscopy analysis suggested that the evenly distributed CNCs-AgNPs composite effectively improve mechanical properties of PMMA resin. Cytotoxicity assay and antibacterial activity tests indicated excellent biocompatibility and high antibacterial activities. Furthermore, PMMA with CNCs-AgNPs of 0.1 wt.% (PMMA-CNCs-AgNPs-0.1) possessed the most desirable mechanical properties owing to the homogeneous distribution of AgNPs throughout the resin matrix. This specific composite resin can be used as a functional dental restoration material with potential of other medical applications.


Nanomaterials ◽  
2019 ◽  
Vol 9 (7) ◽  
pp. 1049 ◽  
Author(s):  
Sheng-Gui Chen ◽  
Junzhong Yang ◽  
Yong-Guang Jia ◽  
Bingheng Lu ◽  
Li Ren

The future of manufacturing applications in three-dimensional (3D) printing depends on the improvement and the development of materials suitable for 3D printing technology. This study aims to develop an applicable and convenient protocol for light-curing resin used in 3D industry, which could enhance antibacterial and mechanical properties of polymethyl methacrylate (PMMA) resin through the combination of nano-fillers of surface modified titanium dioxide (TiO2) and micro-fillers of polyetheretherketone (PEEK). PMMA-based composite resins with various additions of TiO2 and PEEK were prepared and submitted to characterizations including mechanical properties, distribution of the fillers (TiO2 or/and PEEK) on the fractured surface, cytotoxicity, antibacterial activity, and blood compatibility assessment. These results indicated that the reinforced composite resins of PMMA (TiO2-1%-PEEK-1%) possessed the most optimized properties compared to the other groups. In addition, we found the addition of 1% of TiO2 would be an effective amount to enhance both mechanical and antibacterial properties for PMMA composite resin. Furthermore, the model printed by PMMA (TiO2-1%-PEEK-1%) composite resin showed a smooth surface and a precise resolution, indicating this functional dental restoration material would be a suitable light-curing resin in 3D industry.


2017 ◽  
Vol 20 (1) ◽  
pp. 92
Author(s):  
Izabela Cristina Maurício Moris ◽  
Matheus Sakuma ◽  
Adriana Cláudia Lapria Faria ◽  
Ana Paula Macedo ◽  
Ricardo Faria Ribeiro ◽  
...  

<p><strong>Objective</strong>: The aim of the present study was to evaluate wear resistance of two composites resins against alternative alloys. <strong>Material</strong> <strong>and</strong> <strong>Methods</strong>: Fifteen stylus tips samples of composite resin were obtained for each resin Z250 and charisma (CHA). Samples were divided into three groups according to the disk of alloy to be used as antagonist: Nickel-Chromium (Ni-Cr), Cobalt- Chromium (Co-Cr) and commercially pure titanium (cp Ti). Wear tests were performed at a speed of 265 cycles/min and distance of 10mm, in a total of 40,000 cycles. Before and after wear tests, samples were weighed and had their profile designed in an optical comparator to evaluate weight and height loss, respectively. <strong>Results</strong>: For weight and height loss, wear of Z250 was lower than CHA for Co-Cr antagonist, but greater for cp Ti. CHA presents a more regular surface without cracks and similar aspect for all antagonists. Z250 showed some cracks, mainly against cp Ti and Ni-Cr. <strong>Conclusion</strong>: Within the results of the present study, it was concluded that CHA is suitable against cp Ti, and Z250 for association with Co-Cr alloy while any composite resin can be used against Ni-Cr.</p><p class="Default"><strong>Keywords</strong></p><p class="Default">Composite resins; Dental alloys; Dental restoration wear.</p>


2021 ◽  
Vol 23 (1) ◽  
pp. 39-43
Author(s):  
Matheus Bruno Costa ◽  
Erika Terumi Tomisaki ◽  
Daiane Cristina Mendonça dos Santos ◽  
Marcio Grama Hoeppner ◽  
Sueli De Almeida Cardoso

AbstractFactors such as aesthetics and adhesion to dental substrates have consolidated composite resin as a restorative material for posterior teeth, however, the performance is unsatisfactory regarding the longevity of these restorations. The purpose of this retrospective cross-sectional observational study was to evaluate the reasons that resulted in failure of class I and II Black composite resin restorations, performed by undergraduate dental students at the State University of Londrina. The patients were selected from the research of the medical charts filed at the University Dental Clinic's Screening Department. The restorations were evaluated by two calibrated dentists. The data collected were tabulated and analyzed using descriptive statistics, function Cont IF. Of the 261 class I and II restorations evaluated, 150 (57.5%) were in need of replacement. The main causes of failure of class I and II restorations were secondary caries (46.7%), followed by fracture (19.3%) and loss of marginal adaptation (16.7%). Of all the restorations made by the 3rd grade students, 68.4% failed, 57.4% performed by the 4th grade students and 53.9% of the 5th grade students. Based on the results, it is concluded that the main reasons for restorations failure were secondary caries, fracture and loss of marginal adaptation according to the evaluation criteria. Restorations performed by students in the 3rd grade showed a higher percentage of failures compared to those performed by students in the 4th and 5th grades. Keywords: Permanent Dental Restoration. Composite Resins. Dental Restoration Failure. Resumo Fatores como estética e adesão aos substratos dentários têm consolidado a resina composta como material restaurador para dentes posteriores, entretanto, o desempenho mostra-se insatisfatório em relação a longevidade destas restaurações. O objetivo desse estudo observacional transversal retrospectivo foi avaliar as razões que resultaram em falhas das restaurações de resina composta de classe I e II de Black, realizadas por alunos de graduação em Odontologia da Universidade Estadual de Londrina. Os pacientes foram selecionados a partir da pesquisa dos prontuários arquivados no Setor de Triagem da Clínica Odontológica Universitária. As restaurações foram avaliadas por dois avaliadores, cirurgiões-dentistas, calibrados. Os dados coletados foram tabulados e analisados por meio de estatística descritiva, função Cont SE. Das 261 restaurações classes I e II avaliadas, 150 (57,5%) apresentavam-se com necessidade de substituição. As principais causas de falhas das restaurações classes I e II foram: cárie secundária (46,7%), seguido de fratura (19,3%) e perda de integridade marginal (16,7%). Dentre as restaurações realizadas por alunos da 3ª série e avaliadas, 68,4% falharam, da 4ª série 57,4% e da 5ª série 53,9%. Com base nos resultados, conclui-se que as principais razões de falha das restaurações foram cárie secundária, fratura e perda de integridade marginal, de acordo com os critérios de avaliação. As restaurações realizadas por alunos da 3ª série apresentaram maior percentual de falhas, comparadas as realizadas pelos alunos da 4ª e 5ª séries. Palavras-chave: Restauração Dentária Permanente. Resinas Compostas. Falha de Restauração Dentária.


2021 ◽  
pp. 096739112199958
Author(s):  
Vahti Kılıç ◽  
Feridun Hurmuzlu ◽  
Yılmaz Ugur ◽  
Suzan Cangul

The aim of the present study was to investigate and compare the quantity of residual monomers leached from the bulk-fill composites with different compositions polymerized at varying layer thickness. Three bulk-fill (X-tra-fil, Beautifil Bulk Restorative, Fill-Up) and a nanohybrid composite (Filtek Z550) were used for the study. The composite resin samples were prepared with a stainless steel mold. For each composite, two groups were constructed. The samples in the first group were prepared using the 2 + 2 mm layering technique. In the second group, the composite samples were applied as a 4 mm-thick one layer and polymerized. Then, each composite samples were kept in a 75% ethanol solution and residual monomers released from composite resins were analyzed with an HPLC device after 24hour and 1 month. The data were analyzed using Kruskal-Wallis and Mann-Whitney U tests. Except the Fill-Up, all of residual monomer elution from the bulk-fill composites was significantly affected by the layer thickness (p < 0.05). The greatest monomer release was detected at 1 month after polymerization as a single 4 mm layer for Beautifil Bulk Restorative. Fill-Up composite showed similar residual monomer release in polymerization at different layer thicknesses compared to other composite resins. In the 2 + 2 mm layering technique, the least monomer elution was detected in the Filtek Z550 composite group. While Bis-GMA was the most released monomer in X-tra fil composite, UDMA was the most released monomer in all other composite resins. During polymerization of the bulk-fill composite, the layer thickness of the composite applied may affect the amount of residual monomers released from the composite resins. Conventional composites may release less monomer than bulk-fill composites when used with layering.


2012 ◽  
Vol 37 (5) ◽  
pp. 526-531 ◽  
Author(s):  
CRG Torres ◽  
CF Ribeiro ◽  
E Bresciani ◽  
AB Borges

SUMMARY The aim of the present study was to evaluate the effect of 20% and 35% hydrogen peroxide bleaching gels on the color, opacity, and fluorescence of composite resins. Seven composite resin brands were tested and 30 specimens, 3-mm in diameter and 2-mm thick, of each material were fabricated, for a total of 210 specimens. The specimens of each tested material were divided into three subgroups (n=10) according to the bleaching therapy tested: 20% hydrogen peroxide gel, 35% hydroxide peroxide gel, and the control group. The baseline color, opacity, and fluorescence were assessed by spectrophotometry. Four 30-minute bleaching gel applications, two hours in total, were performed. The control group did not receive bleaching treatment and was stored in deionized water. Final assessments were performed, and data were analyzed by two-way analysis of variance and Tukey tests (p&lt;0.05). Color changes were significant for different tested bleaching therapies (p&lt;0.0001), with the greatest color change observed for 35% hydrogen peroxide gel. No difference in opacity was detected for all analyzed parameters. Fluorescence changes were influenced by composite resin brand (p&lt;0.0001) and bleaching therapy (p=0.0016) used. No significant differences in fluorescence between different bleaching gel concentrations were detected by Tukey test. The greatest fluorescence alteration was detected on the brand Z350. It was concluded that 35% hydrogen peroxide bleaching gel generated the greatest color change among all evaluated materials. No statistical opacity changes were detected for all tested variables, and significant fluorescence changes were dependent on the material and bleaching therapy, regardless of the gel concentration.


2007 ◽  
Vol 18 (3) ◽  
pp. 231-234 ◽  
Author(s):  
Álvaro Della Bona ◽  
Vinícius Rosa ◽  
Dileta Cecchetti

This study tested the following hypotheses: 1. increasing light irradiation time (IT) produces greater values of superficial hardness on different depths (0 and 3 mm); and 2. a dark shade composite (A3) needs longer IT than a light shade composite (A1) to produce similar hardness. Disk-shaped specimens (n=24 per shade) were fabricated using a 3-mm-thick increment of composite resin (Z100). Specimens were randomly assigned to 3 groups (n=8) according to the IT (400 mW/cm2) at the upper (U) surface: A1-10 and A3-10: 10 s; A1-20 and A3-20: 20 s; A1-40 and A3-40: 40 s. Specimens were stored in black lightproof containers at 37ºC for 24 h before indentation in a hardness tester. Three Vickers indentations were performed on the U and lower (L) surfaces of each specimen. The indent diagonals were measured and the hardness value calculated. The results were analyzed statistically by ANOVA and Tukey's test (alpha=0.05). Statistically significant differences were found between U and L surfaces of each composite shade-IT combination (p=0.0001) and among the ITs of same shade-surface combination (p=0.0001), except between groups A1-20U and A1-40U, confirming the study hypothesis 1 and partially rejecting the hypothesis 2.


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