THE DIFFICULTIES OF DIAGNOSIS AND CHOICE OF TREATMENT TACTICS OF NEUROENDOCRINE TUMORS OF THE SMALL INTESTINE

The paper presents the clinical case that reflects the difficulties of diagnosis and choice of treatment tactics of patients with neuroendocrine tumors of the small intestine. The sequence of instrumental diagnostic methods made it possible to determine the localization of the tumor in small intestine and to clarify the prevalence of the tumor process. The implementation of active surgical treatment tactics allowed performing cytoreductive surgical intervention, eliminating the risk of complications of the tumor process and improving the quality of life of the patient with generalized neuroendocrine tumor of the small intestine.

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Resection and reconstruction of idiopathic scrotal elephantiasis: surgical approach and quality of life assessment

BMJ Case Reports ◽

10.1136/bcr-2021-244018 ◽

2021 ◽

Vol 14 (10) ◽

pp. e244018

Author(s):

Hasan Gökcer Tekin ◽

Karin Andersen ◽

Vivi Bakholdt ◽

Jens Ahm Sørensen

Keyword(s):

Quality Of Life ◽

Surgical Treatment ◽

Surgical Intervention ◽

Life Assessment ◽

Quality Of Life Assessment ◽

Assess Patient Satisfaction ◽

Industrialised Countries ◽

Disease Specific

Scrotal elephantiasis (SE) is a condition considered rare in western industrialised countries but common in filaria prone regions. If no apparent causes are found for SE, it is called idiopathic SE. Medical and conservative therapies are ineffective against idiopathic SE, and surgical intervention is mandatory to treat this disabling condition. Nevertheless, it remains unclear whether surgical intervention improves quality of life among patients with idiopathic SE. Herein, we report a case of a 41-year-old man who underwent acute scrotal resection and reconstruction, secondary to haemorrhage from his idiopathic SE. The aim of this study was to describe the operative approach and assess patient satisfaction after surgical treatment. The patient had no recurrence of SE after surgical treatment at 6 months follow-up and had considerable improvements assessed by general and disease-specific quality of life questionnaires.

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The problems of delayed diagnostics of neuroendocrine tumors of the gastrointestinal tract and pancreas (clinical case)

Herald of Pancreatic Club ◽

10.33149/vkp.2018.03.07 ◽

2018 ◽

Vol 41 (3) ◽

pp. 46-49

Author(s):

L. G. Vologzhanina ◽

I. V. Petukhova

Keyword(s):

Surgical Treatment ◽

Gastrointestinal Tract ◽

Neuroendocrine Tumor ◽

Neuroendocrine Tumors ◽

Proton Pump Inhibitors ◽

Proton Pump ◽

Clinical Case ◽

Late Detection

Gastrinoma is a rare neuroendocrine tumor, with frequent cases of late detection. A clinical case of late diagnostics of gastrinoma complicated by metastases is presented, with symptomatology remaining after surgical treatment, which is stopped with the help of proton pump inhibitors.

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Surgical treatment of idiopathic normal pressure hydrocephalus (literature rewiew)

Grekov s Bulletin of Surgery ◽

10.24884/0042-4625-2019-178-2-73-78 ◽

2019 ◽

Vol 178 (2) ◽

pp. 73-78

Author(s):

G. V. Gavrilov ◽

A. V. Stanishevskiy ◽

B. V. Gaydar ◽

D. V. Svistov

Keyword(s):

Quality Of Life ◽

Surgical Treatment ◽

Normal Pressure Hydrocephalus ◽

Surgical Intervention ◽

Pathological Condition ◽

Cognitive Disorders ◽

Normal Pressure ◽

Ventriculoperitoneal Shunting ◽

Pump Valve

Normal pressure hydrocephalus is a pathological condition characterized by ventricular expansion in combination with normal intracranial pressure and manifested by a specific triad of symptoms, including gait disorders, cognitive disorders and urinary incontinence. The prevalence of the disease has not been fully studied and according to various population epidemiological researches reaches 0.3–3 % among patients older than 61 years. A feature that differs normal pressure hydrocephalus from other neurodegenerative diseases is the possibility of full or partial regression of neurological symptoms after surgical treatment. The most common surgical intervention for normal pressure hydrocephalus is ventriculoperitoneal shunting. It is an implantation of a system of catheters connected by pump-valve into the patient’s body, that drainage cerebrospinal fluid from ventricles to abdomen cavity. Correct and timely surgical treatment of normal pressure hydrocephalus allows increasing the quality of life of patients with normal pressure hydrocephalus and, as a result, the quality of life of their relatives and friends.

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THE RATIONALE FOR DIAGNOSTIC AND TREATMENT TACTICS IN PATIENTS WITH NEUROENDOCRINE TUMORS OF THE SMALL INTESTINE

Grekov s Bulletin of Surgery ◽

10.24884/0042-4625-2018-177-4-28-37 ◽

2018 ◽

Vol 177 (4) ◽

pp. 28-37

Author(s):

P. N. Romashchenko ◽

N. A. Maistrenko ◽

R. V. Orlova ◽

M. V. Lysanyuk

Keyword(s):

Small Intestine ◽

Neuroendocrine Tumors ◽

Morphological Characteristics ◽

Main Method ◽

Medical Centers ◽

Increased Risk ◽

Choice Of Treatment ◽

Complicated Course ◽

Generalized Net

The OBJECTIVE of the study was to clarify the rational program of diagnosis and choice of treatment tactics for patients with neuroendocrine tumors (NET) of the small intestine, taking into account their clinical and morphological characteristics. MATERIAL AND METHODS. We studied the results of examination and treatment of 39 patients. RESULTS. CT is the main method of topical diagnosis, the sensitivity of which in the detection of NET of the small intestine is 96.4 %. Sign of the localization of NET in the small intestine is the tumor conglomerate of its mesentery, which includes diffuse-infiltrative and nodular variant of changes. The diffuse-infiltrative variant of tumor conglomerate is characterized by increased risk of complicated course of tumor process. Cytoreductive surgical treatment allows to increase the survival rate of patients with generalized NET of the small intestine in 1.7 times. CONCLUSION. Treatment of patients with NET of the small intestine should be carried out in specialized medical centers that have the ability to implement a multidisciplinary approach that can significantly increase the duration and quality of life of patients.

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Severe impairments in health-related quality of life in patients with small intestine neuroendocrine tumors

Endocrine Abstracts ◽

10.1530/endoabs.56.p131 ◽

2018 ◽

Author(s):

Niina Matikainen ◽

Noora Karppinen ◽

Riikka Linden ◽

Harri Sintonen ◽

Maija Tarkkanen ◽

...

Keyword(s):

Quality Of Life ◽

Small Intestine ◽

Neuroendocrine Tumors ◽

Health Related Quality ◽

Related Quality ◽

Health Related

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SURGICAL TREATMENT OF ACUTE INTESTINAL OBSTACLATION CONDITIONED BY A NEUROENDOKRIN TUMOR OF THE THIN INTESTINE, ON THE BACKGROUND OF THE PATIENT INFECTION OF A NEW CORONOVIRUS INFECTION COVID-19

SCIENTIFIC MEDICAL BULLETIN OF UGRA ◽

10.25017/2306-1367-2020-24-2-37-45 ◽

2020 ◽

Vol 24 (2) ◽

pp. 37-45

Author(s):

Ildar Mugallimovich Sharafutdinov ◽

◽

Marat Faritovich Minniakhmetov ◽

Vladimir Petrovich Ionin ◽

Keyword(s):

Small Intestine ◽

Surgical Treatment ◽

Intestinal Obstruction ◽

Neuroendocrine Tumor ◽

Clinical Case ◽

Acute Intestinal Obstruction ◽

Patient Infection

A clinical case of successful surgical treatment of acute intestinal obstruction due to a neuroendocrine tumor of the small intestine in a patient against a new coronovirus infection COVID-19 is described.

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Health-Related Quality of Life in Patients with Small Intestine Neuroendocrine Tumors

Neuroendocrinology ◽

10.1159/000494293 ◽

2018 ◽

Vol 107 (4) ◽

pp. 366-374 ◽

Cited By ~ 8

Author(s):

Noora Karppinen ◽

Riikka Lindén ◽

Harri Sintonen ◽

Maija Tarkkanen ◽

Risto Roine ◽

...

Keyword(s):

Quality Of Life ◽

Small Intestine ◽

Sexual Activity ◽

Neuroendocrine Tumors ◽

Health Related Quality ◽

Sf 36 ◽

Related Quality ◽

Health Related ◽

The Impact

Background: The prevalence of small intestine neuroendocrine tumors (SI-NETs) is increasing. Disease progression is often slow and treatment options and long-term survival rates have improved, but little is known about health-related quality of life (HRQoL) in these patients. Objective: To assess HRQoL and its predictors in SI-NET patients receiving contemporary treatments. Methods: We measured HRQoL with 15D and SF-36 questionnaires in 134 SI-NET patients and compared the 15D results to those of an age- and gender-standardized sample of the general population (n = 1,153). In the patients, we studied the impact of treatments, Ki-67, liver metastases, circulating tumor markers, comorbidities, and/or socioeconomic factors on HRQoL with linear regression analysis. Results: The mean disease duration of the patients was 81 (4–468) months, 91% had metastatic disease, and 79% received somatostatin analog treatment. Hepatic tumor load was 0% in 44.8%, < 10–25% in 44.0%, and > 25% in 11.2%, respectively. Mean fP-CgA and S-5HIAA concentrations were 15 (1.3–250) and 344 (24–7,470) nmol/L, respectively. Overall, HRQoL was significantly impaired in patients compared to controls (15D score 0.864 ± 0.105 vs. 0.905 ± 0.028, p < 0.001). SI-NET patients scored worse on 9 of 15 dimensions: sleep, excretion (i.e., bladder and bowel function), depression, distress, vitality, sexual activity (p < 0.001), breathing, usual activities, and discomfort and symptoms (p < 0.01–0.05). SF-36 scores were impaired and highly correlated with 15D scores (p < 0.001). HRQoL was impaired in patients with (n = 85) compared to patients without (n = 49) impaired excretion (0.828 vs. 0.933, p < 0.001). In the patient group, number of medications predicted impaired HRQoL. Conclusions: Despite contemporary treatments, SI-NET patients have severely impaired HRQoL, including diarrhea, sleep, depression, vitality, and sexual activity.

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Study of impact of surgical intervention (adenotonsillectomy) and conservative management on quality of life in patients with SDB

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20180706 ◽

2018 ◽

Vol 4 (2) ◽

pp. 448

Author(s):

Arshed Ali ◽

Jasif Nisar ◽

Ihsan Ali ◽

Rauf Ahmad

Keyword(s):

Quality Of Life ◽

Conservative Treatment ◽

Conservative Management ◽

Pediatric Patients ◽

Surgical Intervention ◽

Diagnostic Methods ◽

Before And After ◽

The Impact

Background: SDB is an important cause of morbidity in children. SDB has been associated with decreased quality of life (QOL). In this study, we tried to determine The impact of surgical intervention (adenotonsillectomy) and conservative management on quality of life in patients with SDB. Methods: A total of 112 pediatric patients were included with SDB, who visited our OPD. Diagnostic methods include history and physical examination, audiotaping or videotaping, pulse oximetry. OSA 18 questionnaire was used to assess the quality of life with conservative treatment (pre and post-treatment) and after surgical intervention-before and after adenoidectomy or adenotonsillectomy. Results: We had 112 patients with majority being males 69 (61.60%) and females 43 (38.30%), majority of patients were in the age group of 5-7 yrs (49.10%). In 47 patients (who underwent adenotonsillectomy/tonsillectomy), OSA-18 questionnaire was used pre-operatively, at 2 and 6 months. OSA-18 when used pre-operatively showed majority of patients 33 (70.21%) having score >80, and 14 (29.79%) patients having score between 60-80. No patient was below 60 score. Mean OSA-18 score pre-operatively was 84.15. OSA-18 score at 2 months and at 6 months were 30.06 and 26.40 respectively, which showed a lot of improvement in post-operative score and hence the post –operative quality of life. In 65 patients (conservative treatment) OSA-18 was used pre-conservative, at 2 and 6 months of treatment. OSA-18 when used before conservative treatment showed majority of patients 44 (67.6 9%) having score 60-80, and 21 (32.30%) patients having score between >80. No patient was below 60 score. OSA-18 score at 2 months showed improvement in 69.23% patients (<40), OSA-18 at 6 months showed recurrence in 12.33% patients. Conclusions: SDB substantially impact QOL in pediatric patients. QOL significantly improves following adenotonsillectomy. There is subset of patients 12.33% with SDB in whom there was recurrence of symptoms after conservative treatment. Thus showing that conservative management is inferior to surgical management in the treatment of SDB. SDB improved after an observation period. Thus, observation with close follow-up is another treatment option.

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