scholarly journals Modern concepts of the morphofunctional organization of vascularization of liver

2017 ◽  
Vol 16 (4) ◽  
pp. 4-10
Author(s):  
V. E. Milyukov ◽  
H. M. Sharifova

The liver is one of the most significant organs of regulation of vital processes in the human body. The basis of coordination of metabolic processes is the blood vessel vascular bed of the liver. According to most researchers, it is the consequence of hemodynamic disorders that are the metabolic disorders that are caused and then maintained by tissue hypoxia. Modern ideas about the morphofunctional organization of the vascular bed of the liver are necessary for physicians of practical medical practice dealing with both the diagnosis of the degree of changes and the treatment of the organs of the hepato-gastro-duodenal region. Of particular practical interest for surgical interventions in the hepatobiliary zone is the knowledge of options for the formation of arteries of the liver.

Author(s):  
Sonia Kukreti ◽  
Shivi Saxena

Metabolism is a complex process that involves a series of chemical reactions in the human body. Alterations in these metabolic processes constitute the disturbances of metabolism causing metabolic disorders. When studying the pathological mechanisms of protein deficiencies it is necessary not only to take into account the composition of the diet. This research discusses the oral aspects of metabolic diseases. Key Words: Metabolism diseases, protein deficiency syndromes, IEMS, MSUD.


Author(s):  
L. V. Zhuravlyova ◽  
Yu. D. Stoianova

The combination of diabetes mellitus type 2 and gout is common. It has been established that prolonged hyperuricemia leads to insulin resistance and suppresses the effects of insulin, which is why the study of pathogenetic links in the formation of metabolic disorders in synergistic pathologies is relevant. AMPK has been shown to be a regulator of cell energy balance, which plays an important role in preventing the development of insulin resistance. The purpose of this review is to determine the impact of AMPK on carbohydrate, lipid and purine metabolism in patients with diabetes mellitus type 2 and gout. The realization of the effects of AMPK on metabolic processes in the human body occurs in two main ways — inhibition of anabolism and stimulation of catabolism, which will be discussed in the article. It is advisable to consider the mechanisms of action of indirect activators of AMPK as potential components for the comprehensive treatment of patients with metabolic disorders. The mechanisms of activation and inhibition of AMPK are not investigated enough, but it is known that AMPK plays a significant role in the main metabolic processes in the human body. The mechanisms of cell sensitivity to most energy‑containing molecules and substances directly depend on the AMPK activation degree. The presence of these dependencies may be evaluated in the case of metabolic diseases. Thus, further study of the effects of AMPK and its influence on carbohydrate, lipid and purine metabolism is necessary, due to the possibility of predicting the formation of insulin resistance, the severity of diabetes mellitus type 2 in combination with gout, and optimizing treatment in patients with comorbid pathology.


Author(s):  
Anna Koval ◽  

he end of the twentieth century and the beginning of the twentyfirst century has begun the rapid development of scientific researches in the biological and medical fields. This process is associated with using of fundamentally new methods, which are primarily aimed at the disease prevention, as well as the introduction into the treatment of human diseases with the latest scientific and innovative technologies, methods and techniques of their application. These opportunities in the development of scientific technologies in the field of biology and medicine have led to the emergence of such a direction of scientific activity as "biotechnology". The proposed article notes that using of biomedical technologies has caused a number of new problems in the field of law and ethics. Legal arrangement in the field of the health protection have become much more complicated. Thanks to new opportunities, today these relations regulate rights and responsibilities of a fairly large number of people. Modern relations in the field of medical services and medical care lead to the emergence of new approaches to their regulation by both legal and ethical norms. In the past, relations in the field of the health protection were usually between two subjects, a doctor and a healthcare consumer. Nowadays, in a medical practice, relations in the field of the health protection involve: a health-care consumer, his family members (e.g., in the case of hereditary diseases diagnosis, blood and organ donation etc.) and third parties (e.g., organ donation, reproductive cell donation, surrogacy etc.). In the general doctrinal concept, biotechnology is the industrial use of living organisms or their parts (microorganisms, fungi, algae, plant and animal cells, cellular organs, enzymes etc.) for product producing or modifying, improving plants and animals, and in medical practice - in relation of the individual human organs (or body as a whole) functioning. These circumstances require improving the legal regulation of modern medicine public relations, bringing them into line with emerging realities. Moreover, the specifics of relations in this field determines the specifics of their legal regulation. The application of new medical technologiesin relation to human treatment has given rise to a significant number of moral and ethical problems that could not be solved within the framework of medical ethics and deontology alone. In connection with this, the way out of the current situation could be the consolidation of bioethics as an interdisciplinary field of knowledge, as a science, which makes it possible to explain moral, ethical and legal aspects of the medicine. This, for example, determines the allocation of medical law in an independent branch of law in some Western countries and Ukraine. The article focuses on biomedical ethics, which is a component of the medical activities system regulation. In the context of considering the levels of social regulation of medical activities, bioethics (biomedical ethics) is an interdisciplinary science that studies moral and ethical, social and legal problems of medical activities in the context of human rights protection. Bioethics should create a set of moral principles, norms and rules that are binding on all mankind and delineate the limits of scientific interference in the nature of the human body, the transition through which is unacceptable.


2021 ◽  
pp. 438-441
Author(s):  
L.A. Efimov ◽  
K.R. Khasanova ◽  
A.A. Nazmieva ◽  
T.Yu. Gumerov

Functional drinks are intended for systematic consumption as part of food rations; they preserve and improve health, as well as reduce the risk of developing certain diseases. Functional drinks contain ingredients that have the ability to have a positive effect on physiological functions and metabolic processes in the human body. The functional ingredients of alcohol-free beverages are: vitamins, macro- and microelements, dietary fiber, organic acids, phenolic and other compounds. Functional drinks include non-alcoholic energy drinks, fortified juices and sports drinks, therapeutic and therapeutic-table mineral waters.


Author(s):  
N. O. Kravchenko ◽  
L. V. Kovalenko ◽  
O. P. Rudenko ◽  
V. S. Boiko

The purpose of these studies was to determine status of metabolic processes in clinically healthy horses of sport breeds in spring period. Blood samples for biochemical studies were collected from 12 clinically healthy 7–9 month-old stallions of Ukrainian horse breed at Dnipropetrovsk region equestrian club. Protein (albumin, globulin, urea and creatinine) and mineral (common calcium and inorganic phosphorus) metabolic statuses, level of glucose, vitamins A and E and acid, as well as activity of hepatospecific enzymes (ALT, AST and AP) were determined using common techniques. It has been found that common protein level was within the limits of physiologic norm, although the level of albumins was decreased at the average rate of 12.0%, and the level of β- and γ-globulins was increased at the average rates of 5.2 and 11.3% respectively. AST activity was decreased at the rate of 38.0% regarding to physiological norm. Thereby, urea and creatinine concentrations were within the referent levels. Hyperglycaemia was observed in 50.0% of tested animals with maximal excess at the rate of 44.0%. Also, decreasing of common calcium and inorganic phosphorus levels was determined at the rate of 16.0 and 58.6%, vitamins А and Е — at the rate of 64.0 and 48,6% respectively, in comparison to lower level of physiological norm. The average index of acid capacity reached maximal referent levels. At the same time, it was increased in 33.3% of animals. Therefore, detected changes in biochemical indices in horse blood evidence that various metabolic disorders progress in clinically healthy stallions at spring and may furtherly lead to the appearance of metabolic syndrome


2017 ◽  
Vol 7 (6) ◽  
pp. 17
Author(s):  
Wamik Azmi ◽  
Shikha Chauhan ◽  
Manisha Gautam

Collagen is the most widely distributed class of proteins in the human body. Monomers of collagen are constantly being synthesized and degraded throughout the development of a healthy individual to adulthood. The collagenase subfamily found in human matrix (metalloproteinases), are capable of hydrolyzing native collagen under physiological conditions. Collagenases are produced by specific cells involved in repairs and remodelling processes and plays important role in connective tissue metabolism. Present article focus on the major sources, properties and therapeutic aspects of microbial collagenases in their relation with various diseases and its applications in medical and food industry. Collagenolytic enzymes are highly specific for collagen and have been the focus of much practical interest with respect to cosmetic, medical and food based applications. The most common uses of these enzymes appear to be in medicine as they have been used to treat burns and ulcers, to eliminate scar tissue and play an important role in the successful transplantation of specific organs.


2020 ◽  
pp. 251484862093723
Author(s):  
Luis Andueza ◽  
Archie Davies ◽  
Alex Loftus ◽  
Hannah Schling

In this paper, we conceptualise the human body as infrastructure, asking what kind of infrastructure it currently is and what kind of infrastructure it could be. We therefore tease out the historically and geographically specific ways in which human bodies have been (re)produced as infrastructure, emphasising the violence of abstraction in capitalist modernity that transforms the productive body into a technology of calorific inputs and outputs. Nevertheless, through demystifying abstract labour we point to the relations of (re)production (needed for the body’s ongoing repair) and the metabolic processes (responsible for both decay and repair) that are subsumed within a broader capitalist system of accumulation. In so doing, we turn to the immanent contradictions and struggles that resist the body’s production as a one-sided technology of circulation and through which it is, and can become, an infrastructure for life and sociality.


2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Miguel Gonzalez ◽  
Daniel Rivera ◽  
Alam Marcelino ◽  
Gabriela Agront ◽  
Rafael Rodriguez ◽  
...  

An aneurysm is the result of a widening or ballooning of a portion of a blood vessel. The rupture of an aneurysm occurs when the mechanical stress acting on the inner wall exceeds the failure strength of the blood vessel. We propose an innovative approach to prevent the rupture of an aneurysm based on the use of nanotechnology to improve the strength of the blood vessel. We present results on the effect of silver nanofibers on the resistance toward deformation of blood vessels. The silver nanofibers are grown on the surface of the blood vessels. The nanofibers are120±30 nm in diameter and2.7±0.8 μm in length. The deformation per applied force of blood vessels was found to decrease from 0.15 m/N in control blood vessels to 0.003 m/N in blood vessels treated with the nanofibers. This represents an increase in the resistance towards deformation of a factor of 50. The increase in the resistance towards deformation is clinically significant since blood pressure increases by factors slightly larger than one in the human body. Treatment of blood vessels with silver nanofibers is a potential translational clinical tool for preventing rupture of aneurysms in a clinical setting.


2015 ◽  
Vol 2015.21 (0) ◽  
pp. _20708-1_-_20708-2_
Author(s):  
Shuya GOTO ◽  
Junichi NAGASAWA ◽  
Yasuhiro SHINDO ◽  
Kazuo KATO

Sign in / Sign up

Export Citation Format

Share Document