The hydrate is an important issue that the flow assurance has to face in the oil and gas industry, especially in the deepwater area. With high pressure and low temperature, the hydrate formation is easily happened and leads to plug in the pipeline. In addition to the traditional thermodynamic inhibitor, the low dosage hydrate inhibitors (LDHI) has been increasing used as a costly effective technology for gas hydrate control. The LDHI include kinetic hydrate inhibitor (KHI) and anti-agglomerant (AA), the former can inhibit the hydrate formation in the pipeline, and the latter can prevent the agglomeration and plug of hydrate particles. According to the properties of oil and gas of South China Sea, a new KHI and AA were developed, a field test of the KHI has been undertaken and the results indicate that it can prevent the hydrate formation and plug in the pipeline well, the lab evaluation of the developed AA is in progress and the field test will be performed by the next year.