scholarly journals Experience of using an excimer lamp equipped with UVB dose control system in dermatology

2020 ◽  
Vol 9 (1) ◽  
pp. 21-26
Author(s):  
D. V. Schitz ◽  
I. E. Torshina ◽  
N. V. Nekrasova ◽  
T. M. Busko
Keyword(s):  
Skin Diseases ◽  
Single Case ◽  
Control Unit ◽  
Local Effect ◽  
Depth Of Penetration ◽  
Excimer Lamp ◽  
Excimer Lamps ◽  
Small Depth ◽  
Dose Control ◽  
Cosmetic Effect

Intermediate ultraviolet (UVB) therapy is considered a relatively safe method of treating skin diseases with an autoimmune component in development compared to medical drug methods, including PUVA therapy. This is due to the small depth of penetration of the rays of this wavelength range into skin, which provides a purely local effect on the human body. Excimer lamps are an alternative to the expensive excimer laser for phototherapy of psoriasis or vitiligo. However, for effective phototherapy using UVB lamps, the distance from an emitter to a patient’s skin must be considered. In this paper, we report on treatment of patients using an excimer lamp, the control unit of which is equipped with an optical system for controlling of ultraviolet radiation dose, which allows automatically calculating the time for a set UVB dose. The article describes the results of phototherapy using an excimer lamp of several cases of psoriasis, vitiligo and other forms of dermatitis with a good therapeutic and cosmetic effect. When using an excimer lamp, not a single case of exacerbation of dermatological diseases was established.

Beclomethasone dipropionate and betamethasone valerate aerosols

1973 ◽  
Vol 11 (26) ◽  
pp. 101-102
Keyword(s):  
Beclomethasone Dipropionate ◽  
Skin Diseases ◽  
Normal Skin ◽  
Local Effect ◽  
Betamethasone Valerate ◽  
Systemic Effects ◽  
Bronchial Mucosa ◽  
Local Effects ◽  
Local Activity ◽  
Systemic Activity

Adult asthmatics taking not more than 10 mg of prednisone a day with regular supervision seem rarely to suffer serious unwanted effects.1 Hydrocortisone, prednisone and dexamethasone have been given by aerosol to achieve a local effect but their systemic activity2 and uncertain local effects have limited their use in asthma. Hitherto, corticosteroid aerosols have not achieved selective local activity and are readily absorbed. Beclomethasone dipropionate (Becotide - A & H) and betamethasone valerate (Bextasol - Glaxo) have recently been introduced in aerosol form because of their proven topical effectiveness in some skin diseases without unwanted systemic effects.3 Both are potent vasoconstrictors when applied to normal skin. A local action confined to the bronchial mucosa without harmful local or systemic effects would be valuable in asthma.

scholarly journals Tin Carboxylate Complexes of Natural Bacteriochlorin for Combined Photodynamic and Chemotherapy of Cancer è

2021 ◽  
Vol 22 (24) ◽  
pp. 13563
Author(s):  
Sergey Tikhonov ◽  
Petr Ostroverkhov ◽  
Nikita Suvorov ◽  
Andrey Mironov ◽  
Yulia Efimova ◽  
...  
Keyword(s):  
Cell Lines ◽  
Biological Tissues ◽  
Original Method ◽  
Depth Of Penetration ◽  
Small Depth ◽  
Tumor Tissues ◽  
Biological Tests ◽  
Physicochemical Methods ◽  
Combined Action

Photodynamic therapy (PDT) is currently one of the most promising methods of cancer treatment. However, this method has some limitations, including a small depth of penetration into biological tissues, the low selectivity of accumulation, and hypoxia of the tumor tissues. These disadvantages can be overcome by combining PDT with other methods of treatment, such as radiation therapy, neutron capture therapy, chemotherapy, etc. In this work, potential drugs were obtained for the first time, the molecules of which contain both photodynamic and chemotherapeutic pharmacophores. A derivative of natural bacteriochlorophyll a with a tin IV complex, which has chemotherapeutic activity, acts as an agent for PDT. This work presents an original method for obtaining agents of combined action, the structure of which is confirmed by various physicochemical methods of analysis. The method of molecular modeling was used to investigate the binding of the proposed drugs to DNA. In vitro biological tests were carried out on several lines of tumor cells: Hela, A549, S37, MCF7, and PC-3. It was shown that the proposed conjugates of binary action for some cell lines had a dark cytotoxicity that was significantly higher (8–10 times) than the corresponding metal complexes of amino acids, which was explained by the targeted chemotherapeutic action of the tin (IV) complex due to chlorin. The greatest increase in efficiency relative to the initial dipropoxy-BPI was found for the conjugate with lysine as a chelator of the tin cation relative to cell lines, with the following results: S-37 increased 3-fold, MCF-7 3-fold, and Hela 2.4-fold. The intracellular distribution of the obtained agents was also studied by confocal microscopy and showed a diffuse granular distribution with predominant accumulation in the near nuclear region.

The Clinical Efficacy of a Monochromatic 308-nm Excimer Lamp for the Treatment of Various Skin Diseases

2009 ◽  
Vol 71 (2) ◽  
pp. 192-200 ◽  
Author(s):  
Junna OBA-OKADA ◽  
Noriko FUKIWAKE ◽  
Masutaka FURUE
Keyword(s):  
Clinical Efficacy ◽  
Skin Diseases ◽  
Excimer Lamp

scholarly journals The study of patterns of inhibition native microflora of raw materials under the influence of ultraviolet radiation with different processing intensity

2021 ◽  
Vol 82 (4) ◽  
pp. 84-87
Author(s):  
A. Y. Kolokolova ◽  
N. V. Iliukhina
Keyword(s):  
Ultraviolet Radiation ◽  
Uv Radiation ◽  
Raw Materials ◽  
Research Model ◽  
Uv Treatment ◽  
Depth Of Penetration ◽  
Industrial Enterprises ◽  
Small Depth ◽  
Microbiological Stability ◽  
Native Microflora

Ultraviolet radiation has long proven itself as a technological process that allows you to reduce a significant amount or completely inhibit unwanted microorganisms, however, this technology is mainly used for disinfection of air and surfaces in industrial enterprises. The use of food processing with ultraviolet light is poorly developed, this is due to a number of limitations, one of which is the small depth of penetration of ultraviolet radiation. This circumstance introduces a number of restrictions and requires additional research for the active introduction of UV radiation in the food industry. The aim of the work: to study the dynamics of inhibition of native microflora of raw materials during UV treatment with various doses; to determine the degree of development of residual microflora during storage of UV-treated food products. Objects of research: model media containing native microflora of raw materials and fresh mushrooms. An improved UV treatment mode is proposed to reduce the surface injury of fresh mushrooms and ensure their microbiological stability of champignons during storage. The obtained results allowed us to establish the regularities of inhibition of native microflora on the surface of model media and fresh mushrooms depending on the distance to the UV radiation source, the time of irradiation, and the accumulated dose. It is noted that the dynamics of inhibition of native microflora on the surface of model media is not linear, and "Plateau" zones are marked. When developing a technology for processing fresh mushrooms, it is recommended to use a UV source with an accumulated radiation dose of 500 Dg/m2.

scholarly journals The Role of Siravyadha in the management of Psoriasis a case study.

2020 ◽  
Vol 8 (06) ◽  
Author(s):  
DR BHAGYASHREE GOPAL PURANIK DR BHAGYASHREE GOPAL PURANIK
Keyword(s):  
Adverse Effects ◽  
Skin Diseases ◽  
Single Case ◽  
Signs And Symptoms ◽  
Social Aspects ◽  
Single Case Study ◽  
Practical Guidelines ◽  
Therapeutic Measures

In Ayurveda skin disease are described under Kushtha. It is further divided into Mahakushtha and Kshudrakushtha. Rakta Dosha is predominant in Kushtha. Signs and symptoms of Ekakushtha which comes under Kshudrakushtha can be correlate with Psoriasis.  It produces significant adverse effects on psychological and social aspects of life mainly because of visibility. Psoriasis is chronic re-occurring condition that varies in severity from minor localised patches to complete body coverage. Kushtha Chikitsa is classified into Shodhan, Shamana and Nidanparivarjana. Amongst which Shodhan Chikitsa is of greater significance in skin diseases. Raktamokshana is an effective and safe treatment for Kushtha. Acharya Sushruta has mentioned detailed practical guidelines for bloodletting which is considered as Ardhachiktsa. Disease which does not get pacified so quickly by therapeutic measures like Snehana, Swedana etc. are specified by Siravyadha. This is a single case study to evaluate the efficacy of Shodhana in terms of Siravyadha in the management of psoriasis.

The Use of Advanced Analytical Techniques for Characterization of the Chemical, Physical, and Crystallographic Nature of a Surface

1973 ◽  
Vol 31 ◽  
pp. 132-133 ◽  
Author(s):  
R. E. Herfert
Keyword(s):  
Surface Characterization ◽  
Analytical Techniques ◽  
X Ray Diffraction ◽  
Depth Of Penetration ◽  
X Ray ◽  
The Past ◽  
Transmission Electron ◽  
Scanning Electron

Studies of the nature of a surface, either metallic or nonmetallic, in the past, have been limited to the instrumentation available for these measurements. In the past, optical microscopy, replica transmission electron microscopy, electron or X-ray diffraction and optical or X-ray spectroscopy have provided the means of surface characterization. Actually, some of these techniques are not purely surface; the depth of penetration may be a few thousands of an inch. Within the last five years, instrumentation has been made available which now makes it practical for use to study the outer few 100A of layers and characterize it completely from a chemical, physical, and crystallographic standpoint. The scanning electron microscope (SEM) provides a means of viewing the surface of a material in situ to magnifications as high as 250,000X.

Video-Enhanced Microscopy--Better Visibility of Plant Cell Structures

1982 ◽  
Vol 40 ◽  
pp. 182-185
Author(s):  
N.S. Allen ◽  
R.D. Allen
Keyword(s):  
Diffraction Pattern ◽  
Theoretical Basis ◽  
Numerical Aperture ◽  
Gain Control ◽  
Control Unit ◽  
Camera Control ◽  
Variable Gain ◽  
Contrast Method ◽  
Fine Detail ◽  
Cell Structures

Various methods of video-enhanced microscopy combine TV cameras with light microscopes creating images with improved resolution, contrast and visibility of fine detail, which can be recorded rapidly and relatively inexpensively. The AVEC (Allen Video-enhanced Contrast) method avoids polarizing rectifiers, since the microscope is operated at retardations of λ/9- λ/4, where no anomaly is seen in the Airy diffraction pattern. The iris diaphram is opened fully to match the numerical aperture of the condenser to that of the objective. Under these conditions, no image can be realized either by eye or photographically. Yet the image becomes visible using the Hamamatsu C-1000-01 binary camera, if the camera control unit is equipped with variable gain control and an offset knob (which sets a clamp voltage of a D.C. restoration circuit). The theoretical basis for these improvements has been described.

Moving Forward Four Words at a Time: Effects of a Supplemental Preschool Vocabulary Intervention

2020 ◽  
Vol 51 (1) ◽  
pp. 165-175 ◽  
Author(s):  
Lindsey A. Peters-Sanders ◽  
Elizabeth S. Kelley ◽  
Christa Haring Biel ◽  
Keri Madsen ◽  
Xigrid Soto ◽  
...  
Keyword(s):  
Group Intervention ◽  
Single Case ◽  
Single Case Design ◽  
Vocabulary Intervention ◽  
Iterative Development ◽  
At Risk Children ◽  
Before And After ◽  
Child Friendly ◽  
Interactive Lessons ◽  
Case Design

Purpose This study evaluated the effects of an automated, small-group intervention designed to teach preschoolers challenging vocabulary words. Previous studies have provided evidence of efficacy. In this study, we evaluated the effects of the program after doubling the number of words taught from 2 to 4 words per book. Method Seventeen preschool children listened to 1 prerecorded book per week for 9 weeks. Each storybook had embedded, interactive lessons for 4 target vocabulary words. Each lesson provided repeated exposures to words and their definitions, child-friendly contexts, and multiple opportunities for children to respond verbally to instructional prompts. Participants were asked to define the weekly targeted vocabulary before and after intervention. A repeated acquisition single-case design was used to examine the effects of the books and embedded lessons on learning of target vocabulary words. Results Treatment effects were observed for all children across many of the books. Learning of at least 2 points (i.e., 1 word) was replicated for 74.5% of 149 books tested across the 17 participants. On average, children learned to define 47% of the target vocabulary words (17 out of 36). Conclusions Results support including 4 challenging words per book, as children learned substantially more words when 4 words were taught, in comparison to previous studies. Within an iterative development process, results of the current study take us 1 step closer to creating an optimal vocabulary intervention that supports the language development of at-risk children.

A Pilot Study of Early Storybook Reading With Babies With Hearing Loss

2019 ◽  
Vol 62 (9) ◽  
pp. 3397-3412
Author(s):  
Michelle I. Brown ◽  
David Trembath ◽  
Marleen F. Westerveld ◽  
Gail T. Gillon
Keyword(s):  
Hearing Loss ◽  
Pilot Study ◽  
Visual Analysis ◽  
Single Case ◽  
Eye Contact ◽  
Preliminary Evidence ◽  
Storybook Reading ◽  
Book Selection ◽  
Turn Taking ◽  
Parent Child

Purpose This pilot study explored the effectiveness of an early storybook reading (ESR) intervention for parents with babies with hearing loss (HL) for improving (a) parents' book selection skills, (b) parent–child eye contact, and (c) parent–child turn-taking. Advancing research into ESR, this study examined whether the benefits from an ESR intervention reported for babies without HL were also observed in babies with HL. Method Four mother–baby dyads participated in a multiple baseline single-case experimental design across behaviors. Treatment effects for parents' book selection skills, parent–child eye contact, and parent–child turn-taking were examined using visual analysis and Tau-U analysis. Results Statistically significant increases, with large to very large effect sizes, were observed for all 4 participants for parent–child eye contact and parent–child turn-taking. Limited improvements with ceiling effects were observed for parents' book selection skills. Conclusion The findings provide preliminary evidence for the effectiveness of an ESR intervention for babies with HL for promoting parent–child interactions through eye contact and turn-taking.

Sign in / Sign up

Export Citation Format

Share Document