Preparation of chitosan-based nanofiber mats containing Soluplus® as a potential polymeric carrier by electrospinning process

This study demonstrated the processability of sulfur copolymers (SDIB) into polymer blend with polybenzoxazines (PBz) and their compatibility with the electrospinning process. Synthesis of SDIB was conducted via inverse vulcanization using elemental sulfur (S8). Polymer blends produced by simply mixing with varying concentration of SDIB (5 and 10 wt%) and fixed concentration of PBz (10 wt%) exhibited homogeneity and a single-phase structure capable of forming nanofibers. Nanofiber mats were characterized to determine the blending effect on the microstructure and final properties. Fiber diameter increased and exhibited non-uniform, broader fiber diameter distribution with increased SDIB. Microstructures of mats based on SEM images showed the occurrence of partial aggregation and conglutination with each fiber. Incorporation of SDIB were confirmed from EDX which was in agreement with the amount of SDIB relative to the sulfur peak in the spectra. Spectroscopy further confirmed that SDIB did not affect the chemistry of PBz but the presence of special interaction benefited miscibility. Two distinct glass transition temperatures of 97 °C and 280 °C indicated that new material was produced from the blend while the water contact angle of the fibers was reduced from 130° to 82° which became quite hydrophilic. Blending of SDIB with component polymer proved that its processability can be further explored for optimal spinnability of nanofibers for desired applications.

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Dual-Charge Nanofiber Mats Made of Chitosan(CS)/Poly(Vinyl Alcohol) (PVA) and Poly-(Acrylic Acid-Co-Maleic Acid) (PAMA)/PVA

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.819.145 ◽

2019 ◽

Vol 819 ◽

pp. 145-150

Author(s):

Thapakorn Chareonying ◽

Junnasir M. Sakilan ◽

Theerasak Rojanarata ◽

Prasopchai Patrojanasophon ◽

Prasert Akkaramongkolporn ◽

...

Keyword(s):

Acrylic Acid ◽

Maleic Acid ◽

Vinyl Alcohol ◽

Electrospinning Process ◽

Poly Vinyl Alcohol ◽

Water Capacity ◽

Ft Ir ◽

Nanofiber Mats ◽

Positively Charged ◽

Poly Acrylic Acid

Nanofibers have been widely used for tissue engineering. Using charged polymers for the preparation of nanofibers can be useful for the loading of substances or macromolecules. Dual charge nanofiber mats are expected to be able to immobilize both positively charged and negatively charged substances in one versatile nanofiber mat. The purpose of this study was to prepare and characterize dual-charge nanofibers generated from poly (vinyl alcohol) (PVA)/poly-(acrylic acid-co-maleic acid) (PAMA) and chitosan (CS)/PVA. The polymer solutions of PAMA/PVA (1:1.63 w/w) and CS/PVA (1:2.33 w/w) were electrospun to form the nanofibers using dual-jet electrospinning process. The obtained dual-charge nanofibers were thermally crosslinked by leaving the nanofibers in the oven at 110-130 °C for 0.5, 1, 3, 5 h. The appearance of the nanofiber mat was characterized by a scanning electron microscope (SEM), and the diameter of nanofibers were determined by an image analysis software (J-micro vision®). The percentage water insolubilization and FT-IR spectra were also determined. The dual-size nanofiber mats with smooth and bead-free fibers were obtained. The diameter of the PAMA/PVA and CS/PVA fibers was 574.54 ± 142.98 nm and 225.69 ± 41.92 nm, respectively. The desirable temperature and time for the crosslink of the dual-charge nanofiber mats was 130 °C for 1 h which could provide a high insolubilization with water capacity of 93.22 ± 2.23%.

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Water‐born 3D nanofiber mats using cost‐effective centrifugal spinning: comparison with electrospinning process: A complex study

Journal of Applied Polymer Science ◽

10.1002/app.49975 ◽

2020 ◽

Vol 138 (5) ◽

pp. 49975

Author(s):

Martina Rihova ◽

Ahmet Erdem Ince ◽

Veronika Cicmancova ◽

Ludek Hromadko ◽

Klara Castkova ◽

...

Keyword(s):

Cost Effective ◽

Electrospinning Process ◽

Complex Study ◽

Centrifugal Spinning ◽

Nanofiber Mats

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Proton Conductivity through Polybenzimidazole Composite Membranes Containing Silica Nanofiber Mats

Polymers ◽

10.3390/polym11071182 ◽

2019 ◽

Vol 11 (7) ◽

pp. 1182 ◽

Cited By ~ 9

Author(s):

Escorihuela ◽

García-Bernabé ◽

Montero ◽

Andrio ◽

Sahuquillo ◽

...

Keyword(s):

Composite Membranes ◽

Electrospinning Process ◽

Mixed Matrix Membranes ◽

Mixed Matrix ◽

Efficient Energy ◽

The Past ◽

Polar Groups ◽

Nanofiber Mats ◽

Thermal Stability Of ◽

Energy Converting

The quest for sustainable and more efficient energy-converting devices has been the focus of researchers′ efforts in the past decades. In this study, SiO2 nanofiber mats were fabricated through an electrospinning process and later functionalized using silane chemistry to introduce different polar groups OH (neutral), SO3H (acidic) and NH2 (basic). The modified nanofiber mats were embedded in PBI to fabricate mixed matrix membranes. The incorporation of these nanofiber mats in the PBI matrix showed an improvement in the chemical and thermal stability of the composite membranes. Proton conduction measurements show that PBI composite membranes containing nanofiber mats with basic groups showed higher proton conductivities, reaching values as high as 4 mS·cm−1 at 200 C.

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Multi-Nozzle Electrospinning Process to Fabricate Uniform Polymer Nanofiber Mats

Journal of the Korean Society of Manufacturing Process Engineers ◽

10.14775/ksmpe.2018.17.3.120 ◽

2018 ◽

Vol 17 (3) ◽

pp. 120-126

Author(s):

Bong-Kee Lee ◽

◽

Jae-Han Park ◽

Geon-Jung Park ◽

Kwang-Ryun Park

Keyword(s):

Electrospinning Process ◽

Polymer Nanofiber ◽

Nanofiber Mats

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La2O3 nanoparticle/polyacrylonitrile nanofibers for bacterial inactivation based on phosphate control

RSC Advances ◽

10.1039/c6ra22374e ◽

2016 ◽

Vol 6 (101) ◽

pp. 99353-99360 ◽

Cited By ~ 10

Author(s):

Jiaojie He ◽

Wei Wang ◽

Wenxin Shi ◽

Fuyi Cui

Keyword(s):

Electrospinning Process ◽

Bacterial Inactivation ◽

Nanofiber Mats ◽

Pan Nanofiber ◽

Phosphate Control

La2O3 nanoparticle-doped PAN nanofiber mats were prepared by an electrospinning process.

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The Electrospinning Process and Mechanical Properties of Nanofiber Mats under Vacuum Conditions

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.326-328.393 ◽

2006 ◽

Vol 326-328 ◽

pp. 393-396 ◽

Cited By ~ 3

Author(s):

Shin Hur ◽

Wan Doo Kim

Keyword(s):

Vacuum Chamber ◽

Imaging System ◽

Electrospun Fiber ◽

Ccd Camera ◽

Green Laser ◽

Electrospinning Process ◽

Recording Device ◽

Image Recording ◽

Nanofiber Mats ◽

Laser Devices

The structure and morphology of the electrospun nanofiber depend on the parameters such as the physical properties of polymer, the applied voltages, tip to collector distance and ambient condition. Until now, most of studies have been focused on the effects of the above mentioned parameters for electrospinning process. But the study on vacuum conditions in electrospinning process almost not exists. The goal of this study is to investigate the effects of vacuum conditions in electrospinning process. The setup of electrospinning device is installed within homemade vacuum chamber. The polymer jets are ejected from a multi-spinneret connected with a microsyringe pump towards the collector located at fixed distance from the needle tip under a vacuum condition. The nanofiber mats are fabricated using a rotating collector. The visualization and imaging system of electrospinning process are consisted of a green laser devices, microscope, CCD camera and image recording device. During the electrospinning process, the behaviors of nanofiber are visualized and analyzed by this system. The morphologies and dimensions of electrospun fiber mat are measured with SEM. As a final result, the vacuum conditions of electrospinning process influence the behaviors of nanofiber.

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Electrospun PVP/PVA Nanofiber Mat as a Novel Potential Transdermal Drug-Delivery System for Buprenorphine: A Solution Needed for Pain Management

Applied Sciences ◽

10.3390/app11062779 ◽

2021 ◽

Vol 11 (6) ◽

pp. 2779

Author(s):

Fatemeh Rahmani ◽

Hakimeh Ziyadi ◽

Mitra Baghali ◽

Hongrong Luo ◽

Seeram Ramakrishna

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Transdermal Drug Delivery ◽

Electrospinning Process ◽

Vinyl Pyrrolidone ◽

Transdermal Drug Delivery System ◽

Ft Ir ◽

Poly Vinyl Pyrrolidone ◽

Nanofiber Mats ◽

Contact Angle Analysis

Over the past several decades, the formulation of novel nanofiber-based drug-delivery systems has been a frequent focus of scientists around the world. Aiming to introduce a novel nanofibrous transdermal drug-delivery system to treat pain, the nanofiber mats of buprenorphine-loaded poly (vinyl pyrrolidone) (Bup/PVP) and buprenorphine-loaded poly(vinyl alcohol)/poly(vinyl pyrrolidone) (Bup/PVP/PVA) were successfully fabricated by the electrospinning process for transdermal drug delivery. Similarly, PVP and PVP/PVA nanofibers were fabricated in the same conditions for comparison. The viscosity and electrical conductivity of all electrospinning solutions were measured, and nanofiber mats were characterized by scanning electron microscopy (SEM), atomic force microscopy (AFM), Fourier transform infrared (FT-IR) spectroscopy and contact angle analysis. The conductivity of PVP and PVP/PVA solutions showed a considerable increase by the addition of buprenorphine due to the polarity of buprenorphine. SEM images showed a smooth, fine and porous nanofibrous structure without any adhesion or knot for all of the samples. The contact angle analysis showed the increased hydrophilicity and wettability of PVP/PVA and Bup/PVP/PVA nanofibers compared to PVP and Bup/PVP nanofibers which can be attributed to the addition of PVA. Attenuated total reflectance (ATR) FT-IR results confirmed that the electrospinning process did not affect the chemical integrity of the drug. For the modification of the drug release rate, the cross-linking of nanofiber mats was carried out using glutaraldehyde. Drug release measurements using high-performance liquid chromatography (HPLC) analysis demonstrated that Bup/PVP/PVA nanofibers exhibited better physical and chemical properties compared to Bup/PVP. Furthermore, the cross-linking of nanofibers led to an increase in drug release time. Thus, the novel buprenorphine-loaded nanofibers can be efficient biomaterial patches for transdermal delivery against pain improving carrier retention and providing a controlled release of the drug.

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Electrical Conductivity of Poly(3,4-Ethylenedioxythiophene)-Poly(Styrenesulfonate) Coatings on Polyacrylonitrile Nanofibers for Sensor Applications

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.55-57.257 ◽

2008 ◽

Vol 55-57 ◽

pp. 257-260 ◽

Cited By ~ 10

Author(s):

M. Panapoy ◽

M. Saengsil ◽

Bussarin Ksapabutr

Keyword(s):

Electrical Conductivity ◽

Ethylene Glycol ◽

Sem Analysis ◽

Electrospinning Process ◽

Response Sensitivity ◽

Sensor Applications ◽

Coating Layers ◽

Nanofiber Mats ◽

Adsorption Desorption ◽

Pan Nanofiber

Conducting polyacrylonitrile (PAN) nanofiber mats were prepared by dipping non-woven nanofiber mats of PAN in the solution of poly(3,4-ethylenedioxythiophene)/poly(4-styrenesulfonate) (PEDOT/PSS). PAN nanofiber mats were fabricated via the electrospinning process. The solvent used for PEDOT/PSS was ethylene glycol and isopropanol. The morphology of the resulting PAN nanofibers and the coating layers was investigated using SEM analysis. The electrical conductivity of PEDOT/PSS coated PAN nanofiber mats was measured by the four-point probe method, for different concentrations of solvent in the PEDOT/PSS solution. An addition of ethylene glycol resulted in higher electrical conductivity of the coated mats than that of isopropanol. The resistive humidity sensing properties were also investigated. The device reproducibility was presented by vapor adsorption/desorption dynamic cycles. The reproducibility of the PEDOT/PSS coated mats was superior to that of neat PEDOT/PSS films. The response sensitivity of coated mats using isopropanol as solvent was higher than that using ethylene glycol.

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