scholarly journals Systemic inflammation in the pathogenesis of irritable bowel syndrome associated with obesity

2021 ◽  
Vol 14 (4) ◽  
pp. 531-535
Author(s):  
Yuliya Vyacheslavivna Bilooka ◽  
◽  
Olexander Ivanovich Fediv ◽  
Hanna Yaroslavivna Stupnytska ◽  
Vyacheslav Vasilievich Bilookyi ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Blood Serum ◽  
Transforming Growth Factor ◽  
Interleukin 10 ◽  
Transforming Growth Factor Β1 ◽  
Modern Medicine ◽  
Control Group ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Irritable Bowel

Investigation of the mechanisms promoting the development of irritable bowel syndrome (IBS) in obese patients is one of the most important issues of modern medicine. We examined 97 patients suffering from IBS. The group of comparison included 10 individuals with obesity. The control group included 21 practically healthy individuals. The levels of C-reactive protein (CRP) in the blood serum, tumor necrosis factor-α (TFNα), transforming growth factor-β1 (TGFβ1), interleukin-10 (IL-10), 8-isoprostane (IP), ceruloplasmin (CP) were examined. Endotoxicosis intensity was identified by the content of average molecular peptides in the blood and the Limulus Amebocyte Lysate (LAL) test. In the case of IBS with prevailing diarrhea, especially its comorbid course with obesity, cytokine imbalance was observed, which was manifested by a decreased amount of IL-10 in the blood serum and increased levels of TNFα and TGFβ1. Patients suffering from irritable bowel syndrome with prevailing diarrhea associated with obesity were characterized by high levels of C-reactive protein, fibrinogen and average molecules, increased content of pro-inflammatory cytokines (TFNα and TGFβ1) with a decreased content of IL-10, as well as imbalance of the pro-oxidant and anti-oxidant blood systems (increased content of 8-isoprostane and ceruloplasmin).

scholarly journals Personified treatment of patients with irritable bowel syndrome and obesity

2021 ◽  
Vol 25 (3 (99)) ◽  
pp. 12-18
Author(s):  
Yu. Bilooka ◽  
O. Fediv ◽  
H. Stupnytska
Keyword(s):  
Irritable Bowel Syndrome ◽  
Transforming Growth Factor ◽  
Interleukin 10 ◽  
Transforming Growth Factor Β1 ◽  
Polymorphic Variant ◽  
Reactive Protein ◽  
Complex Therapy ◽  
Irritable Bowel ◽  
Factor Α ◽  
Necrosis Factor

The purpose of the work. To evaluate the effectiveness of the use of the probiotic Alflorex and mesalazine in complex therapy in patients with irritable bowel syndrome (IBS) with diarrhea and constipation, combined with obesity, with CT and TT genotypes according to the polymorphic variant C-159T of the CD14 gene. Materials and methods. We examined 48 patients with IBS associated with obesity. In the dynamics of treatment with probiotic Alflorex and mesalazine we determined the content in the serum of C-reactive protein (CRP), tumor necrosis factor-α (TNFα), transforming growth factor-β1 (TGFβ1), interleukin-10 (IL-10), 8 - isoprostane, ceruloplasmin (CP), medium molecular weight peptides and calprotectin in feces. The polymorphic variant of the CD 14 gene (C-159T) was analyzed by polymerase chain reaction. The results of the study. The use of Alflorex and mesalazine in the complex therapy for patients with IBS with diarrhea, combined with obesity, leads to normalization of the IL-10, TGFβ1, medium molecules and a decrease in TNFα (by 37.0%), CRP (1.7 times), 8-isoprostane (by 35.8%), CP (by 44.4%), calprotectin content (by 41.1%). While predominance of constipation in the dynamics of treatment it was showed normalization of IL-10, TGFβ1, medium molecules, CRP, 8-isoprostane, CP, calprotectin and a decrease in TNFα (1.9 times). Conclusions. Probiotic and mesalazine therapy for a month leads to a significant increase in the effectiveness of treatment of patients with IBS with concomitant obesity in the presence of CT and TT genotypes of the polymorphic variant of the CD 14 gene (C-159T) with a predominance of both diarrhea and constipation.

ALDH2 modulated changes in cytokine levels and cognitive function in bipolar disorder: A 12-week follow-up study

2017 ◽  
Vol 52 (7) ◽  
pp. 680-689
Author(s):  
Sheng-Yu Lee ◽  
Tzu-Yun Wang ◽  
Shiou-Lan Chen ◽  
Yun-Hsuan Chang ◽  
Po-See Chen ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Cognitive Function ◽  
Growth Factor ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Follow Up Study ◽  
Cytokine Levels

Objectives: We investigated the association of the aldehyde dehydrogenase 2 ( ALDH2) polymorphism (rs671), which is involved with the dopaminergic function, and with changes in cytokine levels and cognitive function, in a 12-week follow-up study in patients with bipolar disorder. Methods: Patients with a first diagnosis of bipolar disorder were recruited. Symptom severity and levels of plasma cytokines (tumor necrosis factor α, C-reactive protein, interleukin 6 and transforming growth factor β1) were examined during weeks 0, 1, 2, 4, 8 and 12. Neurocognitive function was evaluated at baseline and endpoint. The ALDH2 polymorphism genotype was determined. Results: A total of 541 patients with bipolar disorder were recruited, and 355 (65.6%) completed the 12-week follow-up. A multiple linear regression analysis showed a significant ( p = 0.000226) association between the ALDH2 polymorphism and changes in C-reactive protein levels. Different aspects of cognitive function improved in patients with different ALDH2 genotypes. Only patients with the ALDH2*1*1 genotype showed significant correlations between improvement of cognitive function and increased transforming growth factor -β1. Conclusion: The ALDH2 gene might influence changes in cytokine levels and cognitive performance in patients with bipolar disorder. Additionally, changes in cytokine levels and cognitive function were correlated only in patients with specific ALDH2 genotypes.

scholarly journals Increased Serum AXL Is Associated With Knee Osteoarthritis Severity

2021 ◽  
Author(s):  
Shao Zhenghai
Keyword(s):  
Knee Osteoarthritis ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
Receiver Operating Curve ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Clinical Indicators ◽  
Reactive Protein ◽  
Matrix Metalloproteinase 13 ◽  
Oligomeric Protein

Abstract Objective: Serum AXL expression and clinical significance in patients with knee osteoarthritis (KOA). Methods: 183 patients with knee osteoarthritis were selected and divided based on the Kellgren-Lawrence (KL) score into KL 0 subgroups (n = 42), KL I-II subgroups (n = 90), and KL III-IV subgroups (n = 51). Healthy volunteers (n= 170) in our hospital were selected as the control group. AXL level in serum was detected by enzyme-linked immunosorbent assay (ELISA). The correlation between serum AXL with severity and clinical indicators of osteoarthritis was analyzed. Results: The level of serum AXL was significantly higher in the osteoarthritis group than that in the control group (P<0.05). In the osteoarthritis patients, serum AXL level was increased with the increase of KL score. Serum AXL level was positively correlated with age, body mass index (BMI), erythrocyte sedimentation rate (ESR), serum C-reactive protein (CRP), cartilage oligomeric protein (COMP), matrix metalloproteinase-13 (MMP-13), and transforming growth factor-β1 (TGF-β1) levels. The cut-off value for serum AXL was determined as 33.375 ng/mL by receiver operating curve (ROC) analysis. Conclusion: The level of serum AXL in patients with osteoarthritis is abnormally high, which is closely related to the severity of osteoarthritis.

scholarly journals Tünetek, laboratóriumi paraméterek és a betegségpercepció eltérései irritábilis bél szindróma és gyulladásos bélbetegség esetén. Segíthetnek-e a kérdőívek a két betegség elkülönítésében?

2015 ◽  
Vol 156 (23) ◽  
pp. 933-938 ◽  
Author(s):  
Renáta Bor ◽  
Zsolt Balanyi ◽  
Klaudia Farkas ◽  
Anita Bálint ◽  
Mariann Rutka ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Irritable Bowel Syndrome ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Bowel Disease ◽  
Illness Perception ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Inflammatory Bowel ◽  
Irritable Bowel

Introduction: Symptoms-based differential diagnosis of irritable bowel syndrome and inflammatory bowel disease is often difficult. Aims: To determine the differential diagnostic ability of clinical activity indexes and psychological questionnaires in these conditions, which have never been simultaneously analyzed. Method: 37 irritable bowel syndrome, 54 Crohn’s disease and 41 ulcerative colitis patients were enrolled in the study. The patients completed the Crohn’s Disease Activity Index test, Illness Perception Questionnaire and Inflammatory Bowel Disease Questionnaire. Hematocrit and C-reactive protein level of patients were also analyzed. Results: Patients with irritable bowel syndrome felt their abdominal pain more severe than the other two groups (p = 0.005), while the quality of life was the worst in Crohn’s disease (p = 0.0000001). Significantly more patients with inflammatory bowel disease considered that their condition is lifelong (p = 0.000781). The knowledge about disease was more appropriate in patients with inflammatory bowel disease (p = 0.00629). No significant difference was found in hematocrit levels, but the C-reactive protein level was significantly lower in patients with irritable bowel syndrome (p = 0.001). Conclusions: Illness perception questionnaires and C-reactive protein can help in the differentiation of inflammatory bowel disease from irritable bowel syndrome. Orv. Hetil., 2015, 156(23), 933–938.

scholarly journals High-sensitive C-Reactive Protein as a Marker for Inflammation in Irritable Bowel Syndrome

2016 ◽  
Vol 50 (3) ◽  
pp. 227-232 ◽  
Author(s):  
Keren Hod ◽  
Tamar Ringel-Kulka ◽  
Christopher F. Martin ◽  
Nitsan Maharshak ◽  
Yehuda Ringel
Keyword(s):  
Irritable Bowel Syndrome ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Irritable Bowel

scholarly journals ASSOCIATION OF CD14 (C-159T) GENE POLYMORPHISM AND IRRITATED INTESTINE SYNDROME WITH OBESITY

2021 ◽  
Vol 20 (2) ◽  
Author(s):  
Yu.V. Bilooka
Keyword(s):  
Transforming Growth Factor ◽  
Interleukin 10 ◽  
Transforming Growth Factor Β1 ◽  
Polymorphic Variant ◽  
Blood Levels ◽  
Polymerase Chain ◽  
Irritable Bowel ◽  
Factor Α ◽  
Cd14 Gene ◽  
Necrosis Factor

The purpose of the study – to study the association of the polymorphic variant C-159Tof the CD14 gene in patients with irritable bowel syndrome (IBS) depending on thepredominance of diarrhea or constipation in the clinical course and the relationshipbetween genotypes of the CD14 gene (C-159T) and some blood parameters.Material and methods. The study involved 90 patients with IBS (30 men and 60women aged 22 to 56 years). The polymorphic variant of the CD 14 gene (C-159T)was analyzed by polymerase chain reaction in 90 patients with IBS without and withconcomitant obesity and 30 people in the comparison group. Blood levels of C-reactiveprotein (CRP), tumor necrosis factor α (TNFα), transforming growth factor β1(TGFβ1), interleukin-10 (IL-10), 8-isoprostane, ceruloplasmin, medium molecules andcalprotectin levels in feces were determined.Results. In patients with IBS and obesity, the frequency of TT genotype (36.7%) washigher compared to healthy subjects (TT genotype – 13.3%). Significantly higherserum levels of CRP (3.5 times and 26.7%), TNFα (1.7 times and 19.5%), TGFβ1(29.8% and 19.2%), 8-isoprostane (54.1% and 31.9%), ceruloplasmin (56.7% and33.0%), medium molecules (7, 5% and 12.9%) and calprotectin (55.7% and 37.4%) inthe feces compared to the CC and CT genotype have been determined in patients withIBS, combined with obesity, TT genotype with a predominance of diarrhea.Conclusions. The association of a polymorphic variant of the CD14 (C-159T) gene withthe risk of IBS development in obese patients has been established. The TT genotype ischaracterized by a higher content of proinflammatory cytokines (TNFα), lower levelsof anti-inflammatory cytokines (IL-10), increased CRP, more pronounced changesin the prooxidant and antioxidant blood systems (higher levels of 8-isoprostane andceruloplasmin, local inflammation (increase in calprotectin content) and severity ofendotoxicosis (higher content of medium molecules).

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