scholarly journals Clinical evidence of therapy for genital psoriasis by biologic agents

2021 ◽  
Vol 97 (2) ◽  
pp. 50-55
Author(s):  
Evgeny V. Sokolovskiy ◽  
Muza M. Kokhan
Keyword(s):  
Clinical Evidence ◽  
Biological Therapy ◽  
Biologic Therapy ◽  
Well Being ◽  
Scientific Data ◽  
Therapeutic Approaches ◽  
Comparative Efficacy ◽  
Scalp Psoriasis ◽  
Genital Psoriasis

Data in the scientific literature on the use of biologic therapy in localized forms of psoriasis elucidate mostly the problems of treatment of palmoplantar, scalp psoriasis and nail psoriasis. At the same time, the number of scientific data on the effect of biological therapy on genital psoriasis is extremely limited. Important that the quality of life on patients with genital psoriasis has very low level, which indicates a significant influence on the psychological and social well-being. At the same time, the limited number of therapeutic approaches makes this problem even more urgent. Unfortunately, special clinical trials for such patients are rather an exception. Ixekizumab has been reported an effectiveness for patients with anogenital psoriasis. New data on the comparative efficacy of ixekizumab and secukinumab give hope us for new opportunity for the treatment of genital psoriasis.

Impact of remission on worries experienced by patients receiving biologic therapy for inflammatory bowel disease

2020 ◽  
Vol 18 (7) ◽  
pp. 28-33
Author(s):  
Rikke Edelbo ◽  
Malte Hjerrild ◽  
Palle Bager
Keyword(s):  
Inflammatory Bowel Disease ◽  
Body Image ◽  
Bowel Disease ◽  
Biological Therapy ◽  
Biologic Therapy ◽  
Emotional Impact ◽  
Related Quality ◽  
Health Related ◽  
Inflammatory Bowel

Background: Patients with inflammatory bowel disease (IBD) are more and more often treated with biological therapy, primarily to induce remission and secondarily to maintain remission in IBD. Studies have shown how the patients' health-related quality of life (HRQoL) improves during treatment. However, worry and concern have not improved as rapidly as other HRQoL parameters. Aim: This study aimed to explore the aspects of worry in a population of patients treated with biological therapy. Methods: Patients were asked to score HRQoL on two scales and subsequently asked to elaborate on their worry issues. Findings: The study revealed that worries were independent of disease activity. The main worry issues were lack of energy, emotional impact, sleep, pain, work and body image. Emotional impact and body image were more burdensome for women than men. When elaborating on emotional impact, it was revealed that worries about the future and the burden of IBD were common.

scholarly journals Identifying domains of quality of life in children with cancer undergoing palliative care: A qualitative study with professionals

2017 ◽  
Vol 15 (5) ◽  
pp. 565-574 ◽  
Author(s):  
Josianne Avoine-Blondin ◽  
Véronique Parent ◽  
Magali Lahaye ◽  
Nago Humbert ◽  
Michel Duval ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Palliative Care ◽  
Well Being ◽  
Scientific Data ◽  
Present Moment ◽  
Psychological Suffering ◽  
Centre Hospitalier Universitaire ◽  
Physical Comfort ◽  
Measurement Strategies

ABSTRACTObjective:The goal of pediatric palliative care (PPC) is to maintain the quality of life (QoL) of children whose lives are threatened. However, there are sparse scientific data on the domains of QoL in this particular context, and no measurement strategies are available. The present study aims to describe the domains of QoL in the context of PPC in oncology, according to the perceptions of professional caregivers.Method:Semistructured interviews were conducted with a random sample of 20 professional caregivers from the Division of Hematology/Oncology at Le Centre Hospitalier Universitaire Sainte-Justine (Montréal, Canada). The caregivers were asked about their perceptions about the QoL of the children they have cared for in this context. The data were analyzed using inductive thematic content analysis.Results:The analysis allowed us to identify seven domains of QoL: “physical comfort,” “alleviation of psychological suffering,” “fun and the present moment,” “sense of control,” “feeling valued and appreciated,” “feeling that life goes on,” and “meaningful social relationships.”Significance of Results:Caregivers recount the regard that should be accorded to maintaining well-being and a sense of fun, as well as fostering the child's abilities, taking account of the progression of the disease, and to fulfilling his or her needs, especially social ones. Our results also demonstrate that all domains were positively referred to by professional caregivers. The data from our study will lead to better assessment of QoL according to the trajectory of a child with advanced cancer while undergoing PPC.

Patient-reported Outcomes, Resource Use, and Social Participation of Patients with Rheumatoid Arthritis Treated with Biologics in Alberta: Experience of Indigenous and Non-indigenous Patients

2018 ◽  
Vol 45 (6) ◽  
pp. 760-765 ◽  
Author(s):  
Cheryl Barnabe ◽  
Louise Crane ◽  
Tyler White ◽  
Brenda Hemmelgarn ◽  
Gilaad G. Kaplan ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Rheumatoid Arthritis ◽  
Resource Use ◽  
Daily Living ◽  
Patient Reported Outcomes ◽  
Biologic Therapy ◽  
Well Being ◽  
Sf 36 ◽  
Patient Reported

Objective.To characterize patient-reported outcomes, resource use, and social participation during the course of biologic therapy for indigenous and non-indigenous patients with rheumatoid arthritis (RA).Methods.Patients initiating biologic therapy (2004 to 2012) were characterized longitudinally for patient-reported outcomes including physical function measured by the Health Assessment Questionnaire, EQ-5D, well-being [Medical Outcomes Study Short Form-36 (SF-36)], and visual analog scales for pain, fatigue, sleep, stiffness, and patient’s global assessment. Resource use, participation in activities of daily living, and effect of RA on work productivity were also evaluated for change during therapy.Results.Indigenous patients (n = 90) presented with significantly worse scores for global evaluation, pain, sleep, quality of life, well-being, and physical function compared to non-indigenous patients (n = 1400). All patient-reported outcomes improved significantly during treatment for patients in both groups, but pain, sleep, and SF-36 physical health score changes occurred at slower rates for indigenous patients [difference in slopes 0.09 (p = 0.029), 0.08 (p = 0.043), and −0.35 (p = 0.03), respectively]. Performance of daily activities was affected for 50% of indigenous compared to 37% of non-indigenous patients, with more use of community services and assistance from others. Employed indigenous patients reported twice the number of days being unable to work owing to RA compared to employed non-indigenous patients. Of the unemployed indigenous patients, 82% indicated they had stopped working because of arthritis, versus 48% of non-indigenous patients (p < 0.0001).Conclusions.Indigenous patients have greater consequences of RA regarding experienced symptoms, health-related quality of life, disruption of performance of activities of daily living, and reduced employment participation.

scholarly journals Treatment of Genital, Scalp and Face Psoriasis with Risankizumab

2021 ◽  
Vol 7 (2) ◽  
pp. 1-3
Author(s):  
Okita AL ◽  
Keyword(s):  
Quality Of Life ◽  
Sexually Transmitted Disease ◽  
Transmitted Disease ◽  
Small Surface ◽  
Sexually Transmitted ◽  
Scalp Psoriasis ◽  
The Face ◽  
Small Surface Area ◽  
Genital Psoriasis

Psoriasis affecting the face, scalp, hands, feet, nail and genitals may cause disproportional impact on quality of life despite the small surface area compromised. Genital psoriasis can affect 33 to 63% of psoriasis patients at any time during their lives. Even though GenPs is relatively common, these lesions may be under-reported and under diagnosed because of embarrassment of patients, unfamiliarity with the disease or concerns about having a sexually transmitted disease. Several effective treatments have been reported for plaque psoriasis, however there are few studies and reports regarding GenPs treatment. We report here a case of successful treatment of a patient with genital, face and scalp psoriasis with risankizumab, an anti-IL23 drug

scholarly journals ANTIHISTAMINES

2012 ◽  
Vol 19 (03) ◽  
pp. 386-392
Author(s):  
MEENAKSHI GUPTA ◽  
GEETA SHARMA ◽  
JATINDER SINGH ◽  
Rana Arun Gopal Krishan Pal ◽  
Vinay Gupta
Keyword(s):  
Quality Of Life ◽  
Allergic Rhinitis ◽  
Social Life ◽  
Quantitative Measure ◽  
Well Being ◽  
Efficacy And Safety ◽  
Comparative Efficacy ◽  
Treatment Groups ◽  
Parallel Group

Objectives: Allergic rhinitis impairs social life, but it is not known whether quality of life may be improved when patient are treatedwith H 1 blockers. The present study evaluated the comparative efficacy and safety of cetirizine, loratidine and astemizole in patients of allergicrhinitis. Material &Methods: The design was open, randomized, parallel group comparison of three active treatment groups over a six weekperiod. Sixty patients of either sex in the age group of 16 – 45 years, suffering from allergic rhinitis were selected randomly. The effect ofcetirizine, loratidine and astemizole were observed on various parameters i.e., sneezing, nasal obstruction, watering of eyes, sedation andoverall well being of the patients over a period of six weeks. The Visual Analogue Scale (VAS) was utilized as a quantitative measure of symptomrelief. Results: An improvement in patient's discomfort as assessed by VAS was observed in all treatment groups, with cetirizine 10mg dailybeing significantly more effective than loratidine 10mg and astemizole 10mg. Cetirizine resulted in a significant reduction in sneezing and nasalobstruction as compared to loratidine and astemizole (p<0.05). Cetirizine and loratidine both were equally efficacious in relieving watering ofeyes but cetirizine as well as loratidine were more efficacious as compared to astemizole (p<0.05). Sedation was found to be maximum withcetirizine followed by astemizole and loratidine over six weeks of study period. Conclusion: Cetirizine has been found to be most effective inrelieving the symptoms of allergic rhinitis followed by loratidine and astemizole and it can also improve quality of life for patients with allergicrhinitis.

Perceived Overprotection and Its Association With Quality of Life in Dementia

GeroPsych ◽  
2019 ◽  
Vol 32 (3) ◽  
pp. 125-134
Author(s):  
Mechthild Niemann-Mirmehdi ◽  
Andreas Häusler ◽  
Paul Gellert ◽  
Johanna Nordheim
Keyword(s):  
Quality Of Life ◽  
Patient Autonomy ◽  
Positive Association ◽  
Well Being ◽  
Negative Association ◽  
Significant Positive Association ◽  
Cross Sectional ◽  
People With Dementia ◽  
Mental Well Being

Abstract. To date, few studies have focused on perceived overprotection from the perspective of people with dementia (PwD). In the present examination, the association of perceived overprotection in PwD is examined as an autonomy-restricting factor and thus negative for their mental well-being. Cross-sectional data from the prospective DYADEM study of 82 patient/partner dyads (mean age = 74.26) were used to investigate the association between overprotection, perceived stress, depression, and quality of life (QoL). The analyses show that an overprotective contact style with PwD has a significant positive association with stress and depression, and has a negative association with QoL. The results emphasize the importance of avoiding an overprotective care style and supporting patient autonomy.

Ego Psychoanalytic Rorschach Interpretation

2017 ◽  
Vol 38 (1) ◽  
pp. 22-32 ◽  
Author(s):  
Irving B. Weiner
Keyword(s):  
Differential Diagnosis ◽  
Sequence Analysis ◽  
Treatment Planning ◽  
Well Being ◽  
Adjustment Difficulties ◽  
Behavioral Features ◽  
Defensive Style ◽  
Cognitive Slippage ◽  
Interpretive Process

Abstract. This article concerns the utility of ego psychoanalytic perspectives in Rorschach interpretation. Psychoanalytic ego psychology focuses on how people cope with events in their lives and how effectively they can meet challenges to their sense of well-being. The way people deal with experienced distress constitutes their defensive style and determines to a large extent what kind of person they are. Adequate defenses against anxiety promote comfortable and productive adjustment, whereas ineffective defenses typically cause adjustment difficulties and susceptibility to psychological disorders. In Rorschach assessment, the nature and effectiveness of a person’s defensive style can often be identified with a sequence analysis that integrates the structural, thematic, and behavioral features in the protocol. In particular, the sequential quality of responses, especially preceding and following instances of cognitive slippage, can help identify causes of upsetting concerns, defensive efforts to alleviating these concerns, and the adequacy of these defensive efforts in restoring equanimity. This interpretive process is illustrated with attention to implications for differential diagnosis and treatment planning in the Rorschach protocol of a 20-year-old suicidal woman.

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