scholarly journals Supratentorial intraventricular rosette-forming glioneuronal tumors – Case report and review of treatment paradigms

2020 ◽  
Vol 11 ◽  
pp. 138
Author(s):  
Anil K. Mahavadi ◽  
Caroline Temmins ◽  
Mahesh R. Patel ◽  
Harminder Singh
Keyword(s):  
Cystic Mass ◽  
Uneventful Recovery ◽  
Repeat Surgery ◽  
Term Care ◽  
Who Grade ◽  
Transcallosal Approach ◽  
Fourth Case ◽  
Lateral Ventricles ◽  
Left Lateral Ventricle ◽  
Glioneuronal Tumors

Background: Rosette-forming glioneuronal tumors (RGNT) are slow-growing WHO Grade I tumors that are characterized by mixed histology and rosette formation. Although typically located in the posterior fossa, these tumors can rarely originate elsewhere. Here, we describe the fourth case in literature where an RGNT was localized to the lateral ventricles and detail the treatment approach. Case Description: A 41-year-old male presented with a 10 day history of gradually worsening headaches and mild gait difficulty. Computed tomography and magnetic resonance imaging (MRI) identified a heterogeneously enhancing 6.0 cm left lateral ventricular cystic mass with hydrocephalus. An interhemispheric transcallosal approach was performed for tumor debulking. The mass was emanating from the roof of the left lateral ventricle. Sub-total resection (STR) was achieved. Pathology showed a glioneuronal neoplasm with vague neurocytic rosettes and loose perivascular pseudorosettes. Tumor vessels were thickly hyalinized and contained eosinophilic granular bodies and Rosenthal fibers. Tumor stained positive for GFAP, S-100, OLIG2, and SOX10, and patchy positive for epithelial membrane antigen (EMA), D2-40, CD99, and p16. Neurocytic rosettes and perivascular structures stained positive for synaptophysin. The patient was discharged home uneventfully and remained intact at his 6-month follow-up visit. Long-term care included MRI surveillance with repeat surgery being considered in case of progression. Conclusion: In this report, we describe the fourth case of an RGNT being isolated to the lateral ventricles and the first where it stained positive for EMA and D2-40. Our patient’s uneventful recovery after STR indicates that surgery alone continues to be a viable initial treatment option.

Rosette-forming glioneuronal tumors of the posterior fossa

2010 ◽  
Vol 5 (1) ◽  
pp. 98-103 ◽  
Author(s):  
Manish N. Shah ◽  
Jeffrey R. Leonard ◽  
Arie Perry
Keyword(s):  
Posterior Fossa ◽  
Fourth Ventricle ◽  
Complete Resection ◽  
Glioneuronal Tumor ◽  
Dysembryoplastic Neuroepithelial Tumor ◽  
Tumor Type ◽  
Who Grade ◽  
Pathological Characteristics ◽  
The Mean ◽  
Glioneuronal Tumors

Rosette-forming glioneuronal tumor (RGNT) of the fourth ventricle is a rare, recently described WHO Grade I neoplasm. The authors report 6 examples of RGNT arising primarily from the cerebellar vermis. All the patients were female, and the mean age of presentation was 24.8 years. The original diagnoses included pilocytic astrocytoma, ependymoma, cerebellar dysembryoplastic neuroepithelial tumor (DNT), and oligodendroglioma. The cases showed classic pathological characteristics, although in 2 cases the lesions included DNT-like “floating neurons” involving Purkinje cells, a feature which has not been previously reported to the authors' knowledge. The clinical outcome was excellent with no recurrences after complete resection. These cases expand the known clinical and histological spectrum of this rare tumor type. Given the lack of fourth ventricle involvement in most of these cases, the authors suggest revising the name to RGNT of the posterior fossa.

Intraventricular Cysticercosis

Neurosurgery ◽  
1983 ◽  
Vol 12 (2) ◽  
pp. 148-152 ◽  
Author(s):  
Madrazo N. Ignacio ◽  
José A. GarcÍa-RenterÍa ◽  
Sandoval B. Miguel ◽  
Francisco J. López Vega
Keyword(s):  
Inflammatory Reaction ◽  
Surgical Approach ◽  
Chronic Hydrocephalus ◽  
Neurological Damage ◽  
Transcallosal Approach ◽  
Lateral Ventricles ◽  
3Rd Ventricle ◽  
Microsurgical Approach ◽  
4Th Ventricle

Abstract The authors review their experience with 21 cases of intraventricular cysticercosis, which corresponded to 28% of all cases of neurocysticercosis in their department during an 18-month period. The surgical approach depends on the cyst's location; one uses the transcortical microsurgical approach to reach the lateral ventricles, the transcortical or transcallosal approach to reach the 3rd ventricle, and direct exploration to reach the 4th ventricle. Cysticercus cysts should be removed because they may produce acute or chronic hydrocephalus and, if the parasite dies within the ventricles, it will generate an inflammatory reaction with local and generalized ventriculitis, which produces irreversible neurological damage.

scholarly journals Can Dynamic Contrast-Enhanced Magnetic Resonance Imaging Combined with Texture Analysis Differentiate Malignant Glioneuronal Tumors from Other Glioblastoma?

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Pierre-Antoine Eliat ◽  
Damien Olivié ◽  
Stephan Saïkali ◽  
Béatrice Carsin ◽  
Hervé Saint-Jalmes ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Resonance Imaging ◽  
Who Grade ◽  
Dce Mri ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced ◽  
Glioneuronal Tumors ◽  
Who Grade Iii ◽  
Grade Iii

An interesting approach has been proposed to differentiate malignant glioneuronal tumors (MGNTs) as a subclass of the WHO grade III and IV malignant gliomas. MGNT histologically resemble any WHO grade III or IV glioma but have a different biological behavior, presenting a survival twice longer as WHO glioblastomas and a lower occurrence of metastases. However, neurofilament protein immunostaining was required for identification of MGNT. Using two complementary methods, dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and texture analysis (MRI-TA) from the same acquisition process, the challenge is toin vivoidentify MGNT and demonstrate that MRI postprocessing could contribute to a better typing and grading of glioblastoma. Results are obtained on a preliminary group of 19 patients a posteriori selected for a blind investigation of DCE T1-weighted and TA at 1.5 T. The optimal classification (0/11 misclassified MGNT) is obtained by combining the two methods, DCE-MRI and MRI-TA.

scholarly journals Interhemispheric transcallosal approach for resection of intraventricular central neurocytoma

2013 ◽  
Vol 34 (v1supplement) ◽  
pp. 1 ◽  
Author(s):  
James K. Liu
Keyword(s):  
Third Ventricle ◽  
Complete Removal ◽  
Central Neurocytoma ◽  
Benign Tumors ◽  
Surgical Removal ◽  
Tumor Removal ◽  
Transcallosal Approach ◽  
Lateral Ventricles ◽  
Microsurgical Resection ◽  
Intraventricular Tumors

The interhemispheric transcallosal approach is a versatile approach to access intraventricular tumors of the lateral and third ventricles. The advantages of using a transcallosal approach over a classical transcortical approach include a direct midline orientation with symmetrical access to both lateral ventricles and both walls of the third ventricle. In addition, violation of the cerebral cortex and the risk of postoperative seizures can be avoided. Central neurocytomas are rare benign tumors that represent approximately 0.1 to 0.5% of all primary brain tumors. They are typically located in the lateral ventricles and tend to present clinically with hydrocephalus. Currently, surgical removal with a gross-total resection is the treatment of choice. In this operative video manuscript, the author demonstrates an illustrative step-by-step technique for microsurgical resection of a large central neurocytoma involving both lateral ventricles in a patient with hydrocephalus using the interhemispheric transcallosal approach. A complete removal was performed without the need for permanent shunting. The operative technique and surgical nuances, including the surgical approach, intraventricular tumor removal, and closure are illustrated in this video atlas.The video can be found here: http://youtu.be/KzC8QYsTKeg.

scholarly journals Imaging and Histopathologic Nuances of Epithelioid Glioblastoma

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Brian H. Le ◽  
Richard A. Close
Keyword(s):  
Mass Effect ◽  
Clonic Seizure ◽  
Cystic Mass ◽  
Braf V600e ◽  
World Health ◽  
Significant Past Medical History ◽  
Who Grade ◽  
Epithelioid Glioblastoma ◽  
Health Organization ◽  
The Right

A 27-year-old male without significant past medical history presented following collapse resulting from a syncopal episode at work. There was an episode of vomiting, and one of tonic-clonic seizure activity, which was spontaneously resolved after approximately one minute. His neurologic exam was nonfocal, with full strength in the bilateral upper and lower extremities, and no sensory deficits were elicited. MRI studies demonstrated a 4.7 cm rim-enhancing cystic mass in the right temporal-parietal region, with resultant mass effect and edema. At surgery, intraoperative pathologic consultation favoured a primary glial neoplasm. Subsequent complete histologic examination on permanent sections confirmed the presence of glioblastoma, with a morphologic pattern and immunohistochemical profile most consistent with epithelioid glioblastoma (WHO grade IV). Epithelioid glioblastoma is a rare, especially aggressive variant of IDH-wildtype glioblastoma, recognized in the 2016 World Health Organization classification. Approximately 50% of such tumors harbour the BRAF V600E mutation, which has also been observed in some melanomas where selective inhibitors have demonstrated a therapeutic role. The especially aggressive behaviour and poor clinical outcome typically observed for this variant of glioblastoma demonstrate the importance of emerging areas relevant to neurooncology, specifically those of proteomic characterization and therapeutic nanomedicine.

Intraventricular occurrence of a melanocytoma

2008 ◽  
Vol 109 (3) ◽  
pp. 480-485 ◽  
Author(s):  
Nitin Tandon ◽  
Thomas J O'Neill ◽  
Dennis G. Vollmer ◽  
Min Wang
Keyword(s):  
Residual Tumor ◽  
Vascular Tumor ◽  
Cystic Mass ◽  
Left Lateral Ventricle ◽  
Temporal Horn ◽  
The Central Nervous System ◽  
Microsurgical Resection ◽  
Intraventricular Tumors ◽  
Anterior Choroidal

Melanocytomas are rare tumors of the central nervous system that are believed to arise from leptomeningeal melanocytes. A young girl presented with a contrast-enhancing cystic mass in the temporal horn of the left lateral ventricle. Microsurgical resection of a black-colored vascular tumor supplied by the anterior choroidal artery was performed. Appropriate immunohistochemical staining and electron microscope evaluations were used to confirm the pathological diagnosis. The patient made an excellent recovery; follow-up imaging revealed no recurrent or residual tumor. This is the first documented primary occurrence of a melanocytoma in an intraventricular location. The intraventricular occurrence of this tumor suggests that melanocytes may migrate into the choroidal fissure and may infrequently undergo neoplastic proliferation in that location. This case contains implications for the differential diagnosis of intraventricular tumors.

scholarly journals Surgical approaches to the third ventricle of the brain in children

2021 ◽  
Vol 11 (1) ◽  
pp. 47-54
Author(s):  
Sergey K. Gorelyshev ◽  
Olga A. Medvedeva
Keyword(s):  
Third Ventricle ◽  
Pineal Region ◽  
Anterior Horn ◽  
Surgical Approaches ◽  
Surgical Interventions ◽  
Transcallosal Approach ◽  
Advantages And Disadvantages ◽  
The Third ◽  
Lateral Ventricles ◽  
The Brain

AIM: This study aimed to describe and analyze the advantages and disadvantages of various surgical approaches to neoplasms of the third ventricle of the brain in children. MATERIALS AND METHODS: This study analyzed surgical interventions to the third ventricle in 657 patients, performed at the Academician N.N. Burdenko of the Research Institute of Neurosurgery from 1998 to 2018. These included 375 patients with intra-extraventricular craniopharyngiomas and 282 patients with gliomas of the third ventricle and chiasm. The patients age ranged from 3 mon to 18 years old. RESULTS: The anterior transcallosal approach provides access to the anterior horn and bodies of the lateral ventricles, as well as the third ventricle. The transfornical approach provides more opportunities for access to both the anterior and posterior parts of the third ventricle; however, it has a high risk of trauma to the fornix. The subchoroidal approach provides a very good view of the posterior parts of the third ventricle, especially of the pineal region; however, it has even greater restrictions on viewing its anterior parts. When compared with the transcallosal approach, the transfrontal approach can be used more safely in the absence of hydrocephalus (if the tumor is located in the anterior horn). No specific complications were inherent in a particular approach (seizures were registered in 1%, transient hemiparesis was noted in 10%, and transient memory impairments were revealed in 5% of cases). CONCLUSION: The use of a transcallosal approach is safe even in infants. The transcortical approach is recommended mainly for large tumors of the lateral ventricles, and the transcallosal approach should be used for small tumors of the third ventricle. No specific complications were inherent in a particular approach, and the choice was determined by the assessment of the exact location of the tumor and calculation of the most relevant trajectory for its achievement as well as the aim (biopsy or radical removal). Analysis of magnetic resonance imaging and neuronavigation are significant in the selection of surgical approaches.

scholarly journals Hemangioblastoma of the lateral ventricle

2018 ◽  
Vol 22 (1) ◽  
pp. 94-96
Author(s):  
Carlos Augusto Ferreira Lobão ◽  
Albedy Moreira Bastos ◽  
Leonidas Braga Dias Junior
Keyword(s):  
Lateral Ventricle ◽  
English Literature ◽  
Tumor Resection ◽  
Uneventful Recovery ◽  
Von Hippel Lindau ◽  
Left Lateral Ventricle ◽  
Pubmed Search ◽  
History Of ◽  
Brain Ct Scan

Introduction: Hemangioblastomas are capillary-rich benigntumors mainly found in the infratentorial compartment. When at the supratentorial space, they are rarely located at the lateral ventricle. We report on a case of a 25 years-old female patient treated at our institution. Case report: The patient came to our service with a three months history of progressive headache, bilateral visual loss, and right hemiparesis. Brain CT-scan and MRI showed a heterogeneous intraventricular contrast-enhancing lesion at the left lateral ventricle. Von Hippel-Lindau was investigated but she had neither family history of the disease nor any signs of it. She was submitted to microsurgical tumor resection with a parieto-occipital craniotomy via the intraparietal sulcus, with an uneventful recovery. Hystological examination confirmed the diagnosis of hemangioblastoma. The patient is in outpatient clinic follow-up completely integrated to her familiar and professional life. Discussion: According to a PubMed search, this is the seventh case of lateral ventricle hemangioblastoma reported on English literature. It has a cystic characteristic that differs from other cases, and a bigger volume compared to the previous ones. 

scholarly journals Atraumatic splenic rupture was attributed to intra-cystic haemorrhage and hypersplenism in a patient with cirrhosis and portal hypertension: A case report

2020 ◽  
Vol 8 ◽  
pp. 2050313X2090190
Author(s):  
Hao Li ◽  
Dongyao Guan ◽  
Junqiang Xu ◽  
Enhao Jin ◽  
Shu Sun
Keyword(s):  
Liver Cirrhosis ◽  
Portal Hypertension ◽  
Splenic Rupture ◽  
Liver Steatosis ◽  
Sudden Onset ◽  
Cystic Mass ◽  
Uneventful Recovery ◽  
Free Fluid ◽  
Post Surgery ◽  
Atraumatic Splenic Rupture

Liver cirrhosis with splenomegaly and portal hypertension has been described in the medical literature as increasing the risk of splenic rupture. We report a case of atraumatic splenic rupture in a male with liver cirrhosis associated with splenomegaly, which was further complicated by hypersplenism and intra-cystic haemorrhage in the spleen. The 56-year-old man was hospitalized because of sudden onset of intermittent pain in the left quadrant abdomen with no history of trauma. Upon admission, the patient presented no fever, palpable abdominal tenderness, splenomegaly, and hypersplenism. Enhanced computed tomography revealed a splenic subcapsular haematoma connected to a cystic mass located at the splenic hilum and free fluid in the abdomen, which is indicative of splenic rupture. The patient underwent immediate laparotomy and splenectomy followed by proper management. Post-surgery diagnostic microscopy indicated liver steatosis, perivenular fibrosis, and regenerative nodules, which are suggestive of cirrhosis. The patient was discharged from the hospital with an uneventful recovery.

Alexia without Agraphia in a Musician after Transcallosal Removal of a Left Intraventricular Meningioma

Neurosurgery ◽  
1979 ◽  
Vol 4 (2) ◽  
pp. 168-174 ◽  
Author(s):  
Harvey S. Levin ◽  
James E. Rose
Keyword(s):  
Lateral Ventricle ◽  
Musical Ability ◽  
Verbal Comprehension ◽  
Transcallosal Approach ◽  
Intraventricular Meningioma ◽  
Tactile Stimuli ◽  
Left Lateral Ventricle

Abstract After a meningioma situated in the trigone of the left lateral ventricle was excised by the transcallosal approach of Kempe and Blaylock, a right-handed musician with a right hemianopsia developed alexia without agraphia. In contrast to previously reported cases of this syndrome arising from other etiologies, he was unable to read single letters or numbers. Neuropsychological studies at 42 and 126 days after operation also disclosed an inability to associate auditory or tactile stimuli with visually perceived material, whereas speech and verbal comprehension were intact. Although the alexia extended to musical notes, he could interpret other musical symbols (e.g., treble clef). Appreciation of rhythm and expressive musical ability were relatively preserved, although judgment of other musical features (including discrimination of pitch, duration, and loudness) was compromised. The findings suggest that alexia may occur as a consequence of the transcallosal procedure when a right hemianopsia is present. However, other linguistic abilities may be better preserved by the transcallosal approach to the ventricle than by a transcortical operation.

Sign in / Sign up

Export Citation Format

Share Document