The structure of the clinical variety of macular pathology in patients of diagnostic department

Purpose. To study the frequency and nosological structure of concomitant macular pathology in patients admitted for ophthalmic surgery. Material and methods. A study of the state of the macula was carried out in 337 eyes of 170 patients who underwent a diagnostic examination in the Khabarovsk Branch the S. Fyodorov Eye Microsurgery Federal State Institution in 2020. The patients' age was 58±15.2 years. The selection criterion was sufficient transparency of the optical media for viewing the macular zone. An in-depth examination of the macular zone was carried out using a forehead binocular reflex-free ophthalmoscope (Heine OMEGA500, Germany) and a non-contact lens (VOLK Double Aspheric 20D, USA), as well as optical coherence tomography (Cirrus HD-OCT 5000, «Carl Zeiss», Germany). The proportion of macular pathology among the patients who applied, the frequency and severity of its individual nosological forms were evaluated. Results. Various macular pathologies occurred in 28.2% of cases. Age-related macular degeneration (AMD) (47.9%) and epiretinal fibrosis (27.1%) accounted for a significant share in the structure of macular pathology. The frequency and structure of macular pathology in patients with age-related cataracts was analyzed. The incidence of macular pathology in them was 45.1%, of which AMD was detected in 65.2% of cases, epiretinal fibrosis – 7.8%. Conclusion. Among the group of patients selected by the method of continuous sampling with various ophthalmic surgical pathologies, 28.2% had various pathologies of the macular zone. The most common macular pathology occurred in the age group from 45 to 59 years old, accounting for 56.2% of cases. In the nosological structure of macular pathology, the share of AMD and epiretinal fibrosis prevailed. Key words: macular pathology, age-related macular degeneration, epiretinal fibrosis.

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Population-Based Age Group Specific Annual Incidence Rates of Symptomatic Age-Related Macular Degeneration

The Open Ophthalmology Journal ◽

10.2174/1874364101408010095 ◽

2014 ◽

Vol 8 (1) ◽

pp. 95-100 ◽

Cited By ~ 2

Author(s):

Jukka M Saari

Keyword(s):

Macular Degeneration ◽

Population Based ◽

Incidence Rates ◽

Annual Incidence ◽

Age Related Macular Degeneration ◽

Age Group ◽

Population Based Study ◽

Hospital District ◽

Age Related ◽

One Year

Purpose To study the population-based annual incidence rates of exudative, dry and all cases of symptomatic age-related macular degeneration (AMD) in different age and sex groups. Methods. This is a one year, prospective, population-based study on all consecutive new patients with AMD in the hospital district of Central Finland. The diagnosis was confirmed in all patients with slit lamp biomicroscopy, optical coherence tomography (OCT) using a Spectralis HRA + OCT device, and the Heidelberg Eye Explorer 1.6.2.0 program. Fluorescein angiograms were taken when needed. Results. The population-based annual incidence rates of all cases of symptomatic AMD increased from 0.03% (95% CI, 0.01-0.05%) in the age group 50-59 years to 0.82% (95% CI, 0.55-1.09%) in the age group 85-89 years and were 0.2% (95% CI, 0.17-0.24%) in exudative, 0.11% (95% CI, 0.09-0.14%) in dry, and 0.32% (95% CI, 0.28-0.36%) in all cases of AMD in the age group 60 years and older. During the next 20 years in Central Finland the population-based annual incidence rates can be estimated to increase to 0.27% (95% CI, 0.24-0.30%) in exudative, to 0.13% (95% CI, 0.11-0.15%) in dry, and to 0.41% (95% CI, 0.37-0.45%) in all cases of AMD in the age group 60 years and older. The population-based annual incidence of AMD did not show statistically significant differences between males and females (p>0.1). Conclusion: The population-based age-group specific annual incidence rates of symptomatic AMD of this study may help to plan health care provision for patients of AMD.

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Antioxidant supplements in age-related macular degeneration: are they actually beneficial?

Therapeutic Advances in Ophthalmology ◽

10.1177/25158414211030418 ◽

2021 ◽

Vol 13 ◽

pp. 251584142110304

Author(s):

Mousumi Banerjee ◽

Rohan Chawla ◽

Atul Kumar

Keyword(s):

Macular Degeneration ◽

Visual Loss ◽

Epidemiological Studies ◽

Age Related Macular Degeneration ◽

Age Group ◽

Inappropriate Use ◽

Age Related ◽

False Sense ◽

Antioxidant Supplements

Age-related macular degeneration (ARMD) is one of the prominent causes of central visual loss in the older age group in the urbanized, industrialized world. In recent years, many epidemiological studies and clinical trials have evaluated the role of antioxidants and micronutrients to prevent the progression of ARMD. In this article, we review some of these major studies. In addition, we review the absorption and bioavailability and possible undesirable effects of these nutrients after ingestion. The role of genotypes and inappropriate use of these supplements are also discussed. From all the above evidence, we conclude that it may not be prudent to prescribe these formulations without a proper assessment of the individual’s health and dietary status. The effectiveness of all the components in antioxidant formulations is controversial. Thus, these supplements should not be prescribed just for the purpose of providing patients some kind of therapy, which may give a false sense of mental satisfaction.

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Karakteristik Pasien Age-related Macular Degeneration (AMD) pada Fasilitas Kesehatan Tersier di Masa Pandemi Covid 19

e-CliniC ◽

10.35790/ecl.v9i2.35645 ◽

2021 ◽

Vol 9 (2) ◽

pp. 492

Author(s):

Ade J. Nursalim ◽

Elbetty Simanjuntak ◽

Vera Sumual

Keyword(s):

Macular Degeneration ◽

Health Facilities ◽

Age Related Macular Degeneration ◽

Age Group ◽

Medical Record Data ◽

Central Visual Field ◽

Age Related ◽

Record Data ◽

Age Range ◽

Diabetes Melitus

Abstract: Age-related macular degeneration (AMD) is a neurodegenerative disease that affects the macula and is characterized by age-related loss of the central visual field. AMD contributes greatly to blindness for people over 50 years old in the world. The prevalence of AMD is increasing from year to year. Albeit, during the Covid-19 pandemic the number of patient visits to health facilities tends to decrease. This study was aimed to report the clinical characteristics of patients with AMD in tertiary health facilities during the covid 19 pandemic and to compare them with previous reports. This was a retrospective and descriptive study using medical record data of the Ophthalmology Clinic of Prof. Dr. R. D. Kandou Hospital Manado from March 2020 to June 2021. There were 12 patients in this study consisting of 10 males and two females. Age range of 56-75 years had the highest percentage (58%). The non-neovascular subtype were found in 7 patients (58.3%) meanwhile the neovascular type in 5 patients (41.7%). The identified risks were hypertension (50%), diabetes mellitus (DM) (8.3%), and DM associated with hypertension (16,7%), meanwhile no risk factor was found in 8.3% of patients. The number of patient visits decreased in the study period compared to previous reports conducted before the pandemic. In conclusion, the majority of AMD patients were male, age group of 56-75 years, and had non-neovascular subtype. The identified risk factors were hypertension and diabetes mellitus.Keywords: age related macular degeneration (AMD); characteristics of patients Abstrak: Age-related macular degeneration (AMD) adalah penyakit neourodegeneratif yang mengenai bagian makula dan ditandai dengan hilangnya lapang pandang sentral yang berhu-bungan dengan usia. AMD berkontribusi besar terhadap angka kebutaan untuk usia di atas 50 tahun di dunia. Prevalensi AMD pun semakin meningkat dari tahun ketahun. Pandemi Covid 19 diketahui mengurangi angka kunjungan pasien ke fasilitas kesehatan. Penelitian ini bertujuan untuk melaporkan karakteristik klinik pada pasien AMD pada fasilitas kesehatan tersier di masa pandemi covid 19 dan membandingkannya dengan laporan sebelumya. Jenis penelitian ialah deskriptif retrospektif dengan menggunakan data rekam medik di Poliklinik Mata RSUP Prof. Dr. R. D. Kandou Manado periode Maret 2020-Juni 2021. Hasil penelitian mendapatkan sebanyak 12 pasien AMD; sebagian besar berjenis kelamin laki-laki (83,3%), berada dalam rentang usia 56-75 tahun (58%), dengan subtipe AMD non neovaskular (58,3%). Faktor risiko yang teridentifikasi ialah hipertensi (50%), diabetes melitus (DM) (8,3%), dan DM disertai hipertensi (16,7%), sedangkan yang tanpa faktor risiko hanya 8,3%. Jumlah kunjungan pasien berkurang di periode waktu penelitian dibandingkan dengan laporan yang dilakukan sebelum masa pandemi. Simpulan penelitian ialah mayoritas pasien AMD berjenis kelamin laki-laki, usia 56-75 tahun, dengan subtipe non neovaskular. Faktor risiko teridentifikasi ialah hipertensi dan diabetes melitus.Kata kunci: age-related macular degeneration (AMD); karakteristik pasien

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Increased risk of Alzheimer’s disease among patients with age-related macular degeneration: A nationwide population-based study

PLoS ONE ◽

10.1371/journal.pone.0250440 ◽

2021 ◽

Vol 16 (5) ◽

pp. e0250440

Author(s):

Li-Yen Wen ◽

Lei Wan ◽

Jung-Nien Lai ◽

Chih Sheng Chen ◽

Jamie Jiin-Yi Chen ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Macular Degeneration ◽

Population Based ◽

Age Related Macular Degeneration ◽

Chronic Obstructive ◽

Research Database ◽

Age Group ◽

Age Related ◽

Increased Risk

Objective This study aimed to investigate the risk of Alzheimer’s disease among patients with age-related macular degeneration and its association with confounding comorbidities. Method This was a population-based, retrospective cohort study. By accessing data from the National Health Insurance Research Database of Taiwan, we identified 10,578 patients aged 50–100 years who were newly diagnosed with age-related macular degeneration between 2000 and 2012 and 10,578 non- age-related macular degeneration individuals. The comorbidities assessed were osteoporosis, diabetes, cirrhosis, cerebrovascular disease, chronic kidney disease, hypertension, hyperlipidemia, coronary artery disease, and chronic obstructive pulmonary disease. Results Patients with age-related macular degeneration had a 1.23-fold increased risk of their condition advancing to Alzheimer’s disease (aHR = 1.23, 95% CI = 1.04–1.46). The younger patients were diagnosed with age-related macular degeneration, the more likely patients got Alzheimer’s disease (50–64 age group: aHR = 1.97, 95% CI = 1.04–3.73; 65–79 age group: aHR = 1.27, 95% CI = 1.02–1.58; 80–100 age group: aHR = 1.06, 95% CI = 0.78–1.45). In addition, there were significantly higher risks of Alzheimer’s disease for patients with cirrhosis (aHR = 1.50, 95% CI = 1.09–2.06) in the age-related macular degeneration cohort than in the non-age-related macular degeneration cohort. Conclusion Patients with age-related macular degeneration may exhibit a higher risk of Alzheimer’s disease than people without age-related macular degeneration.

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Prevalence of Age-Related Maculopathy

50 Studies Every Ophthalmologist Should Know ◽

10.1093/med/9780190050726.003.0035 ◽

2020 ◽

pp. 213-218

Author(s):

Alan D. Penman ◽

Kimberly W. Crowder ◽

William M. Watkins

Keyword(s):

Macular Degeneration ◽

Public Health Problem ◽

Population Based ◽

Age Related Macular Degeneration ◽

Age Group ◽

Age Related ◽

Beaver Dam ◽

Exudative Macular Degeneration ◽

Early Indication ◽

Baseline Examination

The Beaver Dam Eye Study was a population-based cohort study designed to collect information on the prevalence and incidence of age-related cataract, macular degeneration, and diabetic retinopathy. The results of the baseline examination for macular degeneration are reported in this chapter. One or more drusen were present in the macular area of at least one eye in 95% of the population. Signs of age-related maculopathy were common in people seventy-five years of age or older. Women of this age group had an incidence of exudative macular degeneration two to three times higher than their male counterparts. This study was an early indication that age-related macular degeneration was becoming a public health problem in an aging American population.

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Age related macular degeneration (ARMD) – pathophysiological and clinical features and therapeutic concepts

Therapeutische Umschau ◽

10.1024/0040-5930.58.1.28 ◽

2001 ◽

Vol 58 (1) ◽

pp. 28-35 ◽

Cited By ~ 1

Author(s):

Ursula Körner-Stiefbold

Keyword(s):

Macular Degeneration ◽

Clinical Features ◽

Altersbedingte Makuladegeneration ◽

Age Related Macular Degeneration ◽

Genetische Faktoren ◽

Age Related ◽

Therapeutic Concepts

Die altersbedingte Makuladegeneration (AMD) ist eine der häufigsten Ursachen für einen irreversiblen Visusverlust bei Patienten über 65 Jahre. Nahezu 30% der über 75-Jährigen sind von einer AMD betroffen. Trotz neuer Erkenntnisse in der Grundlagenforschung ist die Ätiologie, zu der auch genetische Faktoren gehören, noch nicht völlig geklärt. Aus diesem Grund sind die Behandlungsmöglichkeiten zum jetzigen Zeitpunkt noch limitiert, so dass man lediglich von Therapieansätzen sprechen kann. Die derzeit zur Verfügung stehenden Möglichkeiten wie medikamentöse, chirurgische und laser- und strahlentherapeutische Maßnahmen werden beschrieben.

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