Treatment tactics and outcomes of complications of intrastromal MyoRing implantation and corneal crosslinking in keratoconus

Purpose. To analyze the nature and frequency of intra - and postoperative complications during MyoRing implantation and corneal crosslinking in patients with keratoconus and to develop methods for their treatment and prevention. Material and methods. We conducted a study of the results of MyoRing implantation in 131 patients (147 eyes) with keratoconus II-III. Corneal rings with a diameter of 5-6 mm and a thickness of 280-320 µm were implanted. PocketMaker microkeratome (Dioptex GmbH, Austria) was used to create a stromal pocket during the implantation of the ICR. The patients were divided into the control group (32 patients, 34 eyes) – using the standard ICR implantation technology and the main group (38 patients, 42 eyes) – ICR implantation using the developed tools. Results. Among the complications, intraoperatively, the eruption of the stromal pocket was noted due to the loss of vacuum during the application of the applicator in 4 cases. In the long term, after 10 and 12 months, patients underwent ICR reimplantation with a positive result. In 2 cases, the surface location of the implant led to ring extrusion, which may have been due to the thinning of the surface layers, and subsequently keratoplasty was performed on the patients. In 1 case, the patient's pronounced deposition of lamellar deposits caused dissatisfaction of a cosmetic nature. At the request of the patients, the rings were removed, and in the following terms, the patient made up for the visual defect by wearing hard contact lenses. Conclusion. A moderate number of complications indicates the relative safety of the method of intrastromal keratoplasty. The use of the proposed instruments during the operation provides a significant reduction in the frequency of complications compared to the results with the standard technique of forming a corneal tunnel. Thus, it was found that the optimized method of implantation of MyoRing intrastromal rings reduces corneal trauma, simplifies the manipulation of the ring and reduces the total operation time by 1.4 times. Key words: keratoconus, intrastromal corneal rings, MyoRing, corneal crosslinking, complications.

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Clinical Efficacy and Safety of Silicone Elastomer Sheet during Decompressive Craniectomy: Anti-Adhesive Role in Cranioplasty

Brain Sciences ◽

10.3390/brainsci11010124 ◽

2021 ◽

Vol 11 (1) ◽

pp. 124

Author(s):

Young Ha Kim ◽

Chi Hyung Lee ◽

Chang Hyeun Kim ◽

Dong Wuk Son ◽

Sang Weon Lee ◽

...

Keyword(s):

Decompressive Craniectomy ◽

Fluid Collection ◽

Multivariate Logistic Regression Analysis ◽

Operation Time ◽

Silicone Elastomer ◽

Control Group ◽

Estimated Blood Loss ◽

Adhesion Tissue ◽

Skull Bone Defect ◽

Epidural Adhesion

(1) Background: Cranioplasty is a surgery to repair a skull bone defect after decompressive craniectomy (DC). If the process of dissection of the epidural adhesion tissue is not performed properly, it can cause many complications. We reviewed the effect of a silicone elastomer sheet designed to prevent adhesion. (2) Methods: We retrospectively reviewed 81 consecutive patients who underwent DC and subsequent cranioplasty at our institution between January 2015 and December 2019. We then divided the patients into two groups, one not using the silicone elastomer sheet (n = 50) and the other using the silicone elastomer sheet (n = 31), and compared the surgical outcomes. (3) Results: We found that the use of the sheet shortened the operation time by 24% and reduced the estimated blood loss (EBL) by 43% compared to the control group. Moreover, the complication rate of epidural fluid collection (EFC) in the group using the sheet was 16.7%, which was lower than that in the control group (41.7%, p < 0.023). Multivariate logistic regression analysis showed the sheet (OR 0.294, 95% CI 0.093–0.934, p = 0.039) to be significantly related to EFC. (4) Conclusions: The technique using the silicone elastomer sheet allows surgeons to easily dissect the surgical plane during cranioplasty, which shortens the operation time, reduces EBL, and minimizes complications of EFC.

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Clinical Application of a 3D-Printed Positioning Module and Navigation Template for Percutaneous Vertebroplasty

Surgical Innovation ◽

10.1177/15533506211062404 ◽

2021 ◽

pp. 155335062110624

Author(s):

Jing Yang ◽

Penghui Ni ◽

Lina Zhang ◽

Zhanxin Lu ◽

Dapeng Liu ◽

...

Keyword(s):

Percutaneous Vertebroplasty ◽

Operation Time ◽

Vertebral Compression Fractures ◽

Control Group ◽

Compression Fractures ◽

Intraoperative Fluoroscopy ◽

3D Printed ◽

Vas Scores ◽

Experimental Group ◽

Navigation Template

Background This study aimed to evaluate a personalized 3D-printed percutaneous vertebroplasty positioning module and navigation template based on preoperative CT scan data that was designed to treat patients with vertebral compression fractures caused by osteoporosis. Methods A total of 22 patients with vertebral compression fractures admitted to our hospital were included in the study. Positioning was performed with the new 3D-printed positioning module, and the navigation template was used for patients in the experimental group, and the traditional perspective method was used for patients in the control group. The experimental group consisted of 11 patients, 2 males and 9 females, with a mean age of 67.27 ± 11.86 years (range: 48 to 80 years), and the control group consisted of 11 patients, 3 males and 8 females, with a mean age of 74.27 ± 7.24 years (range: 63 to 89 years). The puncture positioning duration, number of intraoperative fluoroscopy sessions, and preoperative and postoperative visual analog scale (VAS) scores were statistically analyzed in both groups. Results The experimental group had shorter puncture positioning durations and fewer intraoperative fluoroscopy sessions than the control group, and the differences were statistically significant (P < .05). There were no significant differences in age or preoperative or postoperative VAS scores between the two groups (P > .05). Conclusions The new 3D-printed vertebroplasty positioning module and navigation template shortened the operation time and reduced the number of intraoperative fluoroscopy sessions. It also reduced the difficulty in performing percutaneous vertebroplasty and influenced the learning curve of senior doctors learning this operation to a certain degree.

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Study on the method of enucleation of anterior uterine fibroids by transverse incision of the lower uterine segment during cesarean section

BMC Pregnancy and Childbirth ◽

10.1186/s12884-021-04226-1 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Yan Dai ◽

Li Xia ◽

Jinxiao Lin ◽

Rongli Xu ◽

Wenqiang You

Keyword(s):

Cesarean Section ◽

Operation Time ◽

Anterior Wall ◽

Control Group ◽

Study Group ◽

Transverse Incision ◽

Postoperative Fever ◽

Postoperative Changes ◽

Perioperative Bleeding ◽

Surgical Data

Abstract Introduction A retrospective study was conducted to investigate the effectiveness and feasibility of fibroid enucleation in the anterior wall of the uterus by transverse uterine incision during cesarean section. Methods The medical history, surgical data, preoperative and postoperative changes in the blood system, and complications of 90 pregnant women who underwent myomectomy of the anterior uterine wall during cesarean section at the second Department of Maternal and Child Health Hospital of Fujian Province were analyzed retrospectively. Results No significant differences were noted in the leiomyoma number, pathological type, preoperative and postoperative hemoglobin level, perioperative bleeding incidence, blood transfusion frequency, postoperative fever incidence, and duration of lochia between the study and control groups. The proportion of large fibroids was slightly higher in the study group than in the control group (p < 0.05), and the operation time and average hospitalization time were slightly longer in the study group than in the control group (p < 0.05). The distribution of type III–V fibroids was slightly more in the study group than in the control group (p < 0.05), and the distribution of type VI fibroids in the study group was less than that in the control group (p < 0.05). Conclusion Fibroid enucleation is safe and effective in the anterior wall of the uterus through the lower uterine transverse incision in cesarean section. It has the potential to reduce the risk of pelvic and intrauterine adhesions in the future.

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CONDITIONAL TISSUE CONDITION IN PATIENTS WITH PROSTHETIC DENTISTS IN THE PROCESS OF ORTHOPEDIC TREATMENT WITH PROSTHESES MODIFIED BY NANOMATER

Ukrainian Dental Almanac ◽

10.31718/2409-0255.4.2021.04 ◽

2021 ◽

pp. 20-25

Author(s):

B.Y. Silenko ◽

V.M. Dvornik ◽

Y.I. Silenko

Keyword(s):

Mucous Membrane ◽

Soft Tissues ◽

Dental Treatment ◽

Fullerene C60 ◽

Control Group ◽

Orthopedic Treatment ◽

Residual Monomer ◽

Minimum Concentration ◽

Treatment And Prevention ◽

Orthopedic Care

The main cause of prosthetic stomatitis belongs to the chemical and toxic action of the residual monomer of the prosthesis base, which is a protoplasmic poison. Occurrence of prosthetic stomatitis depends not only on quality of production of prosthesis in laboratory though at non-observance of technology indicators of residual monomer can reach 2-5%, but also at individual intolerance at its minimum concentration in a prosthesis after polymerization - 0,2-0 .5%. The aim of our study was to increase the effectiveness of orthopedic treatment of patients with prosthetic stomatitis by coating the plastic of removable prostheses with nanoscale materials. Materials and methods. To solve this goal, we studied the condition of the tissues of the prosthetic place of patients with prosthetic stomatitis with prosthetic removable prostheses with modified plastic. Orthopedic dental treatment of 50 people was examined and performed, including 25 people (the second group, prostheses were not covered with nanoparticles) and 25 people (the third group, prostheses were covered with nanoparticles). The first control group consisted of 10 people without signs of pathology. Prior to treatment, all patients had removable acrylic plastic dentures. The reason for seeking orthopedic care was a violation of masticatory function and the inability to use previously made prostheses due to the development of pain in the soft tissues of the prosthetic place. Complaints of pain were observed in all patients of varying intensity, impaired fixation and stabilization of the prosthesis due to swelling of the mucous membrane of the soft tissues of the prosthetic place, heartburn and dryness were observed in 90% of patients. Complaints were also about speech and aesthetic defects. Patients of III group after two weeks of using prostheses were coated with the inner surface of the prosthesis, which is in direct contact with the mucous membrane of the prosthetic place with molecules of fullerene C60, by magnetron sputtering. For this purpose, the prostheses were removed from the patients for several days and returned after the coating with the nanomaterial, after which the observation was continued. The results. After coating the prostheses in patients of group III with Fullerene C60, we observed the disappearance of inflammation of the mucous membrane under the prosthesis and patients noted the absence of discomfort. Рatients in II group had a negative dynamics in 80% and had diffuse inflammation of the mucous membrane under the prosthesis. Within 3 months of use, 18 patients (72%) in II group reported that they stopped using removable dentures during the day, due to unpleasant pain under the prosthesis, and used only during meals and during conversations. In contrast to II group, patients in III group did not notice discomfort when using plate prostheses. Conclusions. Obtained in the course of the work convincingly prove the effectiveness of the use of removable plate prostheses with nanocoating for the treatment and prevention of prosthetic stomatitis in patients. This is evidenced by the data of objective examination and the disappearance of complaints from patients.

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Features of the course and treatment of chronic catarrhal gingivitis in dogs

Scientific Messenger of LNU of Veterinary Medicine and Biotechnology ◽

10.32718/nvlvet10013 ◽

2020 ◽

Vol 22 (100) ◽

pp. 71-77

Author(s):

N. M. Khomyn ◽

A. R. Mysak ◽

S. V. Tsisinska ◽

V. V. Pritsak ◽

N. V. Nazaruk ◽

...

Keyword(s):

Oral Cavity ◽

Periodontal Disease ◽

Mucous Membrane ◽

Inflammatory Process ◽

Recovery Period ◽

Control Group ◽

Treatment And Prevention ◽

Before And After ◽

Medicinal Substances ◽

Effective Treatment Regimen

Periodontal disease is known to be the most common and serious health problem in dogs today. Despite the rather large arsenal of medicinal substances, the problem of treatment and prevention of periodontal disease remains relevant. Based on this, the purpose of the work was to study the features of chronic catarrhal gingivitis and to develop an effective treatment regimen for dentistically ill dogs. For research, two groups of animals with chronic catarrhal gingivitis were formed in 5 dogs in each (control and experimental), selected on the principle of analogues in terms of age, character and localization of the inflammatory process. Animals of the control and experimental groups were performed tartar removal, irrigation of the oral cavity with water and drying of the mucosa with a sterile gauze swab. Dogs of the control group on the mucous membrane was applied 1 ml of septogel 2 times a day, and the experimental – argumentistin 2 times a day. Before and after the procedures on the mucous membrane was applied a 3 % solution of hydrogen peroxide. It was determined the prevalence of dental disease in dogs, the influence of microflora on the condition of the oral cavity of dogs with chronic catarrhal gingivitis, the clinical condition and the main indices and samples were studied, reflecting the intensity of the inflammatory process in the gums of sick dogs and was developed a method of treatment. The results of researches have shown that the use of argumentistin in the complex treatment of dogs with chronic catarrhal gingivitis helps to reduce the recovery period by 5 days.

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Efficacy of carprostol tromethamine combined with mifepristone in the treatment of uterine fibroids

Journal of Clinical and Nursing Research ◽

10.26689/jcnr.v3i1.697 ◽

2019 ◽

Vol 3 (1) ◽

Author(s):

Jun Wang ◽

Xian Zhang

Keyword(s):

Estrogen Receptor ◽

Progesterone Receptor ◽

Treatment Effect ◽

Uterine Fibroids ◽

Operation Time ◽

Clinical Treatment ◽

Control Group ◽

Observation Group ◽

Significant Difference ◽

Better Than

ã€Abstractã€‘Objective: To investigate the clinical efficacy of carboprost tromethamine combined with mifepristone in the treatment of uterine fibroids. METHODS: A total of 66 patients with uterine fibroids admitted to our hospital between April 2018 and January 2019 were selected as subjects. According to the two different treatment methods, patients were divided equally. The observation group and the control group, each group of 33 people. The oxytocin drug treatment was medicated to the control group, and the prostaglandin tromethamine combined with mifepristone was medicated to the observation group. The treatment effect, adverse reaction, operation, and uterine muscle before and after surgery were observed in these two groups. Tumor tissue progesterone receptor and estrogen receptor levels. Results: The clinical treatment effect of the observation group was 93.94%, and the clinical treatment effect of the control group was 60.61%. The clinical treatment effect of the observation group was significantly higher than that of the control group; also the incidence of adverse reactions in the observation group in terms of rash, fatigue, nausea and vomiting was much lower than the control group, and could observe a significant difference. Finally in observation group, the amount of intraoperative blood loss, operation time and hospitalization time were better than those of the control group. The progesterone receptor and estrogen receptor levels in the uterine fibroid tissue after surgery should also be better than the control group, it is worth to make further comparison. Conclusion: Carprostol tromethamine combined with mifepristone is effective in the treatment of uterine fibroids and can be further developed.

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Anesthetic Effect of Compound Artevacaine Hydrochloride in Patients Undergoing Oral Implantation

Journal of Clinical and Nursing Research ◽

10.26689/jcnr.v5i4.2373 ◽

2021 ◽

Vol 5 (4) ◽

pp. 220-224

Author(s):

Chengxi Chi ◽

Mengmeng Zhao ◽

Jiajing He ◽

Yanli Wang

Keyword(s):

Blood Pressure ◽

Heart Rate ◽

Operation Time ◽

Control Group ◽

Study Group ◽

Research Subjects ◽

Implant Surgery ◽

Anesthetic Effect ◽

Significant Difference ◽

Oral Implant

Objective: To investigate and analyze the anesthetic effect of compound artevacaine hydrochloride in patients undergoing oral implantation. Methods: In this study, 60 patients receiving oral implant surgery in our hospital were selected as the research subjects, and the operation time was from July 2019 to March 2021. Patients were randomly selected and divided into groups for the study. 30 patients receiving lidocaine hydrochloride anesthesia were used as the control group, and 30 patients receiving compound artevacaine hydrochloride anesthesia were used as the research group. The anesthetic effect and safety of the two groups were compared and analyzed. Results: The anesthetic effect of the study group was significantly better than that of the control group (P < 0.05). The blood pressure and heart rate in the study group were significantly lower than those in the control group (P < 0.05). There was no significant difference in blood pressure and heart rate between the two groups before anesthesia (P > 0.05). There was no significant difference in the incidence of ADR between the two groups (P > 0.05). Conclusions: For patients undergoing oral implant surgery, choosing compound artevacaine hydrochloride as anesthetic drug has obvious anesthetic effect and can stabilize patients' life indexes. The anesthetic effect is obvious, and there is no obvious adverse reaction, and the clinical value is obvious.

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Comparative Analysis on the Curative Effect of Endoscopic Submucosal Dissection and Mucosal Resection in the Treatment of Gastric Neuroendocrine Tumor

Proceedings of Anticancer Research ◽

10.26689/par.v5i5.2589 ◽

2021 ◽

Vol 5 (5) ◽

Author(s):

Nannan Zhao ◽

Nan Li

Keyword(s):

Endoscopic Submucosal Dissection ◽

Neuroendocrine Tumor ◽

Reference Group ◽

Tumor Resection ◽

Operation Time ◽

Control Group ◽

Study Group ◽

Resection Rate ◽

Mucosal Resection ◽

Submucosal Dissection

Objective: To study the therapeutic effect of endoscopic submucosal dissection and mucosal resection on gastric neuroendocrine tumor. Methods: A hundred patients with gastric neuroendocrine tumor that were treated in the Affiliated Hospital of Chifeng University from January 2016 to May 2021 were randomly selected for this research. They were divided into two groups, which were the control group (endoscopic mucosal resection) and the study group (endoscopic submucosal dissection), by the digital table method. The curative effects of the two groups were observed and compared. Results: Before operation, there were no significant differences in serum CgA, TNF-?, and IL-6 between the two groups, p > 0.05. After surgical treatment, the operation time and hospital stay of the patients in the study group were shorter than those in the control group, the amount of surgical bleeding was also less compared to the control group, and the complete tumor resection rate was higher than that in the control group (p < 0.05); the levels of IL-6 and CgA of the study group were lower than those in the control group, while the levels of TNF-? were higher than those of the control group, p < 0.05; the postoperative complication rate of the study group was lower than that of the reference group (p < 0.05). Conclusion: Endoscopic submucosal dissection is more effective for gastric neuroendocrine tumors. The resection rate of the tumor is high, and the operation risk is low.

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Application of Three-dimensional Visualization assisted Ultrasound for Percutaneous Renal Puncture

10.21203/rs.3.rs-113148/v1 ◽

2020 ◽

Author(s):

Zhibin Xu ◽

Zhenchi Li ◽

Maomao Guo ◽

Hao Bian ◽

Tianli Niu ◽

...

Keyword(s):

Clearance Rate ◽

3D Visualization ◽

Three Dimensional ◽

Operation Time ◽

Control Group ◽

Transfusion Rate ◽

Stone Clearance ◽

Time Operation ◽

Postoperative Blood Transfusion ◽

Experimental Group

Abstract We present here the three-dimensional (3D) visualization fused with ultrasound and to evaluate its clinical application effect preliminarily. One hundred and eighteen patients with renal calculi in our hospital from September 2017 to December 2019 were prospectively randomized into two groups. The experimental group was treated with percutaneous renal puncture guided by the 3D visualization fused with ultrasound. The control group was treated with percutaneous renal puncture guided by B-ultrasonography (B-US). The puncture time, operation time, and the loss of hemoglobin in the experimental group were lower than those in the control group, and the success rate of establishing the channel at one time, and the coincidence rate between the channel and the longitudinal axis of the target renal calyx were higher. The stone clearance rate in the experimental group was higher, while the postoperative blood transfusion rate and interventional embolization rate in the experimental group were significantly lower. The difference was statistically significant (P < 0.05). 3D visualization assisted ultrasound could preliminarily guide precise navigation to puncture tissues, reduced operation time and bleeding, improved stone clearance rate and operation safety.

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Thromboangiitis obliterans: Aggressive angioplasty provides a potential solution (randomized pilot study)

SAGE Open Medicine ◽

10.1177/2050312120927636 ◽

2020 ◽

Vol 8 ◽

pp. 205031212092763

Author(s):

Mosaad Soliman ◽

Khaled Mowafy ◽

NA Elsaadany ◽

Reem Soliman ◽

Ahmed Elmetwally

Keyword(s):

Medical Treatment ◽

Ulcer Healing ◽

Ankle Brachial Index ◽

Peak Systolic Velocity ◽

Standard Technique ◽

Thromboangiitis Obliterans ◽

Control Group ◽

Buerger’S Disease ◽

Buerger's Disease ◽

The Mean

Background: Thromboangiitis obliterans is an inflammatory disease affecting both medium- and small-sized vessels. Vasodilators, antiplatelets were proposed for treatment but the effect was minimal. Objective: This study was conducted to investigate the effect of balloon angioplasty on patients with Buerger’s disease compared to medical treatment. Methods: Between January 2006 and December 2016, 82 patients with Buerger’s disease were enrolled in the study, of whom 52 were randomized to the aggressive endovascular intervention and 30 were randomized medically by cilostazol and aspirin as a control group. In all, 23% of the patients presented with severe claudication, 50% with ischemic rest pain and 27% with ischemic ulcers. Randomization was done using the opaque envelope method. Allocation concealment was maintained to ensure no selection bias. Patient groups were compared for the duration of ulcer healing, ankle–brachial index, peak systolic velocity changes and transcutaneous oximetry (TcPO2) level for 30 months. Results: No major procedural complications occurred in the endovascular group. Angiographic success was achieved in 100% of supragenicular lesions but in 90% of infrapopliteal lesions. The endovascular group showed a statistically significant improvement in the ulcer healing size and duration at 6 months after the procedure with a mean time of 3 ± 0.9 months compared to 5.8 ± 1.69 months for the medical treatment group (p < 0.001), the mean TcPO2 from 27.23 ± 16.75 mm Hg (range: 0–56 mm Hg) before the procedure to 71.32 ± 12.94 mm Hg (range: 52–92 mm Hg) following revascularization (p < 0.01). The mean ankle–brachial index significantly improved from 0.54 ± 0.14 preoperatively to 0.82 ± 0.08 at final follow-up (p < 0.01). Conclusion: The endovascular therapy should be considered as an effective, safe, minimally invasive method in the light of the promising results after a modification of the standard technique.

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