scholarly journals Effects of graded levels of Curcuma longa Powder on in vivo digestibility in Guinea pigs (Cavia porcellus)

2021 ◽  
Author(s):  
Gina France Tobou Djoumessi ◽  
Fernand Tendonkeng ◽  
Emile Miégoué ◽  
Clément Emalé ◽  
David Fokom Wauffo ◽  
...  
Keyword(s):  
Guinea Pigs ◽  
Curcuma Longa ◽  
Cavia Porcellus

L’effet de l’incorporation de la poudre du Curcuma longa comme phytobiotique sur l’ingestion et la digestibilité in vivo des nutriments a été mesuré sur un total de 40 cobayes de race anglaise ayant un poids moyen de 452±75 g. La poudre de racines de Curcuma longa a été incorporée dans l’aliment composé à des niveaux croissants (0 ; 0,25 ; 0,5 et 1%). Chaque ration a été granulée. Pendant l’essai de digestibilité qui a duré 17 jours (10 jours d’adaptation et 07 jours de collecte des données), chaque ration était répétée sur 10 cobayes (5 mâles et 5 femelles). L’inclusion de la poudre de Curcuma longa a amélioré de manière significative (p<0,05) l’ingestion alimentaire des cochons d’inde quel que soit le niveau d’inclusion considéré dans les rations. La digestibilité de la matière sèche de la ration contenant 0,25% de Curcuma longa a été comparable à celle de la ration R0% et R1%. En outre, la digestibilité de la cellulose brute de la ration R0,25% a été comparable à celle des rations R0,5% et R1%, mais significativement plus élevée que celle des rations R0%. L’inclusion de la poudre de Curcuma longa dans les rations a permis d’améliorer l’ingestion et la digestibilité de la ration chez des cochons d’inde. D’autres études doivent être réalisées afin de déterminer les causes de ces effets.

scholarly journals Physiological Features of Pennisetum Purpureum or Panicum Maximum Consumption in Guinea Pigs (Cavia Porcellus)

2018 ◽  
Vol 1 (1) ◽  
pp. 5-19
Author(s):  
Emile Miégoué ◽  
Fernand Tendonkeng ◽  
Nathalie Mweugang Ngouopo ◽  
Loïc Arnauld Mba Tene ◽  
Paulette Ntsafack ◽  
...  
Keyword(s):  
Guinea Pigs ◽  
Pennisetum Purpureum ◽  
Average Weight ◽  
Panicum Maximum ◽  
Cavia Porcellus ◽  
Fresh Matter ◽  
Local Breed ◽  
The University ◽  
Better Than

Guinea pig diet is essentially based on the use of grasses associated with protein sources. Then, in to improve the herbivores nutrition, the evaluation of intake and In vivo digestibility of Pennisetum purpureum or Panicum maximum in guinea pigs (Cavia porcellus) was carried out in January 2017 at the University of Dschang research and experimental farm and animal production and nutrition laboratory. 20 adult animals of local breed on average weight 450 ± 50g and aged about 5 months were used. They were organized into two batches of 10 animals each (5 males and 5 females). The first batch received 250g of fresh matter of Pennisetum purpureum + 60g concentrate/animal/day, while the second received the same treatment with Panicum maximum as grasses. Leftover and animals were weighed every morning before food distributions, and drinking water containing vitamin C was served ad libitum. According to the results, the highest ingestion was obtained with Panicum maximum. However, the digestibility different nutrients was comparable between treatments; nevertheless, males fed on P. maximum digested crude cellulose (63.78%) better than males fed on P. purpureum (51.17%). With regard to the variation of the bacterial rate of the caecal flora, enterobacteria of animals fed P. maximum was high (11.20 CFU/ml) compared to those of the animals receiving P. purpureum (7.27 CFU/ml), although regardless of the treatment, the level of lactobacilli was higher than that of enterobacteria. In view of the results obtained, these grasses can be alternatively used in feeding guinea pigs.

scholarly journals Effect of Dietary Incorporation of <i>Curcuma longa</i> Powder on Haematology and Serological Properties of Guinea Pigs (<i>Cavia porcellus</i>)

2020 ◽  
Vol 10 (04) ◽  
pp. 750-760
Author(s):  
France Gina Djoumessi Tobou ◽  
Fernand Tendonkeng ◽  
Emile Miégoué ◽  
Bertine Marie Noel Noumbissi ◽  
David Fokom Wauffo ◽  
...  
Keyword(s):  
Guinea Pigs ◽  
Curcuma Longa ◽  
Cavia Porcellus

Involvement of 5-Hydroxytryptamine in Platelet Aggregation In Vivo in Rats and Guinea Pigs

1989 ◽  
Vol 61 (03) ◽  
pp. 463-467 ◽  
Author(s):  
G M Smith
Keyword(s):  
Platelet Count ◽  
Guinea Pigs ◽  
Platelet Adhesion ◽  
Adenosine Diphosphate ◽  
Rate Of Return ◽  
Low Doses ◽  
Dose Dependent ◽  
Higher Doses ◽  
Rat Platelets

SummaryIn this study, 5-hydroxytryptamine (5-HT) caused a dose- dependent fall in the circulating platelet count suggesting that 5-HT receptors are activated in rat platelets to cause platelet adhesion and aggregation. When low doses of adenosine diphosphate (ADP) were simultaneously injected with 5-HT, there was a significant potentiation of the responses to ADR Ketanserin significantly reduced the potentiated responses. When higher doses of ADP were infused with bolus injections of 5-HT there was no potentiation and ketanserin did not reduce these responses. Ketanserin did not inhibit the collagen-induced fall in circulating platelet count, but did significantly increase the rate of return to the basal platelet count compared with control. 5-HT did not cause a fall in platelet count in guinea-pigs

Inhibition of Human and Animal Platelet Adhesiveness to Glass Bead Columns by Adenosine, Dipyridamole, Chlorpromazine and Acetylsalicylic Acid

1976 ◽  
Vol 36 (02) ◽  
pp. 401-410 ◽  
Author(s):  
Buichi Fujttani ◽  
Toshimichi Tsuboi ◽  
Kazuko Takeno ◽  
Kouichi Yoshida ◽  
Masanao Shimizu
Keyword(s):  
Guinea Pig ◽  
Acetylsalicylic Acid ◽  
Guinea Pigs ◽  
Glass Bead ◽  
Animal Species ◽  
Inhibitory Effect ◽  
Rabbit Platelet ◽  
Platelet Adhesiveness

SummaryThe differences among human, rabbit and guinea-pig platelet adhesiveness as for inhibitions by adenosine, dipyridamole, chlorpromazine and acetylsalicylic acid are described, and the influence of measurement conditions on platelet adhesiveness is also reported. Platelet adhesiveness of human and animal species decreased with an increase of heparin concentrations and an increase of flow rate of blood passing through a glass bead column. Human and rabbit platelet adhesiveness was inhibited in vitro by adenosine, dipyridamole and chlorpromazine, but not by acetylsalicylic acid. On the other hand, guinea-pig platelet adhesiveness was inhibited by the four drugs including acetylsalicylic acid. In in vivo study, adenosine, dipyridamole and chlorpromazine inhibited platelet adhesiveness in rabbits and guinea-pigs. Acetylsalicylic acid showed the inhibitory effect in guinea-pigs, but not in rabbits.

The Ullrastructure of Platelet Participation in Hemostasis

1965 ◽  
Vol 13 (01) ◽  
pp. 065-083 ◽  
Author(s):  
Shirley A. Johnson ◽  
Ronaldo S. Balboa ◽  
Harlan J. Pederson ◽  
Monica Buckley
Keyword(s):  
Platelet Aggregation ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Guinea Pigs ◽  
Platelet Factor ◽  
Mesenteric Vessels ◽  
Platelet Aggregates ◽  
Electron Lucent

SummaryThe ultrastructure of platelet aggregation in vivo in response to bleeding brought about by transection of small mesenteric vessels in rats and guinea pigs has been studied. Platelets aggregate, degranulate and separating membranes disappear in parallel with fibrin appearance which is first seen at several loci after 30 seconds of bleeding. About 40 per cent of the electron opaque granules, some of which contain platelet factor 3 have disappeared after one minute of bleeding while the electron lucent granules increase by 70 per cent suggesting that some of them may be empty vesicles. Most of the platelet aggregates of the random type disappear leaving clumped red blood cells entrapped by a network of fibrin fibers which emanate from the remains of platelet aggregates of the rosette type to maintain hemostasis.

scholarly journals Potential In Vitro Inhibition of Selected Plant Extracts against SARS-CoV-2 Chymotripsin-Like Protease (3CLPro) Activity

Foods ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1503
Author(s):  
Carla Guijarro-Real ◽  
Mariola Plazas ◽  
Adrián Rodríguez-Burruezo ◽  
Jaime Prohens ◽  
Ana Fita
Keyword(s):  
Plant Extracts ◽  
Curcuma Longa ◽  
Hydrolysis Product ◽  
Resonance Energy ◽  
Significant Inhibition ◽  
Main Role ◽  
Turmeric Extract ◽  
Ic50 Value

Antiviral treatments inhibiting Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication may represent a strategy complementary to vaccination to fight the ongoing Coronavirus disease 19 (COVID-19) pandemic. Molecules or extracts inhibiting the SARS-CoV-2 chymotripsin-like protease (3CLPro) could contribute to reducing or suppressing SARS-CoV-2 replication. Using a targeted approach, we identified 17 plant products that are included in current and traditional cuisines as promising inhibitors of SARS-CoV-2 3CLPro activity. Methanolic extracts were evaluated in vitro for inhibition of SARS-CoV-2 3CLPro activity using a quenched fluorescence resonance energy transfer (FRET) assay. Extracts from turmeric (Curcuma longa) rhizomes, mustard (Brassica nigra) seeds, and wall rocket (Diplotaxis erucoides subsp. erucoides) at 500 µg mL−1 displayed significant inhibition of the 3CLPro activity, resulting in residual protease activities of 0.0%, 9.4%, and 14.9%, respectively. Using different extract concentrations, an IC50 value of 15.74 µg mL−1 was calculated for turmeric extract. Commercial curcumin inhibited the 3CLPro activity, but did not fully account for the inhibitory effect of turmeric rhizomes extracts, suggesting that other components of the turmeric extract must also play a main role in inhibiting the 3CLPro activity. Sinigrin, a major glucosinolate present in mustard seeds and wall rocket, did not have relevant 3CLPro inhibitory activity; however, its hydrolysis product allyl isothiocyanate had an IC50 value of 41.43 µg mL−1. The current study identifies plant extracts and molecules that can be of interest in the search for treatments against COVID-19, acting as a basis for future chemical, in vivo, and clinical trials.

Spontaneously Arising Tumours and Tumour-like Lesions of the Cervix and Uterus in 83 Pet Guinea Pigs ( Cavia porcellus )

2017 ◽  
Vol 156 (4) ◽  
pp. 339-351 ◽  
Author(s):  
C. Laik-Schandelmaier ◽  
R. Klopfleisch ◽  
S. Schöniger ◽  
G. Weiffenbach ◽  
M. Staudacher ◽  
...  
Keyword(s):  
Guinea Pigs ◽  
Cavia Porcellus

scholarly journals Extraction of bioactive compounds from Curcuma longa L. using deep eutectic solvents: In vitro and in vivo biological activities

2021 ◽  
pp. 102697
Author(s):  
Grazielle Oliveira ◽  
Caroline Marques ◽  
Anielle de Oliveira ◽  
Amanda de Almeida dos Santos ◽  
Wanderlei do Amaral ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Biological Activities ◽  
Curcuma Longa ◽  
Deep Eutectic Solvents
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