Does gender or ethnicity influence renal function decline or cardiovascular events post live donation? Single center cohort study

2017 ◽  
Author(s):  
Shafi Malik
Keyword(s):  
Renal Function ◽  
Cohort Study ◽  
Cardiovascular Events ◽  
Single Center ◽  
Renal Function Decline ◽  
Live Donation

scholarly journals Effect of Renamezin upon attenuation of renal function decline in pre-dialysis chronic kidney disease patients: 24-week prospective observational cohort study

PLoS ONE ◽  
2021 ◽  
Vol 16 (6) ◽  
pp. e0252186
Author(s):  
Hayne Cho Park ◽  
AJin Cho ◽  
Do Hyoung Kim ◽  
Kyu-sang Yun ◽  
Juhee Kim ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Function ◽  
Cohort Study ◽  
Kidney Disease ◽  
Adverse Events ◽  
Serum Creatinine ◽  
Observational Cohort Study ◽  
Prospective Observational Cohort Study ◽  
Renal Function Decline ◽  
Observational Cohort

Renamezin® is a modified capsule-type oral spherical adsorptive carbon which lowers indoxyl sulfate levels in patients with advanced chronic kidney disease (CKD). This 24-week prospective observational cohort study was performed to evaluate the effect of Renamezin® upon attenuation of renal function decline. A total of 1,149 adult patients with baseline serum creatinine 2.0–5.0 mg/dL were enrolled from 22 tertiary hospital in Korea from April 2016 to September 2018. Among them, a total of 686 patients completed the study and were included in the intention-to-treat analysis. A total of 1,061 patients were included in the safety analysis. The mean age was 63.5 years and male patients were predominant (63.6%). Most of the patients (76.8%) demonstrated high compliance with study drug (6g per day). After 24 week of treatment, serum creatinine was increased from 2.86±0.72 mg/dL to 3.06±1.15 mg/dL (p<0.001), but estimated glomerular filtration rate was not changed significantly during observation period (22.3±6.8 mL/min/1.73m2 to 22.1±9.1 mL/min/1.73m2, p = 0.243). Patients with age over 65 years old and those under good systolic blood pressure control <130 mmHg were most likely to get benefit from Renamezin® treatment to preserve renal function. A total of 98 (9.2%) patients out of 1,061 safety population experienced 134 adverse events, of which gastrointestinal disorders were the most common. There were no serious treatment-related adverse events. Renamezin® can be used safely to attenuate renal function decline in moderately advanced CKD patients.

Risk factors for renal function decline in adults with normal kidney function: a 7-year cohort study

2015 ◽  
Vol 69 (8) ◽  
pp. 782-788 ◽  
Author(s):  
Xianhui Qin ◽  
Yuejuan Wang ◽  
Youbao Li ◽  
Di Xie ◽  
Genfu Tang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Renal Function ◽  
Cohort Study ◽  
Kidney Function ◽  
Normal Kidney ◽  
Renal Function Decline ◽  
Normal Kidney Function

scholarly journals Foot insensitivity is associated with renal function decline in patients with type 2 diabetes: a cohort study

2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Quratul A. Altaf ◽  
Hamed Sadiqi ◽  
Milan K. Piya ◽  
Abd A. Tahrani
Keyword(s):  
Type 2 Diabetes ◽  
Renal Function ◽  
Cohort Study ◽  
Renal Function Decline

scholarly journals Interrelationship among Obstructive Sleep Apnea, Renal Function and Survival: A Cohort Study

2020 ◽  
Vol 17 (14) ◽  
pp. 4922
Author(s):  
Patrizia Pochetti ◽  
Danila Azzolina ◽  
Beatrice Ragnoli ◽  
Paolo Amedeo Tillio ◽  
Vincenzo Cantaluppi ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Renal Function ◽  
Cohort Study ◽  
Sleep Apnea ◽  
University Hospital ◽  
Rank Test ◽  
P Value ◽  
Renal Function Decline ◽  
Obstructive Sleep

Previous studies showed a bidirectional relationship between renal function decline and obstructive sleep apnea (OSA) syndrome. Continuous Positive Airway Pressure (C-PAP) treatment was shown to preserve the kidney function in OSA patients. This study aims to investigate the progression of long-term renal function in OSA patients treated with different PAP strategies (patients were divided into two groups, fixed C-PAP or other PAP—automatic and bilevel pressure). Comorbidities and 10-years survival were also evaluated. We performed a retrospective, observational, single-center, cohort study, including the first 40 consecutive patients enrolled from 2009 in the Respiratory disease Unit at the Vercelli University Hospital database. The patient inclusion criteria were: age ≥ 18 years with OSA syndrome according to AASM (American Academy of Sleep Medicine) guidelines. Creatinine serum levels (mg/dL) and the estimated Glomerular Filtration Rate (eGFR, mL/min calculated by CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration equation)) were measured at 3 different time points: at baseline, 3 years and 8 years after PAP treatment. The Kaplan–Meier survival curves stratified according to PAP treatment and compliance have been reported together with log-rank test estimation. In our study, we found a significant creatinine serum level reduction after 3 years of fixed C-PAP treatment (p value = 0.006) when compared to baseline values. However, we observed that the long-term C-PAP benefit was not significant (p value = 0.060). Our data confirmed the progressive renal function decline in OSA patients, especially in those using other-PAP treatments; nevertheless, OSA treatment with a fixed C-PAP device has shown, in the short term, a significant improvement in renal function. By contrast, in our study, long-term benefits after 8 years are not been demonstrated probably because of the lack of compliance of the patients and the aging effect.

Original Article (Clinical Investigation) Enhanced Prediction of Renal Function Decline by Replacing Waist Circumference With “a Body Shape Index (Absi)” in Diagnosing Metabolic Syndrome: A Retrospective Cohort Study in Japan

2021 ◽  
Author(s):  
Daiji Nagayama ◽  
Kentaro Fujishiro ◽  
Shinichi Tsuda ◽  
Yasuhiro Watanabe ◽  
Takashi Yamaguchi ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Renal Function ◽  
Cohort Study ◽  
Waist Circumference ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Body Shape ◽  
Shape Index ◽  
Renal Function Decline ◽  
A Body Shape Index

Abstract Background: Abdominal obesity as a risk factor for diagnosing metabolic syndrome (MetS) is conventionally evaluated using waist circumference (WC), although WC does not necessarily reflect visceral adiposity. We aimed to examine whether replacing WC with “A Body Shape Index (ABSI)”, an abdominal obesity index, in MetS diagnosis is useful for predicting renal function decline (RFD). Methods: A retrospective cohort study was conducted in 5438 Japanese urban residents (median age 48 years) who participated in a public health screening program for 4 consecutive years. Systemic arterial stiffness was assessed by cardio-ankle vascular index (CAVI), and high CAVI was defined as CAVI ≥ 9.0. The predictability of the occurrence of RFD (eGFR < 60 mL/min/1.73m 2 ) by replacing high WC with high ABSI (ABSI ≥ 0.080) was examined using three sets of MetS diagnostic criteria: Japanese, International Diabetes Federation (IDF) and National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATPIII). Results: In Japanese and NCEP-ATPIII criteria, MetS diagnosed using ABSI (ABSI-MetS) was associated with significantly higher age-adjusted CAVI compared to non-MetS, whereas MetS diagnosed using WC (WC-MetS) showed no association. Kaplan-Meier analysis of the rate of new-onset RFD over 4 years (total 8.7%) showed remarkable higher rate in subjects with ABSIMetS than in those without (log-rank test p <0.001), but almost no difference between subjects with and without WC-MetS ( p = 0.014-0.617). In Cox analysis including gender, high CAVI and low-density lipoprotein‒cholesterol ≥140 mg/dL as confounders, only ABSI-MetS diagnosed by Japanese criteria contributed independently to the occurrence of RFD (HR = 1.41, p = 0.011). High CAVI was also an independent contributor to the occurrence of RFD. In a subanalysis, ABSI-MetS diagnosed by Japanese criteria contributed significantly to the occurrence of RFD regardless of age or gender, while WC-MetS by Japanese criteria contributed significantly only in older women. Conclusion: In this study, replacing WC with ABSI in MetS diagnostic criteria more efficiently predicted subjects at risk of RFD and arterial stiffening. Further studies are needed to confirm whether MetS diagnosed using ABSI also predicts CVD.

Longer time spent in bed attempting to sleep is associated with rapid renal function decline: the Dongfeng–Tongji cohort study

2018 ◽  
Vol 50 (2) ◽  
pp. 172-179 ◽  
Author(s):  
Yizhun Li ◽  
Liangle Yang ◽  
Hao Wang ◽  
Haijing Jiang ◽  
Gaokun Qiu ◽  
...  
Keyword(s):  
Renal Function ◽  
Cohort Study ◽  
Renal Function Decline

Cardiac autonomic neuropathy predicts renal function decline in patients with type 2 diabetes: a cohort study

Diabetologia ◽  
2014 ◽  
Vol 57 (6) ◽  
pp. 1249-1256 ◽  
Author(s):  
Abd A. Tahrani ◽  
Kiran Dubb ◽  
Neil T. Raymond ◽  
Safia Begum ◽  
Quratul A. Altaf ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Renal Function ◽  
Cohort Study ◽  
Autonomic Neuropathy ◽  
Cardiac Autonomic Neuropathy ◽  
Renal Function Decline

scholarly journals Ultra-Processed Food Consumption is Associated with Renal Function Decline in Older Adults: A Prospective Cohort Study

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 428
Author(s):  
Jimena Rey-García ◽  
Carolina Donat-Vargas ◽  
Helena Sandoval-Insausti ◽  
Ana Bayan-Bravo ◽  
Belén Moreno-Franco ◽  
...  
Keyword(s):  
Older Adults ◽  
Renal Function ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Community Dwelling ◽  
Processed Food ◽  
Renal Function Decline ◽  
Increased Risk

Ultra-processed food (UPF) consumption has been associated with increased risk of cardiovascular risk factors and mortality. However, little is known on the UPF effect on renal function. The aim of this study is to assess prospectively the association between consumption of UPF and renal function decline. This is a prospective cohort study of 1312 community-dwelling individuals aged 60 and older recruited during 2008–2010 and followed up to December 2015. At baseline, a validated dietary history was obtained. UPF was identified according to NOVA classification. At baseline and at follow-up, serum creatinine (SCr) and estimated glomerular filtration rate (eGFR) levels were ascertained and changes were calculated. A combined end-point of renal decline was considered: SCr increase or eGFR decreased beyond that expected for age. Logistic regression with adjustment for potential confounders was performed. During follow-up, 183 cases of renal function decline occurred. The fully adjusted odds ratios (95% CI) of renal function decline across terciles of percentage of total energy intake from UPF were 1.56 (1.02–2.38) for the second tercile, and 1.74 (1.14–2.66) for the highest tercile; p-trend was 0.026. High UPF consumption is independently associated with an increase higher than 50% in the risk of renal function decline in Spanish older adults.

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