scholarly journals Physical activity and its association with white matter integrity and cognitive efficiency in pediatric-onset multiple sclerosis

2017 ◽  
Author(s):  
Elisea De Somma
Keyword(s):  
Physical Activity ◽  
Multiple Sclerosis ◽  
White Matter ◽  
White Matter Integrity ◽  
Cognitive Efficiency ◽  
Pediatric Onset

scholarly journals Brief Computer-Based Information Processing Measures are Linked to White Matter Integrity in Pediatric-Onset Multiple Sclerosis

2018 ◽  
Vol 29 (1) ◽  
pp. 140-150 ◽  
Author(s):  
Elizabeth Bartlett ◽  
Michael Shaw ◽  
Colleen Schwarz ◽  
Charles Feinberg ◽  
Christine DeLorenzo ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Information Processing ◽  
White Matter ◽  
White Matter Integrity ◽  
Computer Based ◽  
Pediatric Onset

scholarly journals A Scoping Review of Modifiable Risk Factors in Pediatric Onset Multiple Sclerosis: Building for the Future

Children ◽  
2018 ◽  
Vol 5 (11) ◽  
pp. 146 ◽  
Author(s):  
Julie Pétrin ◽  
Max Fiander ◽  
Prenitha Doss ◽  
E. Yeh
Keyword(s):  
Physical Activity ◽  
Multiple Sclerosis ◽  
Vitamin D ◽  
Relapse Rate ◽  
Scoping Review ◽  
Full Text ◽  
Lifestyle Factors ◽  
Increased Risk ◽  
Modifiable Lifestyle Factors ◽  
Pediatric Onset

Knowledge of the effect of modifiable lifestyle factors in the pediatric multiple sclerosis (MS) population is limited. We therefore conducted a scoping review, following the framework provided by Arksey and O’Malley. Four databases were searched for pediatric MS and modifiable lifestyle factors using index terms and keywords, from inception to May 2018. All quantitative and qualitative primary articles were included and limited to English and full text. Of the 7202 articles identified and screened, 25 full-text articles were relevant to our objective and were included. These articles focused on diet obesity, physical activity, and sleep. In cross-sectional analyses, these lifestyle factors were associated with increased risk of pediatric onset MS (POMS), and increased disease activity. Diet, particularly vitamin D and vegetable intake, was associated with reduced relapse rate. Obesity was linked to increased risk of POMS, and physical activity was associated with reduced relapse rate and sleep/rest fatigue. Thus, available studies of lifestyle related outcomes in pediatric MS suggest specific lifestyle related factors, including obesity, higher vitamin D levels, and higher physical activity may associate with lower disease burden in POMS. Studies reviewed are limited by their observational designs. Future studies with longitudinal and experimental designs may further clarify the role of modifiable lifestyle factors in this population.

Prospective associations between physical activity levels and white matter integrity in older adults: results from the MAPT study

Maturitas ◽  
2020 ◽  
Vol 137 ◽  
pp. 24-29
Author(s):  
Mathieu Maltais ◽  
Yves Rolland ◽  
Katherine Boisvert-Vigneault ◽  
Lisa Perus ◽  
Jean-François Mangin ◽  
...  
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
White Matter ◽  
White Matter Integrity ◽  
Activity Levels ◽  
Physical Activity Levels

Machine learning to investigate superficial white matter integrity in early multiple sclerosis

2021 ◽  
Author(s):  
Korhan Buyukturkoglu ◽  
Christopher Vergara ◽  
Valentina Fuentealba ◽  
Ceren Tozlu ◽  
Jacob B. Dahan ◽  
...  
Keyword(s):  
Machine Learning ◽  
Multiple Sclerosis ◽  
White Matter ◽  
White Matter Integrity

Altered basal ganglia functional connectivity in multiple sclerosis patients with fatigue

2014 ◽  
Vol 21 (7) ◽  
pp. 925-934 ◽  
Author(s):  
C Finke ◽  
J Schlichting ◽  
S Papazoglou ◽  
M Scheel ◽  
A Freing ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Basal Ganglia ◽  
Functional Connectivity ◽  
Grey Matter ◽  
Matter Density ◽  
White Matter Integrity ◽  
Healthy Controls ◽  
Grey Matter Density ◽  
Fatigue Severity

Background: Fatigue is one of the most frequent and disabling symptoms in multiple sclerosis, but its pathophysiological mechanisms are poorly understood. It is in particular unclear whether and how fatigue relates to structural and functional brain changes. Objective: We aimed to analyse the association of fatigue severity with basal ganglia functional connectivity, basal ganglia volumes, white matter integrity and grey matter density. Methods: In 44 patients with relapsing–remitting multiple sclerosis and 20 age- and gender-matched healthy controls, resting-state fMRI, diffusion tensor imaging and voxel-based morphometry was performed. Results: In comparison with healthy controls, patients showed alteration of grey matter density, white matter integrity, basal ganglia volumes and basal ganglia functional connectivity. No association of fatigue severity with grey matter density, white matter integrity and basal ganglia volumes was observed within patients. In contrast, fatigue severity was negatively correlated with functional connectivity of basal ganglia nuclei with medial prefrontal cortex, precuneus and posterior cingulate cortex in patients. Furthermore, fatigue severity was positively correlated with functional connectivity between caudate nucleus and motor cortex. Conclusion: Fatigue is associated with distinct alterations of basal ganglia functional connectivity independent of overall disability. The pattern of connectivity changes suggests that disruption of motor and non-motor basal ganglia functions, including motivation and reward processing, contributes to fatigue pathophysiology in multiple sclerosis.

scholarly journals A pilot study of the impact of an exercise intervention on brain structure, cognition, and psychosocial symptoms in individuals with relapsing-remitting multiple sclerosis

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Chantel D. Mayo ◽  
Laureen Harrison ◽  
Kristen Attwell-Pope ◽  
Lynneth Stuart-Hill ◽  
Jodie R. Gawryluk
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Pilot Study ◽  
Brain Structure ◽  
Exercise Intervention ◽  
White Matter Integrity ◽  
Post Intervention ◽  
Relapsing Remitting ◽  
The Impact ◽  
The Brain

Abstract Background Despite pharmacological treatment, many individuals with multiple sclerosis (MS) continue to experience symptoms and medication side effects. Exercise holds promise for MS, but changes in brain structure following exercise have not been thoroughly investigated, and important cognitive and psychosocial variables are rarely primary outcomes. The aim of this pilot study was to investigate whether a 12-week exercise intervention would improve white matter integrity in the brain, or cognition, symptoms of fatigue, and depressed mood for individuals with relapsing-remitting MS (RRMS). Method Thirteen participants completed 12 weeks of speeded walking. Baseline and post-intervention testing included 3T diffusion tensor imaging (DTI) to assess white matter and neuropsychological testing to assess cognition, fatigue, and mood. Image pre-processing and analyses were performed in functional magnetic resonance imaging of the Brain Software Library. Results Post-intervention, there were no significant changes in white matter compared to baseline. Post-intervention, individuals with RRMS performed significantly better on the Symbol Digit Modalities Test (SDMT), reported fewer perceived memory problems, and endorsed less fatigue. Performance was not significantly different on Trails or Digit Span, and there were no significant changes in reports of mood. Conclusion Although 12 weeks of speeded walking did not improve white matter integrity, exercise may hold promise for managing some symptoms of RRMS in the context of this study population.

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