Hepatokine, Angiopoietin-like proteins 8 (ANGPTL8) in omental adipose tissue is positively associated with BMI

To examine the effect of high dose vitamin D3 treatment on visceral adipose tissue, we used vitamin D deficient male Wistar rats (18 months old) as a model of sarcopenia. The aging process is not only responsive for the losing muscle mass but also for redistribution of lipid resulting in altered fatty acid storage and dysdifferentiation of mesenchymal precursors. The effect of aging and vitamin D treatment (weekly oral gavage with 0.125 mg vitamin D3 (5000 IU)/100g body weight) on the omental adipose tissue were histological examinated. At the end of the experiment (9 monhs), adaptive changes to the reduction of adipogenesis and increased apoptosis in response to long-term treatment with vitamin D consisted of smaller size of adipocyte and moderate macrophage infiltrate.

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Expression of genes related to glucocorticoid action in human subcutaneous and omental adipose tissue

The Journal of Steroid Biochemistry and Molecular Biology ◽

10.1016/j.jsbmb.2010.02.024 ◽

2010 ◽

Vol 122 (1-3) ◽

pp. 28-34 ◽

Cited By ~ 37

Author(s):

Alain Veilleux ◽

Philippe Y. Laberge ◽

Jacques Morency ◽

Suzanne Noël ◽

Van Luu-The ◽

...

Keyword(s):

Adipose Tissue ◽

Omental Adipose Tissue ◽

Expression Of Genes ◽

Glucocorticoid Action

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Increased regulated on activation, normal T-cell expressed and secreted levels and cysteine–cysteine chemokine receptor 5 upregulation in omental adipose tissue and peripheral blood mononuclear cells are associated with testosterone level and insulin resistance in polycystic ovary syndrome

Fertility and Sterility ◽

10.1016/j.fertnstert.2021.05.093 ◽

2021 ◽

Author(s):

Chi-Chang Juan ◽

Kuo-Hu Chen ◽

Chien-Wei Chen ◽

Chi-Hong Ho ◽

Peng-Hui Wang ◽

...

Keyword(s):

Insulin Resistance ◽

Adipose Tissue ◽

Polycystic Ovary Syndrome ◽

Testosterone Level ◽

Mononuclear Cells ◽

Polycystic Ovary ◽

Ovary Syndrome ◽

Peripheral Blood Mononuclear ◽

Omental Adipose Tissue ◽

Blood Mononuclear Cells

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Vitamin D reduces LPS-induced cytokine release in omental adipose tissue of women but not men

Steroids ◽

10.1016/j.steroids.2015.08.014 ◽

2015 ◽

Vol 104 ◽

pp. 65-71 ◽

Cited By ~ 7

Author(s):

Pascalin Roy ◽

Mélanie Nadeau ◽

Marion Valle ◽

Kerstin Bellmann ◽

André Marette ◽

...

Keyword(s):

Vitamin D ◽

Adipose Tissue ◽

Cytokine Release ◽

Omental Adipose Tissue

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Chronic binge alcohol and ovariectomy dysregulate omental adipose tissue metaboproteome in simian immunodeficiency virus-infected female macaques

Physiological Genomics ◽

10.1152/physiolgenomics.00001.2021 ◽

2021 ◽

Author(s):

Jonquil Marie Poret ◽

Jessie J Guidry ◽

Liz Simon ◽

Patricia E. Molina

Keyword(s):

Metabolic Disease ◽

Adipose Tissue ◽

Simian Immunodeficiency Virus ◽

People Living With Hiv ◽

Infected Female ◽

Omental Adipose Tissue ◽

Immunodeficiency Virus ◽

Z Scores ◽

Functional Pathways

Effective antiretroviral therapy (ART) has significantly reduced mortality of people living with HIV (PLWH), and the prevalence of at-risk alcohol use is higher among PLWH. Increased survival and aging of PLWH is associated with increased prevalence of metabolic comorbidities especially among menopausal women, and adipose tissue metabolic dysregulation may be a significant contributing factor. We examined the differential effects of chronic binge alcohol (CBA) administration and ovariectomy (OVX) on the omental adipose tissue (OmAT) proteome in a subset of simian immunodeficiency virus (SIV)-infected macaques of a longitudinal parent study. Quantitative discovery-based proteomics identified 1429 differentially expressed proteins. Ingenuity Pathway Analysis (IPA) was used to calculate z-scores, or activation predictions, for functional pathways and diseases. Results revealed protein changes associated with functional pathways centered around the "OmAT metaboproteome profile". Based on z-scores, CBA did not affect functional pathways of metabolic disease but dysregulated proteins involved in AMPK signaling and lipid metabolism. OVX-mediated proteome changes were predicted to promote pathways involved in glucose- and lipid-associated metabolic disease. Proteins involved in apoptosis, necrosis, and reactive oxygen species (ROS) pathways were also predicted to be activated by OVX, and these were predicted to be inhibited by CBA. These results provide evidence for the role of ovarian hormone loss in mediating OmAT metaboproteome dysregulation in SIV and suggest that CBA modifies OVX-associated changes. In the context of OVX, CBA administration produced larger metabolic and cellular effects, which we speculate may reflect a protective role of estrogen against CBA-mediated adipose tissue injury in female SIV-infected macaques.

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Release of Inflammatory Mediators by Human Adipose Tissue Is Enhanced in Obesity and Primarily by the Nonfat Cells: A Review

Mediators of Inflammation ◽

10.1155/2010/513948 ◽

2010 ◽

Vol 2010 ◽

pp. 1-20 ◽

Cited By ~ 120

Author(s):

John N. Fain

Keyword(s):

Adipose Tissue ◽

In Vitro Release ◽

Human Adipose Tissue ◽

Fat Cells ◽

Omental Adipose Tissue ◽

Subcutaneous Adipose ◽

Circulating Levels ◽

Pai 1

This paper considers the role of putative adipokines that might be involved in the enhanced inflammatory response of human adipose tissue seen in obesity. Inflammatory adipokines [IL-6, IL-10, ACE, TGFβ1, TNFα, IL-1β, PAI-1, and IL-8] plus one anti-inflammatory [IL-10] adipokine were identified whose circulating levels as well as in vitro release by fat are enhanced in obesity and are primarily released by the nonfat cells of human adipose tissue. In contrast, the circulating levels of leptin and FABP-4 are also enhanced in obesity and they are primarily released by fat cells of human adipose tissue. The relative expression of adipokines and other proteins in human omental as compared to subcutaneous adipose tissue as well as their expression in the nonfat as compared to the fat cells of human omental adipose tissue is also reviewed. The conclusion is that the release of many inflammatory adipokines by adipose tissue is enhanced in obese humans.

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Dexamethasone and the inflammatory response in explants of human omental adipose tissue

Molecular and Cellular Endocrinology ◽

10.1016/j.mce.2009.10.004 ◽

2010 ◽

Vol 315 (1-2) ◽

pp. 292-298 ◽

Cited By ~ 6

Author(s):

John N. Fain ◽

Paramjeet Cheema ◽

Atul K. Madan ◽

David S. Tichansky

Keyword(s):

Adipose Tissue ◽

Inflammatory Response ◽

Omental Adipose Tissue ◽

Human Omental Adipose Tissue

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The in vitro secretion of human leptin is gender-dependent but independent of the body mass index of the donors

Acta Endocrinologica ◽

10.1530/eje.0.1430711 ◽

2000 ◽

pp. 711-714 ◽

Cited By ~ 14

Author(s):

C Menendez ◽

R Baldelli ◽

M Lage ◽

X Casabiell ◽

V Pinero ◽

...

Keyword(s):

Body Mass Index ◽

Adipose Tissue ◽

Body Mass ◽

Tissue Sample ◽

Secretory Activity ◽

The Body ◽

Secretory Rate ◽

Omental Adipose Tissue

OBJECTIVE: Leptin is an adipocyte-secreted hormone acting as a signal to the central nervous system, where it regulates energy homeostasis and neuroendocrine processes. Leptin plasma levels are mainly regulated by the percentage of body fat, but are also controlled by several metabolic and nutritional variables. Data regarding leptin secretion suggest that it is gender regulated, and higher levels are present in women than men; however, the biological basis for this sex-related difference is unknown. To clarify those points, a systematic study with tissue cultures from human omental adipose tissue was performed. DESIGN AND METHODS: Surgically obtained samples from 137 patients (68 women, 69 men) were evaluated. The assay was standardized in periods of 24 h ending at 96 h. Each adipose tissue sample from a single donor was incubated in triplicate and leptin results expressed as the mean of the integrated secretion into the medium (nanograms of leptin/g tissue per time). RESULTS: Tissue adipose cultures showed a steady leptin secretion throughout the 96 h studied, with the peak of secretory activity reached at 48 h; afterwards, the in vitro secretion reached a plateau state. Spontaneous leptin secretion in the 24 h and 48 h period, as well as the area under the curve analyzed in the 0-48 h period, showed a gender-based difference that was significantly (P<0. 05) higher in women than in men. When data of spontaneous leptin secretion were correlated with the body mass index (BMI) of the donors, no correlation was found. This suggests that in vivo leptin levels are dependent on the total amount of fat of the individual, but independent of the leptin secretory rate by the adipose tissue of the donor. CONCLUSIONS: Leptin secretion from omental adipose tissue in vitro is: (i) significantly higher in samples from women than in samples from men; and (ii) not correlated with the BMI, showing that in vitro leptin secretion is not related to the adiposity of the donor.

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