scholarly journals SERUM LIPID LEVELS IN PATIENTS WITH LICHEN PLANUS: مستويات شحوم الدم عند مرضى الحزاز المسطح

2021 ◽  
Vol 5 (4) ◽  
pp. 10-1
Author(s):  
Remi Sameer Alnasser, Hamid Souliman, Jamal Khaddam Remi Sameer Alnasser, Hamid Souliman, Jamal Khaddam
Keyword(s):  
Lipid Profile ◽  
Lichen Planus ◽  
Skin Diseases ◽  
Density Lipoprotein ◽  
University Hospital ◽  
Control Group ◽  
Lipid Levels ◽  
Inflammatory Skin Diseases ◽  
Dermatology Clinic ◽  
Significant Difference

Background: Lichen planus (LP) is a chronic inflammatory disease, involving the skin, mucous membranes, hair, and nails. Cardiovascular risk factors have been assessed with some chronic inflammatory skin diseases such as alopecia and psoriasis. Recently, some studies found that lichen planus (LP) was associated with dyslipidemia. So we did this study to find this association in our patients. Objective: To evaluate lipid levels in patients with L.P and compare it with controls. Materials and Methods: This case- control study included 160 participators (80 with L.P. and 80 controls) admitted to dermatology clinic at Tishreen University Hospital, Lattakia, Syria, from 2020- 2021. Results: Cholesterol, triglyceride and Low- density lipoprotein (LDL) levels in patients were significantly higher than the control group; it was only regarding high- density lipoprotein (HDL) levels that no significant difference was observed between the two groups. Triglyceride levels were significantly higher and HDL levels were lower in patients with diffused disease. There was a recognizable correlation between elevated levels of LDL and cholesterol with disease duration. Conclusion: In this study, a disrupted lipid profile was observed in LP patients, which can be associated with disease severity. This study proposes measuring lipid serum levels prior to commencing the treatment in all known cases of lichen planus, so as to preclude cardiovascular diseases if there is a problem with the lipid profile.

scholarly journals Cytomegalovirus Infection as Risk of Atherogenic Lipid Profile in Iraqi Aborted Women

2020 ◽  
Vol 31 (2) ◽  
pp. 47-51
Author(s):  
Dalya Basil Hanna ◽  
Huda Jaber Waheed ◽  
Zahraa Qasim Ali ◽  
Maysaa Ali Abdul Khaleq
Keyword(s):  
Lipid Profile ◽  
Cytomegalovirus Infection ◽  
Density Lipoprotein ◽  
Predictive Marker ◽  
Endothelial Damage ◽  
Control Group ◽  
Cmv Infection ◽  
Significant Elevation ◽  
Monocyte Chemoattractant Protein 1 ◽  
Significant Difference

Introducion: Atherosclerosis is a form of the cardiovascular diseases which may occur due to a chronic inflammatory reaction to endothelial damage caused by multiple causes which include infection by microorganisms like Cytomegalovirus (CMV). Methods: The present study aims to evaluate the effect of cytomegalovirus infection in patients and its relation to atherosclerosis and to measure the monocyte chemoattractant protein-1 (MCP-1) as a predictive marker for inflammatory process. A total of 30 women who were attending the Gynecology outpatient clinics and were suffering from abortion for first time or with recurrent abortion due to CMV infection were enrolled in the current study. For comparison, twenty blood samples were collected from healthy apparent women as a control group in this study. Serum MCP-1, IL-6 and CMV-IgM were measured by using ELISA technique. Lipid profile which includes total cholesterol, triglycerides, high density lipoprotein (HDL), and low density lipoprotein (LDL) was measured by spectrophotometer. Results: The results of this study showed a significant difference in mean of IL-6 in patients was (570.67 ± 199.27) when compared to control group (pÃ0.0001). While there is no significant difference of MCP-1 level between patients and control group (P=0.134). And the results showed a significant elevation of cholesterol (P<0.05) and a highly significant elevation of triglyceride and LDL in CMV infected patients (P<0.01), while no elevation occurred in HDL values (P=0.977). Conclusion: According to the present data there is a correlation between CMV infection and atherosclerosis. Bangladesh J Medicine July 2020; 31(2) : 47-51

scholarly journals Cannabis sativa and/or melatonin do not alter brain lipid but alter oxidative mechanisms in female rats

2021 ◽  
Vol 3 (1) ◽  
Author(s):  
Halimat Amin Abdulrahim ◽  
Isiaka Abdullateef Alagbonsi ◽  
Oluwasola Amuda ◽  
Noah Adavize Omeiza ◽  
Abdul-Rahuf Aderemi Feyitimi ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Rat Brain ◽  
Cannabis Sativa ◽  
Density Lipoprotein ◽  
Redox Status ◽  
Female Rats ◽  
Control Group ◽  
Brain Lipid ◽  
Significant Difference ◽  
The Brain

Abstract Background Lipid profile and redox status play a role in brain (dys)functions. Cannabinoid and melatonergic systems operate in the brain and contribute to brain (patho)physiology, but their roles in the modulation of brain lipid and redox status are not well-known. We studied the effect of ethanol extract of Cannabis sativa (CS) and/or melatonin (M) on the lipid profile and anti-oxidant system of the rat brain. Methods We randomly divided twenty-four (24) female Wistar rats into 4 groups (n = 6 rats each). Group 1 (control) received distilled water mixed with DMSO. Groups II–IV received CS (2 mg/kg), M (4 mg/kg), and co-administration of CS and M (CS + M) respectively via oral gavage between 8:00 am and 10:00 am once daily for 14 days. Animals underwent 12-h fasting after the last day of treatment and sacrificed under ketamine anesthesia (20 mg/kg; i.m). The brain tissues were excised and homogenized for assay of the concentrations of the total cholesterol (TC), triacylglycerol (TG), high-density lipoprotein cholesterol (HDL-C), nitric oxide (NO), malondialdehyde (MDA), and the activities of glucose-6-phosphate dehydrogenase (G6PD), glutathione reductase (GR), glutathione peroxidase (GPx), catalase (CAT), superoxide dismutase (SOD), and acetylcholinesterase (AChE). One-way analysis of variance (ANOVA) was used to compare means across groups, followed by the least significant difference (LSD) post-hoc test. Results CS and/or M did not affect the lipid profile parameters. However, CS increased the G6PD (from 15.58 ± 1.09 to 21.02 ± 1.45 U/L; p = 0.047), GPx (from 10.47 ± 0.86 to 17.71 ± 1.04 U/L; p = 0.019), and SOD (from 0.81 ± 0.02 to 0.90 ± 0.01 μM; p = 0.007), but decreased NO (from 9.40 ± 0.51 to 6.75 ± 0.21 μM; p = 0.010) and had no effect on MDA (p = 0.905), CAT (p = 0.831), GR (p = 0.639), and AChE (p = 0.571) in comparison with the control group. M augmented the increase in G6PD (from 21.02 ± 1.45 U/L to 27.18 ± 1.81 U/L; p = 0.032) and decrease in NO (from 6.75 ± 0.21 to 4.86 ± 0.13 μM; p = 0.034) but abolished the increase in GPx (from 17.71 ± 1.04 to 8.59 ± 2.06 U/L; p = 0.006) and SOD (from 0.90 ± 0.01 to 0.70 ± 0.00 μM; p = 0.000) elicited by CS in the rat brain in comparison with the CS group. Conclusions CS and M do not alter brain lipid profile. Our data support the contention that CS elicits an anti-oxidative effect on the brain tissue and that CS + M elicits a pro-oxidant effect in rat brain.

scholarly journals A Case-Control Study on Blood Lipid Profile in Patients with COVID-19

2021 ◽  
Author(s):  
Shahab Changaripour ◽  
Hosna Sarvazad ◽  
Maryam Barghi ◽  
Elham Sajadi ◽  
Mahdi Hashempour Sadeghian ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
Severe Form ◽  
Control Group ◽  
Blood Lipid Profile ◽  
Outpatient Group ◽  
Significant Difference ◽  
Patient Groups ◽  
The Mean

Abstract Background Dyslipidemia has been reported in patients with virus infections. This study was performed to evaluate the blood lipid profile in the patients with coronavirus disease 2019 (COVID-19), and exploring the underlying factors in its development and their predictive value for the severity of COVID-19.Methods In a case-control study, the lipid profile of patients with COVID-19 at the first admitted to two clinical centers in the west of Iran (July 2020 to Dec. 2020) and age- and gender-matched healthy people were explored. Three groups of controls, patients with the severe form of Covid-19 (admitted to the intensive care unit (ICU)), patients with Covid-19 with less intensity (outpatient admission), were defined for the subjects included in the study. The predictive values of different variables obtained from medical records for COVID-19 severity were analyzed.Results Generally, 48 outpatients and 49 ICU patients, including 70 men and 23 women with a mean age of 62.4±13.5 years, were included in the study. The control group consisted of 32 people, match sex and age with the patient groups. The mean triglyceride (TG) in the Covid-19 groups was higher than the control group, but there was no significant difference between them. The mean cholesterol in the patient groups was lower than the control group (p=0.001). The mean of low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) was significantly different in the patient groups; HDL-C in the ICU group was more than outpatient, and LDL-C in the outpatient group was more than ICU (P<0.05). LDL-C and HDL-C in the ICU group were less than the control group, but there was no statistically significant difference between the two mentioned groups. The frequency of diabetes and hypertension was higher in the ICU group than in the outpatient group (P<0.001). Furthermore, LDL-C level was associated with disease severity (odds ratio (OR): 0.966, 95% confidence interval (CI): 0.944-0.989, P= 0.004).Conclusion Lipid profiles in Covid-19 patients have different faces from healthy individuals. In the severe form, the lipid status has a different profile from the less severe form of Covid-19 disease. LDL-C level can be used as an indicator to determine the severity of Covid-19 disease.

scholarly journals Evaluation of Serum Leptin Level in Males with Elevated Blood Pressure

2021 ◽  
pp. 87-90
Author(s):  
Maryam Hani Abduljalal ◽  
Nuha Abdulkadir Shareef ◽  
Sarmad Osama Alfeel
Keyword(s):  
Blood Pressure ◽  
Lipid Profile ◽  
Density Lipoprotein ◽  
Elevated Blood Pressure ◽  
Total Serum ◽  
Control Group ◽  
Healthy Controls ◽  
Elevated Blood ◽  
Serum Leptin ◽  
Significant Difference

Leptin is a hormone secreted from adipose tissue, proved to be related to inflammatory, hemostatic, and metabolic factors, and thought to be involved in the development of hypertension. We aim to evaluate serum leptin levels and lipid profile in males with elevated blood pressure to be compared with healthy controls males of matched body mass index (BMI) and age. The present study were included 50 subject, 24 healthy controls males whose BMI (Mean±SD 27.6±4.9) as control group and 26 hypertensive males with essential hypertension whose BMI (Mean±SD 28.3±3.4), those two groups were aged and BMI matched Fasting serum leptin level, triglyceride (TG), total serum cholesterol, high density lipoprotein(HDL) and low density lipoprotein(LDL) were measured. Leptin was found to be significantly higher in the hypertensive males (group2) when compared with the control group (group1) (21.5±2.3ng/ml against 14.3±1.4 ng/ml, respectively; p0.03), while a very high significant difference in triglyceride, systolic and diastolic blood pressure (p 0.0001) and a significant difference in cholesterol was (p 0.01), LDL was (p0.01) and HDLwas (p0.05). The present study concluded that male patients with elevated blood pressure had significantly higher serum leptin level compared with healthy subjects of a same BMI. More over patients with hypertension had an unfavorable lipid profile.

scholarly journals Effects of antiepileptic drugs on serum lipids profile among young adult Sudanese patient with epilepsy at Aljazeera State

2021 ◽  
Vol 14 (1) ◽  
pp. 175-182
Author(s):  
Tarig Mahadi Eltom ◽  
Nasr Eldin Mohamed ◽  
Abdelmahmoud Mokhtar Bashir ◽  
Abdelgadir Elamin Eltom
Keyword(s):  
Valproic Acid ◽  
Young Adult ◽  
Lipid Profile ◽  
Antiepileptic Drugs ◽  
Density Lipoprotein ◽  
High Density Lipoproteins ◽  
Control Group ◽  
P Value ◽  
Cross Sectional ◽  
Significant Difference

consequences that lead to an increase in risk of atherosclerosis in patients with epilepsy, several studies have reported that the patients commonly used antiepileptic drugs like phenytoin, and carbamazepine increase serum total Cholesterol, High Density Lipoproteins Cholesterol (HDL-C) Low Density lipoprotein Cholesterol ( LDL-C ) levels and Triglyceride (TG) .The aim of this study to assess and compare serum lipid profile of young adult patients treated by anti-epileptic drugs (phenytoin, oxcarbazepine and valproic acid) . Materials and Methods a cross-sectional study was conducted in Aljazeera state. Epileptic patients were of recruited. and taking antiepileptic drugs for more than six months and on regular follow up; approximately 120 patients on commonly used antiepileptic drugs (40 on phenytoin, 40 on oxcarbazepine, 40 on valproic Acid). Age and sex matching 40 controls were taken. our results show significant difference in the of mean TC, TG, HDL, and LDL-C levels in the group receiving phenytoin for more than six months when compared with control group P value (0.00) for all lipid profile. Also significant difference between the mean of TC, TG, HDL-C and LDL-C levels in the group receiving oxcarbazepine for more than six months when compared with control P value (0.00 ) for all lipid profile. From the present study we concluded that CYP enzyme inducer anti-epileptic medicines like phenytoin and oxcarbazepine is strongly associated with increased levels of TC, LDL-C, HDL-C and TG, where asvalproate showed no significant change. Therefore, the serum cholesterol level should be regularly monitored in patients undergoing. Therapy with inducer anti-epileptic medicines.

scholarly journals THE EFFECTS OF THE INTENSITY OF CIGARETTE USE AND ANTIRETROVIRAL THERAPY ON THE BLOOD LIPID PROFILE OF AN IRISH HIV PERSON

2017 ◽  
Vol 6 (1) ◽  
pp. 119-125
Author(s):  
Charlie Slowey
Keyword(s):  
Antiretroviral Therapy ◽  
Lipid Profile ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
University Hospital ◽  
Low Density ◽  
Cigarette Use ◽  
Blood Lipid Profile ◽  
Significant Difference

Abstract Context: There are numerous studies on the effects of smoking and antiretroviral use separately on a HIV patient’s blood lipid profile, however there has never been a study conducted that measures the intensity of cigarette use combined with antiretroviral therapy on a patient’s blood lipid profile. Aims: To assess the effects of the intensity of cigarette usage and antiretroviral therapy on a patient’s blood lipid profile. Setting and Design: This cross-sectional study was carried out in a regional HIV clinic in Cork University Hospital between June 2016 and August 2016. Methods: 40 patients were interviewed in order to gather cigarette usage data and patient files were reviewed in order to gather blood lipid profile results and antiretroviral therapy data. Results: There was no statistically significant difference (P>0.05) in the means of cholesterol (4.99 vs 5.47), high-density lipoprotein (1.22 vs 1.07), low-density lipoprotein (3.13 vs 3.03), nor triglycerides (1.54 vs 2.45) in smokers versus non-smokers. Low-density lipoprotein in mild and moderate smokers was increased compared to non-smokers. Conclusions: These results show that smoking combined with nucleoside reverse transcriptase inhibitor use has no significant change in blood lipid measurements when compared to controls.

scholarly journals The effect of artichoke leaf extract supplementation on lipid profile of chronic kidney disease patients; a double-blind, randomized clinical trial

2019 ◽  
Vol 8 (3) ◽  
pp. 225-229 ◽  
Author(s):  
Seyed Mansour Gatmiri ◽  
Ebrahim Khadem ◽  
Toktam Fakhrian ◽  
Mohammad Kamalinejad ◽  
Hamed Hosseini ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Chronic Kidney Disease ◽  
Coronary Heart Disease ◽  
Lipid Profile ◽  
Leaf Extract ◽  
Density Lipoprotein ◽  
Control Group ◽  
Double Blind ◽  
Significant Difference ◽  
Artichoke Leaf Extract

Introduction: Hyperlipidemia is considered a prominent risk factor for coronary heart disease. Coronary heart disease is the most common cause of mortality and morbidity in chronic kidney disease (CKD) patients. Objectives: The aim of this study was to evaluate the effects of artichoke leaf extract (ALE) supplementation on the lipid profile of CKD patients. Patients and Methods: A randomized, double-blind, placebo-controlled clinical trial was conducted in 38 CKD subjects (GFR<60 and >15 mL/min/1.73 m2 ) with hypercholesterolemia (total cholesterol ≥ 200 mg/dL or low-density lipoprotein cholesterol [LDL-C] ≥ 110 mg/dL). The intervention group received an artichoke capsule (320 mg) and an indistinguishable placebo was given to the control group twice daily for 6 weeks. Lipid profile and appetite were assessed at week 8 and the results were compared with the baseline data. Results: ALE supplementation was correlated with a statistically significant decrease in mean total cholesterol (P=0.028) and LDL-C (P=0.005) compared to the control group. The two groups did not show a significant difference in high-density lipoprotein-cholesterol (P=0.071) and triglyceride levels (P=0.22). There was a statistically significant difference in appetite between the two groups (P=0.016). Conclusion: This randomized controlled trial demonstrated that consumption of ALE supplement may improve appetite and lipid profile in CKD patients.

scholarly journals A case-control Study on Blood Lipid Profile in Patients with COVID-19

2021 ◽  
Author(s):  
Shahab Changaripour ◽  
Hosna Sarvazad ◽  
Maryam Barghi ◽  
Elham Sajadi ◽  
Mahdi Hashempour Sadeghian ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
Severe Form ◽  
Control Group ◽  
Blood Lipid Profile ◽  
Outpatient Group ◽  
Significant Difference ◽  
Patient Groups ◽  
The Mean

Abstract Background Dyslipidemia has been reported in patients with virus infections. This study was performed to evaluate the blood lipid profile in the patients with coronavirus disease 2019 (COVID-19), and exploring the underlying factors in its development and their predictive value for the severity of COVID-19.Methods In a case-control study, the lipid profile of patients with COVID-19 at the first admitted to two clinical centers in the west of Iran (July 2020 to Dec. 2020) and age- and gender-matched healthy people were explored. Three groups of controls, patients with the severe form of Covid-19 (admitted to the intensive care unit (ICU)), patients with Covid-19 with less intensity (outpatient admission), were defined for the subjects included in the study. The predictive values of different variables obtained from medical records for COVID-19 severity were analyzed.Results Generally, 48 outpatients and 49 ICU patients, including 70 men and 23 women with a mean age of 62.4±13.5 years, were included in the study. The control group consisted of 32 people, match sex and age with the patient groups. The mean triglyceride (TG) in the Covid-19 groups was higher than the control group, but there was no significant difference between them. The mean cholesterol in the patient groups was lower than the control group (p=0.001). The mean of low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) was significantly different in the patient groups; HDL-C in the ICU group was more than outpatient, and LDL-C in the outpatient group was more than ICU (P<0.05). LDL-C and HDL-C in the ICU group were less than the control group, but there was no statistically significant difference between the two mentioned groups. The frequency of diabetes and hypertension was higher in the ICU group than in the outpatient group (P<0.001). Furthermore, LDL-C level was associated with disease severity (odds ratio (OR): 0.966, 95% confidence interval (CI): 0.944-0.989, P= 0.004).Conclusion Lipid profiles in Covid-19 patients have different faces from healthy individuals. In the severe form, the lipid status has a different profile from the less severe form of Covid-19 disease. LDL-C level can be used as an indicator to determine the severity of Covid-19 disease.

scholarly journals The Correlation of Use of Depo Medroxy Progesterone Acetate (DMPA) In-jections with Lipid Profile Levels in Rats

2021 ◽  
Vol 4 (1) ◽  
pp. 27-31
Author(s):  
Suratiah Suratiah ◽  
Dewa Ayu Surinati ◽  
I Dewa Gede Putu Putra Yasa
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Control Group ◽  
Control Group Design ◽  
Cholesterol Levels ◽  
Significant Difference ◽  
Before And After ◽  
Long Time

Introduction: Family Planning is a national strategy of Indonesia government to manage the population growth. Depo Medroxyprogesterone Acetate (DMPA) is one of injectable contraceptives most widely used because it is simple and easy to obtain. However, it has various side effects causing imbalance of hormone estrogen, in turns to result in a decrease in HDL (High Density Lipoprotein) and an increase in LDL (Low Density Lipoprotein) which will result in an increase in total cholesterol. It will also affect changes in fat metabolism in human body due to hormonal influences. This results in dyslipidemia and atherosclerosis. Method: The method in this study is an experimental study with a pretest-posttest control group design. Results: The purpose of this study was to determine the relationship between duration of use of DMPA injections with lipid profile levels in mice. The data were analyzed by using the Paired t-test parametric test to compare between treatment groups. This study found that there were significant differences in HDL levels and total cholesterol levels between before and after administration of DMPA injections on the 14th and 35th days. There is a significant relationship between the duration of administration of DMPA injections with HDL levels and total cholesterol levels in mice. However, there was no difference in LDL levels and triglyceride levels between before and after administration of DMPA injection on day of 14 and day of 35, while, there was a significant difference between before and after the 35th day. There is no relationship between duration of administration of DMPA injections with LDL levels, while there is a relationship among mice triglycerides. Conclusions: Administration of DMPA injections for a long time lowers HDL.

scholarly journals Effect Of Vêo® Premium and Vitamin C Supplementation on Lipid Profile Before and During Pregnancy in Some Local Iraqi Ewes During Heat Stress

2021 ◽  
pp. 2122-2130
Author(s):  
Othman Ghazi Najeeb Alani ◽  
Yassen Taha Abdul-Rahaman ◽  
Thafer Thabit Mohammed
Keyword(s):  
Heat Stress ◽  
Vitamin C ◽  
Lipid Profile ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Control Group ◽  
Low Density ◽  
Significant Difference ◽  
Vitamin C Supplementation ◽  
Vit C

The present study was designed to investigate the effects of VêO® premium and vitamin C (Vit. C) supplementation on lipid profile before and during pregnancy in local Iraqi ewes during heat stress. The study was conducted in a private field in Fallujah city, west Iraq, during the period from 6/8/2019 to 8/2/2020. Twenty local Iraqi ewes were divided randomly into four equal groups (5 for each group) The first group (T1) was given VêO® premium (4 g/ ewe/ day), the second group (T2) was given VêO® premium (2 g/ ewe/ day), and the third group (T3) was given Vit. C (40 mg/ ewe/ day), and the fourth group (T4) was left without treatment, as a control group. After 14 days of treatment, vaginal sponges were inserted for 14 days and, after their withdrawal, the rams were introduced for 6 days. Blood samples were collected from the jugular vein into vacutainer tubes (10 ml) at 4 periods (periods 1 and 2 before pregnancy; periods 3 and 4 during pregnancy). Lipid profile parameters were also estimated, which includes cholesterol, triglyceride, high density lipoprotein (HDL), low density lipoprotein (LDL), very low density lipoprotein (VLDL), and malondialdehyde (MDA). There were no significant difference in the serum levels of cholesterol, triglyceride, HDL, and LDL among the various treatments before and during pregnancy. The level of VLDL was significantly higher in T2 group as compared to the other treatments (P≤0.05) at the fourth periods. There was a significant difference in the level of MDA (P≤0.05) in treatment T3 in the first period compared with the treatments T1, T2, and T4, whereas treatment T4 showed significantly higher level (P≤0.05) in the second, third, and fourth periods as compared to treatments T1, T2, and T3. In conclusion, different effects of VêO® premium and Vitamin C supplementation were noticed on the lipid profile before and during pregnancy in local Iraqi ewes during heat stress.

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