scholarly journals Assessment of individual risk of food interactions while taking warfarin

2021 ◽  
Vol 93 (2) ◽  
pp. 187-192
Author(s):  
Yu. P. Skirdenko ◽  
N. A. Nikolaev
Keyword(s):  
Warfarin Therapy ◽  
Lifestyle Modification ◽  
Food Preferences ◽  
Initial Assessment ◽  
Individual Risk ◽  
Factors Influencing ◽  
Frequency Of Use ◽  
Test Version ◽  
Simple Product ◽  
The Individual

Aim. To develop a questionnaire to assess the individual risk of food interactions in a patient taking warfarin. Materials and methods. Based on the review of 159 literature sources, a test version of the questionnaire was formed. 196 respondents took part in the pilot part of the study to assess the multiplicity and volume of food consumption. For the initial assessment of the risk limit of the diet, complications of warfarin therapy were registered no earlier than 24 weeks later. Results. The final version of the questionnaire included 25 products that are most frequently consumed and significant in relation to the risk of alimentary interactions. The questionnaire contains 2 groups of products: increasing and decreasing the activity of warfarin. The volume and frequency of use of each product is evaluated in points that are calculated as the simple product of weights of frequency and volume, with a minimum value of 0 and maximum of 12. The number of points for each product is calculated separately. The points obtained are summed for a group of products that increase the activity of warfarin, and for a group of products that reduce it, and the overall risk score is calculated. The average number of points for the use of products that affect the activity of warfarin in patients with AF with complications of therapy was 75.7831.97 b. The calculation of the design validity of the questionnaire (Cronbachs a=0.864) showed a good level for confirmation purposes. Conclusion. A specialized questionnaire was developed, implemented as a computer program, to assess the significance of food preferences in ensuring the safety and effectiveness of warfarin therapy. Further research is required to determine the risk limit of alimentary interactions of warfarin, but now this questionnaire can be used to monitor the uniformity of consumption of products that affect its activity. The authors suggested using a questionnaire for assessing the risk of food interactions as one of the factors influencing the decision to prescribe warfarin to patients with insufficient adherence to lifestyle modification.

scholarly journals The contradiction between traditionalism and reformism in the context of the formation of religious identity

2013 ◽  
pp. 381-389
Author(s):  
Iryna Klimuk
Keyword(s):  
Religious Identity ◽  
Interdisciplinary Approach ◽  
Modern Society ◽  
Religious Studies ◽  
The State ◽  
Religion And Theology ◽  
Factors Influencing ◽  
Scientific Disciplines ◽  
Frequency Of Use ◽  
The Individual

The concept of "religious identity" is now the most popular term in terms of frequency of use. Actualization of religious identity as a problem is considered in science, politics, journalism, literature and other spheres of life. The complexity and at the same time the importance of the problem under study requires an interdisciplinary approach to the study of religious identity. The development of the concept of religious identity is associated with scientific disciplines (religious studies, sociology, philosophy, anthropology). But one can not imagine the consideration of this phenomenon without taking into account the theological approach, without which the study of religious identity would be one-sided. One of the most important aspects of religion and theology, which determines the state of religiosity in modern society, is the contradiction between traditionalists and reformers. In our time, they are considered as important factors influencing the formation of the religious identity of the individual.

scholarly journals Clinically significant food preferences of patients with atrial fibrillation: a nosological and regional peculiarities

2019 ◽  
Vol 91 (1) ◽  
pp. 38-42
Author(s):  
Ju P Skirdenko ◽  
N A Nikolaev
Keyword(s):  
Atrial Fibrillation ◽  
Warfarin Therapy ◽  
Lifestyle Modification ◽  
Food Preferences ◽  
Underlying Disease ◽  
Kolmogorov Smirnov ◽  
Clinically Significant ◽  
Student’S T ◽  
Medical Recommendations ◽  
Student’S T Test

The aim of the investigation was to study the peculiarities of food consumption in patients with atrial fibrillation, capable of influencing the anticoagulant therapy with warfarin, in comparison with healthy volunteers and taking into account geographical specifics. Materials and methods. In an open cohort study, 196 respondents (88 men, 108 women) evaluated food preferences using a questionnaire survey. The quantitative evaluation of adherence to lifestyle modification was studied by QAA-25. Statistical data processing was performed by parametric (Student's t-test) and nonparametric (Wald-Wolfowitz, Kolmogorov-Smirnov, Pearson) analysis methods. Results. There were no statistically significant differences in food rations between the studied categories of respondents, both increasing [37.0±19.5 points versus 37.3±17.98 points; Wald-Wolfowitz (Z), p=0.16] and reducing the activity of warfarin [62.2±26.3 points versus 63.4±23.8 points; Wald-Wolfowitz (Z), p=0.95]. The absence of differences remained in the evaluation, taking into account regional characteristics of nutrition. The respondents were taking warfarin, there is no relationship between the level of commitment to the modification of lifestyle and diet modification. Conclusion: it is shown that medical recommendations aimed at correcting the eating behavior of respondents taking warfarin are not effective, which can be an independent risk factor for complications of both warfarin therapy and the underlying disease.

The importance and significance of gene polymorphisms in preeclampsia

2016 ◽  
pp. 45-49
Author(s):  
P.N. Veropotvelyan ◽  
◽  
I.S. Tsehmistrenko ◽  
N.P. Veropotvelyan ◽  
N.S. Rusak ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Systematic Review ◽  
Early Diagnosis ◽  
Gene Polymorphisms ◽  
Individual Risk ◽  
Extended Study ◽  
Stress Genes ◽  
Detoxification System ◽  
The Individual ◽  
The Relationship

Was to conduct a systematic review of data on the relationship between polymorphisms genes of detoxification system and development of preeclampsia (РЕ). Рresents the main genes of detoxification system (GSTPI, GSTМI, GSTТI, GРХI, ЕРНХI, SOD-2, SOD-3, CYPIAL, MTHЕR, MTR) and their functions. Of interest is the possibility of calculating the individual risk of PE based on the results about the presence of a combination of different polymorphisms in the genotype of the female. Question about early diagnosis of РЕ remains controversial and not fully understood. It is necessary to conduct further in-depth, extended study of this problem. Key words: preeclampsia, oxidative stress, genes of the detoxification system.

Factors that Influence the Durability of Transplanted Kidneys in South Africa

2019 ◽  
Vol 21 (2) ◽  
Author(s):  
Hillary Ndemera ◽  
Busisiwe R. Bhengu
Keyword(s):  
South Africa ◽  
Kidney Transplant ◽  
Lifestyle Modification ◽  
P Value ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Kidney Allograft ◽  
Factors Influencing ◽  
Allograft Loss ◽  
Transplanted Kidneys

Kidney transplantation is the cornerstone for renal treatment in patients with end-stage renal failure. Despite improvements in short-term outcomes of renal transplantation, kidney allograft loss remains a huge challenge. The aim of the study was to assess factors influencing the durability of transplanted kidneys among transplant recipients in South Africa. A descriptive cross-sectional study design was used. A random sampling was used to select 171 participants. Data were collected through structured face-to-face interviews developed from in-depth consideration of relevant literature. Data were coded and entered into the SPSS software, version 24. The entered data were analysed using descriptive and inferential statistics. The results revealed that the average durability of transplanted kidneys was 9.07 years among selected kidney transplant recipients in South Africa. Factors associated with the durability of transplanted kidneys included age, the sewerage system and strict immunosuppressive adherence, all with a P-value = .000, followed by the mode of transport (P-value = .001) and support system (P-value = .004). Other variables including demographics, the healthcare system, medication and lifestyle modification engagement were not associated with the durability of transplanted kidneys. Understanding the factors influencing the durability of transplanted kidneys among kidney transplant recipients in South Africa is crucial. The study revealed associated factors and gaps which may be contributory factors to kidney allograft loss. This study provides an opportunity to introduce specific interventions to nephrology professionals to promote prolonged graft durability. It is recommended that a specific intervention model be developed, which targets South African kidney recipients taking into account the significant variables in this study and the socio-economic status of the country.

Differentiation of endemic areas by incidence rates of tick-borne infectious diseases as the basis for choosing prevention strategy and tactics

2019 ◽  
pp. 56-61
Author(s):  
N.V. Rudakov ◽  
N.A. Penyevskaya ◽  
D.A. Saveliev ◽  
S.A. Rudakova ◽  
C.V. Shtrek ◽  
...  
Keyword(s):  
High Risk ◽  
Infectious Diseases ◽  
Population Based ◽  
Preventive Therapy ◽  
Incidence Rates ◽  
Prevention Strategy ◽  
Individual Risk ◽  
The Individual ◽  
Integral Assessment ◽  
Very High

Research objective. Differentiation of natural focal areas of Western Siberia by integral incidence rates of tick-borne infectious diseases for determination of the strategy and tactics of their comprehensive prevention. Materials and methods. A retrospective analysis of official statistics for the period 2002-2018 for eight sub-federal units in the context of administrative territories was carried out. The criteria of differentiation were determined by means of three evaluation scales, including long-term mean rates of tick-borne encephalitis, tick-borne borreliosis, and Siberian tick-borne typhus. As a scale gradation tool, we used the number of sample elements between the confidence boundaries of the median. The integral assessment was carried out by the sum of points corresponding to the incidence rates for each of the analyzed infections. Results. The areas of low, medium, above average, high and very high risk of tick-borne infectious diseases were determined. Recommendations on the choice of prevention strategy and tactics were given. In areas of very high and high incidence rates, a combination of population-based and individual prevention strategies is preferable while in other areas a combination of high-risk and individual strategies is recommended. Discussion. Epidemiologic zoning should be the basis of a risk-based approach to determining optimal volumes and directions of preventive measures against natural focal infections. It is necessary to improve the means and methods of determining the individual risk of getting infected and developing tick-borne infectious diseases in case of bites, in view of mixed infection of vectors, as well as methods of post-exposure disease prevention (preventive therapy).

scholarly journals A New Medical Record Proposal to the Prognostic Risk Assessment for MRONJ in Oncologic Patients: “Sapienza Head and Neck Unit” Proposal

2021 ◽  
Vol 18 (4) ◽  
pp. 1851
Author(s):  
Edoardo Brauner ◽  
Silvia Mezi ◽  
Alessandro Ciolfi ◽  
Chiara Ciolfi ◽  
Resi Pucci ◽  
...  
Keyword(s):  
Multidisciplinary Approach ◽  
Bone Cancer ◽  
Osteonecrosis Of The Jaw ◽  
Individual Risk ◽  
Medical Report ◽  
Oncologic Patients ◽  
Antiangiogenic Drugs ◽  
Dental Screening ◽  
The Individual

Medication-related osteonecrosis of the jaw (MRONJ) is an adverse event associated with antiresorptive and antiangiogenic drugs. The use of these drugs in the treatment of cancer patients with bone metastasis is necessary and standardized in the literature. A multidisciplinary approach for the patient’s management is strongly recommended. Therefore, it should be necessary to integrate the path of these subjects with a dedicated dental screening in order to first assess the individual risk of developing a MRONJ, and then to plan dental treatments and oral hygiene sessions, and finally to schedule a follow-up to intercept and treat early osteonecrosis. The aim of this manuscript is to propose a new simple medical report to evaluate patients affected by metastatic bone cancer in order to reduce the risk of developing MRONJ.

Bringing the Automation-Related Complacency Scale into the 21st Century

2020 ◽  
Vol 64 (1) ◽  
pp. 1228-1232
Keyword(s):  
Internal Consistency ◽  
21St Century ◽  
Rating Scale ◽  
System Failure ◽  
Individual Values ◽  
Cronbach's Alpha ◽  
Important Measure ◽  
Frequency Of Use ◽  
Performance Error ◽  
The Individual

Complacency potential is an important measure to avoid performance error, such as neglecting to detect a system failure. This study updates and expands upon Singh, Molloy, and Parasuraman’s 1993 Complacency-Potential Rating Scale (CPRS). We updated and expanded the CPRS questions to include technology commonly used today and how frequently the technology is used. The goal of our study was to update the scale, analyze for factor shifts and internal consistency, and to explore correlations between the individual values for each factor and the frequency of use questions. We hypothesized that the factors would not shift from the original and the revised CPRS’s four subscales. Our research found that the revised CPRS consisted of only three subscales with the following Cronbach’s Alpha values: Confidence: 0.599, Safety/Reliability: 0.534, and Trust: 0.201. Correlations between the subscales and the revised complacency-potential and the frequency of use questions are also discussed.

scholarly journals Oral Sensitivity to Flowability and Food Neophobia Drive Food Preferences and Choice

Foods ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 1024
Author(s):  
Sharon Puleo ◽  
Paolo Masi ◽  
Silvana Cavella ◽  
Rossella Di Monaco
Keyword(s):  
Food Choice ◽  
Food Preferences ◽  
Food Neophobia ◽  
Individual Level ◽  
Choice Preference ◽  
Food Liking ◽  
Texture Sensitivity ◽  
The Individual ◽  
Oral Sensitivity

The study aimed to investigate the role of sensitivity to flowability on food liking and choice, the relationship between sensitivity to flowability and food neophobia, and its role in food liking. Five chocolate creams were prepared with different levels of flowability, and rheological measurements were performed to characterise them. One hundred seventy-six subjects filled in the Food Neophobia Scale and a food choice questionnaire (FCq). The FCq was developed to evaluate preferences within a pair of food items similar in flavour but different in texture. Secondly, the subjects evaluated their liking for creams (labelled affective magnitude (LAM) scale) and the flowability intensity (generalised labelled magnitude (gLM) scale). The subjects were clustered into three groups of sensitivity and two groups of choice preference. The effect of individual flowability sensitivity on food choice was investigated. Finally, the subjects were clustered into two groups according to their food neophobia level. The sensitivity to flowability significantly affected the liking of chocolate creams and the solid food choice. The liking of chocolate creams was also affected by the individual level of neophobia (p = 0.01), which, in turn, was not correlated to flowability sensitivity. These results confirm that texture sensitivity and food neophobia affect what a person likes and drives what a person chooses to eat.

Factors influencing the individual effects of blood transfusions on oxygen delivery and oxygen consumption*

2001 ◽  
Vol 29 (Supplement) ◽  
pp. S173-S179 ◽  
Author(s):  
Mattias Casutt ◽  
Burkhardt Seifert ◽  
Thomas Pasch ◽  
Edith R. Schmid ◽  
Marko I. Turina ◽  
...  
Keyword(s):  
Oxygen Consumption ◽  
Oxygen Delivery ◽  
Blood Transfusions ◽  
Factors Influencing ◽  
Individual Effects ◽  
The Individual

Prediction of pre-eclampsia

2021 ◽  
pp. 1753495X2098401
Author(s):  
Konstantinos Giannakou
Keyword(s):  
Early Recognition ◽  
Routine Care ◽  
Current Evidence ◽  
Individual Risk ◽  
Negative Consequences ◽  
Predictive Tool ◽  
Mortality And Morbidity ◽  
Maternal Mortality And Morbidity ◽  
Conducting Research ◽  
The Individual

Pre-eclampsia is a leading cause of neonatal and maternal mortality and morbidity that complicates approximately 2–8% of all pregnancies worldwide. The precise cause of pre-eclampsia is not completely understood, with several environmental, genetic, and maternal factors involved in its pathogenesis and pathophysiology. An accurate predictor of pre-eclampsia will facilitate early recognition, close surveillance according to the individual risk and early intervention, and reduce the negative consequences of the disorder. Current evidence shows that no single test predicts pre-eclampsia with sufficient accuracy to be clinically useful. A combination of markers into multiparametric models may provide a more useful and feasible predictive tool for pre-eclampsia screening in the routine care setting than a test of either component alone. This review presents a summary of the current advances on prediction of pre-eclampsia, highlighting their performance and applicability. Key priorities when conducting research on predicting pre-eclampsia are also analyzed.

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