scholarly journals Aminodihydrophthalazinedione sodium in prevention, therapy and rehabilitation of patients with respiratory diseases

2021 ◽  
Vol 23 (3) ◽  
pp. 296-303
Author(s):  
Dmitry I. Trukhan ◽  
◽  
Natalya V. Bagisheva ◽  
Anna V. Mordyk ◽  
Ekaterina Yu. Nebesnaya ◽  
...  
Keyword(s):  
Viral Infections ◽  
Laboratory Diagnostics ◽  
The Novel ◽  
Modern Approach ◽  
Prevention Therapy ◽  
Prevention And Treatment ◽  
Respiratory Pathology ◽  
Coronavirus Infection ◽  
Respiratory Viral Infections ◽  
Novel Coronavirus

The modern approach to the prevention and treatment of acute respiratory viral infections consists in the use of drugs that increase the body’s defenses, helping to create a barrier to the penetration of the virus. Immunomodulators exhibit a nonspecific effect in acute respiratory viral infections, which makes it possible to use them against various types of respiratory viruses without accurate laboratory diagnostics and expands clinical capabilities. In the first part of the review, the features of sodium aminodihydrophthalazinedione and the experience of its use in respiratory pathology are considered. The pandemic of the novel coronavirus infection (COVID-19), spread by the novel coronavirus SARS-CoV-2, has become a challenge to health systems around the world. The second part of the review reviews the results of the first studies on the use of sodium aminodihydrophthalazinedione for the prevention and treatment of new coronavirus infection. Recently, much attention has been paid to the long-term consequences of the postponed coronavirus infection. In the final part of the review, various aspects of the “post-COVID syndrome” are discussed and the possibilities of aminodihydrophthalazinedione sodium at the stage of rehabilitation after a coronavirus infection are discussed.

scholarly journals Prevention and treatment system of novel coronavirus infection in medical and health institutions: experience in West China Hospital of Sichuan University

2020 ◽  
Vol 37 (10) ◽  
pp. 639-641
Author(s):  
Qiao Zhou ◽  
He Yu ◽  
Zong-An Liang ◽  
Rong Yao ◽  
Feng-Ming Luo ◽  
...  
Keyword(s):  
Treatment System ◽  
The Novel ◽  
West China Hospital ◽  
West China ◽  
Global Pandemic ◽  
Prevention And Treatment ◽  
Coronavirus Infection ◽  
Health Institutions ◽  
Novel Coronavirus

The novel coronavirus infection broke out in Wuhan, China, in December 2019, and progressed to a global pandemic. We describe the measures taken by West China Hospital of Sichuan University to address the diagnosis, prevention and treatment of the infection.

scholarly journals Acute respiratory infections in outpatient care in the era of the COVID-19 pandemic: the role and position of antibacterial therapy

2020 ◽  
Vol 4 (4) ◽  
pp. 214-218
Author(s):  
R.F. Khamitov ◽  
Keyword(s):  
Health Care ◽  
Outpatient Care ◽  
Viral Infections ◽  
Respiratory Infections ◽  
Respiratory Viruses ◽  
Acute Respiratory Infections ◽  
The Novel ◽  
Coronavirus Infection ◽  
Novel Coronavirus ◽  
Care Costs

Acute respiratory infections of the upper and lower respiratory tract are currently the leading cause of human morbidity, mainly due to the seasonal rise of the incidence rates of viral infections. This results in the heavy burden of annual health care costs. The COVID-19 pandemic exacerbated the problem. The associations between respiratory viruses and bacteria are not always clear thus accounting for the diversity of the risks of the complicated course and fatal outcomes of various bacterial viral coinfections. Influenza virus is associated with the high rate of bacterial complications (in particular, during seasonal peaks). Meanwhile, this is less typical of the novel coronavirus infection. In addition, several studies demonstrate the competitive edge of SARS-CoV-2 when interacting with other respiratory viruses. The specificities of viral bacterial associations greatly affect the treatment whose inadequacy (in particular, the prescription of antibiotics) is the leading cause of the increasing antimicrobial resistance of contemporary germs. The novel coronavirus infection SARS-CoV-2 is no exception in terms of inappropriate antibiotic prescribing as occurred often in the seasonal rise of acute respiratory viral infections. The understanding of this issue, the optimization of treatment strategies, and a reduction in health care costs will allow for preserving antibiotics as a class of highly effective medications. KEYWORDS: acute respiratory infections, COVID-19, bacterial coinfection, outpatient care, lung damage, antimicrobial therapy. FOR CITATION: Khamitov R.F. Acute respiratory infections in outpatient care in the era of the COVID-19 pandemic: the role and position of antibacterial therapy. Russian Medical Inquiry. 2020;4(4):214–218. DOI: 10.32364/2587-6821-2020-4-4-214-218.

scholarly journals Pathogenesis, Diagnosis, and Treatment of Hemostatic Disorders in COVID-19 Patients

Acta Naturae ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 79-84
Author(s):  
Airat F. Khalirakhmanov ◽  
Kamilla F. Idrisova ◽  
Raushaniya F. Gajfullina ◽  
Sergey V. Zinchenko ◽  
Rustem I. Litvinov ◽  
...  
Keyword(s):  
Multiple Organ ◽  
Pulmonary Insufficiency ◽  
The Novel ◽  
Thromboembolic Complications ◽  
Short Period ◽  
Prevention And Treatment ◽  
Organ Failures ◽  
Coronavirus Infection ◽  
Novel Coronavirus ◽  
Hemostatic Disorders

The novel coronavirus infection named COVID-19 was first detected in Wuhan, China, in December 2019, and it has been responsible for significant morbidity and mortality in scores of countries. At the time this article was being written, the number of infected and deceased patients continued to grow worldwide. Most patients with severe forms of the disease suffer from pneumonia and pulmonary insufficiency; in many cases, the disease is generalized and causes multiple organ failures and a dysfunction of physiological systems. One of the most serious and prognostically ominous complications from COVID-19 is coagulopathy, in particular, decompensated hypercoagulability with the risk of developing disseminated intravascular coagulation. In most cases, local and diffuse macro- and microthromboses are present, a condition which causes multiple-organ failure and thromboembolic complications. The causes and pathogenic mechanisms of coagulopathy in COVID-19 remain largely unclear, but they are associated with systemic inflammation, including the so-called cytokine storm. Despite the relatively short period of the ongoing pandemic, laboratory signs of serious hemostatic disorders have been identified and measures for specific prevention and correction of thrombosis have been developed. This review discusses the causes of COVID-19 coagulopathies and the associated complications, as well as possible approaches to their early diagnosis, prevention, and treatment.

scholarly journals Experience of international cooperation in developing epidemic control measures during COVID-19 spread in the Republic of Moldova

2021 ◽  
Vol 98 (4) ◽  
pp. 373-382
Author(s):  
A. Yu. Popova ◽  
T. A. Ruzhentsova ◽  
T. Yu. Krasovskaya ◽  
K. V. Аlbul ◽  
N. V. Beril ◽  
...  
Keyword(s):  
Lung Ventilation ◽  
Control Measures ◽  
Laboratory Diagnostics ◽  
The Novel ◽  
Healthcare Organizations ◽  
Epidemic Control ◽  
Republic Of Moldova ◽  
Coronavirus Infection ◽  
The Republic ◽  
Novel Coronavirus

The purpose of the study — to identify the factors contributing to the spread of the novel coronavirus infection within the territory of the Republic of Moldova and to develop measures aimed at their elimination.Materials and methods. In May 2020, experts of Rospotrebnadzor (the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing), together with leading employees of institutions participating in planning and implementing measures aimed at prevention of COVID-19 spread, conducted a detailed analysis of epidemic control and curative measures in 10 healthcare organizations in the Republic of Moldova. They assessed the effectiveness of the undertaken actions in in-patient facilities, in laboratories, and in the country in general.Results. The existing approaches to treatment of patients with COVID-19 and to laboratory diagnostics were in line with the common practices; the adequacy of measures was evidenced by the hospital bed capacity and the stock of artificial lung ventilation machines. In the meantime, the experts came across the factors that obviously contributed to the infection spread. Their elimination could intercept some paths of infection and improve the situation.Conclusion. The analysis of the current measures and their results is important for planning and implementing actions aimed at improvement of the epidemic situation in different regions. The collaborative efforts helped slow down the outbreak in the Bender psychoneurological residential facility; outbreaks were prevented in other limited-access institutions; the incidence among healthcare workers decreased; the daily number of new COVID-19 cases decreased to 0–5 during the summer months in the Dniestrian Moldovan Republic. Presently, there is a clear picture of approaches that should be taken to decrease the incidence. Most likely, the experience obtained in the fight against the novel coronavirus infection will be of great use in future if any new variants of viruses emerge.

Septic shock

2020 ◽  
Author(s):  
V. O. Bitsadze ◽  
T. A. Sukontseva ◽  
S. V. Akinshina ◽  
Ya. Yu. Sulina ◽  
J. Kh. Khizroeva ◽  
...  
Keyword(s):  
Risk Factors ◽  
Septic Shock ◽  
Viral Infections ◽  
The Novel ◽  
The Past ◽  
Obstetrics And Gynaecology ◽  
Coronavirus Infection ◽  
Novel Coronavirus ◽  
Sepsis And Septic Shock ◽  
The Relationship

The problem of sepsis and septic shock has recently become more and more actual. In obstetrics and gynaecology, the number of cases of sepsis has more than doubled over the past 10 years. The review examines the clinical forms of septic conditions, risk factors, pathogenesis of sepsis and septic shock, the main pathogens of septic conditions. Special attention is paid to neonatal sepsis. The relationship between septic shock and viral infections is considered in the context of the novel coronavirus infection caused by SARS-CoV-2 (COVID-19) pandemic. Hemostasis abnormalities have been demonstrated in patients with septic shock, including disseminated intravascular coagulation (DIC). The importance of determining the level of ADAMTS-13 to refine the forecast is discussed.

scholarly journals COVID-19 coronavirus infection. Treatment and prevention

2020 ◽  
Vol 12 (2) ◽  
pp. 31-55
Author(s):  
S. F. Bagnenko ◽  
V. V. Rassokhin ◽  
N. A. Belyakov ◽  
E. V. Boeva ◽  
E. B. Yastrebova
Keyword(s):  
Infectious Disease ◽  
Intensive Care ◽  
Medical Care ◽  
The Novel ◽  
Treatment And Prevention ◽  
Infection Treatment ◽  
Prevention And Treatment ◽  
Infectious Disease Specialists ◽  
Coronavirus Infection ◽  
Novel Coronavirus

The main directions and approaches to the implementation of measures for the prevention and treatment of the disease caused by the novel coronavirus SARS-CoV-2 against the backdrop of the further spread of the COVID-19 epidemic are presented. Experience shows that in infection of many thousands of people, some of them are asymptomatic and pauci-symptomatic, severe or critical cases are observed in up to 1/3 of the patients that may need intensive care. The quality, effectiveness and final result of medical care depend on the level of professional, organizational, material, technical, psychological preparation of the healthcare system, the entire community of specialists, including infectious disease specialists, resuscitators, general practitioners, etc., middle and junior medical workers.

Septic shock

2020 ◽  
Author(s):  
V. O. Bitsadze ◽  
T. A. Sukontseva ◽  
S. V. Akinshina ◽  
Ya. Yu. Sulina ◽  
J. Kh. Khizroeva ◽  
...  
Keyword(s):  
Risk Factors ◽  
Septic Shock ◽  
Viral Infections ◽  
The Novel ◽  
The Past ◽  
Obstetrics And Gynaecology ◽  
Coronavirus Infection ◽  
Novel Coronavirus ◽  
Sepsis And Septic Shock ◽  
The Relationship

The problem of sepsis and septic shock has recently become more and more actual. In obstetrics and gynaecology, the number of cases of sepsis has more than doubled over the past 10 years. The review examines the clinical forms of septic conditions, risk factors, pathogenesis of sepsis and septic shock, the main pathogens of septic conditions. Special attention is paid to neonatal sepsis. The relationship between septic shock and viral infections is considered in the context of the novel coronavirus infection caused by SARS-CoV-2 (COVID-19) pandemic. Hemostasis abnormalities have been demonstrated in patients with septic shock, including disseminated intravascular coagulation (DIC). The importance of determining the level of ADAMTS-13 to refine the forecast is discussed.

The association of respiratory viruses with oxidative stress and antioxidants. Implications for the COVID-19 pandemic

2021 ◽  
Vol 27 ◽  
Author(s):  
Marina Darenskaya ◽  
Liubov Kolesnikova ◽  
Sergei Kolesnikov
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Defense ◽  
Viral Infections ◽  
Respiratory Viruses ◽  
Oxygen Species ◽  
Prevention And Treatment ◽  
Coronavirus Infection ◽  
Influenza Pneumonia ◽  
Respiratory Viral Infections ◽  
Fat Soluble Vitamins

: The spread of a new strain of coronavirus, SARS-CoV-2, a pandemic poses serious health problem for all humanity. In comparison with the previous outbreaks of coronavirus infection in 2002 and 2012, COVID-19 infection has high rates of lethality, contagiousness and comorbidity. The effective methods of prevention and treatment are extremely limited. Oxidative stress is actively involved in the mechanisms of initiation and maintenance of violations of homeostatic reactions in respiratory viral infections. It is important to stop systemic inflammation aimed at "extinguishing" the cytokine "storm", caused by the production of reactive oxygen species. Antioxidant defense medications such as vitamin C, N-acetylcysteine, melatonin, quercetin, glutathione, astaxanthin, polyphenols, fat-soluble vitamins, and polyunsaturated fatty acids have proven well in experimental and clinical studies of influenza, pneumonia, and other respiratory disorders. The use of medications with antioxidant activity could be justified and most probably would increase the effectiveness of the fight against new coronavirus.

scholarly journals The Dermatological Manifestations in the Coronavirus Infection COVID-19

2020 ◽  
Vol 10 (6) ◽  
pp. 422-429
Author(s):  
A. S. Dvornikov ◽  
A. A. Silin ◽  
T. A. Gaydina ◽  
V. N. Larina ◽  
P. A. Skripkina ◽  
...  
Keyword(s):  
Drug Treatment ◽  
Clinical Picture ◽  
Viral Infections ◽  
Skin Lesions ◽  
The Novel ◽  
Skin Manifestations ◽  
Depth Analysis ◽  
Vesicular Rash ◽  
Coronavirus Infection ◽  
Novel Coronavirus

The variety of dermatological manifestations in patients with the novel coronavirus infection COVID-19, the incidence of which depends on concomitant pathology and the characteristics of drug treatment, and their characteristics are similar to those that occur with conventional viral infections is discussed. At the present time it is proposed to distinguish several groups depending on the cause and mechanism of development: angiitis of the skin; papulo-squamous rash and pink lichen; measles rash and infectious erythema; papulo-vesicular rash; toxidermia; urticarial eruptions and artifical lesions. The variety of the clinical picture of the skin manifestations of coronavirus infection requires in-depth analysis in order to interpret correctly the skin lesions and other infectious exanthema and dermatoses in patients with COVID-19.

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