scholarly journals Pathogenesis, Diagnosis, and Treatment of Hemostatic Disorders in COVID-19 Patients

Acta Naturae ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 79-84
Author(s):  
Airat F. Khalirakhmanov ◽  
Kamilla F. Idrisova ◽  
Raushaniya F. Gajfullina ◽  
Sergey V. Zinchenko ◽  
Rustem I. Litvinov ◽  
...  
Keyword(s):  
Multiple Organ ◽  
Pulmonary Insufficiency ◽  
The Novel ◽  
Thromboembolic Complications ◽  
Short Period ◽  
Prevention And Treatment ◽  
Organ Failures ◽  
Coronavirus Infection ◽  
Novel Coronavirus ◽  
Hemostatic Disorders

The novel coronavirus infection named COVID-19 was first detected in Wuhan, China, in December 2019, and it has been responsible for significant morbidity and mortality in scores of countries. At the time this article was being written, the number of infected and deceased patients continued to grow worldwide. Most patients with severe forms of the disease suffer from pneumonia and pulmonary insufficiency; in many cases, the disease is generalized and causes multiple organ failures and a dysfunction of physiological systems. One of the most serious and prognostically ominous complications from COVID-19 is coagulopathy, in particular, decompensated hypercoagulability with the risk of developing disseminated intravascular coagulation. In most cases, local and diffuse macro- and microthromboses are present, a condition which causes multiple-organ failure and thromboembolic complications. The causes and pathogenic mechanisms of coagulopathy in COVID-19 remain largely unclear, but they are associated with systemic inflammation, including the so-called cytokine storm. Despite the relatively short period of the ongoing pandemic, laboratory signs of serious hemostatic disorders have been identified and measures for specific prevention and correction of thrombosis have been developed. This review discusses the causes of COVID-19 coagulopathies and the associated complications, as well as possible approaches to their early diagnosis, prevention, and treatment.

scholarly journals Prevention and treatment system of novel coronavirus infection in medical and health institutions: experience in West China Hospital of Sichuan University

2020 ◽  
Vol 37 (10) ◽  
pp. 639-641
Author(s):  
Qiao Zhou ◽  
He Yu ◽  
Zong-An Liang ◽  
Rong Yao ◽  
Feng-Ming Luo ◽  
...  
Keyword(s):  
Treatment System ◽  
The Novel ◽  
West China Hospital ◽  
West China ◽  
Global Pandemic ◽  
Prevention And Treatment ◽  
Coronavirus Infection ◽  
Health Institutions ◽  
Novel Coronavirus

The novel coronavirus infection broke out in Wuhan, China, in December 2019, and progressed to a global pandemic. We describe the measures taken by West China Hospital of Sichuan University to address the diagnosis, prevention and treatment of the infection.

scholarly journals Aminodihydrophthalazinedione sodium in prevention, therapy and rehabilitation of patients with respiratory diseases

2021 ◽  
Vol 23 (3) ◽  
pp. 296-303
Author(s):  
Dmitry I. Trukhan ◽  
◽  
Natalya V. Bagisheva ◽  
Anna V. Mordyk ◽  
Ekaterina Yu. Nebesnaya ◽  
...  
Keyword(s):  
Viral Infections ◽  
Laboratory Diagnostics ◽  
The Novel ◽  
Modern Approach ◽  
Prevention Therapy ◽  
Prevention And Treatment ◽  
Respiratory Pathology ◽  
Coronavirus Infection ◽  
Respiratory Viral Infections ◽  
Novel Coronavirus

The modern approach to the prevention and treatment of acute respiratory viral infections consists in the use of drugs that increase the body’s defenses, helping to create a barrier to the penetration of the virus. Immunomodulators exhibit a nonspecific effect in acute respiratory viral infections, which makes it possible to use them against various types of respiratory viruses without accurate laboratory diagnostics and expands clinical capabilities. In the first part of the review, the features of sodium aminodihydrophthalazinedione and the experience of its use in respiratory pathology are considered. The pandemic of the novel coronavirus infection (COVID-19), spread by the novel coronavirus SARS-CoV-2, has become a challenge to health systems around the world. The second part of the review reviews the results of the first studies on the use of sodium aminodihydrophthalazinedione for the prevention and treatment of new coronavirus infection. Recently, much attention has been paid to the long-term consequences of the postponed coronavirus infection. In the final part of the review, various aspects of the “post-COVID syndrome” are discussed and the possibilities of aminodihydrophthalazinedione sodium at the stage of rehabilitation after a coronavirus infection are discussed.

scholarly journals COVID-19 coronavirus infection. Treatment and prevention

2020 ◽  
Vol 12 (2) ◽  
pp. 31-55
Author(s):  
S. F. Bagnenko ◽  
V. V. Rassokhin ◽  
N. A. Belyakov ◽  
E. V. Boeva ◽  
E. B. Yastrebova
Keyword(s):  
Infectious Disease ◽  
Intensive Care ◽  
Medical Care ◽  
The Novel ◽  
Treatment And Prevention ◽  
Infection Treatment ◽  
Prevention And Treatment ◽  
Infectious Disease Specialists ◽  
Coronavirus Infection ◽  
Novel Coronavirus

The main directions and approaches to the implementation of measures for the prevention and treatment of the disease caused by the novel coronavirus SARS-CoV-2 against the backdrop of the further spread of the COVID-19 epidemic are presented. Experience shows that in infection of many thousands of people, some of them are asymptomatic and pauci-symptomatic, severe or critical cases are observed in up to 1/3 of the patients that may need intensive care. The quality, effectiveness and final result of medical care depend on the level of professional, organizational, material, technical, psychological preparation of the healthcare system, the entire community of specialists, including infectious disease specialists, resuscitators, general practitioners, etc., middle and junior medical workers.

scholarly journals Management of patients with comorbidity during novel coronavirus (COVID-19) pandemic. National Consensus Statement 2020

2020 ◽  
Vol 19 (4) ◽  
pp. 2630 ◽  
Author(s):  
V. B. Grinevich ◽  
I. V. Gubonina ◽  
V. L. Doshchitsin ◽  
Yu. V. Kotovskaya ◽  
Yu. A. Kravchuk ◽  
...  
Keyword(s):  
Gastrointestinal Disease ◽  
Multiple Organ ◽  
Adverse Outcomes ◽  
Chronic Obstructive ◽  
The Novel ◽  
Vulnerable Group ◽  
Obstructive Pulmonary Disease ◽  
Medical Facilities ◽  
Coronavirus Infection ◽  
Novel Coronavirus

The pandemic of the novel coronavirus infection (COVID-19), caused by SARS‑CoV‑2, has become a challenge to healthcare systems in all countries of the world. Patients with comorbidity are the most vulnerable group with the high risk of adverse outcomes. The problem of managing these patients in context of a pandemic requires a comprehensive approach aimed both at the optimal management in self-isolated patients not visiting medical facilities, and management of comorbidities in patients with COVID-19. The presented consensus covers these two aspects of managing patients with cardiovascular disease, diabetes, chronic obstructive pulmonary disease, gastrointestinal disease, and also pay attention to the multiple organ complications of COVID-19.

scholarly journals Nutritional support for patients with new coronavirus infection

2021 ◽  
Vol 12 (2) ◽  
pp. 102-109
Author(s):  
Igor N. Pasechnik
Keyword(s):  
Intensive Care ◽  
Nutritional Status ◽  
Nutritional Support ◽  
Energy Levels ◽  
Multiple Organ ◽  
The Novel ◽  
Coronavirus Infection ◽  
Severity Of The Disease ◽  
Novel Coronavirus

The novel coronavirus infection (COVID-19) pandemic has become an unprecedented threat to the lives of those affected and has increased the burden on the healthcare system in most countries. The severity of COVID-19 is not always predictable. However, comorbid pathology and advanced age are risk factors for a severe course of the disease with the development of multiple organ failure. When treating COVID-19, clinicians place particular emphasis on nutritional support as part of intensive care. Correction of nutritional status is also important in the rehabilitation of patients with the syndrome after intensive care. The aim of the review was to show the need for a differentiated approach to nutritional support for patients with COVID-19 during treatment and rehabilitation. From more than 200 originally selected literature sources from various databases (Scopus, Web of science, RSCI, etc.), 49 publications were selected for analysis, mostly published over the past 5 years. Earlier articles were used if they were still relevant to clinicians. The review provides methods for assessing the nutritional status of patients with COVID-19. It is emphasized that patients with comorbid pathology and elderly patients often develop malnutrition, which progresses over the disease. The article discusses in detail the issues of correction of malnutrition, depending on the severity of the disease and the stage of treatment. The effectiveness of rehabilitation is enhanced with adequate nutritional support. Current approaches to providing COVID-19 patients with nutrients and energy include a gradation of nutritional support prescription depending on the severity of the disease. Particular attention is paid to the gradual achievement of target protein and energy levels, as well as the preferential use of the enteral method of delivery of food components. Continuity of nutritional status correction at the outpatient, inpatient and rehabilitation stages improves the quality of care for patients with COVID-19.

The features of bone metabolism in COVID-19

2021 ◽  
pp. 36-44
Author(s):  
Timur Bulatovich Minasov ◽  
Denis Enverovich Baikov ◽  
Munavis Munavisovich Khafizov ◽  
Ekaterina Rishatovna Yakupova
Keyword(s):  
Bone Metabolism ◽  
Bone Tissue ◽  
The Elderly ◽  
The Body ◽  
The Novel ◽  
Direct Influence ◽  
Treatment Of Osteoporosis ◽  
Prevention And Treatment ◽  
Coronavirus Infection ◽  
Novel Coronavirus

To date, there is little information about the effect of the novel coronavirus infection COVID-19 on bone metabolism. However, this topic is relevant, since COVID-19 mainly affects the elderly, who are more prone to osteoporosis. In the course of our study, it was found that changes occurring in the body under the direct influence of the SARS-CoV-2 virus affect the parameters of bone metabolism of the spine, reducing the density of bone tissue in the Th5 — Th7 vertebrae, which determines the need for prevention and treatment of osteoporosis after the infection.

Association and treatment of diabetes in patients affected by Covid-19

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 1198-1201
Author(s):  
Syed Yasir Afaque
Keyword(s):  
Diabetes Mellitus ◽  
Prognostic Value ◽  
Heart Diseases ◽  
The Novel ◽  
The World ◽  
Treatment Of Diabetes ◽  
Coronavirus Infection ◽  
Composite Outcomes ◽  
Novel Coronavirus ◽  
The Impact

In December 2019, a unique coronavirus infection, SARS-CoV-2, was first identified in the province of Wuhan in China. Since then, it spread rapidly all over the world and has been responsible for a large number of morbidity and mortality among humans. According to a latest study, Diabetes mellitus, heart diseases, Hypertension etc. are being considered important risk factors for the development of this infection and is also associated with unfavorable outcomes in these patients. There is little evidence concerning the trail back of these patients possibly because of a small number of participants and people who experienced primary composite outcomes (such as admission in the ICU, usage of machine-driven ventilation or even fatality of these patients). Until now, there are no academic findings that have proven independent prognostic value of diabetes on death in the novel Coronavirus patients. However, there are several conjectures linking Diabetes with the impact as well as progression of COVID-19 in these patients. The aim of this review is to acknowledge about the association amongst Diabetes and the novel Coronavirus and the result of the infection in such patients.

High cytokine levels and cytokine storm in the novel coronavirus infection

2021 ◽  
pp. 38-47
Author(s):  
Maksim Leonidovich Maksimov ◽  
Albina Ayratovna Zvegintseva ◽  
Lyudmila Yurievna Kulagina ◽  
Albina Zainutdinovna Nigmedzyanova ◽  
Elvina Ramisovna Kadyseva
Keyword(s):  
Peripheral Blood ◽  
High Frequency ◽  
The Novel ◽  
Cytokine Storm ◽  
The Public ◽  
Systemic Inflammatory Reaction ◽  
Scientific World ◽  
Cytokine Levels ◽  
Coronavirus Infection ◽  
Novel Coronavirus

A review article is based on current foreign sources. The level of cytokines in the peripheral blood can be increased in many diseases, but in some cases there may be an excess of their normal concentration in tens, hundreds or more times with the development of a peculiar clinical picture, which is based on a systemic inflammatory reaction. In the literature this condition has received the figurative name «cytokine storm», which highlights an extremely violent reaction of the immune system with an unknown (often unfavorable) outcome. Close attention of the scientific world and the public to the problem of extremely high levels of cytokines in the peripheral blood (hypercytokinemia) was drawn due to the high frequency of the cytokine storm in the novel coronavirus infection.

FEATURES OF THE COURSE AND TACTICS OF MANAGING CHILDREN WITH KIDNEYS AND URINARY TRACT DISEASES DURING THE PANDEMIC OF NEW CORONAVIRUS INFECTION COVID-19

2021 ◽  
Vol 100 (4) ◽  
pp. 74-79
Author(s):  
I.M. Kagantsov ◽  
◽  
V.V. Sizonov ◽  
V.G. Svarich ◽  
K.P. Piskunov ◽  
...  
Keyword(s):  
Age Groups ◽  
Clinical Manifestations ◽  
Routine Care ◽  
The Novel ◽  
Urinary System ◽  
Death Rates ◽  
Global Pandemic ◽  
Coronavirus Infection ◽  
Novel Coronavirus ◽  
Significant Health

The novel coronavirus infection (SARS-CoV-2), which first appeared in Wuhan, China in December 2019, has been declared a global pandemic by WHO. COVID-19 affects people of all age groups. The disease in children is usually asymptomatic or mild compared to adults, and with a significantly lower death rates. Data on kidney damage in children with COVID-19, as well as the effect of coronavirus infection on the course of diseases of the genitourinary system, are limited, the risks of contracting a new coronavirus infection in children with significant health problems, including those with chronic kidney disease, remain uncertain. The pandemic has affected the activities of surgeons treating diseases of the urinary system in children. Since the prospects for the end of the pandemic are vague, it is necessary to formulate criteria for selecting patients who can and should be provided with routine care in the pandemic. The purpose of this review is to highlight the features of the clinical manifestations and treatment of children with COVID-19, occurring against the background of previous renal pathology or complicating its course.

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