scholarly journals Correction by "Quertin" of the oxidative-antioxidant system of rats at xenobiotics exposure

2018 ◽  
Keyword(s):  
Superoxide Dismutase ◽  
Polyethylene Glycol ◽  
Ethylene Glycol ◽  
Antioxidant System ◽  
Catalase Activity ◽  
The State ◽  
Intragastric Administration ◽  
Polypropylene Glycol ◽  
Polyethylene Glycol 400 ◽  
Flavonoid Quercetin

The objective of this study is to determine the possibility of correcting pathological disorders of the oxidative-antioxidant system in the rat organism under the influence of xenobiotics using the flavonoid quercetin, which has an antioxidant, anti-inflammatory, antibacterial, antiviral and immunomodulating effect. Baseline studies have established that when exposed to xenobiotics at a dose of 1/10 and 1/100 DL50, the content of lipid peroxidation products in the serum of rats increases, including 8-isoprostane, TBA-active products (TBA-AP) and diene conjugates (DK). As a result, the state of the antioxidant system also undergoes changes, evidenced by a decrease in catalase activity under the action of xenobiotics in doses of 1/10 and 1/100 DL50, as well as fluctuations in superoxide dismutase content, namely: a decrease under the influence of xenobiotics in a dose of 1/10 DL50 and increase with the action of substances in a dose of 1/100 DL50. After correction with the flavonoid quercetin, a decrease in the content of both primary and secondary POL products in the rat organism, as well as indicators of the state of the oxidative-antioxidant system was established. At the same time, an important for clinical practice relationship was established between the degree of correction of pathological changes in the state of the oxidative-antioxidant system and the dose of toxic effects of xenobiotics. After intragastric administration of “Quertin” in a dose of 25 mg/kg of body weight to rats exposed to polyethylene glycol 400 at a dose of 1/10 DL50, a decrease in serum levels of 8-isoprostan was determined by 14.5%, TBA-AP – by 17.3%, DK – by 15.5%. After exposure to polyethylene glycol 400 at a dose of 1/100 DL50, the content of 8-isoprostane decreased by 12.4%, TBА-AP by 16.8%, and DK by 11.8%. After exposure to polypropylene glycol in doses of 1/10 and 1/100 DL50, the content of 8-isoprostane decreased by 17.7% and 12.5%, TBA-AP – 11.7% and 9.8%, DK – 16.3% and 12.7% respectively. After exposure to ethylene glycol in doses of 1/10 and 1/100 DL50, the content of 8-isoprostane decreased by 22.1% and 14.9%, TBA-AP – 17.3% and 15.2%, DK – 17.6% and 12.2% respectively. Catalase activity increased after the correction by “Quertin” at exposure to polyethylene glycol 400 at doses 1/10 and 1/100 DL50, respectively, by 25.8% and 20.6%; polypropylene glycol – by 26.5% and 23.4%; ethylene glycol – by 19.4% and 15.6%. Superoxide dismutase activity in the blood of rats after the correction of “Quertin” increased at xenobiotic toxification at a dose of 1/10 DL50 (polyethylene glycol 400 – by 29.3%, polypropylene glycol – by 33.5%; ethylene glycol – by 23.2%) and decreased at toxification with xenobiotics at a dose of 1/100 DL50 (polyethylene glycol 400 – by 21.6%, polypropylene glycol – by 26.7%; ethylene glycol – by 18.6%).

scholarly journals THE STATE OF THE ANTIOXIDANT SYSTEM OF THE INTERNAL ORGANS IN RATS DURING BURN DISEASE

2014 ◽  
Vol 13 (3) ◽  
pp. 51-55
Author(s):  
L. G. Netyukhailo ◽  
T. A. Sukhomlin ◽  
Ya. A. Basarab ◽  
V. V. Bondarenko ◽  
S. V. Kharchenko
Keyword(s):  
Lipid Peroxidation ◽  
Superoxide Dismutase ◽  
Free Radical ◽  
Salivary Glands ◽  
Antioxidant System ◽  
The State ◽  
Antioxidant Systems ◽  
Free Radical Processes ◽  
Burn Disease ◽  
Radical Processes

The objective of research was to study the state of prooxidant and antioxidant systems in the tissues of the lungs, kidneys, pancreas and salivary glands at burn disease. The intensity of the free radical processes was evaluated on the basis of the content of malondialdehyde (MDA) and antioxidant system – based on the indexes of its enzymatic chain: superoxide dismutase and catalase in homogenates of the studied organs. It has been found that changes in experimental burn disease depend on the studied organs and the stage of burn disease. The activation of free radical processes observed in all investigated organs (lungs, kidneys, pancreas and salivary glands). Reactive oxygen species induce lipid peroxidation, which is a universal marker of tissue damage. MDA appears in the body during degradation of polyunsaturated fatty acids and it’s a marker of lipid peroxidation and oxidative stress. It was found the increasing of MDA in all organs, especially in the lungs and kidneys at stage of burn shock. Under these conditions it was observed the decrease of superoxide dismutase and catalase in all investigated organs. At burn disease there is development of disbalance between the action of prooxidant and antioxidant systems due to the activation of free radical processes.

The state of the blood antioxidant system in the patients presenting with acromegaly

2015 ◽  
Vol 61 (2) ◽  
pp. 8-11
Author(s):  
M V Faassen ◽  
M S Pankratova ◽  
N N Molitvoslovova ◽  
A A Baizhumanov ◽  
S S Kovalenko ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Superoxide Dismutase ◽  
Blood Plasma ◽  
Antioxidant System ◽  
The State ◽  
Total Antioxidant Activity ◽  
Sod Activity ◽  
Protein Thiols ◽  
Total Antioxidant

The state of the blood antioxidant system in the patients presenting with acromegaly. The objective of the present study was to evaluate the total antioxidant activity (TAA) of blood plasma, the levels of non-protein thiols and 2-thyobarbituric acid-active products (TBA-AP), superoxide dismutase (SOD) and catalase (CAT) activities as well as ceruloplasmin (CP) level in the patients presenting with acromegaly. It was shown that plasma TAA and SOD activity in this patients was on the average 20 and 30% lower respectively than in the control subjects. At the same time, the TBA-AP and CP levels increased by 50 and 40% respectively. These data suggest the development of oxidative stress in the acromegalic patients.

Abnormal antioxidant system in erythrocytes of mercury-exposed workers

1998 ◽  
Vol 17 (4) ◽  
pp. 225-230 ◽  
Author(s):  
Mary Luci de Souza Queiroz ◽  
Socrates Calvoso Pena ◽  
Tereza Sueko Ide Salles ◽  
Eduardo Melo de Capitani ◽  
Sara Teresinha Olalla Saad
Keyword(s):  
Superoxide Dismutase ◽  
Occupational Exposure ◽  
Antioxidant System ◽  
Catalase Activity ◽  
Chronic Exposure ◽  
Reduced Glutathione ◽  
Red Cell ◽  
Urinary Mercury ◽  
Exposed Workers

To investigate the effects of chronic exposure to mercury we studied the red cell antioxidant system in mercury-exposed workers through the evaluation of reduced glutathione, catalase and superoxide dismutase systems. Oftheseworkers, somewerebeingexposedatthetimeand had presented urinary mercury levels considered safe for occupational exposure for at least 3 months prior to the initiation of this study, and others had been on leave for at least 6 months because of intoxication symptoms. Reduced glutathione levels were lower and catalase activity was higher in the workers which were still being exposed, compared to those on leave and controls. No differences were observed between the workers on leave and controls.

Protective effect of 24-epibrassinolide on wheat plants under water deficit

Biomics ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 47-53
Author(s):  
A.R. Lubynova ◽  
D.R. Maslennikova ◽  
F.M. Shakirova
Keyword(s):  
Hydrogen Peroxide ◽  
Polyethylene Glycol ◽  
Protective Effect ◽  
Water Deficit ◽  
Antioxidant System ◽  
Peroxidase Activity ◽  
Wheat Seedling ◽  
The State ◽  
Proline Content ◽  
Root Cells

We studied the effect of 24-epibrassinolide (EB) on growth, proline content, the state of wheat seedling antioxidant system under water deficit, modeled by 12% polyethylene glycol (PEG). It was found that under drought EB-pretreatment has a protective effect on wheat plants, stabilizing the state of the antioxidant system, regulating the balance of hydrogen peroxide and peroxidase activity, as well as inducing the additional accumulation of proline, which was reflected in maintaining a higher level of mitotic activity in apical root cells of these plants.

Vanillin based polymers: V. Poly(hydrovanilloin–urethane)

2021 ◽  
pp. 204124792198989
Author(s):  
Ananda S Amarasekara ◽  
Rocio Garcia-Obregon
Keyword(s):  
Glass Transition ◽  
Polyethylene Glycol ◽  
Ethylene Glycol ◽  
Renewable Resources ◽  
Equivalent Amount ◽  
Transition Temperatures ◽  
Dsc Analysis ◽  
Polyethylene Glycol 400 ◽  
Thermal Stabilities ◽  
Glass Transition Temperatures

Renewable resources based hydrovanilloin [1,2- bis(4-hydroxy-3-methoxyphenyl)-1,2-ethanediol] was synthesized in 86% yield by electrochemical dimerization of vanillin in aqueous NaOH. This symmetrical bis-phenol monomer was then used for the preparation of urethane polymers by two different methods. In the first method a 1:2 mole ratio mixture of hydrovanilloin and diisocyanate was polymerized in DMF using 1,4-diazabicyclo[2,2,2]octane as the catalyst at 60°C, for 1 h to give poly(hydrovanilloin–urethane)s. In the second method diisocyanates were first reacted with polyethylene glycol-400 to give pre-polymers. Then prepolymers were reacted with equivalent amount of hydrovanilloin at 60°C for 4 days to produce poly(hydrovanilloin-ethylene glycol-urethane)s. The first method resulted hard poly(hydrovanilloin–urethane)s showing Tg values in the range of 121–172°C. The second method yielded softer poly(hydrovanilloin-ethylene glycol-urethane)s and these polymers failed to show distinct glass transition temperatures in the DSC analysis. However, poly(hydrovanilloin-ethylene glycol-urethane)s showed better thermal stabilities than polymers without polyethylene glycol units.

scholarly journals Solubility Data, Solubility Parameters and Thermodynamic Behavior of an Antiviral Drug Emtricitabine in Different Pure Solvents: Molecular Understanding of Solubility and Dissolution

Molecules ◽  
2021 ◽  
Vol 26 (3) ◽  
pp. 746
Author(s):  
Faiyaz Shakeel ◽  
Nazrul Haq ◽  
Ibrahim Alsarra ◽  
Sultan Alshehri
Keyword(s):  
Polyethylene Glycol ◽  
Ethylene Glycol ◽  
Antiviral Drug ◽  
Solubility Parameters ◽  
Hansen Solubility Parameters ◽  
Polyethylene Glycol 400 ◽  
Thermodynamic Behavior ◽  
Peg 400 ◽  
Experimental Solubility ◽  
Hansen Solubility

The solubility values, various Hansen solubility parameters (HSPs) and thermodynamic behavior of emtricitabine (ECT) in twelve different pure solvents (PS) were estimated using various experimental as well as computational methods. Experimental solubility values (xe) of ECT in twelve different PS were obtained at T = 298.2 K to 318.2 K and p = 0.1 MPa. The xe values of ECT were correlated by “van’t Hoff, Apelblat and Buchowski-Ksiazaczak λh models”. Various HSPs for ECT and twelve different PS were also calculated using “HSPiP software”. The xe values of ECT were estimated maximum in polyethylene glycol-400 (PEG-400; 1.41 × 10−1), followed by ethylene glycol, Transcutol-HP, propylene glycol, methanol, water, isopropanol, ethanol, 1-butanol, dimethyl sulfoxide, 2-butanol and EA (1.28 × 10−3) at T = 318.2 K. “Apparent thermodynamic analysis” showed an “endothermic and entropy-driven dissolution” of ECT. Overall, PEG-400 was found as the best/ideal solvent for solubility/miscibility of ECT compared to other solvents studied.

scholarly journals Activity of antioxidant enzymes and processes of free radical oxidation in experimental hypothyroidism and correction of thyroid shifts with iodized polysaccharide complexes

2012 ◽  
Vol 93 (1) ◽  
pp. 116-119
Author(s):  
F Kh Kamilov ◽  
A N Mamtsev ◽  
V N Kozlov ◽  
G M Abdullina ◽  
O V Lobyreva
Keyword(s):  
Superoxide Dismutase ◽  
Antioxidant Enzymes ◽  
Glutathione Peroxidase ◽  
Catalase Activity ◽  
Activity Level ◽  
Biologically Active ◽  
Superoxide Dismutase Activity ◽  
Control Group ◽  
Intragastric Administration ◽  
Standard Diet

Aim. To determine the activity of antioxidant enzymes in rat liver tissue on the background of thiamazole hypothyroidism, and also after its correction with iodine-containing organo-mineral complexes. Methods. Studies were conducted on rats, which were divided into four groups: the first group - the control, in animals of the second, third and fourth groups hypothyroidism was induced by daily intragastric administration of thiamazole at a dose 2.5 mg per 100 g body weight for the duration of 3 weeks. Beginning from the 22-day of the experiment the animals of the fourth group for the duration of a month received a biologically active additive in a dose that provides the daily requirement of iodine in rats, while the animals of the third group were on the standard diet of the vivarium. The activity of superoxide dismutase and glutathione peroxidase was determined using a set of reagents «RANSOD Randox» manufactured by «Laboratories Ltd.», the catalase activity was determined by the method of M.A. Korolyuk. Results. Experimental hypothyroidism in rats was characterized by a decrease in the concentrations of free thyroxine, an increase in the content of total triiodothyronine and thyroid-stimulating hormone. In animals treated with tiamazol, the superoxide dismutase activity was 85.6% of the activity level of the control animals, glutathione activity - 77.3% of the level of intact animals. The catalase activity in hypothyroidism decreased significantly - down to 40% of the control level (p ≤0.001). In the liver homogenate of rats, treated for 1 month with «iodine biopolymer» after hypothyroidism induction, the superoxide dismutase activity almost reached the control values and accounted for 95.5% of the activity of intact animals. The activity of glutathione peroxidase and catalase, was even slightly higher than the control values, reaching 115.6 and 112.7% of levels of activity in the control group, respectively (p ≤0,05). At the same time in the animals, which were on a standard diet, the activity of the studied enzymes remained below the control values, with the catalase activity - significantly lower (49.9% of the control, p ≤0,001). Conclusion. The introduction of an iodine-containing biologically active compound on the background of hypothyroidism made it possible to restore the activity of thyroid-dependant antioxidant enzymes, to normalize the functional state of the pituitary-thyroid system and to inhibit the processes of lipid peroxidation in the liver the of animals.

scholarly journals Extraction of pyridine using systems based on water-soluble polymers

2022 ◽  
Vol 1212 (1) ◽  
pp. 012015
Author(s):  
V O Solovev ◽  
S V Soloveva ◽  
N A Milevsky
Keyword(s):  
Polyethylene Glycol ◽  
Negative Impact ◽  
Water Soluble ◽  
Polypropylene Glycol ◽  
Two Phase ◽  
Polyethylene Glycol 400 ◽  
Promising Alternative ◽  
Nitrogenous Compounds ◽  
Water Soluble Polymers ◽  
Soluble Polymers

Abstract In the process of using hydrocarbon fractions containing a large amount of nitrogenous compounds, nitrogen oxides are released into the atmospheric air, which have a negative impact on the environment and human health. The traditional cleaning method is treatment with a 25% sulfuric acid solution and subsequent hydrotreating. However, this process becomes disadvantageous due to its inability to achieve ultra-low concentrations of nitrogen-containing compounds (<10 ppm). Extraction using non-toxic and environmentally friendly water-soluble polymers is a promising alternative compared to traditional methods. This work presents the dependence of the interphase distribution of pyridine on the composition of extraction systems based on water-soluble polymers. According to the results of the study, it was found that polyethylene glycol-400, polypropylene glycol-425 and methyl ether of polyethylene glycol-350 exhibit effective extraction properties in relation to pyridine and extract it by 90.95%, 90.33% and 87.82% in one extraction stage, respectively. It was also found that the use of two-phase aqueous systems based on water-soluble polymers in the process of extracting pyridine is promising.

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