scholarly journals Attributions for Brain Injured Persons' Actions: Effects of Cause of Injury and Familiarity

2021 ◽  
Author(s):  
◽  
Lynette Ann Foster
Keyword(s):  
Brain Injury ◽  
Brain Tumour ◽  
Brain Injuries ◽  
Illegal Drugs ◽  
Negative Consequences ◽  
The Public ◽  
Brain Injured ◽  
The Brain ◽  
Undesirable Behavior

<p>Misunderstanding the behaviours of individuals with brain injuries is common and may result in negative consequences, especially when visible markers of brain injury are absent. Previous research on this issue manipulated the visibility of a brain injury with photographs of an adolescent with either a head scar or no scar (McClure, Buchanan, McDowall, & Wade, 2008). Scenarios stated that the adolescent had suffered a brain injury, followed by undesirable changes in four behaviours. Participants attributed the behaviors more to adolescence relative to brain injury when there was no scar than when there was a scar. The current research extends this research by examining the effects of visible markers of injury combined with three other factors: whether people are informed about the injury, the stated cause of injury, and familiarity with individuals with brain injury. Experiment 1 (N = 98) examined the effects of informing people about brain injury and found that when participants were not informed about the brain injury, visible markers of injury had no effect on attributions; participants made higher attributions to adolescence than brain injury in both scar conditions. In contrast, when participants were informed about the injury, in the no scar condition, attributions were higher for adolescence than brain injury whereas in the scar condition, both causes were rated equally. Experiment 2 (N = 148) examined the effects of putative causes of the injury and the participants' familiarity with the brain injury. The results found that visible markers of injury had no effect on attributions when the described cause was a brain tumour, but when the described cause was abusing illegal drugs, participants made higher attributions to brain injury than adolescence in the scar condition, with the reverse found in the no scar condition. In the scar condition, participants with high familiarity attributed the behaviours more to the brain injury than participants with low familiarity and participants with low familiarity attributed the behaviours more to adolescence than participants with high familiarity. In the no scar condition, participants in both familiarity groups attributed the behaviours equally to adolescence and brain injury. This research shows that the visibility of a brain injury, the etiology of an injury and familiarity with individuals with brain injury influence people's attributions for an adolescent's undesirable behavior. This information can be used by professionals and caregivers to inform survivors about these effects and used in campaigns to educate the public.</p>

scholarly journals Attributions for Brain Injured Persons' Actions: Effects of Cause of Injury and Familiarity

2021 ◽  
Author(s):  
◽  
Lynette Ann Foster
Keyword(s):  
Brain Injury ◽  
Brain Tumour ◽  
Brain Injuries ◽  
Illegal Drugs ◽  
Negative Consequences ◽  
The Public ◽  
Brain Injured ◽  
The Brain ◽  
Undesirable Behavior

<p>Misunderstanding the behaviours of individuals with brain injuries is common and may result in negative consequences, especially when visible markers of brain injury are absent. Previous research on this issue manipulated the visibility of a brain injury with photographs of an adolescent with either a head scar or no scar (McClure, Buchanan, McDowall, & Wade, 2008). Scenarios stated that the adolescent had suffered a brain injury, followed by undesirable changes in four behaviours. Participants attributed the behaviors more to adolescence relative to brain injury when there was no scar than when there was a scar. The current research extends this research by examining the effects of visible markers of injury combined with three other factors: whether people are informed about the injury, the stated cause of injury, and familiarity with individuals with brain injury. Experiment 1 (N = 98) examined the effects of informing people about brain injury and found that when participants were not informed about the brain injury, visible markers of injury had no effect on attributions; participants made higher attributions to adolescence than brain injury in both scar conditions. In contrast, when participants were informed about the injury, in the no scar condition, attributions were higher for adolescence than brain injury whereas in the scar condition, both causes were rated equally. Experiment 2 (N = 148) examined the effects of putative causes of the injury and the participants' familiarity with the brain injury. The results found that visible markers of injury had no effect on attributions when the described cause was a brain tumour, but when the described cause was abusing illegal drugs, participants made higher attributions to brain injury than adolescence in the scar condition, with the reverse found in the no scar condition. In the scar condition, participants with high familiarity attributed the behaviours more to the brain injury than participants with low familiarity and participants with low familiarity attributed the behaviours more to adolescence than participants with high familiarity. In the no scar condition, participants in both familiarity groups attributed the behaviours equally to adolescence and brain injury. This research shows that the visibility of a brain injury, the etiology of an injury and familiarity with individuals with brain injury influence people's attributions for an adolescent's undesirable behavior. This information can be used by professionals and caregivers to inform survivors about these effects and used in campaigns to educate the public.</p>

scholarly journals The Expanding Role of Quantitative Pupillometry in the Evaluation and Management of Traumatic Brain Injury

2021 ◽  
Vol 12 ◽  
Author(s):  
Jason H. Boulter ◽  
Margaret M. Shields ◽  
Melissa R. Meister ◽  
Gregory Murtha ◽  
Brian P. Curry ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Brain Injuries ◽  
Ease Of Use ◽  
Brain Injured ◽  
The World ◽  
Injured Patients ◽  
Austere Environments ◽  
Active Investigation

Traumatic brain injury is a rapidly increasing source of morbidity and mortality across the world. As such, the evaluation and management of traumatic brain injuries ranging from mild to severe are under active investigation. Over the last two decades, quantitative pupillometry has been increasingly found to be useful in both the immediate evaluation and ongoing management of traumatic brain injured patients. Given these findings and the portability and ease of use of modern pupillometers, further adoption and deployment of quantitative pupillometers into the preclinical and hospital settings of both resource rich and medically austere environments.

scholarly journals Lack of mitochondrial ferritin aggravated neurological deficits via enhancing oxidative stress in a traumatic brain injury murine model

2017 ◽  
Vol 37 (6) ◽  
Author(s):  
Ligang Wang ◽  
Libo Wang ◽  
Zhibo Dai ◽  
Pei Wu ◽  
Huaizhang Shi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Knockout Mice ◽  
Brain Injuries ◽  
Brain Infarction ◽  
Neurological Deficits ◽  
Important Correlation ◽  
The Brain ◽  
And Oxidative Stress

Oxidative stress has been strongly implicated in the pathogenesis of traumatic brain injury (TBI). Mitochondrial ferritin (Ftmt) is reported to be closely related to oxidative stress. However, whether Ftmt is involved in TBI-induced oxidative stress and neurological deficits remains unknown. In the present study, the controlled cortical impact model was established in wild-type and Ftmt knockout mice as a TBI model. The Ftmt expression, oxidative stress, neurological deficits, and brain injury were measured. We found that Ftmt expression was gradually decreased from 3 to 14 days post-TBI, while oxidative stress was gradually increased, as evidenced by reduced GSH and superoxide dismutase levels and elevated malondialdehyde and nitric oxide levels. Interestingly, the extent of reduced Ftmt expression in the brain was linearly correlated with oxidative stress. Knockout of Ftmt significantly exacerbated TBI-induced oxidative stress, intracerebral hemorrhage, brain infarction, edema, neurological severity score, memory impairment, and neurological deficits. However, all these effects in Ftmt knockout mice were markedly mitigated by pharmacological inhibition of oxidative stress using an antioxidant, N-acetylcysteine. Taken together, these results reveal an important correlation between Ftmt and oxidative stress after TBI. Ftmt deficiency aggravates TBI-induced brain injuries and neurological deficits, which at least partially through increasing oxidative stress levels. Our data suggest that Ftmt may be a promising molecular target for the treatment of TBI.

Severe Traumatic Brain Injury: Some Effects on Family Caregivers

2002 ◽  
Vol 90 (2) ◽  
pp. 415-425 ◽  
Author(s):  
Gregory J. Boyle ◽  
Sandra Haines
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Family Member ◽  
Family Environment ◽  
Severe Traumatic Brain Injury ◽  
Brain Injuries ◽  
Comparison Group ◽  
Brain Injured ◽  
The Family ◽  
Time And Energy

This study assesses the effects of severe traumatic brain injuries on family members and functioning—a topic of interest for those working with survivors and their families. This issue is receiving increased attention as recent findings suggest that family adjustment influences outcome for brain-injured persons. The Family Environment Scale and the Profile of Mood States were completed by 25 individuals who had a family member with a severe traumatic brain injury. These scales were also completed by a comparison group of 32 individuals who had no brain-injured family member. In terms of family functioning, the findings suggest that, when a family member suffers a severe traumatic brain injury, depression may be elevated, along with a decreased ability to express feelings, decreased time and energy for social and recreational activities, and increased control in comparison to families without a brain-injured member. While this might contribute to family isolation which could last for many years, the overall finding of the present study was that caregiver families were coping adequately.

scholarly journals Residual Pituitary Function after Brain Injury-Induced Hypopituitarism: A Prospective 12-Month Study

2005 ◽  
Vol 90 (11) ◽  
pp. 6085-6092 ◽  
Author(s):  
Gianluca Aimaretti ◽  
Maria Rosaria Ambrosio ◽  
Carolina Di Somma ◽  
Maurizio Gasperi ◽  
Salvatore Cannavò ◽  
...  
Keyword(s):  
Brain Injury ◽  
High Risk ◽  
Gh Deficiency ◽  
Pituitary Function ◽  
Brain Injured ◽  
Injured Patients ◽  
The Brain ◽  
Over Time

Abstract Context: Traumatic brain injury (TBI) and subarachnoid hemorrhage (SAH) are conditions at high risk for the development of hypopituitarism. Objective: The objective of the study was to clarify whether pituitary deficiencies and normal pituitary function recorded at 3 months would improve or worsen at 12 months after the brain injury. Design and Patients: Pituitary function was tested at 3 and 12 months in patients who had TBI (n = 70) or SAH (n = 32). Results: In TBI, the 3-month evaluation had shown hypopituitarism (H) in 32.8%. Panhypopituitarism (PH), multiple (MH), and isolated (IH) hypopituitarism had been demonstrated in 5.7, 5.7, and 21.4%, respectively. The retesting demonstrated some degree of H in 22.7%. PH, MH, and IH were present in 5.7, 4.2, and 12.8%, respectively. PH was always confirmed at 12 months, whereas MH and IH were confirmed in 25% only. In 5.5% of TBI with no deficit at 3 months, IH was recorded at retesting. In 13.3% of TBI with IH at 3 months, MH was demonstrated at 12-month retesting. In SAH, the 3-month evaluation had shown H in 46.8%. MH and IH had been demonstrated in 6.2 and 40.6%, respectively. The retesting demonstrated H in 37.5%. MH and IH were present in 6.2 and 31.3%, respectively. Although no MH was confirmed at 12 months, two patients with IH at 3 months showed MH at retesting; 30.7% of SAH with IH at 3 months displayed normal pituitary function at retesting. In SAH, normal pituitary function was always confirmed. In TBI and SAH, the most common deficit was always severe GH deficiency. Conclusion: There is high risk for H in TBI and SAH patients. Early diagnosis of PH is always confirmed in the long term. Pituitary function in brain-injured patients may improve over time but, although rarely, may also worsen. Thus, brain-injured patients must undergo neuroendocrine follow-up over time.

Oral-Movement Abilities and Articulatory Characteristics of Brain-Injured Adults

1974 ◽  
Vol 39 (1) ◽  
pp. 39-46 ◽  
Author(s):  
Leonard L. La Pointe ◽  
Robert T. Wertz
Keyword(s):  
Brain Injury ◽  
Apraxia Of Speech ◽  
Oral Motor ◽  
Brain Injured ◽  
History Of ◽  
Injured Patients ◽  
The Brain ◽  
Normal Adults

We compared the performance of 28 brain-injured adults who displayed articulation problems with that of 28 adults with no history of brain-injury on tests of isolated oral movement and oral-motor sequencing. An attempt was made to classify the brain-injured patients by administering an articulation test and employing three criteria for differentiating apraxia of speech from dysarthria: presence of initiation errors, more substitution errors than combined omission and distortion errors, and the presence of islands of error-free production. While the brain-injured group performed significantly worse on the isolated oral-movement and oral-motor sequencing tests than the normal adults, not all brain-injured patients demonstrated difficulty on these tasks. We were able to identify 13 patients who met all three criteria (apraxia of speech), 3 who met none (dysarthria), and 12 who met one or two but not all (mixed apraxia of speech and dysarthria). Isolated oral-movement and oral-motor sequencing deficits were found in all three groups, but no significant differences among groups on these tasks were observed.

scholarly journals Traumatic Injury to the Developing Brain: Emerging Relationship to Early Life Stress

2021 ◽  
Vol 12 ◽  
Author(s):  
Kaila N. Parker ◽  
Michael H. Donovan ◽  
Kylee Smith ◽  
Linda J. Noble-Haeusslein
Keyword(s):  
Brain Injury ◽  
Life Stress ◽  
Early Life ◽  
Brain Injuries ◽  
Traumatic Injury ◽  
Early Life Stress ◽  
Early Age ◽  
Functional Impairments ◽  
The Brain

Despite the high incidence of brain injuries in children, we have yet to fully understand the unique vulnerability of a young brain to an injury and key determinants of long-term recovery. Here we consider how early life stress may influence recovery after an early age brain injury. Studies of early life stress alone reveal persistent structural and functional impairments at adulthood. We consider the interacting pathologies imposed by early life stress and subsequent brain injuries during early brain development as well as at adulthood. This review outlines how early life stress primes the immune cells of the brain and periphery to elicit a heightened response to injury. While the focus of this review is on early age traumatic brain injuries, there is also a consideration of preclinical models of neonatal hypoxia and stroke, as each further speaks to the vulnerability of the brain and reinforces those characteristics that are common across each of these injuries. Lastly, we identify a common mechanistic trend; namely, early life stress worsens outcomes independent of its temporal proximity to a brain injury.

scholarly journals Children with Acquired Brain Injury (ABI)

2020 ◽  
Vol 11 (1) ◽  
pp. 19
Author(s):  
Daphin Nazareth Fernandez
Keyword(s):  
Brain Injury ◽  
Brain Tumour ◽  
Traffic Accidents ◽  
Brain Injuries ◽  
Road Traffic ◽  
Acquired Brain Injury ◽  
Traumatic Brain Injuries ◽  
Road Traffic Accidents ◽  
The Uk

Traumatic brain injuries following road traffic accidents, stroke, brain tumour, and its treatment constitute a large proportion of children with acquired brain injury (ABI). There are at least 35,000 children being admitted due to traumatic acquired brain injury (ABI) annually in the UK (1).

scholarly journals Circulating Tight-Junction Proteins Are Potential Biomarkers for Blood-Brain Barrier Function in a Model of Neonatal Hypoxic/Ischemic Brain Injury

2020 ◽  
Author(s):  
Axel Erik Andersson ◽  
Carina Mallard ◽  
Carl Joakim Ek
Keyword(s):  
Brain Injury ◽  
Blood Brain Barrier ◽  
Brain Injuries ◽  
Brain Barrier ◽  
Neonatal Brain ◽  
Ischemic Brain ◽  
Blood Brain ◽  
Hypoxia Ischemia ◽  
The Brain ◽  
Junction Proteins

Abstract BackgroundNeonatal hypoxia-ischemia often leads to lifelong disabilities with limited treatments currently available. The brain vasculature is an important factor in many neonatal brain pathologies but there is a lack of diagnostic tools to evaluate the brain vascular health of neonates in a clinical setting. Measurement of blood-brain barrier tight-junction proteins have shown promise as biomarkers for brain injury in the adult. Here we tested the biomarker potential of tight-junctions in the context of neonatal brain injury.MethodsThe levels of TJ-proteins (occluding, claudin-5, and zonula occludens-1) in both blood plasma and cerebrospinal fluid (CSF) as well as blood-brain barrier function were measured in a clinically relevant hypoxia/ischemia model in neonatal rats.ResultsTemporally acute elevated levels of occludin and claudin-5 could be measured in blood and CSF after hypoxia/ischemia with males generally having higher levels than females. The levels of claudin-5 in CSF correlated with the severity of the brain injury at 24h post- hypoxia/ischemia. Simultaneously, we detected early increase in blood-brain barrier-permeability at 6 and 24h after hypoxia/ischemia.ConclusionsLevels of circulating claudin-5 and occludin are increased after hypoxic/ischemic brain injuries and blood-brain barrier-impairment and have promise as early biomarkers for cerebral vascular health and as a tool for risk assessment of neonatal brain injuries.

scholarly journals P015: Efficacy of the Brain Injury Guidelines for complicated mild traumatic brain injuries

CJEM ◽  
2020 ◽  
Vol 22 (S1) ◽  
pp. S69-S70
Author(s):  
J. Tourigny ◽  
C. Malo ◽  
V. Boucher ◽  
P. Blanchard ◽  
J. Chauny ◽  
...  
Keyword(s):  
Brain Injury ◽  
Brain Injuries ◽  
Penetrating Trauma ◽  
Historical Cohort ◽  
Radiological Data ◽  
Level 1 ◽  
Head Computed Tomography ◽  
The Brain ◽  
Significant Health ◽  
Neurosurgical Intervention

Introduction: The Brain Injury Guidelines (BIG) stratifies complicated mild traumatic brain injury (mTBI) patients into 3 groups to guide hospitalization, neurosurgical consultation and repeat head-CT. BIG-1 patients could be managed safely without neurosurgical consultation or transfer. Systematic transfer to neurotrauma centers provide few benefits to this subgroup leading to overtriage. Similarly, unnecessary clinical and radiological follow-ups utilize significant health-care resources. Objective: to validate the safety and efficacy of the BIG for complicated mTBIs. Methods: We performed a multicenter historical cohort study in 3 level-1 trauma centers in Quebec. Patients ≥16 years old assessed in the Emergency Department (ED) with complicated mTBI between 2014 and 2017 were included. Patients with penetrating trauma, cerebral aneurysm or tumor were excluded. Clinical, demographic and radiological data, BIG variables, TBI-related death and neurosurgical intervention were collected using a standardized form. A second reviewer assessed all ambiguous files. Descriptive statistics, over- and under-triage were calculated. Results: A total of 342 patients’ records were assessed. Mean age was 63 ± 20,7 and 236 (69 %) were male. Thirty-five patients were classified under BIG-1 (10.2%), 110 under BIG-2 (32.2%) and 197 under BIG-3 (57.6%). Twenty-six patients (7%) required neurosurgical intervention, all were BIG-3. 90% of TBI-related deaths occurred in BIG-3 and none were classified BIG-1. Among the 192 transfers (51%), 14 were classified under BIG-1 (7.3%) and should not have been transferred according to the guidelines and 50 under BIG-2 (26%). In addition, 40% of BIG-1 received a repeat head computed tomography, although not indicated. Similarly, 7 % of all patients had a neurosurgical consult even if not required. Projected implementation of BIG would lead to 47% of overtriage and 0.3% of undertriage. Conclusion: Our results suggest that the Brain Injury Guidelines could safely identify patients with negative outcomes and could lead to a safe and effective management of complicated mTBI. Applying these guidelines to our cohort could have resulted in significantly fewer repeat head CTs, neurosurgical consults and transfers to level 1 neurotrauma centers.

Sign in / Sign up

Export Citation Format

Share Document