scholarly journals Study on the Clinical Effect and Safety of Oxycodone Hydrochloride Sustained-release Tablets in the Treatment of Advanced Malignant Tumor Pain

2017 ◽  
Vol 1 (3) ◽  
Author(s):  
Surong Song
Keyword(s):  
Sustained Release ◽  
Malignant Tumor ◽  
Clinical Effect ◽  
Endoscopic Therapy ◽  
Control Group ◽  
Study Group ◽  
Sustained Release Tablets ◽  
Male Patients ◽  
Oxycodone Hydrochloride ◽  
Tumor Pain

Objective: To investigate the clinical effect and safety of oxycodone hydrochloride sustained-release tablets in the treatment of advanced malignant tumor pain. Methods: From January 2016 to November 2016, 128 patients with advanced malignancy, 42 patients with gastric cancer, 18 patients with hepatocellular carcinoma, 35 patients with esophageal cancer and 33 patients with breast cancer were selected. All patients were randomly divided into study group and control group, 64 cases in each group, the study group of 42 male patients, 22 females, aged 32-68 years, mean 52.1 ± 1.8 years; control group of 38 male patients, female the patients in the study group received endoscopic therapy and antibiotics to prevent infection. The control group received only endoscopic therapy. Results: The pain relief rate of the study group was significantly lower than that of the control group andthe quality of life was higher than that of the control group. The incidence of adverse reactions was less in the study group than in the control group (P<0.05). Conclusion: The oxycodone hydrochloride sustained-release tablets has a significant clinical effect and a small side-effect in the treatment of advanced malignant tumor pain. It is of high clinical value.

Serum testosterone level and its relation to aggressive behavior in schizophrenia

2017 ◽  
Vol 41 (S1) ◽  
pp. s845-s846
Author(s):  
M. Zholob ◽  
S. Godinova ◽  
M. Zelman
Keyword(s):  
Aggressive Behavior ◽  
Testosterone Level ◽  
Laboratory Evaluation ◽  
Serum Testosterone Level ◽  
Control Group ◽  
Study Group ◽  
Average Value ◽  
Intergroup Comparison ◽  
History Of ◽  
Male Patients

This work is presenting partial preliminary outcomes of our study focused on evaluating the levels of testosterone in psychotic patients and its relationship to aggressive behavior.Our study group included 10 male patients (from planned 20), with history of aggressive behavior at baseline and 24 male patients (from planned 40), without history of aggressive behavior. Non-aggressive patients were considered as control group. All included patients were hospitalized in psychiatric hospital Hronovce with diagnose of psychotic disorder. Levels of testosterone were measured by laboratory evaluation. Aggressive behavior was assessed by HCR scale, which was linked with every TSH evaluation. The level of testosterone was measured in all subjects at the baseline and in the group of aggressive patients was realized next measurement after 14 days of hospitalization.According to our preliminary findings, the average level of TSH in our whole study group was 478.66 ng/dl (range from 158.06 to 767.81). The control group showed average value of TSH 486,84 ng/dl (range from 158.06 to 767.81). The group of patients with history of aggressive behavior showed average value of TSH 459.04 ng/dl (range from 191.81 to 638.02) and after 14 days of cure the levels were of average value 452.55 ng/dl (range from 253.53 to 657.92).These preliminary findings don’t show significant intergroup differences, but there are some clear casuistic declines in TSH. After collecting the envisaged group of patients we plan to correlate values of testosterone level with the score of HCR, intergroup comparison and detailed analysis (including demography, pharmacology).Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Anthropometric Assessment after Slow Breathing Exercise in Type 2 Diabetic Male Patients

2020 ◽  
Vol 5 (2) ◽  
Keyword(s):  
Statistical Significance ◽  
Control Group ◽  
Study Group ◽  
Physical And Mental Health ◽  
Anthropometric Parameters ◽  
Breathing Exercise ◽  
Male Patients ◽  
Slow Breathing ◽  
The Impact

Background: Yoga based slow breathing exercise (SBE) has several beneficial effects on physical and mental health. Objectives: To observe the impact of slow breathing exercise on anthropometric parameters in male patients with type 2 diabetes mellitus (T2DM). Methods: This prospective interventional study was conducted on sixty (60) male diagnosed T2DM patients aged 45-55 years with duration of disease 5-10 years enrolled from Out Patients Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University, and Dhaka. By simple random technique the subjects were divided into control group (n=30) and study group (n=30). Yoga based slow breathing exercise was practiced by the study group for 30 minutes twice daily for 3 months. Height, weight, body mass index (BMI), waist circumference, hip circumference and waist/hip ratio were assessed at the start of the study and after 3 months. Independent sample and paired t-test were used for statistical analysis and p<0.05was considered as statistical significance. Results: In this study the value of mean BMI was significantly (p=<0.05) reduced after 3 months of SBE. Again, all the anthropometric parameters were significantly (p=>0.05) increased after 3 months in the group who did not undergo SBE. Conclusion: Anthropometric parameters were improved after slow breathing exercise for 3 months.

scholarly journals Clinical Effect of Auricular Point Sticking in Patients with Lung Cancer Receiving Chemotherapy

2021 ◽  
Vol 5 (6) ◽  
pp. 73-77
Author(s):  
Xiaorui Zhu
Keyword(s):  
Lung Cancer ◽  
Stress Response ◽  
Adverse Reactions ◽  
Clinical Effect ◽  
Clinical Symptoms ◽  
Auricular Point Sticking ◽  
Jiangxi Province ◽  
Control Group ◽  
Study Group ◽  
Auricular Point

Objective: To discuss and analyze the clinical effect of auricular point sticking in lung cancer chemotherapy. Methods: Sixty-two patients with lung cancer treated with chemotherapy in Suqian Traditional Chinese Medicine Hospital of Jiangxi Province were selected for case evaluation and analysis. The time span of the research was from June 2020 to June 2021. The patients were divided into two groups: a study group (n = 31) and a control group (n = 31) based on their medical record numbers. All the patients were treated with conventional western medicine before and after chemotherapy to prevent adverse reactions; however, the patients in the study group were also treated with auricular point sticking in addition to the former. The relevant indexes of the two groups were compared. Results: The incidence of adverse reactions was significantly lower in the study group compared to the control group (P < 0.05); the rate of symptomatic relief of the patients in the study group was higher than that of the control group (P < 0.05); the stress response indexes toward chemotherapy of the study group were better than those of the control group (P < 0.05). Conclusion: Auricular point sticking for patients with lung cancer who are receiving chemotherapy can reduce the incidence of adverse reactions, alleviate clinical symptoms, such as chest distress, asthma, and poor appetite, significantly alleviate stress response caused by chemotherapy, as well as promote the treatment effect; thus, it is worthy of promotion.

scholarly journals Application of Cluster Intervention Strategy in Patients with Stroke Associated Pneumonia

2021 ◽  
Vol 5 (2) ◽  
Author(s):  
Hongfang Jia ◽  
Jing Hao
Keyword(s):  
Clinical Effect ◽  
Random Number ◽  
Intervention Strategy ◽  
Time Span ◽  
Control Group ◽  
Study Group ◽  
Stroke Patients ◽  
Table Model ◽  
Random Number Table

Objective: To study and analyze the clinical effect of cluster intervention strategy in patients with stroke associated pneumonia. Methods: The time span of the study was from April 2018 to March 2019. 70 stroke patients were selected and divided into the study group and the control group according to the random number table model. The control group was treated with routine nursing, and the study group was treated with cluster intervention. The indicators of the two groups were compared and analyzed. Results: Compared with the incidence of aspiration and stroke associated pneumonia, the study group had more advantages (P< 0.05). Conclusion: Cluster intervention can significantly reduce the incidence of associated pneumonia in stroke patients, which is worthy of comprehensive promotion.

Effectiveness of transcutaneous electrical nerve stimulation as an adjunct to selected physical therapy exercise program on male patients with pudendal neuralgia: A randomized controlled trial

2021 ◽  
pp. 026921552199533
Author(s):  
Marwa M Eid ◽  
Mohamed F Rawash ◽  
Moussa A Sharaf ◽  
Hadaya Mosaad Eladl
Keyword(s):  
Physical Therapy ◽  
Rating Scale ◽  
Exercise Program ◽  
Control Group ◽  
Study Group ◽  
Pain Rating ◽  
Pudendal Neuralgia ◽  
Numerical Pain Rating Scale ◽  
Male Patients ◽  
Pain Rating Scale

Objective: To assess the effectiveness of Transcutaneous Electrical Nerve Stimulation (TENS) combined with selected physical therapy exercise program on male patients with pudendal neuralgia. Design: A double-blinded randomized controlled study. Setting: Out-patient setting. Participants: Fifty-two male participants with pudendal neuralgia (30–50 years) were allocated randomly into two groups; study and control. The same physical therapy exercises were applied to all participants, plus the same prescribed analgesic medication (Etodolac). Participants in the study group received additional TENS and sham TENS were given to those in control group. Intervention: Intervention lasted for 12 weeks, three sessions per week (60 minutes/session). Outcome measures: Numerical pain rating scale and daily Etodolac intake dose were measured before and after intervention. Results: Statistically significant differences were detected in numerical pain rating scale and daily Etodolac intake in favor of the study group ( P < 0.05). After 12 weeks of intervention, the mean ± SD for numerical pain rating scale and daily Etodolac intake were 4.25 ± 1.9 and 259.25 ± 84.4 mg, in the study group, and 6.22 ± 2.22 and 355.55 ± 93.36 mg in the control group, respectively. The mean difference (95% CI) for numerical pain rating scale and daily Etodolac intake was −1.97 (−3.09: −0.83) and −96.3 (−144.9: −47.69), between groups post treatment, respectively. Conclusion: Adding TENS to physical therapy exercise program is more effective than physical therapy program alone in improving pain in male patients with pudendal neuralgia as measured by numerical pain rating scale and daily analgesic intake dose.

scholarly journals Target determination for transcranial magnetic stimulation in patients with a pharmacotherapy-resistant depressive episode based on the individual parameters of resting-state functional magnetic resonance imaging (a pilot blind controlled trial)

2019 ◽  
Vol 11 (4) ◽  
pp. 44-50
Author(s):  
A. G. Poydasheva ◽  
D. O. Sinitsyn ◽  
I. S. Bakulin ◽  
N. A. Suponeva ◽  
N. V. Maslennikov ◽  
...  
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
High Frequency ◽  
Magnetic Stimulation ◽  
Clinical Effect ◽  
Target Selection ◽  
Control Group ◽  
Study Group ◽  
Sf 36 ◽  
Before And After ◽  
Target Determination

High-frequency repetitive transcranial magnetic stimulation (rTMS) is approved by the Food and Drug Administration (FDA) for the treatment of pharmacotherapy-resistant depressive disorders (DD). Individual target determination for stimulation can be one of the approaches that can increase the efficiency of the technique. Objective: to compare of the effectiveness and tolerability of standard and personalized rTMS protocols.Patients and methods. The investigation enrolled 30 patients with pharmacotherapy-resistant DD who were pseudo-randomized into two groups matched for age, gender, and episode severity. In the study group, the target was located at a point within the left dorsolateral prefrontal cortex (DLPFC) with maximum negative functional connectivity of the subgenual cingulate cortex. In the control group, the stimulation point was 5 cm anterior to the primary motor cortex (hand area). All the patients underwent 20 sessions of high-frequency rTMS DLPFC. For clinical evaluation, the investigators used the Beck Depression Inventory (BDI) and the 36-item Short Form Health Survey (SF-36) questionnaire before and after 10 and 20 rTMS sessions, respectively. Tolerability was assessed using the standardized questionnaires during and within 24 hours after each session. Results and discussion. The study group showed a significant reduction in BDI scores and an increase in the SF-36 (“Mental Health” section) scores after both 10 and 20 rTMS sessions; the control group had those only after 20 sessions. The two groups exhibited no significant differences in the reduction of BDI scores before and after 10 and 20 sessions, respectively. The investigation can be considered to be pilot in searching for algorithms to enhance the efficiency of rTMS DLPFC in pharmacotherapy-resistant depression using the algorithm for personification of target selection. It demonstrated the more rapid onset of a clinical effect in the study group patients. No serious adverse events were reported. The patients had dizziness, headache, and contraction of the facial muscles during the session; headache and mood changes within 24 hours after it. Conclusion. In both groups, rTMS was satisfactorily tolerated and effective; however, personalized target selection accelerated the onset of a clinical effect.

Clinical Effect Analysis of Acupuncture Combined with Cupping Exercise in The Treatment of Chronic Pelvic Inflammatory Disease

2021 ◽  
Vol 7 (6) ◽  
pp. 6460-6468
Author(s):  
Xijing Yu ◽  
Xiuwu Hu ◽  
Shuisheng Hua ◽  
Rong Guo ◽  
Xiaoyan Zhu
Keyword(s):  
Pelvic Inflammatory Disease ◽  
Inflammatory Disease ◽  
Clinical Effect ◽  
Abdominal Distension ◽  
Plasma Viscosity ◽  
Inflammatory Factors ◽  
Control Group ◽  
Study Group ◽  
Clinical Effects ◽  
Significant Difference

Objective: To explore the clinical efficacy of acupuncture combined with cupping exercise in the treatment of chronic pelvic inflammation. Methods: The subjects of this study were all patients with chronic pelvic inflammation who visited our hospital from November 2018 to November 2019, a total of 90 cases. The patients were divided into control group and research group according to the single and double numbers of the beds, 45 cases in each group. The patients in the control group were treated with conventional Western medicine, while the patients in the study group were treated with acupuncture and cupping exercise, and the clinical effects of the two treatment methods were compared. Results: The total effective rate was 95.56% in the study group and 84.44% in the control group, which was significantly higher in the study group than in the control group. The data between the two groups were statistically significant (P<0.05). The scores of menstrual disorder, abdominal distension, abnormal leucorrhea and lumbosacral pain in the two groups were significantly lower than those before treatment (P<0.05), and the corresponding scores of syndromes in the study group after treatment were (1.05+0.40), (0.73+0.38), (0.74+0.24) and (0.53+0.16), which were significantly lower than those in the control group (P<0.05). The plasma viscosity and hematocrit in both groups were significantly lower than those before treatment (P<0.05). The plasma viscosity and hematocrit in the study group after treatment were (1.14+0.32) mPa * s and (0.41+0.06) %, respectively, which were significantly lower than those in the control group (P<0.05). There was no significant difference in the levels of inflammatory factors between the two groups before treatment (P>0.05). The level of inflammatory factors in the study group after treatment was (5.74 + 2.35) mg/L, which was significantly lower than that in the control group after treatment, and the difference between tne groups was statistically significant (P < 0.05). Conclusion: Acupuncture combined with cupping exercise has a very significant clinical effect in the treatment of chronic pelvic inflammatory disease, can effectively improve the TCM syndrome score of patients, and improve the hemorheology and inflammation level of patients, so it can be widely used in clinical practice.

Analysis of the Clinical Effect of Vacuum Sealing Drainage on Patients with Limb Trauma

2021 ◽  
Vol 7 (5) ◽  
pp. 1686-1690
Author(s):  
Meifang Dou ◽  
Fenghua Yan ◽  
Kemei Li ◽  
Yanbin Li ◽  
Li’an Yi
Keyword(s):  
Clinical Effect ◽  
Control Group ◽  
Study Group ◽  
Wound Area ◽  
Vacuum Sealing ◽  
Limb Trauma ◽  
Before And After ◽  
Wound Healing Effect ◽  
Dressing Change ◽  
Vacuum Sealing Drainage

To analyze the clinical effect of vacuum sealing drainage (VSD) on patients with limb trauma. Methods: 136 patients with limb trauma received by our hospital from October 2018 to October 2019 were selected as the study objects. According to the random number method, they were divided into two groups, 68 cases in each group. The control group was treated with conventional dressing change. The study group was treated with VSD to observe the wound healing effect, wound area and complications before and after treatment for 7 days. Result: After 7 days of treatment, the area of wound in the study group was significantly smaller than that in the control group, and the effect of wound treatment in the study group was significantly higher than that in the control group (P < 0.05); the incidence of complications in the study group was significantly lower than that in the control group (P < 0.05). Conclusion: VSD can effectively repair the wounds of patients with limb trauma, significantly improve the clinical treatment effect, and effectively prevent the occurrence of treatment complications, which is worth promoting.

scholarly journals The Effect of Cardiac Rehabilitation Program on Depression in Patients After Acute Coronary Events

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
S A Alsioufy ◽  
E Elfiky ◽  
A M Shabana ◽  
R Raymond
Keyword(s):  
Secondary Prevention ◽  
Cardiac Rehabilitation ◽  
Rehabilitation Program ◽  
Psychological Status ◽  
Control Group ◽  
Depression Symptoms ◽  
Study Group ◽  
Cardiac Rehabilitation Program ◽  
Male Patients ◽  
Coronary Events

Abstract Background Cardiac Rehabilitation (CR) is a multidisciplinary approach for secondary prevention of coronary heart diseases as well as its comorbid psychological disorders such as depression. Its importance is not well established like other secondary prevention measures although it is one of the most cost-effective methods. Objectives The aim of this study is to examine the effect of the cardiac rehabilitation on depression symptoms in patients after acute coronary events and potential improvement in patient prognosis and reduction of overall morbidity and mortality. Methods This analysis is a double armed intervention study that was conducted in the period between March 2018 and August 2018 on 60 patients who were referred to the CR clinic after surviving acute coronary events. Patient selection was done so that a study group of 30 patients who completed the CR program and a control group of 30 patients who dropped out early from the CR program were included. It included mainly Egyptian patients who were referred the Ain Shams University Hospital CR clinic. The patients were studied as regard their full history and examination, and their psychological status was assessed using the Patient Health Questionnaire 9 (PHQ-9) before and after the rehabilitation program. Verbal consent was taken from each patient, confidentiality was ensured, patients were informed about findings in their results and they had the right to refuse inclusion Results The study included a majority of male patients: 51 male patients (85%) and 9 female patients (16.5%). The mean age was 52 years. 15% of the patients were diabetic and 40% hypertensive, 46.7% were smokers and 48.3% were dyslipidemic. There was no statistically significant correlation between age, gender and risk factors and whether or not the patients completed the cardiac rehabilitation program or dropped out. Most patients were presenting after anterior STEMI (63.3%) followed by inferior STEMI (21.7%) with a minority of NSTE-ACS patients (15%). There was a statistically significant effect of the CR on the CCS class but not on the NYHA class. The median PHQ-9 score before joining the program in the control group of 15.5, while that of the study group ranged from 8 to 20 with a median of 13, which was a significantly different score (P 0.03). Right after finishing the program the study groups PHQ-9 score median was 6.5. Three months after the beginning of the CR program the median PHQ-9 score was 23.5 and 0 for the control group. The change of the PHQ-9 over the course of 3 month from the beginning of the CR program was significantly improved for the study group with (P 0.00) and the median PHQ-9 score decreased from 13 to 0, while the control groups PHQ-9 score significantly deteriorated with a median score changing from 15.5 to 23.5. Conclusion CR is a highly effective method in reduction of the comorbid depression in coronary disease patient and should be recommended as a routine management after acute coronary events.

scholarly journals Clinical Study on Treatment of Patients with Acute Cerebral Infarction by Huayu Tongluo Decoction Combined with Edaravone Injection

2020 ◽  
Vol 185 ◽  
pp. 03011
Author(s):  
Wentao Zhang ◽  
Ping Zuo ◽  
Feng Wang ◽  
Zhihua Liu ◽  
Yinglin Cui
Keyword(s):  
Quality Of Life ◽  
Cerebral Infarction ◽  
Clinical Effect ◽  
Clinical Symptoms ◽  
Effective Rate ◽  
Acute Cerebral Infarction ◽  
Control Group ◽  
Study Group ◽  
Nihss Score

To study the clinical effect of Huayu Tongluo Decoction combined with edaravone injection in the treatment of patients with acute cerebral infarction.86 patients with acute cerebral infarction received from our hospital from October 2016 to May 2018 were randomly divided into study group (n=43) and control group (n=43). Routine treatment was performed in both groups. On the basis of this, the control group was treated with edaravone injection, and the research group was treated with Huayu Tongluo Decoction combined with edaravone injection. The effects of treatment, the degree of neurological deficit (NIHSS score), TCM syndrome scores and quality of life (QLI score) before and after treatment were compared. The total effective rate of the study group [95.35% (41/43)] was higher than that of the control group [79.07% (34/43)] (P<0.05). After treatment, the main symptoms, secondary diseases and tongue and pulse of the two groups were treated. The scores were lower than before treatment, and the study group was lower than the control group (P<0.05). After treatment, the NIHSS and QLI scores of the two groups were better than before treatment, and the NIHSS score of the study group was lower than that of the control group, and the QLI score was higher than the control. Group (P<0.05). The clinical effect of Huayu Tongluo Decoction combined with edaravone injection in the treatment of patients with acute cerebral infarction is significant, which can further improve the clinical symptoms, improve neurological function and improve the quality of life.

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