scholarly journals Analysis on the Clinical Characteristics of 10 Cases of Asymptomatic SARS-CoV-2 Novel Coronavirus Infection

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Lijun Chen ◽  
Xiaoyong Ma ◽  
Juanxia Chen ◽  
Liting Ma
Keyword(s):  
Clinical Features ◽  
Asymptomatic Infection ◽  
Chest Ct ◽  
Clinical Classification ◽  
Asymptomatic Group ◽  
Ct Examination ◽  
Asymptomatic Patients ◽  
Significant Difference ◽  
The Difference ◽  
Novel Coronavirus

Objective: To analyze the clinical features of asymptomatic patients infected with the SARS-CoV-2 novel coronavirus. Methods: The clinical data of 10 asymptomatic cases and 12 symptomatic cases of COVID-19 diagnosed during February 2020 to April 2020 was collected and the clinical features of the two groups of patients were compared. Results: 10 cases of asymptomatic infection and 12 cases of symptomatic patients were tested positive for the novel coronavirus nucleic acid test. There was no significant difference in gender distribution between the two groups (P?0.05); the average age of patients in the asymptomatic group was lower than that of the symptomatic group ( P?0.05), the difference in clinical classification between the two groups was statistically significant (P?0.05); there was no statistically significant difference in the results of chest CT examination involving lung lobes between the two groups (P?0.05), and there was no statistically significant difference in mortality between the two groups (P>0.05). Conclusion: The average age of asymptomatic novel coronavirus infections was lower than that of confirmed cases of COVID-19, mainly among young people. There was no significant difference in clinical classification, mortality and chest CT examination results between symptomatic and asymptomatic cases.

scholarly journals 458. Molecular SARS-CoV-2 Testing During the COVID-19 Outbreak: Experiences of a Hospital in Southeast Michigan, USA

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S296-S297
Author(s):  
Trini A Mathew ◽  
Jonathan Hopkins ◽  
Diane Kamerer ◽  
Shagufta N Ali ◽  
Daniel Ortiz ◽  
...  
Keyword(s):  
Clinical Features ◽  
Diagnostic Testing ◽  
Beaumont Hospital ◽  
High Capacity ◽  
Turnaround Time ◽  
Molecular Diagnostic ◽  
The Novel ◽  
Repeat Testing ◽  
Asymptomatic Patients ◽  
Novel Coronavirus

Abstract Background The novel Coronavirus SARS CoV-2 (COVID-19) outbreak was complicated by the lack of diagnostic testing kits. In early March 2020, leadership at Beaumont Hospital, Royal Oak Michigan (Beaumont) identified the need to develop high capacity testing modalities with appropriate sensitivity and specificity and rapid turnaround time. We describe the molecular diagnostic testing experience since initial rollout on March 16, 2020 at Beaumont, and results of repeat testing during the peak of the COVID-19 pandemic in MI. Methods Beaumont is an 1100 bed hospital in Southeast MI. In March, testing was initially performed with the EUA Luminex NxTAG CoV Extended Panel until March 28, 2020 when testing was converted to the EUA Cepheid Xpert Xpress SARS-CoV-2 for quicker turnaround times. Each assay was validated with a combination of patient samples and contrived specimens. Results During the initial week of testing there was > 20 % specimen positivity. As the prevalence grew the positivity rate reached 68% by the end of March (Figure 1). Many state and hospital initiatives were implemented during the outbreak, including social distancing and screening of asymptomatic patients to increase case-finding and prevent transmission. We also adopted a process for clinical review of symptomatic patients who initially tested negative for SARS-CoV-2 by a group of infectious disease physicians (Figure 2). This process was expanded to include other trained clinicians who were redeployed from other departments in the hospital. Repeat testing was performed to allow consideration of discontinuation of isolation precautions. During the surge of community cases from March 16 to April 30, 2020, we identified patients with negative PCR tests who subsequently had repeat testing based on clinical evaluation, with 7.1% (39/551) returning positive for SARS- CoV2. Of the patients who expired due to COVID-19 during this period, 4.3% (9/206) initially tested negative before ultimately testing positive. Figure 1 BH RO testing Epicurve Figure 2: Screening tool for repeat COVID19 testing and precautions Conclusion Many state and hospital initiatives helped us flatten the curve for COVID-19. Our hospital testing experience indicate that repeat testing may be warranted for those patients with clinical features suggestive of COVID-19. We will further analyze these cases and clinical features that prompted repeat testing. Disclosures All Authors: No reported disclosures

scholarly journals A Comparative Study on the Clinical Features of Coronavirus 2019 (COVID-19) Pneumonia With Other Pneumonias

2020 ◽  
Vol 71 (15) ◽  
pp. 756-761 ◽  
Author(s):  
Dahai Zhao ◽  
Feifei Yao ◽  
Lijie Wang ◽  
Ling Zheng ◽  
Yongjun Gao ◽  
...  
Keyword(s):  
Clinical Features ◽  
Clinical Symptoms ◽  
Severe Pneumonia ◽  
Ground Glass Opacity ◽  
Chest Ct ◽  
Rt Pcr ◽  
Bilateral Involvement ◽  
Radiological Features ◽  
History Of ◽  
Novel Coronavirus

Abstract Background A novel coronavirus (COVID-19) has raised world concern since it emerged in Wuhan, China in December 2019. The infection may result in severe pneumonia with clusters of illness onsets. Its impacts on public health make it paramount to clarify the clinical features with other pneumonias. Methods Nineteen COVID-19 and 15 other patients with pneumonia (non-COVID-19) in areas outside of Hubei were involved in this study. Both COVID-19 and non-COVID-19 patients were confirmed to be infected using throat swabs and/or sputa with/without COVID-2019 by real-time RT-PCR. We analyzed the demographic, epidemiological, clinical, and radiological features from those patients, and compared the differences between COVID-19 and non-COVID-19. Results All patients had a history of exposure to confirmed cases of COVID-19 or travel to Hubei before illness. The median (IQR) duration was 8 (6–11) and 5 (4–11) days from exposure to onset in COVID-19 and non-COVID-19 cases, respectively. The clinical symptoms were similar between COVID-19 and non-COVID-19. The most common symptoms were fever and cough. Fifteen (78.95%) COVID-19 but 4 (26.67%) non-COVID-19 patients had bilateral involvement while 17 COVID-19 patients (89.47%) but 1 non-COVID-19 patient (6.67%) had multiple mottling and ground-glass opacity on chest CT images. Compared with non-COVID-19, COVID-19 presents remarkably more abnormal laboratory tests, including AST, ALT, γ-GT, LDH, and α-HBDH. Conclusions The COVID-19 infection has onsets similar to other pneumonias. CT scan may be a reliable test for screening COVID-19 cases. Liver function damage is more frequent in COVID-19 than non-COVID-19 patients. LDH and α-HBDH may be considerable markers for evaluation of COVID-19.

Application of CT Image in Diagnosis of Pulmonary Tuberculosis

2020 ◽  
Vol 10 (4) ◽  
pp. 868-872
Author(s):  
Yulei Wan ◽  
Jiwei Xiao ◽  
Dawei Wang ◽  
Xiaoyan Wang ◽  
Ying Liu ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Detection Rate ◽  
Lower Lobe ◽  
Spiral Ct ◽  
Clinical Classification ◽  
Basal Segment ◽  
X Ray ◽  
Ct Examination ◽  
The Difference

In order to study the diagnosis of computed tomography (CT) image-assisted pulmonary tuberculosis patients, patients who are diagnosed as tuberculosis in Wuhan No. 6 Hospital Affiliated to Jianghan University are selected as a research object, and multi-slice spiral CT and routine X-ray examination are performed. By analyzing and comparing multi-slice spiral CT and routine X-ray examination, the diagnostic value of tuberculosis is evaluated and the detection rate of lesions in the lung and clinical classification of tuberculosis are also evaluated (including the anterior segment of the upper lobe, the posterior segment of the superior lobe, the dorsal segment of the lower lobe, the basal segment of the lower lobe, and concealment). The results show that compared with conventional X-ray examination, the sensitivity and accuracy of multi-slice spiral CT examination for diagnosis of pulmonary tuberculosis are higher, and the difference is statistically significant. In the upper part of the upper lobe, the posterior part of the upper lobe, the lower part of the lower lobe, and the tuberculosis lesions in the basal segment and hidden part of the lower lobe, the detection rate of multi-slice spiral CT examination is significantly higher than the X-ray examination, and the difference is statistically significant. In the diagnosis of tuberculosis classification, the misdiagnosis rate of multi-slice spiral CT examination is significantly lower than the conventional X-ray examination, and the difference is statistically significant. Therefore, CT images have important reference value in the diagnosis of tuberculosis, the examination of lesions, and the clinical classification of tuberculosis. Although there are still some shortcomings in the research process, it still provides some basis and ideas for more precise research.

scholarly journals A study on the demographic, clinical, and radiological profile of lineage B.1.1.7 (United Kingdom) strain Covid-19 patients at Telangana institute of medical sciences and research, Hyderabad

2022 ◽  
Vol 13 (1) ◽  
pp. 13-18
Author(s):  
Jayasri Helen Gali ◽  
Manasa Musku ◽  
Devireddy Pallavi Reddy ◽  
Vimala Thomas ◽  
Ehsan Ahmed Khan
Keyword(s):  
United Kingdom ◽  
Statistical Tests ◽  
Medical Sciences ◽  
Rt Pcr ◽  
Asymptomatic Group ◽  
Cross Sectional ◽  
The People ◽  
Asymptomatic Patients ◽  
Significant Difference ◽  
The Uk

Background: Emergence of variants with specific mutations in key epitopes in the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) raises concerns pertinent to its severity. Aims and Objectives: To assess the demographics, clinico-radiological pattern, and outcome of reverse transcription-polymerase chain reaction (RT-PCR) positive isolated coronavirus disease 2019 (COVID-19) patients arrived from the United Kingdom (UK). Materials and Methods: A cross-sectional, observational study was conducted in RT-PCR positive COVID-19 patients arrived from the UK, from December 2020 to February 2021. Nasopharyngeal samples of all patients were sent for whole-genome sequencing of SARS-CoV-2. The aimed parameters were compared between the B.1.17 positive and non-B.1.1.7 groups, among the people, arrived from the UK. All statistical tests with P<0.05 were considered significant. Results: A total of 59 SARS-CoV2 infected patients, who arrived from the UK, were isolated from December 2020 to February 2021 at Telangana Institute of Medical Sciences hospital, Hyderabad, were enrolled in the study. Of these, 27 patients (mean age-31.81±11.28 years) were infected with the B.1.1.7, diagnosed by whole genomic sequencing. Males were predominant in our study. Personal habits such as smoking, alcohol intake were higher among the sequenced group with a significant P<0.05. The most common symptoms observed in the sequenced group were cough (22.22%), sore throat (22.22%), cold (11.11%), fever (11.11%), and in the unsequenced group were cough (22.22%), cold (6.25%), fever (6.25%). In the sequenced group, chest X-ray posteroanterior view was normal in 74%, patchy ground-glass opacities was observed in 25.92% patients, whereas in the unsequenced group it was 84.37% and 15.62%, respectively. Asymptomatic patients, observed in the sequenced and unsequenced group were 48.18% and 78.12%, respectively, and symptomatic patients were 51.85% and 21.87%, respectively. We found a statistically significant difference between sequenced and unsequenced patients in the asymptomatic group with a significant P<0.05. In the sequenced and unsequenced group, mild cases were 48.18% and 18.75%, moderate cases were 3.7% and 3.12%, respectively. We found no evidence of an association between disease severity and lineage B.1.17. Conclusion: Our data, within the context and limitations of a real-world study, provide initial reassurance that severity in hospitalized patients with B.1.1.7 is not markedly different from severity in those without B.1.1.7.

scholarly journals Epidemiological characteristics and the effectiveness of countermeasures to control coronavirus disease 2019 in Ningbo City, China

2020 ◽  
Author(s):  
Xuying Lao ◽  
Li Luo ◽  
Zhao Lei ◽  
Ting Fang ◽  
Yi Chen ◽  
...  
Keyword(s):  
Attack Rate ◽  
Asymptomatic Infection ◽  
Assessment Data ◽  
Exact Test ◽  
Imported Cases ◽  
Asymptomatic Infections ◽  
The Difference ◽  
Novel Coronavirus ◽  
Epidemiological Characteristics ◽  
High Disease Burden

Abstract Background: A novel coronavirus (SARS-CoV-2) has spread widely and led to high disease burden around the world. This study aimed to explore key parameters of SARS-CoV-2 infection and to assess the effectiveness of interventions to control the coronavirus disease 2019 (COVID-19).Methods: A susceptible – exposed – infectious – asymptomatic – recovered (SEIAR) model was developed for the assessment. Data of symptomatic and asymptomatic infection of SARS-CoV-2 were collected to calculate the key parameters of the model in Ningbo City, China.Results: A total of 157 confirmed COVID-19 cases (including 51 imported cases and 106 secondary cases) and 30 asymptomatic infections were reported in Ningbo City. The proportion of asymptomatic has an increasing trend. The proportion of asymptomatic of elder people was lower than younger people, and the difference was statistical significant (Fisher’s Exact Test, P = 0.034). There were 22 clusters associated with 167 SARS-CoV-2 infections, among which 29 cases were asymptomatic, with a proportion of 17.37%. We found that the secondary attack rate of asymptomatic was almost the same as that of symptomatic cases, and no significance was observed (χ2 = 1.350, P = 0.245) by Kruskal-Wallis test. The effective reproduction number (Reff) was 1.43 which revealed that the transmissibility of SARS-CoV-2 was moderate. If the interventions were not strengthened, the duration of the outbreak would last about 16 months with a simulated attack rate of 44.15%. The total attack rate and duration of the outbreak would increase along with the increasing delay of intervention.Conclusions: SARS-CoV-2 had moderate transmissibility in Ningbo City, China. Asymptomatic infection has the same transmissibility as symptomatic. The integrated interventions were implemented at different stages during the outbreak, which found to be exceedingly effective in China.

scholarly journals Molecular epidemiology of SARS-CoV-2 clusters caused by asymptomatic cases in Anhui Province, China

2020 ◽  
Author(s):  
yuan yuan ◽  
Jun He ◽  
Lei Gong ◽  
Weiwei Li ◽  
Liangliang Jiang ◽  
...  
Keyword(s):  
Disease Transmission ◽  
Close Contact ◽  
Control Strategies ◽  
Asymptomatic Infection ◽  
Droplet Spreading ◽  
Close Link ◽  
Spike Gene ◽  
Asymptomatic Patients ◽  
Asymptomatic Infections ◽  
Novel Coronavirus

Abstract Background: COVID-19 is a newly emerging disease caused by a novel coronavirus (SARS-CoV-2), which spread globally in early 2020. Asymptomatic carriers of the virus contribute to the propagation of this disease, and the existence of asymptomatic infection has caused widespread fear and concern in the control of this pandemic.Methods: In this study, we investigated the origin and transmission route of SARS-CoV-2 in Anhui’s two clusters, analyzed the role and infectiousness of asymptomatic patients in disease transmission, and characterized the complete spike gene sequences in the Anhui strains.Results: We conducted an epidemiological investigation of two clusters caused by asymptomatic infections sequenced the spike gene of viruses isolated from 12 patients. All cases of the two clusters we investigated had clear contact histories, both from Wuhan, Hubei province. The viruses isolated from two outbreaks in Anhui were found to show a genetically close link to the virus from Wuhan. In addition, new single nucleotide variations were discovered in the spike gene.Conclusions: Both clusters may have resulted from close contact and droplet-spreading and asymptomatic infections were identified as the initial cause. We also analyzed the infectiousness of asymptomatic cases and the challenges to the current epidemic to provided information for the development of control strategies.

scholarly journals Transmission and clinical characteristics of asymptomatic patients with SARS-CoV-2 infection

2020 ◽  
Vol 15 (6) ◽  
pp. 373-380 ◽  
Author(s):  
Jie Tan ◽  
Shousheng Liu ◽  
Likun Zhuang ◽  
Lizhen Chen ◽  
Mengzhen Dong ◽  
...  
Keyword(s):  
Viral Load ◽  
Clinical Features ◽  
Theoretical Basis ◽  
Clinical Characteristics ◽  
Transmission Characteristics ◽  
Asymptomatic Carriers ◽  
Source Of Infection ◽  
Asymptomatic Patients ◽  
Novel Coronavirus

The 2019 novel coronavirus disease, SARS-CoV-2, is now spreading globally and is characterized by person-to-person transmission. However, it has recently been found that individuals infected with SARS-CoV-2 can be asymptomatic, and simultaneously a source of infection in others. The viral load detected in nasopharyngeal swabs of asymptomatic carriers is relatively high, with a great potential for transmission. More attention should be paid to the insidious spread of disease and harm contributed by asymptomatic SARS-CoV-2 carriers. To provide a theoretical basis for the accurate and early clinical identification of asymptomatic patients, this review objectively summarizes the epidemic status, transmission characteristics and clinical features of asymptomatic patients with SARS-CoV-2 infection.

scholarly journals Correlation Between Chest CT Findings and Clinical Features of 211 COVID-19 Suspected Patients in Wuhan, China

2020 ◽  
Vol 7 (6) ◽  
Author(s):  
Songlin Song ◽  
Feihong Wu ◽  
Yiming Liu ◽  
Hongwei Jiang ◽  
Fu Xiong ◽  
...  
Keyword(s):  
Clinical Features ◽  
Area Under The Curve ◽  
High Sensitivity ◽  
Pulmonary Involvement ◽  
Chest Ct ◽  
Chain Reaction ◽  
Basic Model ◽  
Group 4 ◽  
Significant Difference ◽  
Polymerase Chain

Abstract Background Chest computed tomography (CT) has been widely used to assess pulmonary involvement in COVID-19. We aimed to investigate the correlation between chest CT and clinical features in COVID-19 suspected patients with or without fever. Methods We retrospectively enrolled 211 COVID-19 suspected patients who underwent both chest CT and reverse transcription polymerase chain reaction in Wuhan, China. The performance of CT in patients with relevant onset of symptoms, with fever (n = 141) and without fever (n = 70), was assessed respectively. Results The sensitivity of CT for COVID-19 was 97.3%, with area under the curve (AUC) of 0.71 (95% confidence interval [CI], 0.66–0.76). There were 141 suspected patients with fever and 70 without fever. In the fever group, 4 variables were screened to establish the basic model: age, monocyte, red blood cell, and hypertension. The AUC of the basic model was 0.72 (95% CI, 0.63–0.81), while the AUC of the CT-aided model was 0.77 (95% CI, 0.68–0.85), a significant difference (P &lt; .05). In the nonfever group, only dry cough was screened out to establish the basic model. The AUC was 0.76 (95% CI, 0.64–0.88), which was not significantly different than the CT-aided model (P = .08). Conclusions Chest CT has a high sensitivity in patients with COVID-19, and it can improve diagnostic accuracy for COVID-19 suspected patients with fever during the initial screen, whereas its value for nonfever patients remains questionable.

Lack of gender differences in familial schizophrenia

1997 ◽  
Vol 14 (4) ◽  
pp. 128-131
Author(s):  
Bernadette M Murphy ◽  
John G Burke ◽  
Joseph C Bray ◽  
Dermot Walsh ◽  
Kenneth S Kendler
Keyword(s):  
Gender Differences ◽  
Clinical Features ◽  
Negative Symptoms ◽  
Age At Onset ◽  
Gender Effects ◽  
Final Sample ◽  
Significant Difference ◽  
Schizophrenic Patients ◽  
Males And Females ◽  
The Difference

AbstractObjective: Gender appears to have a significant impact on the prevalence, age at onset, symptoms and outcome of schizophrenia. This study examines gender effects in a population of familial schizophrenic patients in Ireland.Method: Families with two or more siblings suffering from schizophrenia, as defined by DSM-III-R were ascertained in Ireland. The final sample comprised 169 siblings from 80 families. Siblings were interviewed using the Structured Clinical Interview for DSM-III-R (SCID), the Scale for the Assessment of Negative Symptoms (SANS) and the Strauss-Carpenter Levels of Functioning Scale. The difference between males and females for various clinical features were calculated.Result: There was a marked excess of affected males (65% male and 35% female). When the excess of male subjects was taken into account there was no significant excess of same-sex as compared to opposite-sex pairs. There were no significant difference between males and females for age at onset, age at first admission, symptoms or level of outcome.Conclusion: The excess of males and the lack of gender differences for clinical features found in this study may, in part, be due to the narrow diagnostic criteria used. Alternatively, at least some of these findings may be specific to this Irish sample. Further research is a need to see if these findings can be replicated in other countries.

scholarly journals Collateral perfusion using arterial spin labeling in symptomatic versus asymptomatic middle cerebral artery stenosis

2017 ◽  
Vol 39 (1) ◽  
pp. 108-117 ◽  
Author(s):  
Xin Lou ◽  
Xiaoxiao Ma ◽  
David S Liebeskind ◽  
Ning Ma ◽  
Chenglin Tian ◽  
...  
Keyword(s):  
Middle Cerebral Artery ◽  
Cerebral Artery ◽  
Arterial Spin Labeling ◽  
Three Dimensional ◽  
Spin Labeling ◽  
Asymptomatic Group ◽  
Asymptomatic Patients ◽  
The Difference ◽  
Continuous Arterial Spin Labeling ◽  
Antegrade Flow

The purpose was to assess the difference of collaterals in symptomatic versus asymptomatic patients with unilateral middle cerebral artery (MCA) stenosis by comparing cerebral blood flow (CBF) at two post labeling delays (PLD) using three-dimensional pseudo-continuous arterial spin labeling (3D pCASL). Eighty-one patients (49 symptomatic and 32 asymptomatic) with unilateral MCA stenosis ≥50% who underwent pCASL with two PLDs were included. Mean CBF and CBF subtraction images between two PLDs of MCA territories were compared in symptomatic and asymptomatic groups, respectively. Compared with the asymptomatic group, patients with symptomatic MCA stenosis had significantly lower CBF in the MCA territory of stenotic side at each PLD. The CBF of stenotic territory showed greater increase than that of normal side from PLD 1.5 to 2.5 s. The CBF of asymptomatic MCA territory increased similarly with that of symptomatic MCA territory from PLD of 1.5 to 2.5 s in stenotic side, while symptomatic patients experienced significantly slower antegrade flow. On CBF subtraction images, asymptomatic patients showed larger volume of differences between PLD of 1.5 and 2.5 s compared with those of symptomatic patients ( p = 0.037). The results suggest that more robust collateral perfusion on two-delay 3D pCASL is present in asymptomatic patients compared with symptomatic patients.

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