scholarly journals The Diagnostic Value of Multislice Computed Tomography (MSCT) and Semiotics of Lung Tissue Damage in the Early Stages of Clinical Manifestations of СOVID-19

Author(s):  
Petr M Kotlyarov
Author(s):  
Дмитрий Валериевич Судаков ◽  
Олег Валериевич Судаков ◽  
Артём Николаевич Шевцов ◽  
Евгений Владимирович Белов ◽  
Оксана Александровна Андросова

Статья посвящена анализу возникающих осложнений различных органов и систем органов у пациентов перенесших новую коронавирусную инфекцию. Данная тематика в настоящее время представляет большой интерес для врачей самых разнообразных специальностей. Подобный интерес обусловлен тем, что пандемия Covid-19 возникла лишь в 2020 году. Врачам и ученым, несмотря на все прилагаемые ими усилия еще не удалось полностью расшифровать природу вирусной инфекции, не удалось определить все аспекты этиологии и патогенеза. В настоящее время множество ресурсов различного плана практически во всех странах мира направлены, как на решение данных аспектов, так и на изучение основных клинических проявлений новой коронавирусной инфекции, вариантов ее лечения и предупреждения возможных осложнений, изучение которых и стало целью данной работы. Объектами исследования послужило 200 пациентов, мужчин и женщин трудоспособного возраста, перенесших Covid-19 и обращающихся в стационар и в поликлинику с различными жалобами. Все больные были разделены на 4 группы по 50 человек. 1 группу составили пациенты, которые перенесли данную инфекцию бессимптомно или в легкой форме, зачастую узнав о болезни по результатам определения антител в крови (иммуноглобулины G). 2 группу составили больные, которым был поставлен диагноз «пневмония» 1 степени (по объему поражения легочной ткани). 3 группу составили пациенты, которым был поставлен диагноз «пневмония» 2 степени (по объему поражения легочной ткани). 4 группу составили больные, которым был поставлен диагноз «пневмония» 3 степени (по объему поражения легочной ткани). Было установлено, что наиболее часто встречались осложнения дыхательной, сердечно-сосудистой и пищеварительной систем. Осложнения на нервную систему, опорно-двигательную и выделительную у данных испытуемых встречались гораздо реже. При этом по отдельным нозологиям и симптомам наиболее часто выделяли: дыхательная система - кашель и одышка при физической нагрузки (которой ранее не наблюдалось); сердечно-сосудистая система - боли в области сердца и различные нарушения ритма; пищеварительная система - симптоматика панкреатита и холецистита. Подобное исследование может быть интересным не только для врачей, занимающихся лечением пациентов с Covid-19, но и для врачей, занимающихся лечением последствий данной инфекции The article is devoted to the analysis of emerging complications of various organs and organ systems in patients who have undergone a new coronavirus infection. This topic is currently of great interest for doctors of various specialties. This interest is due to the fact that the Covid-19 pandemic only emerged in 2020. Doctors and scientists, despite all their efforts, have not yet been able to fully decipher the nature of the viral infection, have not been able to determine all aspects of the etiology and pathogenesis. Currently, many resources of various kinds in almost all countries of the world are aimed both at solving these aspects and at studying the main clinical manifestations of a new coronavirus infection, options for its treatment and prevention of possible complications, the study of which became the purpose of this work. The objects of the study were 200 patients, men and women of working age, who had undergone Covid-19 and went to a hospital and a polyclinic with various complaints. All patients were divided into 4 groups of 50 people. Group 1 consisted of patients who underwent this infection asymptomatically or in a mild form, often learning about the disease by the results of the determination of antibodies in the blood (immunoglobulins G). Group 2 consisted of patients who were diagnosed with pneumonia of the 1st degree (by the volume of lung tissue damage). Group 3 consisted of patients who were diagnosed with grade 2 pneumonia (by the volume of lung tissue damage). Group 4 consisted of patients who were diagnosed with grade 3 pneumonia (by the volume of lung tissue damage). It was found that the most common complications of the respiratory, cardiovascular and digestive systems. Complications of the nervous system, musculoskeletal and excretory systems were much less common in these subjects. At the same time, according to individual nosologies and symptoms, the following were most often distinguished: respiratory system - cough and shortness of breath during physical exertion (which was not previously observed); cardiovascular system - pain in the heart and various rhythm disturbances; digestive system - symptoms of pancreatitis and cholecystitis. Such a study may be interesting not only for doctors treating patients with Covid-19, but also for doctors treating the consequences of this infection


2020 ◽  
Vol 03 (04) ◽  
pp. 43-46
Author(s):  
Sabir Nurgalam Amiraliev ◽  

Studies have shown that the severity and outcome of acute pneumonia largely depends on the prevalence of the focus of inflammation in the lung tissue, which is determined radiologically. We analyzed and determined a statistically significant effect of the degree of lung tissue damage on the severity and prognosis of pneumonia in young children, taking into account the conditions of infection. In pneumonia, χ² = 47.13 (p <0.001), indicates that the greater the degree of damage, the greater the likelihood of a severe course and unfavorable outcome of pneumonia. Key words: pneumonia, severity of the course, outcome, young children


2017 ◽  
Vol 17 (1) ◽  
pp. 22
Author(s):  
Arini Pradita Roselyn ◽  
Endang Linirin Widiastuti ◽  
G. Nugroho Susanto ◽  
Sutyarso '

Lung cancer is a disease that causes high mortality. Drugs used to prevent and cure cancer mostly causes intoxicity to the normal tissues due to its less effectiveness. Therefore, it is necessary to find out any agent or substance which works much more effective and safe for cancer treatment. The aim of the study was to elucidate the role of taurine on the lung tissue of mice (Mus musculus) induced by carcinogenic benzo(α)pyrene. The experiment was conducted in a completely randomized design with 5 replications. Six treatment groups were perfomed. Group I was given 0.2 mL of corn oil and given aquadest until the end of the study period, group II was induced by benzo(α)pyrene without administration of taurine, group III before induced with benzo(α)pyrene, was given taurine dosage 7.8 mg/BW/day for two weeks, group IV after induced benzo(α)pyrene, was given taurine with dosage 3.9 mg/BW/day, group V after induced benzo(α)pyrene, was given taurine with dosage7. 8 mg/BW/day, group VI after induced with benzo(α)pyrene, was given taurine with dosage 15.6 mg/BW/day. The results of the Kruskal-Wallis analysis and one way ANOVA with LSD (p>0,05) showed that taurine reduced lung tissue damage 72.73% due to the administration of benzo(α)pyrene of 0.3 mg/BW/day. In addition, the effective dose of taurine reduce lung tissue damage was 15.6 mg/BW/day.


1991 ◽  
Vol 16 (4) ◽  
pp. 733-741
Author(s):  
VALDEMAR KOBRLE ◽  
JOSEF HURYCH ◽  
MIROSLAV CIKRT ◽  
MARK M. JONES

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