scholarly journals "Serum Calcium in Relation to COVID-19 in Asian Population: A Two-Sample Mendelian Randomization Study"

2021 ◽  
Vol 40 (1) ◽  
Author(s):  
LiLi Wang
Keyword(s):  
Serum Calcium ◽  
Mendelian Randomization ◽  
Asian Population

Serum calcium changes and risk of type 2 diabetes mellitus in Asian population

2017 ◽  
Vol 133 ◽  
pp. 109-114 ◽  
Author(s):  
Sunghwan Suh ◽  
Ji Cheol Bae ◽  
Sang-Man Jin ◽  
Jae Hwan Jee ◽  
Mi Kyoung Park ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Serum Calcium ◽  
Asian Population

scholarly journals Mendelian randomization study of telomere length and lung cancer risk in East Asian population

2019 ◽  
Vol 8 (17) ◽  
pp. 7469-7476
Author(s):  
Xuguang Cao ◽  
Mingtao Huang ◽  
Meng Zhu ◽  
Rui Fang ◽  
Zijian Ma ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Telomere Length ◽  
Lung Cancer Risk ◽  
Mendelian Randomization ◽  
East Asian ◽  
Asian Population ◽  
East Asian Population

scholarly journals Genetically increased serum calcium levels reduce Alzheimer’s disease risk

2018 ◽  
Author(s):  
Qinghua Jiang ◽  
Yang Hu ◽  
Shuilin Jin ◽  
Guiyou Liu
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Genetic Association ◽  
Serum Calcium ◽  
Genetic Variants ◽  
Large Scale ◽  
Mendelian Randomization ◽  
European Descent ◽  
Gwas Dataset ◽  
Weighted Median

AbstractIMPORTANCE Alzheimer’s disease (AD) is the leading cause of disability in the elderly. It has been a long time about the calcium hypothesis of AD on the basis of emerging evidence since 1994. However, most studies focused on the association between calcium homeostasis and AD, and concerned the intracellular calcium concentration. Only few studies reported reduced serum calcium levels in AD. Until now, it remains unclear whether serum calcium levels are genetically associated with AD risk.OBJECTIVE To evaluate the genetic association between increased serum calcium levels and AD riskDESIGN, SETTING, AND PARTICIPANTS We performed a Mendelian randomization study to investigate the association of increased serum calcium with AD risk using the genetic variants from the large-scale serum calcium genome-wide association study (GWAS) dataset (N=61,079 individuals of European descent) and the large-scale AD GWAS dataset (N=54,162 individuals including 17,008 AD cases and 37,154 controls of European descent). Inverse-variance weighted meta-analysis (IVW) was used to provide a combined estimate of the genetic association. Meanwhile, we selected the weighted median regression and MR-Egger regression as the complementary analysis methods to examine the robustness of the IVW estimate.EXPOSURES Genetic predisposition to increased serum calcium levelsMAIN OUTCOMES AND MEASURES The risk of AD.RESULTS We selected 6 independent genetic variants influencing serum calcium levels as the instrumental variables. IVW analysis showed that a genetically increased serum calcium level (per 1 standard deviation (SD) increase 0.5-mg/dL) was significantly associated with a reduced AD risk (OR=0.56, 95% CI: 0.34-0.94, P=5.00E-03). Meanwhile, both the weighted median estimate (OR=0.60, 95% CI: 0.34-1.06, P=0.08) and MR-Egger estimate (OR=0.66, 95% CI: 0.26-1.67, P=0.381) were consistent with the IVW estimate in terms of direction and magnitude.CONCLUSIONS AND RELEVANCE We provided evidence that genetically increased serum calcium levels could reduce the risk of AD. Meanwhile, randomized controlled study should be further conducted to assess the effect of serum calcium levels on AD risk, and further clarify whether diet calcium intake or calcium supplement, or both could reduce the risk of AD.Key PointsQuestion Is there a genetic relationship between elevated serum calcium levels and the risk of Alzheimer’s disease?Findings This Mendelian randomization study showed that the genetically increased serum calcium levels were associated with the reduced risk of Alzheimer’s disease.Meaning These findings provide evidence that genetically increased serum calcium levels could reduce the risk of Alzheimer’s disease.

scholarly journals Mendelian randomization does not support serum calcium in prostate cancer risk

2018 ◽  
Author(s):  
James Yarmolinsky ◽  
Katie Berryman ◽  
Ryan Langdon ◽  
Carolina Bonilla ◽  
George Davey Smith ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Risk ◽  
Causal Inference ◽  
Serum Calcium ◽  
Observational Studies ◽  
Advanced Prostate Cancer ◽  
Mendelian Randomization ◽  
Prostate Cancer Risk ◽  
A Genome ◽  
Increased Risk

AbstractBackground: Observational studies suggest that dietary and serum calcium are risk factors for prostate cancer. However, such studies suffer from residual confounding (due to unmeasured or imprecisely measured confounders), undermining causal inference. Mendelian randomization uses randomly assigned (hence unconfounded and pre-disease onset) germline genetic variation to proxy for phenotypes and strengthen causal inference in observational studies.Objective: We tested the hypothesis that serum calcium is associated with an increased risk of overall and advanced prostate cancer.Design: A genetic instrument was constructed using 5 single nucleotide polymorphisms robustly associated with serum calcium in a genome-wide association study (N ≤ 61,079). This instrument was then used to test the effect of a 0.5 mg/dL increase (1 standard deviation, SD) in serum calcium on risk of prostate cancer in 72,729 men in the PRACTICAL (Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome) Consortium (44,825 cases, 27,904 controls) and risk of advanced prostate cancer in 33,498 men (6,263 cases, 27,235 controls).Results: We found weak evidence for a protective effect of serum calcium on prostate cancer risk (odds ratio [OR] per 0.5 mg/dL increase in calcium: 0.83, 95% CI: 0.63-1.08; P=0.12). We did not find strong evidence for an effect of serum calcium on advanced prostate cancer (OR per 0.5 mg/dL increase in calcium: 0.98, 95% CI: 0.57-1.70; P=0.93).Conclusions: Our Mendelian randomization analysis does not support the hypothesis that serum calcium increases risk of overall or advanced prostate cancer.

scholarly journals Serum Calcium Levels and Parkinson’s Disease: A Mendelian Randomization Study

2020 ◽  
Vol 11 ◽  
Author(s):  
Yanchao Wang ◽  
Luyan Gao ◽  
Wenjing Lang ◽  
He Li ◽  
Pan Cui ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Serum Calcium ◽  
Mendelian Randomization

Impact of Serum Calcium Levels on Alzheimer’s Disease: A Mendelian Randomization Study

2020 ◽  
pp. 1-12 ◽  
Author(s):  
Yating He ◽  
Haihua Zhang ◽  
Tao Wang ◽  
Zhifa Han ◽  
Qing-bin Ni ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Serum Calcium ◽  
Mendelian Randomization

scholarly journals Serum calcium and risk of migraine: a Mendelian randomization study

2016 ◽  
pp. ddw416 ◽  
Author(s):  
Peter Yin ◽  
Verneri Anttila ◽  
Katherine M. Siewert ◽  
Aarno Palotie ◽  
George Davey Smith ◽  
...  
Keyword(s):  
Serum Calcium ◽  
Mendelian Randomization

Relationship between serum nutritional factors and bone mineral density: a Mendelian randomization study

2021 ◽  
Author(s):  
Zihao Qu ◽  
Fangkun Yang ◽  
Yishang Yan ◽  
Jianqiao Hong ◽  
Wei Wang ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin E ◽  
Bone Mineral ◽  
Serum Calcium ◽  
Mendelian Randomization ◽  
Serum Selenium ◽  
Serum Retinol ◽  
Mineral Density ◽  
Nutritional Factors ◽  
Serum Selenium Levels

Abstract Purpose Multiple risk factors have been implicated in the development of osteoporosis. This study examined potential associations between serum nutritional factors and bone mineral density (BMD). Methods Six nutritional factors were selected as exposures. Outcomes included total body BMD (n = 66 945); BMD at the forearm (FA), femoral neck (FN) and lumbar spine (LS) (n = 8143, 32 735 and 28 498, respectively); estimated heel BMD (HL eBMD) (n = 394 929); and HL eBMD stratified by sex (n = 206 496). A two-sample Mendelian randomization (MR) approach was adopted to estimate the association between serum nutritional factors and BMD. The threshold for adjusted p-value was 1.39×10 -3. Results Serum calcium levels were inversely associated with LS BMD (effect = -0.55; 95% CI, -0.86 to -0.24; P = 0.001), whereas serum selenium levels were positively correlated with HL eBMD (effect = 0.22; 95% CI, 0.10 to 0.33; P = 1.70×10 -4). Regarding nominal significance, there was a positive association between serum selenium levels and FA BMD. Nominally significant results were also obtained for serum retinol as well as vitamin E levels and HL eBMD. Moreover, sex-specific effects of serum retinol and vitamin E levels on BMD were observed in men. Main Conclusions Serum calcium and selenium levels influence BMD at specific skeletal sites. This implies that these nutritional factors play crucial roles in bone metabolism.

Correlation of Serum Calcium with severity of acute ischemic stroke

2021 ◽  
pp. 1-8
Author(s):  
Ainan Arshad ◽  
Saad Bin Zafar Mahmood ◽  
Ahmed Ayaz ◽  
Mehsa Hashim ◽  
Eisha Hanan
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
South Asian ◽  
Serum Calcium ◽  
Medical Records ◽  
Asian Population ◽  
Stroke Severity ◽  
Severity Scale ◽  
South Asian Population ◽  
Exclusion Criteria

Abstract Introduction: Stroke results in death of around 5.5 million people annually with approximately 20% of these deaths occurring in South Asia. It is the foremost cause of disability worldwide. Among the various risk factors identified, serum calcium has been hypothesized to play a significant role in the development of ischemic stroke and act as a prognosticator. This study was conducted to determine the correlation if any between serum calcium and severity of acute ischemic stroke in our population. Methods: A retrospective review of medical records of those patients admitted with a diagnosis of acute stroke and fulfilling the inclusion and exclusion criteria was conducted at Aga Khan University from a period of January 2018 to December 2018. Characteristics of stroke patients were compared stroke severity. Results: 279 patients were inducted, 58% (n = 162) were male with a mean age of 62.4 ± 13.8. Mean albumin corrected serum calcium and Scandinavian stroke severity score was 9.1 ± 5.6 and 33.67 ± 15.2 respectively. Hypertension and mean GCS on admission were significantly associated with increases stroke severity. However, mean serum calcium was not significant associated with stroke severity. Conclusion: No correlation was observed between serum calcium and severity of acute ischemic stroke. Further studies targeting South Asian population are required to assess the significance of serum calcium as a prognostic marker of stroke outcome. Key Words: Stroke, calcium, scandinavian stroke severity scale, cerebral ischemia Continuous.....

Sign in / Sign up

Export Citation Format

Share Document