Kesh (Arabic, in its sources Kashsh, Kass, Kise) is a historical city and region. It occupies the north-eastern part of the present-day Kashkadarya region of Uzbekistan. Initially, it was located on the site of Kitab district, then in the 9th-10th centuries it moved to Shakhrisabz. Extensive research has been conducted in the Kesh oasis over the years, which has provided valuable information on the ancient and medieval history of the oasis. Important information about the ancient and medieval history of the oasis is given in the sources. These sources provide detailed information on the geographical location of the Kesh oasis, the lifestyle of the population of the oasis, the socio-economic life of the oasis, the structure of the city of Kesh. Historians such as Ibn Hawqal and Al-Muqaddas have provided such valuable information in their works. From the 20th century, archeological excavations began in the oasis. Preliminary research was conducted by orientalists in the oasis. In the oasis V.V.Bartold, V.A.Vyatkin, B.Denike conducted scientific research. In 1926, A.Yu.Yakubovsky was sent to Shakhrisabz to study historical topography. In the 1930s, the monuments of Shakhrisabz were studied by Y.G.Gulomov, T.M.Mirgiyosov, S.K.Kabanov, S.A.Sudakov and the artist N.S.Lojkin. Archaeological excavations in the oasis were also carried out by M.E. Masson in the 1940s. Archaeological excavations were carried out by S.K.Kabanov in 1946-1950. In 1955, V.D.Zhukov conducted excavations at the site of Kindiklitepa. The research conducted by N.I.Krasheninnikova in 1970-1980 is also important. Similar expeditions were carried out in later periods. Among them are R.H.Suleymanov, E.V.Rtveladze and A.S.Sagdullaev. The archeological researches and scientific researches of these scientists are served as an important basis in determining the age of the cities of the eastern (Kesh) and western (Karshi) oasis of Kashkadarya and their place in the urban culture of Central Asia.