The Effects of Ferric Carboxymaltose Versus Iron Sucrose on the Ferritin Level in Pregnant Women with Anemia: A Meta-Analysis

2020 ◽  
Author(s):  
Astika Candra Nirwana ◽  
◽  
Yulia Lanti Retno Dewi ◽  
Bhisma Murti ◽  
◽  
...  
Keyword(s):  
Pregnant Women ◽  
Ferritin Level ◽  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
Iron Sucrose ◽  
Ferric Carboxymaltose ◽  
Inclusion Criteria ◽  
Anemia In Pregnancy ◽  
In Pregnancy

ABSTRACT Background: Prophylactic oral iron is recommended during pregnancy to meet the increased requirement during the antenatal period. The most commonly used iron preparation for anemia in pregnancy is iron sucrose complex (ISC). The purpose of this study was to compare the effects of ferric carboxymaltose versus iron sucrose on the ferritin level in pregnant women with anemia. Subjects and Method: This was a meta-analysis study. The study was conducted by collecting published articles from 2010 to 2019 in PubMed, Science Direct, and Google Scholar databases. The keywords used to search the articles including “Ferric Carboxymaltose”, “Ferric Carboxymaltose and anemia in pregnancy”, and “the effect of Ferric Carboxymaltose for anemia”. The inclusion criteria was full text with randomized control trial study, anemia therapy provision using ferric carboxymaltose versus iron sucrose, and the study subjects were pregnant women with anemia. The selected articles were analyzed using Revman 5.3. Results: 5 articles that meet the inclusion criteria were selected for this study. There was high heterogeneity between experiment group (I2 = 96%; p= 0.020). Therefore, this study used random effect model. Ferric carboxymaltose provision increased feritin level 0.89 times than iron sucrose (Mean Difference= 0.89; 95% CI= 0.12 to 1.66; p<0.001). Conclusion: Ferric carboxymaltose is effective to increased feritin level in pregnant women. Keywords: ferric carboxymaltose, iron sucrose, randomized controlled trial Correspondence: Astika Candra Nirwana. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir Sutami 36A, Surakarta 57126, Central Java. Email: [email protected]. Mobile: 085640018896 DOI: https://doi.org/10.26911/the7thicph.05.48

A Meta-Analysis on the Effectiveness of Prenatal Yoga in Reducing Cortisol Hormone in Pregnancy

2020 ◽  
Author(s):  
Shiva Aflahiyah ◽  
◽  
Didik Gunawan Tamtomo ◽  
Hanung Prasetya ◽  
◽  
...  
Keyword(s):  
Pregnant Women ◽  
Cortisol Level ◽  
Controlled Trial ◽  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
Well Being ◽  
The Body ◽  
Inclusion Criteria ◽  
In Pregnancy

ABSTRACT Backgrund: A growing body of evidence suggests that activity of the stress-responsive hypothalamic-pituitary-adrenal axis and its end-product cortisol also may be associated with perinatal emotional well-being. A number of preventive interventions, such as Yoga, targeting psychosocial and physiological risk factors for perinatal depression have utilized mind-body practices, which embody the idea that the mind interacts with the body to influence physical functioning, improve symptoms, and promote health. This study aimed to investigate effectiveness of prenatal yoga in reducing cortisol hormone in pregnancy Subjects and Method: This was a meta-analysis and systematic review. This study collected published articles during 2000 to 2020 from PubMed, Science Direct, Springer, Proquest, and Chocrane electronic databases. The inclusion criteria were full text, randomized controlled trial, and prenatal yoga intervention. The study subjects were pregnant women who received prenatal yoga for 8 to 20 weeks. Outcome was cortisol hormone reduction during pregnancy. The selected articles were analyzed by PRISMA flow chart and RevMan 5.3. Results: 5 articles from America and Asia were met the inclusion criteria. This study had high heterogeneity (I2=88%; p<0.001). Therefore, this study used random effect model (REM). Prenatal yoga reduced cortisol level 0.59 times in pregnancy (Mean Difference= -0.59; 95% CI= 1.18 to 0.01; p= 0.050). Conclusion: Prenatal yoga is effective to reduce cortisol level in pregnant women. Keywords: prenatal yoga, cortisol hormone, pregnant women Correspondence: Shiva Aflahiyah. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36 A, Surakarta 57126, Central Java. Email: [email protected]. DOI: https://doi.org/10.26911/the7thicph.05.47

scholarly journals The Effect of Ferric Carboxymaltose Versus Iron Sucrose on Hemoglobin Levels in Pregnant Women with Anemia: Meta-Analysis

2021 ◽  
Vol 6 (1) ◽  
pp. 15-24
Author(s):  
Astika Candra Nirwana ◽  
◽  
Yulia Lanti Retno Dewi ◽  
Bhisma Murti ◽  
◽  
...  
Keyword(s):  
Pregnant Women ◽  
Randomized Control Trial ◽  
Meta Analysis ◽  
Iron Sucrose ◽  
World Health ◽  
Ferric Carboxymaltose ◽  
World Population ◽  
The World ◽  
Randomized Control ◽  
In Pregnancy

Background: Anemia in pregnant women is one of the global health problems experienced by developed or developing countries affecting 1.62 billion world population, which corresponds to 24.8% of the population in the world. Anemia is a serious problem for maternal health because it is one of the five problems that becomes the target of solving the World Health Organization (WHO) in 2025. This study aimed to estimate the magnitude of the effect of Ferric Carboxymaltose on hemoglobin levels in pregnant women with anemia compared to Iron Sucrose. Subjects and Method: This study was a metaanalysis study. The study was conducted by looking for data from the study results in the period 2010-2019. The data of this study was from Pubmed, DOAJ, Science Direct, Springer Link, Web of Science, Cochrane, Google Scholar, BMJ, BMC, Research Gate, J Stor, Wiley, Clinical Key, J Gate, SAGE, IEEE Xplore, ERIC Institute of Education Science, BASE, SciELO, WorldCat, Microsoft Academic, Index Copernicus, CABI, Cambridge, Nature, Oxford, ProQuest, and BJOG using the keyword "ferric carboxymaltose" AND "iron sucrose" AND "anemia in pregnancy" AND "randomized control trial" OR RCT, "ferric carboxymaltose" AND "iron sucrose" AND "hemoglobin in pregnancy" AND "randomized control trial". The subjects of this study were pregnant women with anemia. The study used a Revman 5.3 application to analyze the article. Results: The eight articles were reviewed using the meta-analysis technique in this study. Pregnant women who were given ferric carboxymaltose therapy had a higher mean hemoglobin level than those who were not treated carboxymaltose therapy and it was statistically significant (SMD= 1.11; 95% CI= 0.37 to 1.85; p= 0.003). The heterogeneity of the data showed I2= 98% so that the distribution of the data was stated to be heterogeneous (random effect model). Conclusion: Ferric Carboxymaltose is effective in increasing hemoglobin levels in pregnant women with anemia. Keywords: Ferric Carboxymaltose, Iron Sucrose, Randomized Controlled Trial. Correspondence: Astika Candra Nirwana. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: [email protected]. Mobile: 085640018896.

scholarly journals Mean Platelet Volume and Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Zhongwei Zhou ◽  
Hongmei Chen ◽  
Mingzhong Sun ◽  
Huixiang Ju
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Mean Platelet Volume ◽  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
Cochrane Library ◽  
Platelet Volume

Aim. To evaluate the association between mean platelet volume (MPV) and gestational diabetes mellitus (GDM). Methods. A systematic literature search was performed in PubMed, EMBASE, Web of Science, and The Cochrane Library up to 4 September 2017. Pooled standardized mean differences (SMD) and 95% confidence interval (CI) were calculated using a random-effect model. Results. Nineteen studies comprising 1361 GDM patients and 1911 normal pregnant women were included. MPV was increased in GDM patients when compared with healthy pregnant women (SMD: 0.79; 95% CI: 0.43–1.16; P<0.001). Subgroup analyses revealed that such trend was consistent in the third-trimester (SMD: 1.35; 95% CI: 0.72–1.98), Turkish (SMD: 0.81; 95% CI: 0.43–1.19), and Italian (SMD: 2.78; 95% CI: 2.22–3.34) patients with GDM and the patients diagnosed based on Carpenter and Coustan criteria (SMD: 1.04; 95% CI: 0.42–1.65). Significantly higher MPV also were observed within cross-sectional studies (SMD: 0.99; 95% CI: 0.49–1.49). Remarkable between-study heterogeneity and potential publication bias were observed in this meta-analysis; however, sensitivity analysis indicated that the results were not unduly influenced by any single study. Conclusions. GDM patients are accompanied by increased MPV, strengthening the clinical evidence that MPV may be a predictive marker for GDM.

scholarly journals Effect of Secondary Education on Exclusive Breastfeeding: Meta-Analysis

2020 ◽  
Author(s):  
Ferda Fibi Tyas Nurkholifa ◽  
◽  
Eti Poncorini Pamungkasari ◽  
Hanung Prasetya ◽  
◽  
...  
Keyword(s):  
Secondary Education ◽  
Exclusive Breastfeeding ◽  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
South Australia ◽  
Inclusion Criteria ◽  
Or Education ◽  
Cross Sectional ◽  
Central Java

ABSTRACT Background: Many studies reported the importance of exclusive breastfeeding for infants. However, there are many obstacles faced by lactating mothers to provide exclusive breastfeeding for their children. This study aimed to investigate the effect of secondary education on exclusive breastfeeding using a meta-analysis. Subjects and Method: Meta-analysis and systematic review were conducted by collecting articles from PubMed, Science Direct, and Google Scholar databases. Keywords used exclusive breastfeeding” AND “secondary education” OR “education for breastfeeding” AND “cross sectional” AND “adjusted odd ratio”. The study population was postpartum mothers. Intervention was secondary education with comparison primary education. The study outcome was exclusive breastfeeding. The inclusion criteria were full text, using English or Indonesian language, and reporting adjusted odds ratio. The articles were selected by PRISMA flow chart. The quantitative data were analyzed using random effect model run on Revman 5.3. Results: 7 studies from Peru, China, Nigeria, Korea, Ireland, Sub-Sahara, and South Australia were met the inclusion criteria. There was high heterogeneity between groups (I2= 94%; p<0.001). This study reported that secondary education reduced exclusive breastfeeding, but it was statistically non-significant (aOR= 0.86; 95% CI= 0.60 to 1.24; p= 0.430). Conclusion: Secondary education reduced exclusive breastfeeding, but it was statistically non-significant. Keywords: exclusive breastfeeding, secondary education, postpartum Correspondence: Ferda Fibi Tyas Nurkholifa. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: [email protected]. Mobile: +6285655778863. DOI: https://doi.org/10.26911/the7thicph.03.131

scholarly journals Toxoplasmosis infection among pregnant women in Africa: A systematic review and meta-analysis

PLoS ONE ◽  
2021 ◽  
Vol 16 (7) ◽  
pp. e0254209
Author(s):  
Tamirat Tesfaye Dasa ◽  
Teshome Gensa Geta ◽  
Ayalnesh Zemene Yalew ◽  
Rahel Mezemir Abebe ◽  
Henna Umer Kele
Keyword(s):  
Systematic Review ◽  
Pregnant Women ◽  
Democratic Republic Of Congo ◽  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
Congenital Toxoplasmosis ◽  
Protozoan Parasite ◽  
P Value ◽  
Toxoplasma Infection

The epidemiology of toxoplasmosis in pregnancy is a major issue in public health. Toxoplasmosis is caused by the protozoan parasite. Toxoplasma parasite is at high risk for life-threatening diseases during pregnancy. Congenital toxoplasmosis results from a maternal infection acquired during gestation. Therefore, this systematic review and meta-analysis was aimed to determine the seropositive prevalence of toxoplasmosis infection among pregnant women who attended antenatal care in a health facility in Africa. A systematic review and meta-analysis of published and unpublished studies were included. Databases such as MEDLINE, PubMed, EMBASE, CINAHL, Web of Science, African Journals Online were used with relevant search terms. The quality of the articles was critically evaluated using the tool of the Joanna Briggs Institute. Data were extracted on Microsoft word 2016. Meta-analysis was conducted using STATA 14 software. The heterogeneity and publication bias were assessed using the I2 statistics and Egger’s test, respectively. Forest plots were used to present the pooled prevalence and odds ratio with a 95% confidence interval of meta-analysis using the random effect model. In total, 23 studies comprising 7,579 pregnant women across ten countries in Africa were included in this meta-analysis. The overall prevalence of seropositive toxoplasmosis among pregnant women in Africa was 51.01% (95% CI; 37.66, 64.34). The heterogeneity test showed that heterogeneity was high, I2 = 99.6%, P-value < 0.001. The variables responsible for the source of heterogeneity were included from Cameroon, the Democratic Republic of Congo, and Ethiopia. Overall prevalence of toxoplasmosis in Africa showed that more than one-half of pregnant women were infected. The risk of acquiring toxoplasmosis infection during pregnancy is high; hence, preventive measures to avoid exposure of pregnant women to Toxoplasma infection should be strictly applied.

Effect of Malaria Infection on Premature Birth Delivery: Meta-Analsysis

2020 ◽  
Author(s):  
Feri Yuda Anggara ◽  
◽  
Setyo Sri Rahardjo ◽  
Bhisma Murti ◽  
◽  
...  
Keyword(s):  
Pregnant Women ◽  
Preterm Delivery ◽  
Premature Birth ◽  
Malaria Infection ◽  
Random Effect ◽  
Random Effect Model ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
In Pregnancy

ABSTRACT Background: Malaria infection in pregnancy contributes to low birth weight through preterm delivery and intrau-uterine growth restriction (IUGR). Maternal haemoglobin concentrations were found lower in malaria infected than non-infected women and reduced haemoglobin was the main determinant of preterm delivery. This study aimed to investigate the effect of malaria infection on premature birth delivery. Subjects and Method: Meta-analysis ad systematic review was conducted by collecting published articles from Google Scholar, PubMed, Springer Link, and Science Direct databases, from year 2010 to 2020. Keywords used “malaria in pregnancy”, “malaria during pregnant AND preterm”, malaria during pregnant AND preterm AND cross sectional study AND adjusted ratio”. The inclusion criteria were full text, using cross sectional study design, and reporting adjusted odds ratio. The articles were selected by PRISMA diagram. The quantitative data were analyzed by Review Manager 5.3 using random effect model. Results: 6 articles reported that malaria infection in pregnant women increased the risk of premature birth delivery (aOR= 1.72; 95% CI= 1.15 to 2.57; p= 0.009). Conclusion: Malaria infection in pregnant women increases the risk of premature birth delivery. Keywords: malaria infection, premature birth delivery Correspondence: Feri Yuda Anggara. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: [email protected]. Mobile: 085220426805. DOI: https://doi.org/10.26911/the7thicph.03.119

scholarly journals Anemia in Ugandan pregnant women: a cross-sectional, systematic review and meta-analysis study

2021 ◽  
Vol 49 (1) ◽  
Author(s):  
Felix Bongomin ◽  
Ronald Olum ◽  
Andrew Peter Kyazze ◽  
Sandra Ninsiima ◽  
Gloria Nattabi ◽  
...  
Keyword(s):  
Public Health ◽  
Systematic Review ◽  
Blood Pressure ◽  
Pregnant Women ◽  
Meta Analysis ◽  
Referral Hospital ◽  
Cross Sectional ◽  
Anemia In Pregnancy ◽  
Prevalence Of Anemia ◽  
In Pregnancy

Abstract Background Anemia in pregnancy represents a global public health concern due to wide ranging maternal and neonatal adverse outcomes in all peripartum periods. We estimated the prevalence and factors associated with anemia in pregnancy at a national obstetrics and gynecology referral hospital in Uganda and in addition performed a systematic review and meta-analysis of the overall burden of anemia in pregnancy in Uganda. Methods We conducted a cross-sectional study among 263 pregnant women attending the antenatal care clinic of Kawempe National Referral Hospital, Kampala, Uganda, in September 2020. Anemia in pregnancy was defined as a hemoglobin level of < 11.0 g/dl and microcytosis as a mean corpuscular volume (MCV) of < 76 fL. We also performed a systematic review (PROSPERO Registration ID: CRD42020213001) and meta-analysis of studies indexed on MEDLINE, Embase, African Journal Online, ClinicalTrials.gov, ICTRP, and the Cochrane Library of systematic review between 1 January 2000 and 31 September 2020 reporting on the prevalence of anemia in pregnancy in Uganda. Results The prevalence of anemia was 14.1% (n= 37) (95%CI 10.4–18.8), of whom 21 (56.8%) had microcytic anemia. All cases of anemia occurred in the second or third trimester of pregnancy and none were severe. However, women with anemia had significantly lower MCV (75.1 vs. 80.2 fL, p<0.0001) and anthropometric measurements, such as weight (63.3 vs. 68.9kg; p=0.008), body mass index (25.2 vs. 27.3, p=0.013), hip (98.5 vs. 103.8 cm, p=0.002), and waist (91.1 vs. 95.1 cm, p=0.027) circumferences and mean systolic blood pressure (BP) (118 vs 125 mmHg, p=0.014). Additionally, most had BP within the normal range (59.5% vs. 34.1%, p=0.023). The comparison meta-analysis of pooled data from 17 published studies of anemia in pregnancy in Uganda, which had a total of 14,410 pregnant mothers, revealed a prevalence of 30% (95% CI 23–37). Conclusions Despite our study having a lower prevalence compared to other studies in Uganda, these findings further confirm that anemia in pregnancy is still of public health significance and is likely to have nutritional causes, requiring targeted interventions. A larger study would be necessary to demonstrate potential use of basic clinical parameters such as weight or blood pressure as screening predictors for anemia in pregnancy.

scholarly journals Snoring Is Associated With Increased Risk of Stroke: A Cumulative Meta-Analysis

2021 ◽  
Vol 12 ◽  
Author(s):  
Jing Bai ◽  
Bing He ◽  
Nan Wang ◽  
Yifei Chen ◽  
Junxiang Liu ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
Analysis Method ◽  
Inclusion Criteria ◽  
Relative Risks ◽  
Active Approach ◽  
Effect Model ◽  
Increased Risk ◽  
Initial Discovery

Background: Several studies have suggested that snoring is associated with an increased risk of stroke; however, the results are inconsistent. We aim to conduct a systematic review and meta-analysis of observational studies assessing the association between snoring and the risk of stroke in adults.Methods: We searched PubMed for relevant studies. A random-effect model was adopted to summary relative risks (RRs), and forest plots from a cumulative meta-analysis method were used for a better presentation of how the pooled RRs changed as updated evidence accumulated.Results: The literature search yielded 16 articles that met our inclusion criteria, and a total of 3,598 stroke patients and 145,901 participants were finally included in our analysis. A consistent trend toward association was found after the initial discovery, and the summary analysis indicated that snoring is associated with a 46% (RR, 1.46; 95%CI, 1.29–1.63; p &lt; 0.001) increased risk of stroke.Conclusions: Snoring is associated with a significantly increased risk for stroke, up to 46%. The importance of the current study lies in that we provide an imputes to take a more active approach against the increased risk of stroke in snorers.

scholarly journals Acute Effect of Citrulline Malate on Repetition Performance During Strength Training: A Systematic Review and Meta-Analysis

2021 ◽  
pp. 1-9
Author(s):  
Fredrik Tonstad Vårvik ◽  
Thomas Bjørnsen ◽  
Adam M. Gonzalez
Keyword(s):  
Strength Training ◽  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
Acute Effect ◽  
Upper Body ◽  
Lower Body ◽  
Inclusion Criteria ◽  
Double Blind ◽  
Citrulline Malate

Citrulline malate (CitMal) is a dietary supplement that is suggested to enhance strength training performance. However, there is conflicting evidence on this matter. Thus, the purpose of this meta-analysis was to determine whether supplementing with CitMal prior to strength training could increase the total number of repetitions performed before reaching voluntary muscular failure. A systematic search was conducted wherein the inclusion criteria were double-blind, placebo-controlled studies in healthy participants that examined the effect of CitMal on repetitions to failure during upper body and lower body resistance exercises. The Hedges’s g standardized mean differences (SMD) between the placebo and CitMal trials were calculated and used in a random effect model. Two separate subanalyses were performed for upper body and lower body exercises. Eight studies, including 137 participants who consisted of strength-trained men (n = 101) and women (n = 26) in addition to untrained men (n = 9), fulfilled the inclusion criteria. Across the studies, 14 single-joint and multijoint exercises were performed with an average of 51 ± 23 total repetitions during 5 ± 3 sets per exercise at ∼70% of one-repetition maximum. Supplementing with 6–8 g of CitMal 40–60 min before exercise increased repetitions by 3 ± 5 (6.4 ± 7.9%) compared with placebo (p = .022) with a small SMD (0.196). The subanalysis for the lower body resulted in a tendency for an effect of the supplement (8.1 ± 8.4%, SMD: 0.27, p = .051) with no significant effect for the upper body (5.7 ± 8.4%, SMD: 0.16, p = .131). The current analysis observed a small ergogenic effect of CitMal compared with placebo. Acute CitMal supplementation may, therefore, delay fatigue and enhance muscle endurance during high-intensity strength training.

scholarly journals Do Lifestyle Interventions in Pregnant Women with Overweight or Obesity Have an Effect on Neonatal Adiposity? A Systematic Review with Meta-Analysis

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1903
Author(s):  
Naiara F. Baroni ◽  
Nayara R. Baldoni ◽  
Geisa C. S. Alves ◽  
Lívia C. Crivellenti ◽  
Giordana C. Braga ◽  
...  
Keyword(s):  
Systematic Review ◽  
Pregnant Women ◽  
Randomized Clinical Trials ◽  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
Developed Countries ◽  
Lifestyle Interventions ◽  
Neonatal Adiposity ◽  
Overweight Or Obesity

Excessive body fat at birth is a risk factor for the development of childhood obesity. The aim of the present systematic review with meta-analysis was to evaluate the effect of lifestyle interventions in pregnant women with overweight or obesity on neonatal adiposity. The PubMed, Embase, Web of Science, Scopus, and Virtual Health Library databases were used as information sources. Original articles from randomized clinical trials of lifestyle intervention studies on pregnant women with excessive body weight and the effect on neonatal adiposity were considered eligible. The risk of bias was assessed using Cochrane criteria. The meta-analysis was calculated using the inverse variance for continuous data expressed as mean difference (MD), using the random effect model with a 95% confidence interval (CI). The outcomes were submitted to the GRADE evaluation. Of 2877 studies, four were included in the qualitative and quantitative synthesis (n = 1494). All studies were conducted in developed countries, with three including pregnant women with overweight or obesity, and one only pregnant women with obesity. The interventions had no effect on neonatal adiposity (Heterogeneity = 56%, MD = −0.21, CI = (−0.92, 0.50)) with low confidence in the evidence, according to GRADE. Studies are needed in low- and medium-developed countries with different ethnic-racial populations. PROSPERO (CRD42020152489).

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