Antimycobacterials from natural sources: ancient times, antibiotic era and novel scaffolds

10.2741/4024 ◽  
2012 ◽  
Vol 17 (1) ◽  
pp. 1861 ◽  
Author(s):  
Juan, D. Guzman
Keyword(s):  
Natural Sources ◽  
Ancient Times

scholarly journals Anticancer Agents from Diverse Natural Sources

2014 ◽  
Vol 9 (11) ◽  
pp. 1934578X1400901 ◽  
Author(s):  
Jabeena Khazir ◽  
Darren L. Riley ◽  
Lynne A. Pilcher ◽  
Pieter De-Maayer ◽  
Bilal Ahmad Mir
Keyword(s):  
Clinical Trials ◽  
Natural Products ◽  
Anticancer Agents ◽  
Marine Organisms ◽  
New Drugs ◽  
Human Diseases ◽  
Cancer Drugs ◽  
Natural Sources ◽  
Anti Cancer ◽  
Ancient Times

This review attempts to portray the discovery and development of anticancer agents/drugs from diverse natural sources. Natural molecules from these natural sources including plants, microbes and marine organisms have been the basis of treatment of human diseases since the ancient times. Compounds derived from nature have been important sources of new drugs and also serve as templates for synthetic modification. Many successful anti-cancer drugs currently in use are naturally derived or their analogues and many more are under clinical trials. This review aims to highlight the invaluable role that natural products have played, and continue to play, in the discovery of anticancer agents.

scholarly journals Junipers of Various Origins as Potential Sources of the Anticancer Drug Precursor Podophyllotoxin

Molecules ◽  
2021 ◽  
Vol 26 (17) ◽  
pp. 5179
Author(s):  
Diana I. Ivanova ◽  
Paraskev T. Nedialkov ◽  
Alexander N. Tashev ◽  
Marta Olech ◽  
Renata Nowak ◽  
...  
Keyword(s):  
Comparative Investigation ◽  
Bioactive Metabolites ◽  
Leaf Extracts ◽  
Natural Sources ◽  
The World ◽  
Identification Of Species ◽  
Ancient Times ◽  
Folk Remedies ◽  
Sinopodophyllum Hexandrum ◽  
Antiproliferative Activities

Juniper representatives are natural sources of plenty of bioactive metabolites and have been used since ancient times as folk remedies against tapeworms, warts, cancer, etc. The antiproliferative activities of junipers are attributed to podophyllotoxin (PPT), which is a precursor for the synthesis of efficient anticancer drugs. However, the natural sources of PPT, Sinopodophyllum hexandrum (Royle) T. S. Ying and Podophyllum peltatum L., are already endangered species because of their intensive industrial exploitation. Therefore, identification of other sources of PPT is necessary. This study is a broad comparative investigation of junipers, for which original sources have been accessed from different continents of the world. The present research is aimed at the identification of species, producing PPT and other lignans at concentrations that are sufficient for the high antiproliferative activity of the corresponding extracts. Cytotoxic juniper leaf extracts demonstrated a broad spectrum of activity on a panel of cancer cell lines. The antiproliferative properties of junipers were attributed to the combined activity of great diversity of lignans (podophyllotoxin, deoxypodophyllotoxin, β-peltatin, yatein, matairesinol, anhydropodorhizol, etc.), detected by UHPLC-HRMS and LC-ESI-MS/MS in the corresponding extracts. Several species of the genus Juniperus L. were outlined as perspective sources of drug precursors with potential pharmaceutical applications.

scholarly journals In-House Preparation and Standardization of Herbal Face Pack

2017 ◽  
Vol 11 (1) ◽  
pp. 72-80 ◽  
Author(s):  
Rashmi Saxena Pal ◽  
Yogendra Pal ◽  
Pranay Wal
Keyword(s):  
Milk Powder ◽  
Quality Standards ◽  
Flow Property ◽  
Local Area ◽  
Human Beings ◽  
Flow Properties ◽  
Organoleptic Evaluation ◽  
Natural Sources ◽  
Ancient Times ◽  
Good Flow

Background: Since the ancient times, there has been awareness among people regarding the use of plants for the essential needs of a healthy and beautiful skin. Cosmetics are the products used to clean, beautify and promote attractive appearance. Cosmetics designed via incorporating natural sources such as herbs have been proven very fulfilling, in coping up with the present needs of different skin types. Objective: As due to increased pollution, allergy, microbes etc, human skin has become more sensitive and prone to faster aging. An attempt has been made to synthesize a pack ideal for all skin types. After the synthesis, all the parameters have been calculated in order to meet up the quality standards. Materials and Methods: The constituents were extracted from herbal ingredients such as Multani mitti, green tea, saffron, gram flour, turmeric, shwet chandan and milk powder. They were purchased from the local area and were dried separately, grinded, passed through sieve no 40, mixed homogenously and then evaluated for parameters including organoleptic, physicochemical, rheological features, phytochemical, stability, and irritancy examination. Results: The dried powders of combined pack showed good flow property which is suitable for a face pack. Organoleptic evaluation showed that the pack is smooth and pleasant smelling powder. Rheological findings justified the flow properties of the pack as it was found to be free flowing and non-sticky in nature. The results proved that the formulation was stable on all aspects. Irritancy test showed the negative. Stability tests performed revealed the inert nature of the pack. Conclusion: Thus, in the present work, we formulated a pack, which can be easily made with the easily available ingredients. It showed all the benefits of a face pack and further optimization studies are required on its various parameters to find its useful benefits on the human beings.

A Review on “Phytochemical and Pharmacological activity of Bauhinia racemosa”

2021 ◽  
pp. 256-260
Author(s):  
Habeeba S Shaikh ◽  
Ravindra S Jadhav ◽  
Dattaprasad N Vikhe
Keyword(s):  
Pharmaceutical Industry ◽  
Antitumor Activity ◽  
Natural Product ◽  
Clinical Medicine ◽  
Higher Plants ◽  
Dominant Role ◽  
Stem Bark ◽  
Development Programs ◽  
Natural Sources ◽  
Ancient Times

Nature has provide a medicinal agents since, for thousands of years and a impressive number of modern medicines. The medicines are isolated from natural sources; several supported their use in ancient medication. Higher plants, as sources of medicinal compounds, have continuing to play a dominant role in the upkeep of human health since ancient times. Over five hundredth of all trendy clinical medicine area units of natural product origin and play an necessary role in drug development programs in the pharmaceutical industry. Bauhinia racemosa Lam. are the plant which is broadly distributed in tropical climate regions. Bauhinia species are flowering trees found in Caesalpiniaceae family. The root and stem bark fibers which possesses curative properties. Ethnopharmacologically, varied elements of the plant starting from the bark of the plant to the gum obtained has been used in diseases like, Diarrhea, dysentery, fever etc. B. racemosa have the different photochemical constituents like flavonoids, glycosides, phenols, saponins, and tannins. several pharmacological actions of the plant already proved, that embrace anti-microbial, anthelmintic, antitumor activity. This review focus on the pharmacological actions and phytoconstituets of Bauhinia racemosa.

scholarly journals Engineering of a borneol dehydrogenase from P. putida for the enzymatic resolution of camphor

2021 ◽  
Vol 105 (8) ◽  
pp. 3159-3167
Author(s):  
Michael Hofer ◽  
Julia Diener ◽  
Benjamin Begander ◽  
Robert Kourist ◽  
Volker Sieber
Keyword(s):  
Kinetic Resolution ◽  
Enzyme Engineering ◽  
Medical Applications ◽  
Natural Sources ◽  
Alpha Pinene ◽  
Enzymatic Kinetic Resolution ◽  
Key Points ◽  
Reliable Source ◽  
Ancient Times

Abstract Several thousand different terpenoid structures are known so far, and many of them are interesting for applications as pharmaceuticals, flavors, fragrances, biofuels, insecticides, or fine chemical intermediates. One prominent example is camphor, which has been utilized since ancient times in medical applications. Especially (−)-camphor is gaining more and more interest for pharmaceutical applications. Hence, a commercial reliable source is needed. The natural sources for (−)-camphor are limited, and the oxidation of precious (−)-borneol would be too costly. Hence, synthesis of (−)-camphor from renewable alpha-pinene would be an inexpensive alternative. As the currently used route for the conversion of alpha-pinene to camphor produces a mixture of both enantiomers, preferably catalytic methods for the separation of this racemate are demanded to yield enantiopure camphor. Enzymatic kinetic resolution is a sustainable way to solve this challenge but requires suitable enzymes. In this study, the first borneol dehydrogenase from Pseudomonas sp. ATCC 17453, capable of catalyzing the stereoselective reduction of camphor, was examined. By using a targeted enzyme engineering approach, enantioselective enzyme variants were created with E-values > 100. The best variant was used for the enzymatic kinetic resolution of camphor racemate, yielding 79% of (−)-camphor with an ee of > 99%. Key points • Characterization of a novel borneol dehydrogenase (BDH) from P. putida. • Development of enantioselective BDH variants for the reduction of camphor. • Enzymatic kinetic resolution of camphor with borneol dehydrogenase. Graphical abstract

History of thyroid surgery

2020 ◽  
Vol 99 (11) ◽  
Keyword(s):  
Surgical Technique ◽  
20Th Century ◽  
Thyroid Surgery ◽  
History Of ◽  
Ancient Times

The authors present an outline of the development of thyroid surgery from the ancient times to the beginning of the 20th century, when the definitive surgical technique have been developed and the physiologic and pathopfysiologic consequences of thyroid resections have been described. The key representatives, as well as the contribution of the most influential czech surgeons are mentioned.

Heracles and epilepsy: the sacred disease

2020 ◽  
Vol 78 (10) ◽  
pp. 660-662
Author(s):  
Eduardo ORREGO-GONZÁLEZ ◽  
Ana PERALTA-GARCÍA ◽  
Leonardo PALACIOS-SÁNCHEZ
Keyword(s):  
Current Knowledge ◽  
Greek Mythology ◽  
Corpus Hippocraticum ◽  
Ancient Times ◽  
The Many

ABSTRACT Epilepsy is one of the most dreaded and terrifying human afflictions. One of the many names it has received was Sacred Disease, during Greek times. Heracles served as a source of the divine connotation that epilepsy received in ancient times, as he was one of the most important demigods in Greek mythology. However, several authors have attributed Heracles’ actions to a seizure, including Hippocrates, who described the sacred disease on his “Corpus Hippocraticum.” This paper reviewed some of the publications on the myth and content of the text of Hippocrates, in relation to the current knowledge of the disease.

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