scholarly journals Junipers of Various Origins as Potential Sources of the Anticancer Drug Precursor Podophyllotoxin

Molecules ◽  
2021 ◽  
Vol 26 (17) ◽  
pp. 5179
Author(s):  
Diana I. Ivanova ◽  
Paraskev T. Nedialkov ◽  
Alexander N. Tashev ◽  
Marta Olech ◽  
Renata Nowak ◽  
...  

Juniper representatives are natural sources of plenty of bioactive metabolites and have been used since ancient times as folk remedies against tapeworms, warts, cancer, etc. The antiproliferative activities of junipers are attributed to podophyllotoxin (PPT), which is a precursor for the synthesis of efficient anticancer drugs. However, the natural sources of PPT, Sinopodophyllum hexandrum (Royle) T. S. Ying and Podophyllum peltatum L., are already endangered species because of their intensive industrial exploitation. Therefore, identification of other sources of PPT is necessary. This study is a broad comparative investigation of junipers, for which original sources have been accessed from different continents of the world. The present research is aimed at the identification of species, producing PPT and other lignans at concentrations that are sufficient for the high antiproliferative activity of the corresponding extracts. Cytotoxic juniper leaf extracts demonstrated a broad spectrum of activity on a panel of cancer cell lines. The antiproliferative properties of junipers were attributed to the combined activity of great diversity of lignans (podophyllotoxin, deoxypodophyllotoxin, β-peltatin, yatein, matairesinol, anhydropodorhizol, etc.), detected by UHPLC-HRMS and LC-ESI-MS/MS in the corresponding extracts. Several species of the genus Juniperus L. were outlined as perspective sources of drug precursors with potential pharmaceutical applications.

Author(s):  
Vasyl Karpo ◽  
Nataliia Nechaieva-Yuriichuk

From ancient times till nowadays information plays a key role in the political processes. The beginning of XXI century demonstrated the transformation of global security from military to information, social etc. aspects. The widening of pandemic demonstrated the weaknesses of contemporary authoritarian states and the power of human-oriented states. During the World War I the theoretical and practical interest toward political manipulation and political propaganda grew definitely. After 1918 the situation developed very fast and political propaganda became the part of political influence. XX century entered into the political history as the millennium of propaganda. The collapse of the USSR and socialist system brought power to new political actors. The global architecture of the world has changed. Former Soviet republic got independence and tried to separate from Russia. And Ukraine was between them. The Revolution of Dignity in Ukraine was the start point for a number of processes in world politics. But the most important was the fact that the role and the place of information as the challenge to world security was reevaluated. The further annexation of Crimea, the attempt to legitimize it by the comparing with the referendums in Scotland and Catalonia demonstrated the willingness of Russian Federation to keep its domination in the world. The main difference between the referendums in Scotland and in Catalonia was the way of Russian interference. In 2014 (Scotland) tried to delegitimised the results of Scottish referendum because they were unacceptable for it. But in 2017 we witness the huge interference of Russian powers in Spain internal affairs, first of all in spreading the independence moods in Catalonia. The main conclusion is that the world has to learn some lessons from Scottish and Catalonia cases and to be ready to new challenges in world politics in a format of information threats.


Plant Disease ◽  
1999 ◽  
Vol 83 (1) ◽  
pp. 62-65 ◽  
Author(s):  
A. De Cal ◽  
P. Melgarejo

The effect of long-wave UV/dark period on mycelial growth of 46 isolates of Monilinia sp. collected in Spain and 16 isolates collected from other parts of the world was investigated. Typical isolates of M. laxa, M. fructigena, and M. fructicola were grown in the dark and identified by morphological characteristics. Long-wave UV/dark conditions reduced the growth rates of M. laxa, M. fructigena, and M. fructicola on potato dextrose agar. All isolates of M. fructigena grew more slowly than those of M. fructicola. Typical and atypical isolates of M. fructigena and M. fructicola were placed in their respective species based on long-wave UV/dark growth rate data. M. laxa isolates were readily distinguished by the short distance from their conidium to the first germ tube branch. The involvement of different photoreceptors in photoresponses by M. fructicola and M. fructigena is discussed. Differences in mycelial growth under long-wave UV may be a useful tool to identify Monilinia spp.


1967 ◽  
Vol 60 (5) ◽  
pp. 210
Author(s):  
Richard M. Haywood ◽  
Carl Roebuck
Keyword(s):  

Molecules ◽  
2021 ◽  
Vol 26 (4) ◽  
pp. 965
Author(s):  
Renan Campos e Silva ◽  
Jamile S. da Costa ◽  
Raphael O. de Figueiredo ◽  
William N. Setzer ◽  
Joyce Kelly R. da Silva ◽  
...  

Psidium (Myrtaceae) comprises approximately 266 species, distributed in tropical and subtropical regions of the world. Psidium taxa have great ecological, economic, and medicinal relevance due to their essential oils’ chemical diversity and biological potential. This review reports 18 Psidium species growing around the world and the chemical and biological properties of their essential oils. Chemically, 110 oil records are reported with significant variability of volatile constituents, according to their seasonality and collection sites. Monoterpenes and sesquiterpenes with acyclic (C10 and C15), p-menthane, pinane, bisabolane, germacrane, caryophyllane, cadinane, and aromadendrane skeleton-types, were the primary constituents. The essential oils showed various biological activities, including antioxidant, antifungal, antibacterial, phytotoxic, larvicidal, anti-inflammatory, and cytotoxic properties. This review contributes to the Psidium species rational and economic exploration as natural sources to produce new drugs.


Author(s):  
Muhittin Gümüş

ÖZET. Milletlerin çok eski zamanlardan bugüne kadar yaşayarak edinmiş oldukları tecrübeler, bilgiler, kazanımlar ve değerler o milletin kültürünü oluşturur. Edinilen değerlerin dil aracılığıyla hayat bulması kültürdilbilim alanı çerçevesinde kültür-dil-insan arasındaki ilişkiyi incelemeye değer bulmuştur. Herhangi bir varlığın şekline, işlevine, görevine, görüntüsüne her toplumda farklı anlam veya dilsel dünya görüşünü yansıtan adlar verilir. Kültür-dil-insan çerçevesinde dil ve kültür ilişkilerinin belli bir disiplin altında incelenmesi ancak kültürdilbilim yoluyla mümkündür. Dilbilim alanına ait kültürdilbilim çalışmalarında ele alınan dilsel dünya görüşü kavramı her bir dilin dolayısıyla toplumun ya da ortak değerlere sahip toplumlarının oluşturduğu milletlerin dünyayı nasıl algılayıp yansıttığını, çevresindeki varlıkların ve kavramların hangi niteliklerini ayırt ettiğini, insanın duygu ve düşüncelerini, değer yargılarını nasıl betimledikleri incelenmektedir. Bu makalede kültürdilbilim çerçevesinde Türkçede “gibi”, Kırgızcada -DAy eki ve “sıyaktuu”, “öndüü” bağlacıyla yapılan benzetmeler ve deyimler Türkçe ile karşılaştırmalı olarak incelenmekte, böylelikle iki toplum arasındaki dış dünya algısı arasındaki farklılıklar veya benzerlikler tespit edilecektir. Адам баласы алмустактан бери топтогон маалыматы, турмуштан топтогон тажрыйбасы жана баалуулуктары менен улуттук маданиятын түзгөн. Тилдик каражаттар аркылуу чагылдырылган турмуштук тажрыйбалар улуттук маданият чөлкөмүндө маданият-тил-адам баласы деген чөйрөдө изилдөөгө алынат. Сөз, форма, иш аракет, көрүнүштөр ар бир коомдо ар кандай маанини туюндурган лексикалар менен берилген. Маданият-тил-адам баласы аттуу чөйрөдө тилдик жана маданий байланыштар белгилүү бир тартипте изилдениши бир гана маданияттаануу жолу менен ишке ашат. Тил илимине тиешелүү маданияттаануу илиминде каралган тилдик дүйнө тааным түшүнүгү ар бир тилдин, ошол эле учурда орток баалуулуктарга ээ болгон коомдун дүйнөнү кабыл алышы жана аны чагылдырышы, анын чөйрөнү жана түшүнүктөрдү айырмалаган сапаттарын, адамдын ички уйгу-туйгусун жана түшүнүктөрүн кандай сүрөттөгөнүн изилденет. Бул макалада маданияттаанууда Түрк тилиндеги “gibi” Кыргыз тилиндеги –ДАй мүчөсү, сыяктуу жана өндүү жандоочтор менен бе-рилиши, фразеологиялык каражаттар Түрк тили менен салыштырылып, эки тилдин ортосундагы сырткы дүйнө тааным менен болгон айырмасы жана окшоштуктары аныкталат. The experiences, knowledge, achievements and values that have been gained by nations starting from ancient times and up today constitute the culture of that nation. It has become worthy of examining the relationship between culture-language-human within the frameworks of cultural linguistics. Names are attached to any entity in accordance with its shape, function, tasks, and appearance that reflect different meanings in each society or their linguistic worldview. Analyzing language and culture relations within the scope of a certain discipline in the frameworks of culture-language-human is only possible by means of Cultural Linguistics. The concept of linguistic worldview, which is discussed in cultural-linguistics studies in the field of linguistics, deals with studying how each language and therefore the societies or societies with common values perceive the world and reflect it through the language they use, what qualities of entities and concepts surrounding them they distinguish, how they describe feelings and thoughts of a human being and their value judgments. This paper studies analogies and idioms that are formed by means of preposition “gibi” in the Turkish language and “sıyaktuu” with the suffix –Day in the Kyrgyz language, which are examined in the context of comparative cultural linguistics. Thus, the differences and/or similarities between the perception of external world between the two societies are revealed.


Keruen ◽  
2020 ◽  
Vol 67 (2) ◽  
Author(s):  
N. Nabiolla ◽  

From ancient times our people, who grazed four food animals, believed that they had an owner. The owners of the four food animals were considered to be their "ancestors" or "peers". That is why he gave them a mythical character. He leaned on his holy ancestors and asked them to help him. He wished them well and wished them well. He thought that only then he could have cattle. That is why various rituals and ceremonies have come to everyone. Currently in the country spread a lot of myths, indicating that the cow was the cow skorlupok animal. Special attention was paid to cattle, including bull. Even the purpose of the human earth that applies to spelled. He was known in myths as the blue bull, sometimes the blue bull, which was known in folklore with special vividness. This is mostly associated with myths about the injury of the earth. In the mythology of the peoples of the world say that the earth put on, fish, elephant (for the concept of the ancient Indians), snake Cotes, the myth, widespread among the peoples of Turkic origin, including among Kazakh people put on the surface of the blue ox, and sometimes on a blue bull to pick it up. He draws attention to the myths of the bull or bull and one case depends on the blue bull. In General, the blue color has a special property, for example, "blue Bor", "blue bull", etc. "Blue" is formed from mythical concepts: " blue sky","bull of the blue God". In this regard, it should be noted that in nomadic life, it became the first cargo transport.


Author(s):  
Yusuf Ziya Tengiz ◽  
Zehra Meliha Tengiz

Beekeeping is one of the most common agricultural activities in the world. In addition to the world and human life, it is very important in the pollination and the efficiency of the plants. Beekeeping activities have been done since ancient times as the tradition of Anatolian people. In Turkey grows 75% of the honey plants species determined in the world. This provides a variety of honey in different aroma and flavors. Turkey with 7 796 666 beehives is in 3rd rank, with 114 471 tons of honey production is in 2nd rank and with 4 488 tons of beeswax production in 2017 is in 4th rank in the world bee products have an important role. It is important to determine future trends in developing appropriate policies for our country, which is one of the leading countries in beekeeping activities. The main aims of this study are to forecast honey and beeswax product in Turkey for 2019-2025. Arima model, which is one of the time series analysis, was used in this study. According to the results, it is expected that honey production will increase in these years. However, it is expected the increase in the production of beeswax until 2021. After 2021 year is expected to decrease a little. In our country which has great potential for beekeeping, it will be able to take place among the countries which have a significant influence in foreign trade with the effective use of production resources in the realization of activities.


2021 ◽  
Vol 3 (S-1) ◽  
pp. 183-187
Author(s):  
Kalaiselvan P

Different beliefs and practices are found in human life from birth to death. These beliefs are created by the people and are followed and protected by the mother’s community. Man has been living with nature since ancient times. Beliefs appeared in natural human life. Hope can be traced back to ancient Tamils and still prevails in Tamil Nadu today. The hope of seeing the omen in it is found all over the world. Proverbs show that people have faith in omens. Our ancestors wrote the book 'Gauli Shastri' because the lizard omen is very important in our society. The word lizard played a major role in Tamil life during the Sangam period. It is possible to know that people have lived by the benefit of the lizard. There is hope from the public that the sound of the lizard will predict what will happen next. The purpose of this article is to illustrate the lizard word that has been around for a long time in folklore.


Author(s):  
Anita Sh. Ishmukhametova ◽  

Identification of names of plant curatives and substances in folk and fiction texts shows close interactions between man and the world, attitudes of people towards nature. Research in phytonyms and medicinal plant names proper is most essential for the understanding of a nation’s cultural heritage. The paper examines the lexeme балтырған in Bashkir discourse. Materials. The analyzed materials include linguistic dictionaries, folklore and fiction texts of the Machine Fund of the Bashkir Language, and etymological dictionaries of Altaic languages. Goals. The study aims at a comparative investigation of the lexeme балтырған ‘hogweed’. Results. The term proves a widespread phytonym in Bashkir discourse, which is attested by that it denotes a wide range of plant species in Bashkir and has parallels in other Turkic and Mongolic languages. The lexeme is included in academic, explanatory, dialectal, phrasal, and mythological dictionaries of the Bashkir language. The comparative analysis shows that baltyrγan ‘hogweed’ usually denotes a plant of the order Apiales, a medicinal herb. Baltyrγan~ baltirγana contains the initial bal / baltïr / baldïr with the meaning ‘green, young, fresh’.


Kavkaz-forum ◽  
2021 ◽  
Author(s):  
Р.Н. АБИСАЛОВА

В статье рассмотрен один из мотивов осетинского Даредзановского эпоса – мотив прикованного героя, еще в древности вошедший в мифологию, фольклор, литературу многих народов и получивший название «мотив Прометея». Образ Прометея относится к «вечным образам» мировой художественной культуры. История прикования и освобождения Прометея и в древнегреческой мифологии, и в трагедии Эсхила позиционируется как топонимически привязанная к Кавказу. Именно здесь сюжет о наказанном Богом и прикованном богатыре получил распространение в национальных мифах и эпических преданиях – грузинских, осетинских, кабардинских, абхазских, вайнахских, армянских и др. Эти лаконичные предания об Амиране-Амране, по мнению Вс.Ф. Миллера, – кульминационные во всех источниках, рассказывающих об этом герое. Рассмотрены как древнегреческий Прометей, так и кавказские, в первую очередь осетинские, прикованные герои, представленные в работах Вс.Ф. Миллера, Г.Н. Потанина, Дз. Гатуева, Д.А. Калоевой, З.Г. Тменовой, Ю.А. Дзиццоты, Х.Ф. Цгоева и др. Образ Амирана сравнивается с соответствующими ему героями кавказских эпосов. При всей схожести мотивов богоборчества и наказания героя прикованием к скале или столбу нельзя не отметить отличия осетинского Амирана от остальных. В Даредзановских сказаниях он героическая личность, истинный богатырь, совершающий множество подвигов, побеждающий великанов, помогающий всем нуждающимся. Сын племянницы Бога, герой близок к народу, он побеждает врагов не только ради демонстрации силы, ловкости, хитрости, но и для спасения родных и друзей. В отличие от большинства кавказских прикованных героев, освобождение Амирана не предвещает гибель мира, напротив, осетинский Амиран, в случае освобождения, даст людям свободу и счастье. Многие мотивы в преданиях об Амране соотносятся с мотивами Нартовского эпоса. Амиран-Амран приравнивается к любимым героям осетинской Нартиады – Сослану, Батразу, Урузмагу, Шатане. В работе его образ рассмотрен для подтверждения объективной закономерности подобной репрезентации осетинского героя. The article deals with one of the motives of the Ossetian Daredzanian epic − the motive of the chained hero, which in ancient times entered the mythology, folklore, literature of many peoples and was called the "Prometheus motive". The image of Prometheus belongs to the "eternal images" of world art culture. The history of the chaining and liberation of Prometheus, both in ancient Greek mythology and in the tragedy of Aeschylus, is positioned as toponymically tied to the Caucasus. It was here that the plot about the God-punished and chained hero became widespread in national myths and epic legends − Georgian, Ossetian, Kabardian, Abkhaz, Vainakh, Armenian, etc. These laconic legends about Amiran-Amran, according to Vs.F. Miller, are culminating in all the sources telling about this hero. Both the ancient Greek Prometheus and the Caucasian, primarily Ossetian, chained heroes presented in the works of Vs.F. Miller, G.N. Potanin, Dz. Gatuev, D.A. Kaloeva, Z.G. Tmenova, Yu.A. Dzizzoity, Kh.F. Tsgoev and others. The image of Amiran is compared with the corresponding heroes of the Caucasian epics. With all the similarity of the motives of fighting against God and the punishment of the hero by being chained to a rock or a pillar, one cannot fail to note the difference between the Ossetian Amiran and the others. In Daredzan's legends, he is a heroic person, a true hero who performs many feats, conquers giants, and helps all those in need. The son of the niece of God, the hero is close to the people, he defeats enemies not only for the sake of demonstrating strength, dexterity, cunning, but also to save family and friends. Unlike most of the Caucasian chained heroes, the release of Amiran does not portend the death of the world, on the contrary, the Ossetian Amiran, if liberated, will give people freedom and happiness. Many motives in the legends about Amran correlate with the motives of the Nartov epic. Amiran-Amran is equated with the favorite heroes of the Ossetian Nartiada - Soslan, Batraz, Uruzmag, Shatana. In the work, his image is considered to confirm the objective regularity of such a representation of the Ossetian hero.


Sign in / Sign up

Export Citation Format

Share Document