scholarly journals Isotretinoin, Acne and Depression: A Prospective Controlled Study

2021 ◽  
Vol 79 (3) ◽  
pp. 241-245
Author(s):  
Laura V. Langer ◽  
Lucas Prim ◽  
Thelma Skare ◽  
Virginia Wrublevski ◽  
Renato Nisihara

Introduction: Acne and isotretinoin, one of its treatment, have been linked to the occurrence of depression. Our aim was to study if isotretinoin is associated with depression in a sample of acne patients followed for 6 months comparing them with acne patients under other treatment modalities and control patients without acne. Methods: One hundred individuals were included: 50 controls and 50 with acne (24 using and 26 not using isotretinoin). Patients and controls answered the Beck Depression Inventory (BDI) and the 12 Item-Short Form Health Survey for quality of life (SF-12). Acne patients repeated this evaluation in 90 and 180 days. Results: No differences were found between controls and acne patients regarding BDI results but controls performed worse in the SF-12 mental domain (p=0.004). No differences were found within the acne group between those treated and not treated with isotretinoin in the comparison of the BDI and SF-12 (mental and physical domains) in days 0. 90 and 180 (all with p>0.05). Conclusion: In this small sample isotretinoin treatment showed to be safe regarding the occurrence of depression.

2021 ◽  
Vol 79 (1) ◽  
Author(s):  
Chadia Haddad ◽  
Hala Sacre ◽  
Sahar Obeid ◽  
Pascale Salameh ◽  
Souheil Hallit

Abstract Background In clinical practice, quality of life measures can be used alongside some types of assessment to give valuable information that can identify areas that influence an individual and help the clinician make the best healthcare choices. This study aimed to investigate the psychometric properties of the Arabic version of the 12-item short-form health survey (SF-12) in a sample of Lebanese adults. Methods This cross-sectional study performed between July and November 2019 recruited 269 participants. Cronbach’s alpha was used to assess the reliability of the SF-12 questionnaire, and a factor analysis using the principal component analysis was performed to confirm its construct validity. Results The mean score for the “physical component summary (PCS-12)” was 50.27 ± 8.94 (95 % CI: 49.18–51.36) and for the “Mental component summary (MCS-12)” was 44.95 ± 12.17 (95 % CI: 43.47–46.43). A satisfactory Cronbach’s alpha was found for the two components: MCS (α = 0.707) and PCS (α = 0.743). The principal component analysis converged over a two-factor solution (physical and mental), explaining a total variance of 55.75 %. Correlations between the SF-12 scales and single items were significant, showing a good construct validity. The “physical functioning”, “role physical”, “bodily pain”, and “general health” subscales were highly associated with “PCS-12”, while the “vitality”, “social functioning”, “role emotional”, and “mental health” subscales were more associated with MCS-12. Conclusions The Arabic version of the SF-12 is a reliable, easy-to-use, and valid tool to measure health-related quality of life in the general population. Future studies using a larger sample size and focusing on questionnaire psychometric properties are necessary to confirm our findings.


2013 ◽  
Vol 47 (4) ◽  
pp. 843-851 ◽  
Author(s):  
Rafaela Batista dos Santos Pedrosa ◽  
Roberta Cunha Matheus Rodrigues ◽  
Kátia Melissa Padilha ◽  
Maria Cecília B.J. Gallani ◽  
Neusa Maria Costa Alexandre

Este estudo estimou a validade de constructo pelo teste de grupos conhecidos do Instrumento para Mensuração do Impacto da Doença no Cotidiano do Valvopata (IDCV) quanto a sinais e sintomas, função ventricular sistólica, fração de ejeção do ventrículo esquerdo (FEVE) e qualidade de vida relacionada à saúde (QVRS) em 153 coronariopatas em seguimento ambulatorial. Os dados foram obtidos pela aplicação do IDCV e das versões brasileiras do The Medical Study 36-item Short Form Health Survey – SF-36 e MacNew Heart Disease Health-related Quality of Life Questionnair e. Foi utilizado o teste de Mann-Whitney para verificar a capacidade do IDCV em discriminar o impacto quanto a sinais e sintomas, FEVE e disfunção sistólica ventricular, bem como o teste de Kruskal-Wallis para verificar seu poder de discriminação em relação à QVRS. Constatou-se que o IDCV discriminou o impacto entre aqueles que pontuaram nos quartis (≤Q1, Q1-Q3, ≥Q3) de QVRS. Os achados deste estudo contribuem para o refinamento do IDCV na mensuração do impacto da doença entre coronariopatas.


Author(s):  
Hugo Parent-Roberge ◽  
Thomas A. Deshayes ◽  
Catherine Fortier ◽  
Karine Marquis ◽  
Christiane Lacharité-Lemieux ◽  
...  

Intradialytic exercise is feasible and yields substantial clinical benefits in middle-aged patients. However, evidence is scarce in older hemodialysis patients. Objective: To assess the feasibility and clinical benefits of supervised, intradialytic exercise in older patients. Methods: Multicenter one-arm feasibility study. The main outcome was feasibility (ease of recruitment, dropout rate, adherence, affective valence, and adverse events). The secondary outcomes were physical capacity (five-repetition sit-to-stand, 60-s sit-to-stand tests, and grip strength), quality of life (36-Item Short-Form Health Survey), quality of sleep (Pittsburgh Sleep Quality Index), depressive symptoms (Beck Depression Inventory), and dialysis efficacy (Kt/V and urea reduction ratio). Results: About 79% of the screened patients agreed to participate (n = 25, 73 [66–77] years). The dropout rate was high (32%), but adherence remained high among the participants who completed the study (94%). Improvements were found in the five-repetition sit-to-stand (p < .001), 60-s sit-to-stand tests (p = .028), 36-Item Short-Form Health Survey mental component score (p = .008), depressive symptoms (p = .006), and quality of sleep (p = .035). Conclusion: Supervised intradialytic exercise seems safe and beneficial in older patients.


2019 ◽  
Vol 11 (1) ◽  
pp. 186-191
Author(s):  
Camila Zanesco ◽  
Erica De Brito Pitilin ◽  
Maíra Rossetto ◽  
Débora Tavares de Resende e Silva

Objetivo: Caracterizar os pacientes com DRC em tratamento de hemodiálise (HD) de uma clínica do oeste catarinense, suas relações e variáveis sociodemográficas, e, a sua QV. Metodologia: Estudo transversal descritivo, com 116 pacientes com DRC em HD. Para coleta dos dados usou-se questionário sociodemográfico e o intrumento Medical Outcomes Study 36 – Item Short – Form Health Survey (SF-36). Resultados: Houve prevalência da população com idade igual ou > 60 anos, caucasianos (74,77%), do sexo masculino (54,31%), destaca-se a presença de profissões relacionadas a classe média ebaixa e quantidade de anos de estudo reduzidos. Em relação a comorbidades, prevaleceu a Hipertensão Arterial Sistêmica(38,79%). Quanto a QV as limitações por aspectos físicos tiveram menores médias (29,09) e limitações em atividades sociais maior média (73,71). Conclusão: A QV negativa têm repercussões pessoais, familiares e sociais devido ao impacto da doença na rotina de atividades de vida diária dos doentes renais.


2015 ◽  
Vol 28 (3) ◽  
pp. 347 ◽  
Author(s):  
Cristina Nogueira-Silva ◽  
Patrício Costa ◽  
Carla Martins ◽  
Sónia Barata ◽  
Conceição Alho ◽  
...  

<strong>Introduction:</strong> Endometriosis Health Profile Questionnaire-30 is currently the most used questionnaire for quality of life measurement in women with endometriosis. The aim of this study is to evaluate the psychometric properties and to validate the Portuguese Endometriosis Health Profile Questionnaire-30 version.<br /><strong>Material and Methods:</strong> A sequential sample of 152 patients with endometriosis, followed in a Portugal reference center, were asked to complete a questionnaire on social and demographic features, the Portuguese version of the Endometriosis Health Profile Questionnaire-30 and of the Short Form Health Survey 36 Item – version 2. Appropriate statistical analysis was performed using descriptive statistics, factor analysis, internal consistency, item-total correlation and convergent validity.<br /><strong>Results:</strong> Factorial analysis confirmed the validity of the five-dimension structure of the Endometriosis Health Profile Questionnaire-30 core questionnaire, which explained 83.2% of the total variance. All item-total correlations presented acceptable results and high internal consistency, with Cronbach’s alpha ranging between 0.876 and 0.981 for the core questionnaire and between 0.863 and 0.951 for the modular questionnaire. Significant negative associations between similar scales of Endometriosis Health Profile Questionnaire-30 and Short Form Health Survey 36 Item – version 2 were demonstrated. Data completeness achieved was high for all dimensions. The emotional well-being scale in the core questionnaire and the infertility scale in the modular section had the highest median scores, and therefore the most negative impact on the quality of life of participating women.<br /><strong>Discussion:</strong> The test-retest reliability and responsiveness of the questionnaire should be evaluated in future studies.<br /><strong>Conclusion:</strong> The present study demonstrates that the Portuguese version of the Endometriosis Health Profile Questionnaire-30 is a valid, reliable and acceptable tool for evaluating the health-related quality of life of Portuguese women with endometriosis.


2012 ◽  
Vol 101 (1-2) ◽  
pp. 157-165 ◽  
Author(s):  
Ji Wang ◽  
Yi Wang ◽  
Li Bo Wang ◽  
Hui Xu ◽  
Xiao-lei Zhang

2013 ◽  
Vol 26 (2) ◽  
pp. 205-212 ◽  
Author(s):  
Edja Solange Souza Rangel ◽  
Angélica Gonçalves Silva Belasco ◽  
Solange Diccini

OBJETIVOS: Avaliar e correlacionar a qualidade de vida e depressão de pacientes após acidente vascular cerebral em reabilitação. MÉTODOS: Estudo transversal realizado em dois serviços de reabilitação, com pacientes de acidente vascular cerebral. As informações coletadas foram sociodemográficas, o Medical Outcome Study 36 - item short-form health survey, o Stroke Specific Quality of Life Scale, o Índice de Barthel e o Inventário de Depressão de Beck. RESULTADOS: A amostra foi constituída de 139 pacientes, idade média 59,4 anos e 59% eram homens. Houve comprometimento dos escores da qualidade de vida geral e específica. Segundo o Índice de Barthel 49,6% dos pacientes apresentavam dependência moderada a severa e 49,7% tinham sintomas depressivos, conforme Inventário de Depressão de Beck, não havendo correlação positiva entre estes dados e qualidade de vida geral e específica. CONCLUSÃO: A qualidade de vida geral e específica dos pacientes com acidente vascular cerebral, em reabilitação, apresentou domínios comprometidos.


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