Eating Difficulties among Older Adults with Dementia in South Korean Long-Term Care Facilities: A Scoping Review

This study aims to synthesize existing literature concerning eating difficulties among older adults with dementia in long-term care facilities. A scoping review, using the framework proposed by Arksey & O'Malley (2005) and improved and supplemented by Levac et al. (2010), was conducted. Literature was searched from five bibliographic databases—Research Information Sharing Service (RISS), Korean studies Information Service System (KISS), National Digital Science Library (NDSJ), Korean Medical Database (KMBASE), DataBase Periodical Information Academic(DBPia), Google Scholar, and gray literature. Literature selection and characteristics were approved by two independent reviewers, using pre-tested forms to determine final inclusion. Eventually, 111 articles from 2012–2020 were identified, and the 11 articles were used for the final analysis. We found that primarily utilized Eating behavior scale (EBS) and Edinburgh feeding evaluation in dementia scale (EdFED) had utilized as measurement tools for evaluating eating behavior. The most common factors related to eating behavior of older adults with dementia included cognitive and physical functions in the individual domain, the caregiver's attitude toward eating in the inter-individual domain, and types of meal in the environmental domain. Therefore, it is essential to develop measurement tools that reflect the eating behavior of older adults with dementia, a comprehensive understanding of the eating behavior of old adults with dementia, and create effective interventions that can be implemented in the specificity of long-term care facilities in Korea. The results of this analysis are intended to be used as basis to develop a meal support programs for older adults with dementia.

Eating Difficulties among Older Adults with Dementia in South Korean Long-Term Care Facilities: A Scoping Review

Purpose: This study synthesized the literature on eating difficulties among older adults with dementia in long-term care facilities.Methods: A scoping review, using the framework proposed by Arksey & O'Malley (2005) and supplemented by Levac et al. (2010), was conducted. Literature was searched from RISS, KISS, DBpia, PubMed, and CINAHL. Two reviewers independently selected studies and extracted their characteristics, using pre-tested forms to determine final inclusion. In total, 1283 articles were identified, and 13 articles were used for the final analysis.Results: The Eating Behavior Scale and the Edinburgh Feeding Evaluation in Dementia scale were the most widely utilized measurement tools. The most common factors related to eating behavior in older adults with dementia were cognitive and physical functions in the individual domain, the caregiver's attitude toward eating in the inter-individual domain, and meal type in the environmental domain.Conclusion: Measurement tools reflecting the eating behavior of older adults with dementia must be developed to obtain a comprehensive understanding of this issue and create effective interventions for the specific context of long-term care facilities in Korea. The results of this study are intended to serve as a basis to develop meal support programs for older adults with dementia.

Socioecological factors' effect on the subjective experience of COVID-19 quarantine policy in Korea: Consensual qualitative research

Background: In face of the COVID-19, South Korea has provided the ‘Global Golden Standard’ of containment effort. Mandatory quarantine, one of the core policies in place, has proven its efficacy in ensuring public health. Nonetheless, no previous study has examined the policy’s comprehensive impact on its subjects. In addition to providing an account of holistic subjective experience of quarantine, this study also examines the socioecological factors’ influence on the subjective experience by applying the Bronfenbrenner’s model. In order to gather unconstrained information in relation to the contextual background, Consensual Qualitative Research method was used. 17 adults of Korean nationality were interviewed about their experience.Results: 10 categories within four domains of Subjective experience were found: (a) changed life style because of quarantine, continued pre-quarantine life, lasting effect of quarantine in Lifestyle domain; (b) Physical health domain with no subcategory; (c) discomfort, infection anxiety, accepting, satisfying, and gratitude within Psychological Experience domain; and (d) suggestion and change of perspective within Reflection domain. Next, 13 categories of socioecological factors belonged to four different levels of domain: (a) personality and belief in Within-individual domain; (b) quarantine space, personal relationship, coresident, student status, and employment status in Microsystem; (c) Korea’s quarantine policy, maintenance, resources, and abroad’s preventive measure against COVID in Exosystem; and (d) stigma and social responsibility in Macrosystem.Conclusions: The reported subjective experiences of self-quarantine were not uniformly negative or positive, which is unlike previous research findings that were dominantly negative. Identifying socioecological factors that shape an individual’s quarantine experience shed light onto how the government can protect its people from the potential threats of quarantine. The examples include promoting sense of safety through clear and coherent communication about the disease and the measures that are being placed, maximizing opportunities for the subjects to exert control over their lives during quarantine, devising ways to make virtual social connection accessible, and etc.

POLITICAL ETHICS IN BERGER DIALECTICS AGAINST THE MEANING OF POWER OF THE SOUTH NIAS DPRD MEMBERS FOR THE 2014-2019 PERIOD

The establishment of South Nias Regency is of course accompanied by the formation of new legislatif and executive institutions to run the government. The formation of these institutions provided an opportunity for the emergence of local Nias Selatan elites to take up positions as legislators and regional heads. Reflecting from the above view, this research is a case study that focuses on developing in-depth descriptions and explanations of the meaning of the position of legislatif members in South Nias in 2014. specifically the perspective of Peter L Berger's social construction.At a practical level, this study can be a "mirror" for local political elites in South Nias to understand the political dynamics in the district more sharply and deeply, and can be considered in formulating more appropriate strategies and tactics.The method in this study uses the phenomenology approach. This approach prioritizes human existence as something that must be interpreted or interpreted. Phenomenology in this study basically seeks to uncover and describe the meaning of the position of DPRD members for competing local South Nias elites. The conclusions in this study reveal that the reality of the meaning of office is in the view of members of the South Nias DPRD, namely as a mandate, arena of contestation, and aspects of interests. The factors underlying the interest of South Nias DPRD members towards positions were formed in two spheres, namely the individual domain and the community domain. In the individual domain, their interest in the position is motivated by four factors, namely internal motivation, external motivation, skills, and goals. While in the community domain there are three factors, namely the previous orientation, current orientation, and future orientation. The motive of South Nias DPRD members in choosing to become officials in the ranks of the government bureaucracy is to become a direct actor in South Nias regional development. Being an official for members of the South Nias DPRD is important than that position held by people who do not care about the development of South Nias. If the position is held by people who do not understand the history, culture and customs of South Nias, it will be fatal.

Architecturally complex O-glycopeptidases are customized for mucin recognition and hydrolysis

A challenge faced by peptidases is the recognition of highly diverse substrates. A feature of some peptidase families is the capacity to specifically use post-translationally added glycans present on their protein substrates as a recognition determinant. This is ultimately critical to enabling peptide bond hydrolysis. This class of enzyme is also frequently large and architecturally sophisticated. However, the molecular details underpinning glycan recognition by these O-glycopeptidases, the importance of these interactions, and the functional roles of their ancillary domains remain unclear. Here, using the Clostridium perfringens ZmpA, ZmpB, and ZmpC M60 peptidases as model proteins, we provide structural and functional insight into how these intricate proteins recognize glycans as part of catalytic and noncatalytic substrate recognition. Structural, kinetic, and mutagenic analyses support the key role of glycan recognition within the M60 domain catalytic site, though they point to ZmpA as an apparently inactive enzyme. Wider examination of the Zmp domain content reveals noncatalytic carbohydrate binding as a feature of these proteins. The complete three-dimensional structure of ZmpB provides rare insight into the overall molecular organization of a highly multimodular enzyme and reveals how the interplay of individual domain function may influence biological activity. O-glycopeptidases frequently occur in host-adapted microbes that inhabit or attack mucus layers. Therefore, we anticipate that these results will be fundamental to informing more detailed models of how the glycoproteins that are abundant in mucus are destroyed as part of pathogenic processes or liberated as energy sources during normal commensal lifestyles.

A qualitative study of seven simulation models for tendon repairs

Seven models for tendon repair simulation (urinary catheter, liquorice, fishing lure, dental rolls, drinking straw, silicone sealant and the authors’ modification of silicone sealant with Micropore™ tape) were assessed for their performance in a number of domains. The silicone sealant and surgical tape model scored highest overall and for each individual domain. This was significantly higher than all other models with the exception of the silicone sealant alone. The lowest scoring model was the drinking straw model.

Effects of electrostatic interactions on global folding and local conformational dynamics of a multidomain Y-family DNA polymerase

Electrostatic interactions can facilitate the folding of the multidomain DNA polymerase Dpo4 by refining the folding order of the individual domain and promote the functional conformational dynamics of Dpo4 during the DNA-binding recognition.

Abstract 16353: Effects of Dapagliflozin on Physical and Social Activity Limitations in Patients With Heart Failure and Reduced Ejection Fraction: An Analysis of DAPA-HF

Background: Patients with heart failure and reduced ejection fraction (HFrEF) suffer limitations in physical and social activities. We examined whether the SGLT2 inhibitor dapagliflozin improved the degree of physical and social activity limitation measured using the Kansas City Cardiomyopathy Questionnaire (KCCQ) in DAPA-HF. Hypothesis: Dapagliflozin, compared with placebo, would reduce the limitations of physical and social activity experienced by patients with HFrEF. Methods: We examined the effect of dapagliflozin on the physical and social limitation domains of the KCCQ at 8 months (prespecified analysis time point). Mean change from baseline was calculated using a linear regression model adjusted for baseline values with no imputation for missing data. Scores range from 0-100, with higher scores indicating better health status. Findings: At baseline, 4443 (94%) patients had available KCCQ data. Mean baseline physical limitations and social limitations scores were 66.0±24.0 and 65.5±27.4, respectively. Of the 10 individual domains that constitute these scores, the greatest limitations reported by patients at baseline were in doing gardening or housework or carrying groceries, hurrying/jogging and sexual relationships. Dapagliflozin improved physical and social limitations scores at 8 months (placebo-corrected mean difference +1.88 [95%CI 0.66,3.10] and +1.60 [0.18,3.01], respectively). Each individual domain reflecting physical and social limitations improved with dapagliflozin with the exception of sexual relationships (Table); the greatest improvements were seen in doing gardening or housework or carrying groceries (+2.48 [0.63,4.33]), hobbies and recreational activities (+2.46 [0.75-4.17]), and walking 100yd on level ground (+2.29 [0.62,3.96]). Interpretation: In DAPA-HF, dapagliflozin, compared with placebo, improved physical and social limitations as measured by the KCCQ in patients with HFrEF.