scholarly journals Capacidad antioxidante y mecanismo de acción de pigmentos en organismos marinos

CienciaUAT ◽  
2021 ◽  
pp. 186-197
Author(s):  
Josafat Marina Ezquerra-Brauer ◽  
Jesús Enrique Chan-Higuera
Keyword(s):  
Web Of Science ◽  
Microsoft Academic

Los organismos marinos poseen maravillosos colores que los hacen muy atractivos. Las características únicas de los compuestos sintetizados por especies de origen marino van más allá de su apariencia. Los pigmentos responsables de esos colores son capaces también de generar diversas actividades biológicas, como la capacidad antioxidante, la cual puede ocurrir a través de diversos mecanismos. Esto ha propiciado un aumento de su investigación, debido a su amplia aplicación en la biotecnología, farmacéutica, cosmética y alimentación de organismos vivos, expandiendo los estudios tanto in vitro como en ensayos in vivo. El objetivo de este trabajo fue compilar y describir diversos estudios recientes, enfocados en demostrar y elucidar los mecanismos de acción de los diferentes compuestos bioquímicos con actividad antioxidante, provenientes de algunos organismos marinos. Para ello, se utilizaron las bases de datos Scopus®, Web of Science™ y Microsoft Academic. Los pigmentos provenientes de organismos marinos representan una alternativa promisoria frente a los antioxidantes y aditivos sintéticos utilizados en la actualidad. El establecimiento y comprensión de los mecanismos de acción de los componentes pigmentados bioactivos, aislados de los organismos marinos, permitirá determinar con mayor precisión su posible aplicación en la industria.

scholarly journals Glycemic Index of Gluten-Free Bread and Their Main Ingredients: A Systematic Review and Meta-Analysis

Foods ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 506
Author(s):  
Bernardo Romão ◽  
Ana Luísa Falcomer ◽  
Gabriela Palos ◽  
Sandra Cavalcante ◽  
Raquel Braz Assunção Botelho ◽  
...  
Keyword(s):  
Systematic Review ◽  
Glycemic Index ◽  
Resistant Starch ◽  
Web Of Science ◽  
Meta Analysis ◽  
Gluten Free ◽  
Inclusion Criteria ◽  
Glycemic Profile

This study aimed to perform a systematic review and meta-analysis of the glycemic index (GI) of gluten-free bread (GFB) and its main ingredients. The systematic review followed PRISMA guidelines, using seven electronic databases (PubMed, EMBASE, Scopus, Science Direct, Web of Science, gray literature research with Google Scholar, and patents with Google Patent tool), from inception to November 2020. Eighteen studies met the inclusion criteria evaluating 132 GFB samples. Five articles tested GI in vivo, eleven in vitro; and two studies tested both methods. The analysis showed that 60.7% (95% CI: 40.2–78.1%) of the samples presented high glycemic indexes, evidencing a high glycemic profile for GFB. Only 18.2% (95% CI: 11.7–27.2%) of the bread samples presented in the studies were classified as a low GI. Meta-analysis presented moderate/low heterogenicity between studies (I2 = 61% and <1% for both high and low GIs) and reinforced the proportion of high GIs. Lower GIs were found in formulations based on Colocasia esculenta flour or enriched with fiber, yogurt and curd cheese, sourdough, psyllium, hydrocolloids, enzymes, fructans, and resistant starch, highlighting the efficacy of these ingredients to lower GFBs’ GI. GFB tends to present high GI, impacting the development of chronic diseases when consumed.

scholarly journals Estudo experimental in vivo e in vitro de plantas medicinais nos processos de embriotoxicidade e teratogenicidade

2021 ◽  
Vol 10 ◽  
pp. 227-240
Author(s):  
Regineide Xavier Santos ◽  
Iara Pacheco Gomes Volejo
Keyword(s):  
Medicinal Plants ◽  
Web Of Science ◽  
Teratogenic Effects

Este trabalho tem como objetivo contribuir na compilação de artigos científicos sobre as plantas medicinais que possuem efeitos embriotóxicos e teratogênicos comprovados através de testes experimentais in vivo e in vitro. Foi realizado um levantamento nas bases de dados Medline, Pubmed, Web of Science, Cochrane, Biblioteca virtual em saúde, Lilacs e Scielo com os descritores, “Medicinal plants, embryotoxicity”; “Medicinal plants, Teratogenic effects”; “Medicinal plants, teratogenicity” e seus correspondentes em português: “Plantas medicinais, embriotoxicidade”; “Plantas medicinais, efeitos Teratogênicos”; “Plantas Medicinais Teratogenicidade”. Oito artigos de ensaios in vivo e quatro de in vitro e um que apresenta os dois ensaios, preencheram os critérios de inclusão e exclusão e foram selecionados para esta revisão. Destes, cinco foram realizados na América, um na Europa, três na África e dois na Ásia. Na maioria dos estudos in vivo o extrato da planta foi injetado no animal, observando assim seus efeitos. A partir deste estudo, foi verificado que as plantas podem apresentar algum tipo de efeito no processo embrionário, portanto, o consumo durante o estado gravidico deve ser avaliado por um profissional da área. Palavras-chave: Gestação. Planta medicinal. Embriotoxicidade. Teratogênico.

scholarly journals Efectos de Bloqueadores del Receptor de Angiotensina II e inhibidores de la Enzima Convertidora de Angiotensina en COVID-19: Una revisión narrativa de la literatura

2020 ◽  
Vol 7 (2) ◽  
Author(s):  
Juan David Muñoz Loaiza ◽  
Heitmar Santiago Infante ◽  
Brenda Stefanía Pérez Mahecha ◽  
Juan Esteban Herrera Cardona ◽  
David Ricardo Salamanca
Keyword(s):  
Web Of Science ◽  
Antihypertensive Drugs ◽  
Epidemiological Studies ◽  
Clinical Indication ◽  
Angiotensin Converting Enzyme 2 ◽  
In Vivo Tests ◽  
Antihypertensive Treatments ◽  
The Relationship

Introduction: An outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is currently affecting worldwide. The association between this virus and the upregulation of Angiotensin-Converting Enzyme 2 (ACE2) has been suggested as a potential as an important factor in the development of Coronavirus Disease- 19 (COVID-19). Objective: To describe the relationship between some antihypertensive treatments and COVID-19. Methods:  A research was conducted with the components of the PIO (Population, Intervention, Outcomes) strategy, including the literature of the last 20 years available in central PubMed, Web of Science, Scopus, and Embase databases. All relevant articles that assessed the epidemiological relationship between SARS-CoV-2 and hypertension, the treatment and outcomes of the patients who have this comorbidity, as well as the relationship between the RAA axis and COVID-19 were included in the analysis. Results: A total of 292 items were found in the databases. After a thorough analysis, 17 papers were selected, including in vitro and in vivo tests, clinical trials, and epidemiological studies related to the topic analyzed. Conclusion: Due to the systemic benefits of antihypertensive drugs targeting the RAA axis, and the lack of evidence of these treatments being a risk factor, It is not recommended to withdraw these medications from hypertensive patients infected with SARS-CoV 2, unless there is a clinical indication.

scholarly journals Nanocompuestos de quitosano aplicados al campo de la medicina regenerativa. Una revisión sistemática

2020 ◽  
Vol 25 (4) ◽  
pp. 604-615
Author(s):  
Yeidy Viviana Arias-Andrade ◽  
Luz Angela Veloza ◽  
Juan Carlos Sepúlveda-Arias
Keyword(s):  
Web Of Science ◽  
Assessment Tool ◽  
Reliability Assessment ◽  
Data Reliability ◽  
Revisión Sistemática ◽  
Toxicological Data

El quitosano es un biopolímero obtenido de la quitina presente en el exoesqueleto de crustáceos, insectos, arácnidos y en la pared celular de los hongos. Investigaciones recientes han confirmado el uso del quitosano como biomaterial prometedor debido a características como estructura porosa, facilidad de modificación química, alta afinidad hacia macromoléculas in vivo, entre otras. El objetivo de este trabajo fue evaluar las aplicaciones del quitosano como biomaterial en medicina regenerativa. Se realizó una búsqueda de la literatura en el período comprendido entre 2013-2018 en las bases de datos PubMed, Scopus, Web of Science y Embase. En esta revisión, la herramienta “ToxRTool” (Toxicological data Reliability Assessment Tool) se usó para evaluar la calidad y confiabilidad metodológica de los estudios evaluados. Los nanocompuestos de quitosano se están evaluando con metodologías in vitro (92.59%), empleando diversos componentes de acople y en múltiples aplicaciones. Sin embargo, la falta de información metodológica con relación al uso de controles en los estudios dificulta la reproducibilidad de los mismos e introducen limitaciones para el posterior desarrollo de estudios in vivo. La herramienta ToxRTool fue útil para identificar ocho estudios (29.6%) como “Confiable sin restricciones” y 19 estudios (70.4%) como “Confiable con restricciones”, indicando que se requieren estudios más cuidadosos con relación a la toxicidad de los nanocompuestos de quitosano. El quitosano es un biomaterial versátil lo que ha permitido su incorporación en una amplia variedad de componentes mejorando sus propiedades biológicas, mecánicas y físicas, obteniendo así nanocompuestos cada vez más útiles y eficaces para uso nanomedicina.

scholarly journals Bioactivities of extracts and phytochemicals of Indigofera aspalathoides Vahl ex DC.

2021 ◽  
pp. 1-16
Keyword(s):  
Plant Species ◽  
Web Of Science ◽  
Scientific Evidence ◽  
Anticancer Compounds ◽  
Traditional Medicines ◽  
Anti Inflammatory ◽  
Phytochemical Studies ◽  
The Web

Indigofera aspalathoides Vahl ex DC. belongs to the Fabaceae family. I. aspalathoides is applied to heal tumors, inflammations, diabetes, leprosy, and kidney illnesses in traditional medicines. Compounds including kaempferol, kaempferol 5-O-β-D-glucopyranoside, 5,4'-dihydroxy 6,8-dimethoxy 7-O-rhamnosyl flavone, indigocarpan, and mucronulatol have isolated from this plant species. Hitherto, there is no comprehensive review available regarding the reported bioactivities of I. aspalathoides. Thus, this article goals to analyze, summarize and document the published bioactivities-related publications. Electronic databases the Web of Science, Scopus, ScienceDirect, and PubMed used to find relevant publications from 1900 to December 2020. Thus far, only in vivo and in vitro scientific evidence levels of bioactivities are available. I. aspalathoides holds such as anti-inflammatory, anticancer, antihepatotoxic, anti-arthritic, immunomodulatory, and antidiabetic properties. Overall, immunomodulatory, anti-inflammatory, and anticancer compounds have been isolated from this plant species Therefore, additional bioactivity and phytochemical-related researches would need to perform to generate more scientific evidence for other applications. This work will be useful for further bioactivity and phytochemical studies using this plant species.

scholarly journals Plantas brasileiras com ação anticolinesterásica – uma revisão

2022 ◽  
Vol 11 (1) ◽  
pp. e6211124262
Author(s):  
Francisco Flávio da Silva Lopes ◽  
Lucas Soares Frota ◽  
Gilson Araújo Fontenele ◽  
Marcus Vinícius Ferreira da Silva ◽  
Victor Borges Fernandes ◽  
...  
Keyword(s):  
Web Of Science ◽  
Google Scholar

O Brasil possui uma grande flora distribuída por todo seu território, contendo a maior diversidade genética em espécies do mundo, muitas delas utilizadas para fins terapêutico. As plantas são as melhores fontes para a descoberta de compostos bioativos contra as doenças. A Doença de Alzheimer é uma doença neurodegenerativa caracterizada pela perda de memória, afeta principalmente a população com mais de 65 anos de idade. Este trabalho descreve um levantamento sobre extratos e óleos obtidos a partir de plantas da flora brasileira com potencial ação anticolinesterásica. Realizou-se uma revisão bibliográfica sistemática da produção científica em bases de dados da CAPES, Google Scholar, PubMed, Scielo, Science Direct, SciFinder, Scopus e Web of Science. Selecionou-se 41 artigos publicados entre 2011 e 2021. Foram identificadas 152 espécies vegetais distribuídas em 49 famílias botânicas, onde a Fabaceae foi a mais citada com 32 espécies (21,05%). A produção de extrato foi a principal forma escolhida, 253 vezes (93,36%). As folhas foram as partes mais utilizada, 94 vezes (43,12%). As extrações por etanol se destacaram com 140 vezes (51,66%). A maioria dos ensaios avaliou a inibição da acetilcolinesterase em microplaca de 96 poços, 182 ensaios (54,17%). De todas as espécies relatadas 110 promoveram a inibição, desse total 66,36% obtiveram uma alta intensidade. O estudo atingiu seu objetivo ao mostrar resultados relevantes na inibição da AChE, porém vale ressaltar que diante do tamanho da nossa flora, poucas espécies foram investigadas, tampouco foram testadas in vivo para se corroborar com os resultados dos ensaios in vitro.

scholarly journals BIOACTIVITIES OF GUETTARDA SPECIOSA L. EXTRACTS

2020 ◽  
Vol 5 (1) ◽  
pp. 20-22
Author(s):  
Saravanan Vivekanandarajah Sathasivampillai ◽  
Moon Jain ◽  
Pholtan Rajeev Sebastian Rajamanoharan
Keyword(s):  
Systematic Review ◽  
Plant Species ◽  
Web Of Science ◽  
Antioxidant Activities ◽  
Bioactive Compound ◽  
Scientific Data ◽  
Anti Inflammatory

Guettarda speciosa L. is a tree of the Rubiaceae family. G. specious has been used to treat diarrhea, abscesses, wounds, epilepsy, and malaria in ethnomedicinal systems. So far, there is no systematic review for the bioactivities of G. speciosa. Therefore, the purpose of this minireview is to analyze, summarize and document the reported bioactivities of G. speciosa. Major electronic databases (Web of Science, Scopus, ScienceDirect, PubMed, and Semantic Scholar) were used to identify related studies from 1900 to January 2021. So far, in vivo and in vitro scientific data are available for the bioactivities of this plant species. Studies have reported that G. speciosa contains antidiarrheal, antiepileptic, anti-inflammatory, anti-ulcer, antimalarial, antineurodegenerative, and antioxidant activities. Furthermore, no bioactive compound of G. speciosa has been isolated. This work will be useful for researchers interested in bioactivity and phytochemical researches.

scholarly journals Diplazium esculentum (Retz.) Sw.: Ethnomedicinal, Phytochemical, and Pharmacological Overview of the Himalayan Ferns

2021 ◽  
Vol 2021 ◽  
pp. 1-15
Author(s):  
Prabhakar Semwal ◽  
Sakshi Painuli ◽  
Kartik M. Painuli ◽  
Gizem Antika ◽  
Tugba Boyunegmez Tumer ◽  
...  
Keyword(s):  
Web Of Science ◽  
Biological Activities ◽  
Therapeutic Effects ◽  
Sustainable Utilization ◽  
Action Mechanism ◽  
Pharmacological Activities ◽  
Therapeutic Properties ◽  
Cns Stimulant

The genus Diplazium (family: Athyriaceae) comprises approximately 350 species of pteridophytes. Diplazium esculentum (Retz.) Sw. is an important member of this genus and commonly known as a wild vegetable in the Himalayan and sub-Himalayan communities. According to the literature analysis, D. esculentum was traditionally used for the prevention or treatment of several diseases such as diabetes, smallpox, asthma, diarrhea, rheumatism, dysentery, headache, fever, wounds, pain, measles, hypertension, constipation, oligospermia, bone fracture, and glandular swellings. Various extracts of D. esculentum were evaluated to elucidate their phytochemical and pharmacological activities. A wide array of pharmacological properties such as antioxidant, antimicrobial, antidiabetic, immunomodulatory, CNS stimulant, and antianaphylactic activities have been recognized in different parts of D. esculentum. The review covers a systematic examination of pharmacognosy, phytochemistry, and pharmacological applications of D. esculentum, but scientifically, it is not fully assessed regarding complete therapeutic effects, toxicity, and safety in the human body. The published literature on D. esculentum and its therapeutic properties were collected from different search engines including Wiley online, PubMed, Springer Link, Scopus, Science Direct, Web of Science, Google Scholar, and ACS publications by using specific terms such as “Diplazium esculentum, bioactive compounds, biological activities and health benefits” from 1984 to 2021 (March). Therefore, further studies are required to identify the detailed action mechanism of D. esculentum in vitro/in vivo, and also, more studies should focus on conservation, cultivation, and sustainable utilization of the species.

Anti-Trichophyton Effects of Curcumin: A Systematic Review

2021 ◽  
Vol 19 ◽  
Author(s):  
Pegah Shakib ◽  
Ali Safar Maken Ali ◽  
Ehsan Javanmard ◽  
Omid Mardanshah ◽  
Mohammad Ali Mohaghegh ◽  
...  
Keyword(s):  
Systematic Review ◽  
Web Of Science ◽  
Fungal Infections ◽  
Good Alternative ◽  
Potent Effect ◽  
Antifungal Effects ◽  
Review Study ◽  
Different Strains

Introduction: Today we see advances in the use of medicinal plants in the treatment of fungal infections. Curcumin has major antimicrobial, antifungal, antimutagenic, and anticancer activity. This systematic review study is designed to evaluate the effectiveness of curcuminon a dermatophyte fungus, Trichophyton spp. Methods: In this study, antifungal effects of curcumin on the different strains of Trichophytonwereevaluated. For this reason, several databases, including PubMed, Scopus, Web of Science, Embase and Google Scholar were searched systematically in years from1995 to 2020. Only articles with at least English abstracts were evaluated. The syntax was constructed with the combination of some key words along with specific tags used for each of the databases. Results: In this systematic review, studies showed that curcumin has a potent effect on the inhibition of Trichophyton growth. Of the 2,500 studies in the search step, only 11articleswere eligible for survey, 6 of which were on T.rubrum, 3 on T. mentagrophytes, 1 on both T. mentagrophyte and T. rubrum, and 1 on T. longifusus. Conclusion: Today, due to an increase in drug resistance to antifungal agents, plant extracts can be a good alternative in controlling fungal diseases. Curcumin and its compounds are effective in inhibiting or reducing Trichophyton infections in vitro and in vivo.

Reseaches to Study the Improvement Solubility of Curcumin in the Development of a Dosage form with Methionine and Turmeric Extract (Curcuma Longa)

2021 ◽  
Vol 18 (1) ◽  
pp. 43-51
Author(s):  
A.A. Khisamova ◽  
Keyword(s):  
Water Solubility ◽  
Web Of Science ◽  
Raw Materials ◽  
Curcuma Longa ◽  
Solid Dispersions ◽  
Google Scholar ◽  
Plant Raw Materials ◽  
Effective Delivery

Introduction. Turmeric (Curcuma longa) is a medicinal plant and seasoning in Asia. Curcumin (diferuloylmethane) is the main active ingredient; a hydrophobic bioactive component contains in the rhizomes of turmeric (Curcuma longa). In recent years, curcumin has attracted tremendous attention not only for its use in cooking, but also for pleiotropic biological and pharmacological effects. However, its poor water solubility, low bioavailability and rapid metabolism are serious disadvantages for implementation in therapeutic practice. Therefore, researchers are attempting to increase the biological and pharmacological activity of curcumin using effective delivery systems and the addition of bioenhancers. Aim. Generalization and analysis of data presented in the databases PubMed, Web of science, Scopus, Google Scholar on methods of increasing the solubility and bioavailability of curcumin in the development of pharmaceutical compositions based on it. Materials and methods. Materials and methods. The object of research and search in the PubMed, Web of science, Scopus, Google Scholar databases was the substance curcumin, obtained from plant raw materials of long turmeric (Curcuma longa). We analyzed the data presented in the open press for the last 20 years (2000-2021), the request included indicators of the solubility and bioavailability of curcumin in vitro and in vivo. Conclusion. Various pharmaceutical studies of the use of oral combinations, including solid dispersions, nano/microparticles, polymer micelles, nanosuspensions, lipid-based nanocarriers, cyclodextrins, conjugates, have been developed to improve the oral bioavailability of curcumin. They have been shown to increase the solubility of curcumin, improve intestinal stability, and alter the absorption pathway.

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