HAEMATOLOGICAL PARAMETERS AMONG SUDANESE PATIENTS WITH CHRONIC RENAL FAILURE

Chronic renal failure is one of the more common causes of morbidity and mortality among Sudanese. This study describes altered haemoglobin concentration (Hb), haematochrit percent (Hct), red blood cells count (RBCs), platelet count (Plts) and white blood cells count (WBCs) in patients with chronic renal failure and describes the effect of disease duration on haemoglobin concentration and red blood cells count. Methods: Haematological parameters in (50) patients with Chronic renal failure and (50) age and sex matched controls were evaluated, living in Shendi locality in northern Sudan. The results of this study showed that mean of Hb concentration, RBCs count, Hct percent and platelet count were exhibited significant decreased, but mean of WBCs count was insignificantly increased. Increased duration of the disease lead to significantly decreased on mean of Hb concentration and RBCs count. Chronic renal failure is associated with different degrees of reduced haematological parameters. Also increase duration of the disease lead to significantly decrease in mean of Hb concentration and RBCs count.

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Haematological Changes in Donors Post Apheresis

JOURNAL FOR CLINICAL AND DIAGNOSTIC RESEARCH ◽

10.7860/jcdr/2021/48896.15157 ◽

2021 ◽

Author(s):

. Nikhil ◽

Subhashish Das ◽

. Snigdha

Keyword(s):

Platelet Count ◽

Blood Cells ◽

Complete Blood Count ◽

White Blood Cells ◽

Haemoglobin Concentration ◽

Point Of View ◽

Haematological Parameters ◽

Cross Sectional ◽

Wbc Count ◽

Rbc Count

Introduction: The productivity, quality of platelet apheresis collection has improved because of the considerable advancement in the automated cell separators. Automated cell separators have lot of sizeable scientific advances, but the alertness has been centered to Platelet Concentrates (PCs) quality than on safety of donor. Aim: To find the changes in haematological parameters and the consequences of apheresis and plateletpheresis on donor’s health. Materials and Methods: It was observational cross-sectional study done in laboratory at RL Jalappa Blood Bank, Tamaka, Kolar, Karnataka, India. The study was done from March 2019 to August 2020. A total of 300 healthy donors (plateletpheresis donors) were involved in the study. The plateletpheresis (Haemonetics MCS), predonation and postdonation haematological parameters such as haemoglobin concentration, Haematocrit (Hct), platelet, white and red blood cell count were calculated in all donors. The samples for Complete Blood Count (CBC) were secured from the donors, at the beginning and end of the procedure. Postdonation haematological parameters such as platelet count, haemoglobin, haematocrit, White Blood Cells (WBC), Red Blood Cells (RBC) counts of the donor was inscribed and comparison was done with the pre donation haematological parameters. Quality control of all Single Donor Platelet (SDP) products was done. All donors were evaluated for adverse donor reactions. The mean pre and post plateletpheresis values comparison was done utilising paired t-test. Statistical analysis was accomplished utilising Statistical Package for the Social Sciences (SPSS) software version 16.0. Results: Platelet count, haemoglobin, WBC count, RBC count and haematocrit were jotted down from 262 donors and a significant decrease was noticed in these parameters postdonation. Donor parameter platelet count (lac/mL) value was decreased from 273.57-224.28 whereas WBC count (cu/mm) predonation value decreased from 9.91-8.86 Postdonation, haemoglobin (g/dL) value decreased from 14.46-12.91, haematocrit (%) decreased slightly from 45.19-44.19, RBC count (million/mm3) decreased from 5.21-5.01. This concluded that the values decreased postdonation. Conclusion: The study conducted was safe from donor’s point of view. SDP is very effective in treatment of thrombocytopenia and is safe from recipient’s point of view.

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Haematology values and effect of age and reproductive stage on haematological parameters of Chios sheep

Journal of the Hellenic Veterinary Medical Society ◽

10.12681/jhvms.14979 ◽

2017 ◽

Vol 58 (2) ◽

pp. 124 ◽

Cited By ~ 3

Author(s):

N. K. PANOUSIS (Ν.Κ. ΠΑΝΟΥΣΗΣ) ◽

M. KRITSEPI-KONSTANTINOU (Μ. ΚΡΙΤΣΕΠΗ-ΚΩΝΣΤΑΝΤΙΝΟΥ) ◽

N. D. GIADINIS (Ν.Δ. ΓΙΑΔΙΝΗΣ) ◽

E. KALAITZAKIS (Ε. ΚΑΛΑΪΤΖΑΚΗΣ) ◽

Z. POLIZOPOULOU (Ζ. ΠΟΛΥΖΟΠΟΥΛΟΥ) ◽

...

Keyword(s):

Red Blood Cells ◽

Blood Cells ◽

White Blood Cells ◽

Haemoglobin Concentration ◽

Reproductive Stage ◽

Haematological Parameters ◽

Mean Values ◽

Group A ◽

Chios Sheep ◽

Effect Of Age

The main aim of the present study was to determine the values of the haematological parameters of dairy sheep reared under intensive and semi-intensive conditions, as well as to test for the effects of age and reproductive stage of the animals on the values of these parameters. In total, 200 clinically healthy Chios sheep from 10 farms of Central Macedonia were used in the study. For the determination of the effect of age 150 sheep were assigned in three groups. Group A consisted of 50 lambs aged 3-6 months (meantSD: 4.45±1.22 months), group Β of 50 non-pregnant ewes into lactation aged 1-3 years (meantSD: 2.18±0.74 years) and group C of 50 non-pregnant ewes into lactation aged more than 3 years (meantSD: 5.88±1.87 years). For evaluating the effect of reproductive status 50 pregnant ewes in dry period were used, 15-30 days before the expected day of lambing (group D), along with the 100 non-pregnant ewes into lactation of groups Β and C (group E). Blood sampling was performed once, in dry ewes from December to January, and in lambs and lactating ewes from March to May. The mean values of the determined haematological parameters were within the range provided by the literature, except for red blood cells count of ewes. The results also showed that haematocrit, haemoglobin concentration and red blood cells, white blood cells, neutrophils, lymphocytes, eosinophils and platelets count were significantly affected by the age; only monocytes and eosinophils count by the reproductive stage of the animals.

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Metabolism of Red Blood Cells in Chronic Renal Failure

Nephron ◽

10.1159/000181677 ◽

1979 ◽

Vol 24 (1) ◽

pp. 21-24 ◽

Cited By ~ 8

Author(s):

J.L. Rodríguez-Commes ◽

J.M. Tabernero ◽

P. Martin-Vasallo ◽

S. DeCastro ◽

E. Battaner

Keyword(s):

Renal Failure ◽

Chronic Renal Failure ◽

Red Blood Cells ◽

Blood Cells

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Comparative assessment of Chemosuppressive activity of three Chinese teas on Plasmodium berghei infected mice

The Journal of Phytopharmacology ◽

10.31254/phyto.2018.7405 ◽

2018 ◽

Vol 7 (4) ◽

pp. 376-383

Author(s):

Bankole Olukayode Olusola ◽

◽

Oderinde Abdulganiyu Olumuyiwa ◽

Keyword(s):

Body Weight ◽

Red Blood Cells ◽

Plasmodium Berghei ◽

Blood Cells ◽

Haemoglobin Concentration ◽

Treated Group ◽

Antimalarial Drugs ◽

Comparative Assessment ◽

Haematological Parameters ◽

Weight Changes

Malaria, a hazardous infirmity caused by a parasitic malady of the red blood cells, is without question harming to the wellbeing. In the present investigation, the chemosuppresive and haematopoietic activities of 200 mg/kg and 400 mg/kg body weight of unrefined ethanolic concentrates of three Chinese green teas (BIA 849, TD 570 and GB/T19598) were assessed using the 4-day suppressive anti-plasmodial assay in mice Plasmodium berghei (NK65 strain) pre-infected mice. The effect of the extracts on weight of the animals was evaluated. It was observed that 200 mg/kg bw (body weight) of BIA 849 and GB/T19598 were as potent as 5 mg/kg bw of chloroquine, with percentage suppressions of 58.97 ± 5.04, 57.63 ± 5.62 and 57.50 ± 4.5, respectively. TD570 at 200 mg/kg bw was more effective in suppressing plasmodium. 400 mg/kg body weight of TD570 and GB/T19598 extracts were more potent than 5 mg/kg bw of chloroquine having 100 % chemosuppression. The chemosuppression of BIA 849 did not change altogether at 400 mg/kg bw. The haematological parameters, WBC, RBC and MCV did not significantly change in the groups treated with the tea extracts utilizing suppressive model of malaria treatment contrasted with the uninfected group and were comparable to those treated with chloroquine. Haemoglobin concentration nonetheless, varied significantly with respect to the uninfected group. Weight changes were most significant with 200 mg/kg bw of TD 570 treated group (32 % increase) on suppression. All in all, the green teas displayed high chemosuppressive and haematopoietic possibilities and are thusly prescribed as contender for additionally screening as elective antimalarial drugs

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Hematological indices and abnormalities among patients with uncomplicated falciparum malaria in Kosti city of the White Nile State, Sudan: A comparative study

10.21203/rs.3.rs-210869/v2 ◽

2021 ◽

Author(s):

Ahmed M. E. Elkhalifa ◽

Rashad Abdul-Ghani ◽

Abdelhakam G. Tamomh ◽

Nur Eldin Eltaher ◽

Nada Y. Ali ◽

...

Keyword(s):

Platelet Count ◽

Falciparum Malaria ◽

Blood Cells ◽

Large Scale ◽

White Blood Cells ◽

Hematological Indices ◽

Low Level ◽

White Nile ◽

Hb Concentration ◽

Rbc Count

Abstract Background: Hematological abnormalities are common features in falciparum malaria but vary among different populations across countries. Therefore, we compared hematological indices and abnormalities between Plasmodium falciparum-infected patients and malaria-negative subjects in Kosti city of the White Nile State, Sudan. Methods: A comparative, cross-sectional study was conducted at the Medical Technology Laboratory Unit of Kosti Teaching Hospital from June to December 2018. A total of 392 participants (192 P. falciparum-infected patients and 200 malaria-negative subjects) were recruited in the study. Hematological indices of hemoglobin (Hb), red blood cells (RBCs), white blood cells (WBCs) and platelets were measured and their median values were statistically compared. Results: The majority of P. falciparum-infected patients (64.6%) showed a low-level parasitemia. The median values of Hb concentration, RBC count, mean corpuscular Hb and mean corpuscular Hb concentration were significantly lower in P. falciparum-infected patients, with anemia being significantly higher among infected patients than malaria-negative subjects (60.4% vs. 29.5%, respectively). The median total WBC count was non-significantly higher in P. falciparum-infected patients, with leucopenia being non-significantly different between both groups. The median platelet count was significantly lower in P. falciparum-infected patients, with thrombocytopenia being significantly higher among infected patients than malaria-negative subjects (72.4% vs. 5.0%, respectively).Conclusions: Most falciparum malaria infections among patients in Kosti city of the White Nile State – Sudan are of low-level parasitemia. Nevertheless, falciparum malaria is significantly associated with anemia and thrombocytopenia with lower median values of Hb, RBC count, MCH, MCHC and platelet count in P. falciparum-infected patients than malaria-negative subjects. In contrast, leucopenia is not useful to predict falciparum malaria. Further large-scale studies in community and healthcare settings and inclusion of patients with complicated or severe malaria and those with high parasite densities are recommended.

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Haematology of air breathing mud eel, Monopterus cuchia (Hamilton, 1822) of Mymensingh and Kishoreganj districts of Bangladesh

Dhaka University Journal of Biological Sciences ◽

10.3329/dujbs.v22i2.46288 ◽

2013 ◽

Vol 22 (2) ◽

pp. 127-134

Author(s):

AFM Nazmus Salehin ◽

Shankar Chandra Mandal

Keyword(s):

Blood Cells ◽

White Blood Cells ◽

Haemoglobin Concentration ◽

Air Breathing ◽

Corpuscular Haemoglobin ◽

Significant Difference ◽

Haematological Profile ◽

Mean Corpuscular Haemoglobin ◽

Hb Concentration ◽

Corpuscular Haemoglobin Concentration

Haematological profile of air breathing mud eel, Monopterus cuchia (Hamilton) from Mymensinghh and Kishoreganj were determined in the present study. Erythrocytes, lymphocytes, monocytes, neutrophils, eosinophils and platelet were evaluated. Significantly higher (p < 0.05) haemoglobin (Hb) concentration was found in air breathing mud eel of Kishoreganj than that of Mymensinghh area. The haematocrit (HCT), erythrocyte sedimentation rate (ESR), total red blood cells (TRBC), mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH), mean corpuscular haemoglobin concentration (MCHC), total white blood cells (TWBC), lymphocytes, neutrophils, monocytes, eosinophils did not show any significant difference. Findings of the present study showed little variation of haematological profile in air breathing mud eel sampled from Mymensinghh and Kishoreganj. Dhaka Univ. J. Biol. Sci. 22(2): 127-134, 2013 (July)

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Hematological Indices and Abnormalities Among Patients With Uncomplicated Falciparum Malaria in Kosti City of the White Nile State, Sudan: a Comparative Study

10.21203/rs.3.rs-210869/v1 ◽

2021 ◽

Author(s):

Ahmed M. E. Elkhalifa ◽

Rashad Abdul-Ghani ◽

Abdelhakam G. Tamomh ◽

Nur Eldin Eltaher ◽

Nada Y. Ali ◽

...

Keyword(s):

Platelet Count ◽

Falciparum Malaria ◽

Blood Cells ◽

Large Scale ◽

White Blood Cells ◽

Hematological Indices ◽

Low Level ◽

White Nile ◽

Hb Concentration ◽

Rbc Count

Abstract Background: Hematological abnormalities are common features in falciparum malaria but vary among different populations across countries. Therefore, we compared hematological indices and abnormalities between Plasmodium falciparum-infected patients and malaria-negative subjects in Kosti city of the White Nile State, Sudan. Methods: A comparative, cross-sectional study was conducted at the Medical Technology Laboratory Unit of Kosti Teaching Hospital from June to December 2018. A total of 392 participants (192 P. falciparum-infected patients and 200 malaria-negative subjects) were recruited in the study. Hematological indices of hemoglobin (Hb), red blood cells (RBCs), white blood cells (WBCs) and platelets were measured and their median values were statistically compared.Results: The majority of P. falciparum-infected patients (64.6%) showed a low-level parasitemia. The median values of Hb concentration, RBC count, mean corpuscular Hb and mean corpuscular Hb concentration were significantly lower in P. falciparum-infected patients, with anemia being significantly higher among infected patients than malaria-negative subjects (60.4% vs. 29.5%, respectively). The median total WBC count was non-significantly higher in P. falciparum-infected patients, with leucopenia being non-significantly different between both groups. The median platelet count was significantly lower in P. falciparum-infected patients, with thrombocytopenia being significantly higher among infected patients than malaria-negative subjects (72.4% vs. 5.0%, respectively).Conclusions: Most falciparum malaria infections among patients in Kosti city of the White Nile State – Sudan are of low-level parasitemia. Nevertheless, falciparum malaria is significantly associated with anemia and thrombocytopenia with lower median values of Hb, RBC count, MCH, MCHC and platelet count in P. falciparum-infected patients than malaria-negative subjects. In contrast, leucopenia is not useful to predict falciparum malaria. Further large-scale studies in community and healthcare settings and inclusion of patients with complicated or severe malaria and those with high parasite densities are recommended.

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Antibody Response and Haematological Changes of Nigerian Locally Adapted Turkeys to Sheep Red Blood Cells (SRBC)

Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca Animal Science and Biotechnologies ◽

10.15835/buasvmcn-asb:2020.0005 ◽

2020 ◽

Vol 77 (2) ◽

pp. 20

Author(s):

Ayodele Emmanuel OGUNDERO ◽

Mofoyeke Oluwayemisi SANDA ◽

Adeyemi Sunday ADENAIKE ◽

Michael Irewole TAKEET ◽

Christian Obiora Ndubuisi IKEOBI

Keyword(s):

Red Blood Cells ◽

Antibody Titre ◽

Blood Cells ◽

White Blood Cells ◽

Primary Response ◽

Haematological Parameters ◽

High Antibody ◽

Sheep Red Blood Cells ◽

Antibody Titres ◽

High Antibody Titre

Haemagglutination assay and haematological analysis of 143 poults generated as F1 individuals by artificial insemination from randomly selected turkeys of White, Black and Lavender genotypes which are classified by antibody titre was carried out so as to confirm their antibody titre levels in response to sheep red blood cells (SRBC). Results showed that mean values obtained for high and low antibody titres were 7.31 and 2.67 respectively, resulting in the classification of the turkeys into Black high and low, Lavender high and black, and White high and low antibody titres. The genotype’s titre had significant (P <0.05) effect on the packed cell volume (PCV), haemoglobin (Hb), red blood cells (RBC), white blood cells (WBC) and basophil (BAS) of the basal haematological parameters. Genotype’s titre had no significant (P >0.05) effect on the primary response haematological parameters. Meanwhile, the primary response haematological parameters to SRBC antigen varied along the genotypes with the WBC increasing drastically in all the genotypes, signifying the presence of an antigen. The study concluded that the F1 turkey poult population studied diverged along the high and low antibody titre in response to SRBC. Thus, the F1 generation of the high antibody titre genotypes (Black high, White high and Lavender high) can be used as foundation stock for selection of local turkeys for high antibody titre.

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Changes in Haematological Parameters in Plasmodium falciparum Infected Malaria Patients in an Urban Slum of Lagos, Nigeria

Asian Journal of Biochemistry, Genetics and Molecular Biology ◽

10.9734/ajbgmb/2020/v5i430137 ◽

2020 ◽

pp. 20-29

Author(s):

U. O. Ozojiofor ◽

O. O. Bankole ◽

N. Anene ◽

A. U. Hassan ◽

S. A. Emaleku

Keyword(s):

Red Blood Cells ◽

Parasite Density ◽

Blood Cells ◽

Malaria Parasite ◽

Human Subjects ◽

White Blood Cells ◽

Urban Slum ◽

Haematological Parameters ◽

Distribution Width ◽

The Mean

The present study was carried to determine the changes in haematological parameters in P. falciparum infected patients in Ajeromi Ifelodun area of Lagos, Nigeria. Seventy (70) human subjects comprising of 50 P. falciparum malarial infected and 20 non-infected (control) subjects between 10-60 years were selected for this study. RDT test and microscopy were carried out to ascertain the presence of P. falciparum. They were grouped based on age criteria and level of parasitaemia. This work was carried out in the Department of Biochemistry, Nigeria Institute for Medical Research Laboratory, Yaba, Lagos, Nigeria between August 2016 and January 2017. Blood samples were collected for the determination of P. falciparum, level of parasitaemia and haematological parameters. Haematological parameters were determined using a Coulter A-T Pierce haematology analyzer (Beckman Coulter, Inc. Fullerton, CA, USA), P. falciparum was determined by rapid diagnostic test (RDT) and Microscopy. There was a significant increase in the mean level of total white blood cells (WBC) and red blood cells distribution width (RDW), and a significant decrease in the mean level of haematocrit (HCT), haemoglobin (HGB), red blood cells (RBC), and platelets (PLT) in the malaria infected patients than in the controls (p<0.05). There was also a higher malaria parasite density among malaria infected patients for ages above 20 and a lower malaria parasite density for ages below 20 in this study. The findings of this study show that infection with P. falciparum produces changes in haematological parameters in those infected and tested positive for malaria. The most commonly affected parameters are haemoglobin, haematocrit, white blood cells and platelet count.

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