scholarly journals Comparative assessment of Chemosuppressive activity of three Chinese teas on Plasmodium berghei infected mice

2018 ◽  
Vol 7 (4) ◽  
pp. 376-383
Author(s):  
Bankole Olukayode Olusola ◽  
◽  
Oderinde Abdulganiyu Olumuyiwa ◽  
Keyword(s):  
Body Weight ◽  
Red Blood Cells ◽  
Plasmodium Berghei ◽  
Blood Cells ◽  
Haemoglobin Concentration ◽  
Treated Group ◽  
Antimalarial Drugs ◽  
Comparative Assessment ◽  
Haematological Parameters ◽  
Weight Changes

Malaria, a hazardous infirmity caused by a parasitic malady of the red blood cells, is without question harming to the wellbeing. In the present investigation, the chemosuppresive and haematopoietic activities of 200 mg/kg and 400 mg/kg body weight of unrefined ethanolic concentrates of three Chinese green teas (BIA 849, TD 570 and GB/T19598) were assessed using the 4-day suppressive anti-plasmodial assay in mice Plasmodium berghei (NK65 strain) pre-infected mice. The effect of the extracts on weight of the animals was evaluated. It was observed that 200 mg/kg bw (body weight) of BIA 849 and GB/T19598 were as potent as 5 mg/kg bw of chloroquine, with percentage suppressions of 58.97 ± 5.04, 57.63 ± 5.62 and 57.50 ± 4.5, respectively. TD570 at 200 mg/kg bw was more effective in suppressing plasmodium. 400 mg/kg body weight of TD570 and GB/T19598 extracts were more potent than 5 mg/kg bw of chloroquine having 100 % chemosuppression. The chemosuppression of BIA 849 did not change altogether at 400 mg/kg bw. The haematological parameters, WBC, RBC and MCV did not significantly change in the groups treated with the tea extracts utilizing suppressive model of malaria treatment contrasted with the uninfected group and were comparable to those treated with chloroquine. Haemoglobin concentration nonetheless, varied significantly with respect to the uninfected group. Weight changes were most significant with 200 mg/kg bw of TD 570 treated group (32 % increase) on suppression. All in all, the green teas displayed high chemosuppressive and haematopoietic possibilities and are thusly prescribed as contender for additionally screening as elective antimalarial drugs

scholarly journals Amodiaquine and Ciprofloxacin Combination in Plasmodiasis Therapy

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Peace Mayen Edwin Ubulom ◽  
Chinweizu Ejikeme Udobi ◽  
Mark Iheukwumere Madu
Keyword(s):  
Body Weight ◽  
Combination Therapy ◽  
Red Blood Cells ◽  
Plasmodium Berghei ◽  
Blood Cells ◽  
Dosage Level ◽  
Recommended Dosage ◽  
Swiss Albino Mice ◽  
Better Than

Objective. The study was designed to determine the efficacy of combined Amodiaquine and Ciprofloxacin in plasmodiasis therapy.Method. The in vivo antiplasmodial effect of different dosage levels of Amodiaquine, Ciprofloxacin, and their combinations againstPlasmodium berghei bergheiwas evaluated using Swiss albino mice.Results. Amodiaquine (a known antiplasmodial agent) had a fairly significant antiplasmodial effect reducing the parasites for every 100 red blood cells (RBC) from 66 to 16 (75.75%) at the tolerable dosage level of 7.5 mg/kg body weight while Ciprofloxacin (an antibiotic known to have antimalarial effect) showed an insignificant antiplasmodial effect reducing the parasites for every 100 RBC from 65 to 64 (1.53%) at the tolerable dosage level of 10.7 mg/kg body weight. Conversely, the combination therapy of Amodiaquine and Ciprofloxacin had a significant antiplasmodial effect at all the doses administered. The combination of 7.5 mg/kg of Amodiaquine and 12.8 mg/kg of Ciprofloxacin, however, showed the most significant antiplasmodial effect of the doses used reducing the number of parasites per 100 RBC from 60 to 10 (83.33%).Conclusions. Appropriate Amodiaquine and Ciprofloxacin combination will be effective for the treatment of malaria and better than either Amodiaquine or Ciprofloxacin singly at their recommended dosage levels.

scholarly journals HAEMATOLOGICAL PARAMETERS AMONG SUDANESE PATIENTS WITH CHRONIC RENAL FAILURE

2016 ◽  
Vol 4 (1) ◽  
pp. 50-54
Author(s):  
RaianBakhet Yassein ◽  
Nada Omer Alseedig ◽  
SihamKhalifaAbd Allah ◽  
AreegAlsail Mohmmed ◽  
NosibaAbdelmajid Alballah ◽  
...  
Keyword(s):  
Renal Failure ◽  
Platelet Count ◽  
Chronic Renal Failure ◽  
Red Blood Cells ◽  
Blood Cells ◽  
White Blood Cells ◽  
Haemoglobin Concentration ◽  
Haematological Parameters ◽  
Common Causes ◽  
Hb Concentration

Chronic renal failure is one of the more common causes of morbidity and mortality among Sudanese. This study describes altered haemoglobin concentration (Hb), haematochrit percent (Hct), red blood cells count (RBCs), platelet count (Plts) and white blood cells count (WBCs) in patients with chronic renal failure and describes the effect of disease duration on haemoglobin concentration and red blood cells count. Methods: Haematological parameters in (50) patients with Chronic renal failure and (50) age and sex matched controls were evaluated, living in Shendi locality in northern Sudan. The results of this study showed that mean of Hb concentration, RBCs count, Hct percent and platelet count were exhibited significant decreased, but mean of WBCs count was insignificantly increased. Increased duration of the disease lead to significantly decreased on mean of Hb concentration and RBCs count. Chronic renal failure is associated with different degrees of reduced haematological parameters. Also increase duration of the disease lead to significantly decrease in mean of Hb concentration and RBCs count.

scholarly journals Haematology values and effect of age and reproductive stage on haematological parameters of Chios sheep

2017 ◽  
Vol 58 (2) ◽  
pp. 124 ◽  
Author(s):  
N. K. PANOUSIS (Ν.Κ. ΠΑΝΟΥΣΗΣ) ◽  
M. KRITSEPI-KONSTANTINOU (Μ. ΚΡΙΤΣΕΠΗ-ΚΩΝΣΤΑΝΤΙΝΟΥ) ◽  
N. D. GIADINIS (Ν.Δ. ΓΙΑΔΙΝΗΣ) ◽  
E. KALAITZAKIS (Ε. ΚΑΛΑΪΤΖΑΚΗΣ) ◽  
Z. POLIZOPOULOU (Ζ. ΠΟΛΥΖΟΠΟΥΛΟΥ) ◽  
...  
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
White Blood Cells ◽  
Haemoglobin Concentration ◽  
Reproductive Stage ◽  
Haematological Parameters ◽  
Mean Values ◽  
Group A ◽  
Chios Sheep ◽  
Effect Of Age

The main aim of the present study was to determine the values of the haematological parameters of dairy sheep reared under intensive and semi-intensive conditions, as well as to test for the effects of age and reproductive stage of the animals on the values of these parameters. In total, 200 clinically healthy Chios sheep from 10 farms of Central Macedonia were used in the study. For the determination of the effect of age 150 sheep were assigned in three groups. Group A consisted of 50 lambs aged 3-6 months (meantSD: 4.45±1.22 months), group Β of 50 non-pregnant ewes into lactation aged 1-3 years (meantSD: 2.18±0.74 years) and group C of 50 non-pregnant ewes into lactation aged more than 3 years (meantSD: 5.88±1.87 years). For evaluating the effect of reproductive status 50 pregnant ewes in dry period were used, 15-30 days before the expected day of lambing (group D), along with the 100 non-pregnant ewes into lactation of groups Β and C (group E). Blood sampling was performed once, in dry ewes from December to January, and in lambs and lactating ewes from March to May. The mean values of the determined haematological parameters were within the range provided by the literature, except for red blood cells count of ewes. The results also showed that haematocrit, haemoglobin concentration and red blood cells, white blood cells, neutrophils, lymphocytes, eosinophils and platelets count were significantly affected by the age; only monocytes and eosinophils count by the reproductive stage of the animals.

scholarly journals High khat dose and long-term exposure impairs spermatogenesis: experimental study using rabbit model

2017 ◽  
Vol 34 (03) ◽  
pp. 156-167
Author(s):  
A. Nyongesa ◽  
N. Patel ◽  
E. Wango ◽  
D. Onyango
Keyword(s):  
Body Weight ◽  
Body Temperature ◽  
Blood Cell ◽  
Haematological Parameters ◽  
Long Term Effects ◽  
Weight Changes ◽  
Blood Cell Count ◽  
Body Weight Changes ◽  
Testicular Morphology

Abstract Introduction: This study investigated short- and long-term effects of khat (Catha edulis) on hypophyseal, epididymal and testicular morphology, body weight and temperature changes and haematological parameters of rabbits. Materials and Methods: Twenty five male New Zealand White rabbits, divided into five groups were used. First four groups were administered, via intra-gastric tube, 1.5, 4.5, 13.5 and 40.5 g/kg body weight respectively of khat extract thrice a week for 8 weeks while controls received normal saline. Short-term and long-term effects were evaluated for hypophyseal, epididymal and testicular morphology, body temperature as well as body weight changes, food consumption and haematological parameters. Data on haematological parameters, body weight changes, body temperature and food consumption was done using one-way ANOVA at 95% confidence interval using SPSS version 12.0. Results: There was vacuolation in spermatogonia and spermatocytes at high doses while epididymides and hypophyses were unaffected. A significant decrease (P<0.05) in body weight of treatment groups correlated with reduced food intake with increasing doses and chronicity of exposure. Packed cell volume, red blood cell count and haemoglobin concentration decreased while white blood cell count increased with increasing doses. Conclusion: Khat extract had direct effects on spermatogenesis compounded by poor body weight gain, hyperthermia and blood volume loss.

scholarly journals Haematological parameters in relation to age, sex and body weight of free-range village chickens (Gallus gallus domesticus) in Maiduguri, Nigeria

2021 ◽  
pp. 78-84
Keyword(s):  
Body Weight ◽  
Haemoglobin Concentration ◽  
The Body ◽  
Haematological Parameters ◽  
Jugular Veins ◽  
Important Indicator ◽  
Free Range ◽  
Body Weights ◽  
Leukocyte Counts ◽  
Apparently Healthy

The haematology of animals including chickens is an important indicator of their health status. It is therefore considered a useful tool in clinical diagnosis. The aim of this study was to investigate the haematological parameters of apparently healthy free range domesticated chickens as influenced by their sex, age and body weights. Blood samples taken from the jugular veins were analysed using standard haematological protocols. PCV, haemoglobin concentration, TRBC, TWBC, differential leukocyte counts, erythrocytes indices (MCV, MCHC and MCH) were measured. The study showed that there were no significant (P>0.05) age-dependent variation in all the measured haematological parameters. However, sex had effect on PCV, TRBC and heterophil count. Male chickens had higher PCV value of (34.4%) and TRBC value of (2.4 × 1012/L) as compared to female chickens with PCV value of (30.5%) and TRBC value of (2.1 × 1012/L). On the other hand, female chickens had higher mean heterophil value of (22.0 × 109/L) and MCHC value of (29.5g/dl) as compared to male chickens with mean heterophil and MCHC values of (16.8 × 109/L) and (25.7g/dl) respectively. There was significant (P<0.05) increase in PCV with increasing body weights in males but not in females. The MCHC decreased significantly (P<0.05) as the body weight increased also in males but not in females. The results of the study indicate that sex and body weights influenced normal haematological parameters of apparently healthy free range domestic chickens in the study environment. Keywords: Age, body weight, haematology, sex, village chicken.

Effect Of Citrullus Lanatus Juice On Hemoglobin, Red Blood Cells And Liver Enzyme; An Experimental Study

2019 ◽  
Vol 09 (04) ◽  
pp. 257-260
Author(s):  
Shahid Ali ◽  
Nuzhat Sultana ◽  
Muslim Abbas ◽  
Zareen Naz ◽  
Muhammad Akbar Hassan ◽  
...  
Keyword(s):  
Experimental Study ◽  
Red Blood Cells ◽  
Liver Enzyme ◽  
Blood Cells ◽  
Citrullus Lanatus ◽  
Treated Group ◽  
Control Group ◽  
Group A ◽  
Group B ◽  
Post Hoc

Objective: To determine effect of citrullus lanatus juice on hemoglobin and Serum Glutamic Pyruvic Transaminase (SGPT) level. Study design and setting: It was an experimental study conducted on healthy rabbits for sixty days in the research department of pharmacy University of Karachi. Methodology: Current study was planned to evaluate effect of Citrullus lanatus juice on red blood cells, hemoglobin and liver enzyme. 60 days study was performed at 2 different doses i.e 3and 6ml/kg on rabbits. These rabbits were from either gender and were divided into 3 groups their weight ranges from 1200 to 1800 grams. Group A is control group (Normal saline 6ml/kg), Group B is treated group (3 ml/kg), Group C is treated group (6ml/kg). After taking mean of all values they are compared with control group. Significance of mean can be estimated by Tukes Post Hoc Test. P<0.05 estimated as significant. Results: It was found that count of red blood cells rises significantly along with rise in hemoglobin level. As far as liver enzyme serum glutamate pyruvate transaminase (SGPT) was concerned its concentration decreases slightly. Conclusion: Citrullus lanatus juice contain ingredients which are important for RBC hemoglobin and synthesis .It also contains important antioxidants that have organoprotective role due to which SGPT level decreases even in healthy animals as compared to control groups

scholarly journals Humoral Factors Influencing Erythropoiesis in the Fish (Blue Gourami—Trichogaster trichopterus)

Blood ◽  
1969 ◽  
Vol 33 (4) ◽  
pp. 573-581 ◽  
Author(s):  
ESMAIL D. ZANJANI ◽  
MAN-LIM YU ◽  
ALFRED PERLMUTTER ◽  
ALBERT S. GORDON
Keyword(s):  
Body Weight ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Test Animal ◽  
Humoral Factors ◽  
Highly Active ◽  
Factors Influencing ◽  
Lower Vertebrates ◽  
Stimulating Factor

Abstract Evidence is presented for the existence of a circulating erythropoiesis stimulating factor in the bled fish (blue gourami). Erythropoiesis is inhibited by starvation and increased following a single bleeding in the gourami. Administration of serum from the bled gourami to the starved gourami evokes a highly significant increase in erythropoiesis. Serum from normal non-bled fish fails to produce this effect. Large doses of sheep plasma ESF and human urinary ESF (16 units/100 Gm. body weight) stimulate erythropoiesis in the starved gourami. Smaller amounts, highly active in the polycythemic mouse, are without effect in the gourami. No in vitro stimulatory effect on radioiron uptake by peripheral red blood cells of the gourami was exerted by anemic gourami serum or mammalian ESF. The starved gourami may find use as a test animal for erythropoietic factors from other lower vertebrates.

Blood Volumes of Dairy Calves Comparing Cr51-Tagged Red Blood Cells and T-1824 Plasma Dilution Methods

1958 ◽  
Vol 193 (2) ◽  
pp. 244-248 ◽  
Author(s):  
Perry Ruth Stahl ◽  
Homer E. Dale
Keyword(s):  
Body Weight ◽  
Red Blood Cells ◽  
Whole Blood ◽  
Blood Cells ◽  
Dairy Calves ◽  
Computation Method ◽  
Blood Samples ◽  
Whole Blood Samples ◽  
Blood Volumes

In a repeated study on 17 dairy calves, T-1824 dye plasma dilution showed significantly higher blood volumes than were found by any other technique or computation method using Cr51-tagged red blood cells. Five blood samples taken at 20-minute intervals after injection showed consistent decrease in radioactivity count from the first to the last sample, indicating greater accuracy in radioactivity dilution regressed to zero time figures than in average counts of several postinjection samples. In vitro studies suggest a loss of Cr51 from red blood cells to plasma after saline washings are Cr-free. Percentage blood volumes computed from whole blood samples of calves injected with Cr51-tagged red blood cells decreased in a straight line relationship with increase of body weight. Percentage plasma and whole blood volumes estimated with the T-1824 dye technique decreased regularly with body weight increase until a second determination was made when there was a rapid rise nearly to the level of the smallest calves, followed by another regular decrease with increase in weight. It is suggested that repeated dye injections do not always measure the same space. Regressed values of five whole blood samples taken at 20-minute intervals after injection of Cr51 tagged red blood cells gave more consistent blood volume determinations than either the weighed red cells or the plasma dye dilutions of the same samples.

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