scholarly journals Actual possibilities of pathogenetic treatment of patients with with purine dismetabolism

2021 ◽  
Vol 14 (3) ◽  
pp. 100-110
Author(s):  
V.I. Rudenko ◽  
◽  
Yu.L. Demidko ◽  
I.G. Krayev ◽  
◽  
...  
Keyword(s):  
Uric Acid ◽  
Conservative Therapy ◽  
Treatment Options ◽  
Stone Disease ◽  
Purine Metabolism ◽  
Urinary Ph ◽  
Surgical Interventions ◽  
Scientific Database ◽  
Urate Nephropathy ◽  
Methods Of Treatment

Introduction. Purine dysmetabolism is occured by increased production of uric acid, which leads to hyperuricemia and hyperuricuria. The most common forms of purine metabolism disorders are the uratenephropathy, gout, and asymptomatic hyperuricemia. Purpose. To evaluate the data published from 1992 to 2021 on the prevalence, forms of purine metabolism disorders, diagnostics and methods of their treatment. Two hundred and seventy original publications were identified, of which 37 were selected and analyzed. Materials and methods. The search results in the scientific database PubMed, Web of Sciеnce, Sciеnce Direct were analyzed for the queries «urates», «gout», «uric acid», «purine metabolism», «hyperuricosuria», «treatment of urate nephrolithiasis», «luteolin; quercetin», «Smilax riparia». Results. Urates are formed as a result of the metabolism of purine bases, two-thirds of which are excreted with urine. The most common form of purine dysmetabolism is urate nephrolithiasis, which accounts for up to 10% of all forms of kidney stone disease. The main risk factors include low urinary pH, decreased urine output and hyperuricosuria. Treatment options for such stones depend on the size, chemical composition, location, and concomitant diseases. The main methods of treatment are conservative therapy and surgical interventions. Conclusions. Since the available conservative therapy may not be suitable for all patients, and surgical intervention carries certain risks, a unique herbal complex «Uralix®» was created to treat patients with urate stones in the kidneys and urinary tract. Its components luteolin, quercetin and sarsaparilla extract reduce uric acid levels and improve renal function in urate nephropathy.

CONSERVATIVE METHODS OF TREATMENT OF ECTOPIA OF THE CERVIX, CAUSED BY SOME SEXUALLY TRANSMITTED INFECTIONS

2020 ◽  
pp. 81-83
Author(s):  
Kalinkina O.B.
Keyword(s):  
Sexually Transmitted Infections ◽  
Young Women ◽  
Conservative Therapy ◽  
Surgical Interventions ◽  
Sexually Transmitted ◽  
Methods Of Treatment ◽  
Infectious Etiology ◽  
Management Tactics

The aim of this study was to prove the effectiveness of differentiated conservative therapy, taking into account the type of pathogen and reducing the volume of surgical interventions in young women with cervical ectopia associated with STIs and CIN 1. 50 patients aged 20 to 32 years with identified cervical ectopia of infectious etiology were examined. As a result of the proposed management tactics, the pathology was cured in 89 % of patients.

Chlorogenic acid supplementation ameliorates hyperuricemia, relieves renal inflammation, and modulates intestinal homeostasis

2021 ◽  
Author(s):  
Xiaofei Zhou ◽  
Bowei Zhang ◽  
Xiuli Zhao ◽  
Yongxi Lin ◽  
Jin Wang ◽  
...  
Keyword(s):  
Uric Acid ◽  
Chlorogenic Acid ◽  
Serum Uric Acid ◽  
Inflammatory Responses ◽  
Elevated Serum ◽  
Purine Metabolism ◽  
Intestinal Homeostasis ◽  
Renal Inflammation ◽  
Acid Supplementation

Hyperuricemia (HUA) is induced by abnormal purine metabolism and elevated serum uric acid (UA) concentrations, and it is often accompanied by inflammatory responses and intestinal disorders. This study aims to...

scholarly journals Method of alkalization and monitoring of urinary pH for prevention of recurrent uric acid urolithiasis: a systematic review

2019 ◽  
Vol 8 (S4) ◽  
pp. S448-S456
Author(s):  
Guido Maarten Kamphuis ◽  
Jons Wouter van Hattum ◽  
Prim de Bie ◽  
Bhaskar K. Somani
Keyword(s):  
Systematic Review ◽  
Uric Acid ◽  
Urinary Ph

scholarly journals Percutaneous Versus Surgical Interventions for Hepatic Cystic Echinococcosis: A Systematic Review and Meta-Analysis

2021 ◽  
Author(s):  
G. L. E. Mönnink ◽  
C. Stijnis ◽  
O. M. van Delden ◽  
R. Spijker ◽  
M. P. Grobusch
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Treatment Options ◽  
Length Of Hospital Stay ◽  
Percutaneous Treatment ◽  
Invasive Treatment ◽  
Surgical Interventions ◽  
Percutaneous Therapy ◽  
Registration Number ◽  
Hepatic Echinococcosis

Abstract Purpose This systematic review and meta-analysis summarises the current literature on invasive treatment options of cystic hepatic echinococcosis (CE), comparing percutaneous radiological interventions to surgery, still the cornerstone of treatment in many countries. Methods A literature search was conducted in Medline and EMBASE databases (PROSPERO registration number: CRD42019126150). The primary outcome was recurrence of cysts after treatment. Secondary outcomes were complications, duration of hospitalisation, mortality and treatment conversion. Results The number of eligible prospective studies, in particular RCTs, was limited. In the four included studies, only conventional surgery is compared directly to percutaneous techniques. From the available data, in terms of recurrence, percutaneous treatment of hydatid cysts is non-inferior to open surgery. With regard to complications and length of hospital stay, outcomes favour percutaneous therapy. Conclusion Although evidence from prospective research is small, percutaneous treatment in CE is an effective, safe and less invasive alternative to surgery.

Percutaneous Management of Benign Biliary Strictures

2021 ◽  
Vol 38 (03) ◽  
pp. 291-299
Author(s):  
Adam Fang ◽  
Il Kyoon Kim ◽  
Ifechi Ukeh ◽  
Vahid Etezadi ◽  
Hyun S. Kim
Keyword(s):  
Treatment Options ◽  
Balloon Dilation ◽  
Percutaneous Transhepatic Cholangiography ◽  
Team Approach ◽  
Biliary Strictures ◽  
Surgical Interventions ◽  
Benign Biliary Strictures ◽  
Elevated Liver Enzymes ◽  
Biodegradable Stents ◽  
Asymptomatic Disease

AbstractBenign biliary strictures are often due to a variety of etiologies, most of which are iatrogenic. Clinical presentation can vary from asymptomatic disease with elevated liver enzymes to obstructive jaundice and recurrent cholangitis. Diagnostic imaging methods, such as ultrasound, multidetector computed tomography, and magnetic resonance imaging (cholangiopancreatography), are used to identify stricture location, extent, and possible source of biliary obstruction. The management of benign biliary strictures requires a multidisciplinary team approach and include endoscopic, percutaneous, and surgical interventions. Percutaneous biliary interventions provide an alternative diagnostic and therapeutic approach, especially in patients who are not amenable to endoscopic evaluation. This review provides an overview of benign biliary strictures and percutaneous management by interventional radiologists. Diagnostic evaluation with percutaneous transhepatic cholangiography and treatment options, including biliary drainage, balloon dilation, retrievable/biodegradable stents, and other innovative minimally invasive options, are discussed.

MO120STONE COMPOSITION AND CARDIOVASCULAR DISEASE  IN PATIENTS WIITH NEPHROLITHIASIS

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Ana Lucía Valencia ◽  
Armando Coca ◽  
Arturo Lorenzo ◽  
Veronica Fidalgo ◽  
Vicente Perez ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Chronic Kidney Disease ◽  
Logistic Regression ◽  
Uric Acid ◽  
Regression Analysis ◽  
Kidney Disease ◽  
Kidney Stone ◽  
Stone Disease ◽  
Stone Composition ◽  
Adjusted Logistic Regression

Abstract Background and Aims Kidney stone disease is widely prevalent in the general population and has been associated with multiple comorbidities including hypertension, diabetes, chronic kidney disease and cardiovascular disease. We aimed to describe the possible link between stone composition and cardiovascular disease and its differential effect among women and men. Method Retrospective review of patients with known stone composition seen in a nephrolithiasis unit in the last five years. Anthropometric and clinical data were gathered from the hospital records. Stone composition was defined as such if ≥50% of the stone was made from a single component. Cardiovascular disease included coronary artery disease, stroke and peripheral vascular disease. Unadjusted and adjusted logistic regression analysis were applied to describe the potential relationship between stone composition and cardiovascular disease. Results 337 patients were included in the study sample. Median age was 57 (IQR 47-67), 61.1% males. 58.2% suffered from recurrent stone disease and 28.5% from family history of stone formation. 32.9% of patients had hypertension, 22,4% diabetes and 13,1% chronic kidney disease. The most common kidney stone component was calcium oxalate (38.6%) followed by calcium phosphate (21.3%), uric acid (14.2%), struvite (8%) and brushite (0.9%). Only uric acid as main stone component was associated with cardiovascular disease among men but not women in our sample in univariate analysis. That relationship was lost in adjusted logistic regression analysis. Conclusion Calcium oxalate and phosphate were the most common components of kidney stones. No relationship was found between stone composition and cardiovascular disease in the study sample.

Simultaneous Treatment of Calcium Oxalate and Uric Acid Stone Disease in Saudi Arabia

1994 ◽  
pp. 581-586 ◽  
Author(s):  
W. G. Robertson ◽  
H. Hughes ◽  
I. Husain ◽  
S. Al-Faqih ◽  
A. Arafat ◽  
...  
Keyword(s):  
Saudi Arabia ◽  
Uric Acid ◽  
Calcium Oxalate ◽  
Stone Disease ◽  
Uric Acid Stone ◽  
Simultaneous Treatment

scholarly journals Diagnostics and Treatment of Cervical Causes of Infertility

2019 ◽  
Vol 12 (1) ◽  
pp. 33-39
Author(s):  
Aleksandar K. Kunev
Keyword(s):  
Intrauterine Insemination ◽  
Treatment Options ◽  
Cervical Canal ◽  
Male Factor ◽  
Gynaecological Examination ◽  
The Common ◽  
Common Problems ◽  
Cervical Diseases ◽  
And Function ◽  
Methods Of Treatment

Summary Nowadays, infertility is a problem that affects an increasing number of people. The causes of infertility in a couple may be due to a variety of factors – female, male or unexplained. One of the common problems associated with infertility in women is related to uterine cervical diseases. The cervix is an essential part of the sperm passage, so various disorders in the cervix structure and function may be the cause of infertility. The study aimed to identify the leading cervical causes of female infertility, methods of treatment and their success. The most common problems of cervical origin are cervical polyps and stenosis of the cervical canal. They are easily diagnosed with a routine gynaecological examination and ultrasound examination. Polyps are removed through polypectomy, and after that, a natural pregnancy can be achieved. In the case of stenosis of the cervical canal, there are two treatment options – dilation or intrauterine insemination (IUI). In younger patients and lack of male factor in the couple, dilation is performed. Dilation is mechanical with classic Hegar dilatiors or with synthetic hygroscopic dilatiors (Dilapan). If, in addition to the stenosis of the cervical canal in a woman, there is a male factor, treatment with IUI is preferred. Methods for cervical factor treatment vary in their success rate but are generally characterised by good results.

scholarly journals Clinical Outcomes of Surgical Treatment of Hypertrophic Pyloric Stenosis with Application of Various Operational Access

2020 ◽  
Vol 13 (3) ◽  
pp. 201-205
Author(s):  
Vasily Petrovich Gavrilyuk ◽  
Stanislav Vitalyevich Kostin ◽  
Maria Igorevna Statina ◽  
Dmitry Andreevich Severinov ◽  
Farkhod Sharifzhanovich Primov
Keyword(s):  
Clinical Outcomes ◽  
Pyloric Stenosis ◽  
Enteral Feeding ◽  
Recovery Rate ◽  
Treatment Options ◽  
Hypertrophic Pyloric Stenosis ◽  
Surgical Interventions ◽  
Duration Of Stay ◽  
Congenital Hypertrophic Pyloric Stenosis ◽  
Group 3

Introduction. Treatment options of congenital hypertrophic pyloric stenosis (HPS) appear to be an acute issue nowadays due to the fact that this pathology is often detected in children of the first year of life - according to statistics, the incidence rate of congenital hypertrophic pyloric stenosis in children is 3:1000 live newborns. Since there are various treatment options of the given congenital pathology, there is no general consensus in the opinions of surgeons regarding the superiority of different treatment methods. Therefore, it is necessary to search for a single most relevant treatment technique for this pathology.The aim of the study was to analyze clinical outcomes for treatment of congenital hypertrophic pyloric stenosis in children with application of various surgical techniques: open pylorotomy (transverse, circumbilical incision) and laparoscopic pylorotomy.Materials and methods. The study included 67 patients, who received treatment in Kursk Regional Pediatric Hospital №2 in 2014-2018. Patients with congenital HPS were divided into 3 groups, depending on the performed surgical interventions. Group 1 included patients who underwent an open pylorotomy with transverse access, group 2 included patients who underwent an open pylorotomy with circumbilical access, and group 3 included patients who underwent laparoscopic pylorotomy. The following parameters were used to assess the efficiency of the treatment performed: the duration of the operative intervention, the duration of stay of a child in the ICU, the duration of stay of a child in the hospital, extubation time, initiation of enteral feeding, recovery rate of enteral feeding volume. The data were statistically performed using the Mann-Whitney test to determine the significance of differences between the mean values (p0.05).Results. The study results demonstrated that the shortest duration of operational intervention was observed in patients of group 3, it constituted 41,4 3,5 minutes. In addition, patients of this group spent the shortest average time in the ICU - 4,2 0,3 days - and in the hospital in general - 12,1 0,8 days; initiation of enteral feeding in patients of this group was registered in 10,8 1,2 hours and the recovery rate of enteral feeding volume was 4,8 0,5 days.Conclusions. Having analyzed clinical outcomes for treatment of pilorostenosis in the studied groups of children, it is possible to conclude that laparoscopic pyloromyotomy is preferred to open surgical interventions not only for reasons of cosmetic result, but also according to the criteria of the postoperative course of the disease in patients.

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