scholarly journals Role of the ducktal secretion dysfunction in the pathogenesis of chronic pancreatitis

2020 ◽  
Vol 17 (1) ◽  
pp. 122-128
Author(s):  
L. A. Mozheiko
Keyword(s):  
Chronic Pancreatitis ◽  
Rheological Properties ◽  
Pancreatic Secretion ◽  
Transport Mechanism ◽  
Early Stage ◽  
Fluid Secretion ◽  
Scientific Data ◽  
Ductal System ◽  
Stage Of Development

The review presents an analysis of current scientific data on the role of ductal secretion disorders in the pathogenesis of chronic pancreatitis. It is shown that under the influence of alcohol or other provoking factors, the CFTR transport mechanism of duct cells undergoes damage, which leads to the decrease in the bicarbonate and fluid secretion. Dehydration and acidification contribute to the hyperconcentration of protein and mucous components of pancreatic secretion and to the change in its rheological properties, which complicates further transport through the ductal system. Current conditions are favorable for the formation of mucoprotein plugs and the ductal obstruction that may have an important role in the pathogenesis of chronic pancreatitis at the early stage of development of the disease.

The Significance of Blockchain Technology in Digital Transformation of Logistics and Transportation

2020 ◽  
Vol 12 (1) ◽  
pp. 1-20 ◽  
Author(s):  
Zvonko Merkaš ◽  
Davor Perkov ◽  
Vesna Bonin
Keyword(s):  
Early Stage ◽  
Digital Transformation ◽  
Theory Building ◽  
Comprehensive Overview ◽  
Blockchain Technology ◽  
Stage Of Development ◽  
Multiple Case ◽  
Multiple Case Studies ◽  
Business Process Optimization

The purpose of this article is to identify blockchain's role in achieving logistic objectives, with the aim of pointing out the significance of blockchain technology in the digital transformation of logistics and transportation. Implementation of the blockchain technology in combination with IoT elements in logistics and transportation contributes to business process optimization, supply chain traceability and transparency, and significant financial savings. There are limitations as blockchain is at a relatively early stage of development with most projects. Therefore, the approach of theory building from multiple case studies was used. The article provides a comprehensive overview of current blockchain initiatives and use-cases. This article is believed to be the first to address the role of blockchain technology in achieving logistics objectives. Results from this research indicate that blockchain technology contributes to the achievement of logistics objectives.

The Energy Consumption-Environmental Quality Nexus in BRICS Countries: The Role of Outward Foreign Direct Investment (OFDI)

2021 ◽  
Author(s):  
Saileja Mohanty ◽  
Narayan Sethi
Keyword(s):  
Developing Countries ◽  
Foreign Direct Investment ◽  
Energy Consumption ◽  
Environmental Quality ◽  
Direct Investment ◽  
Early Stage ◽  
Outward Foreign Direct Investment ◽  
Stage Of Development ◽  
Long Run

Abstract This paper examines the role of outward foreign direct investment (OFDI) on energy consumption and environmental quality in BRICS from 1990 to 2019. We use cross-sectional dependence (CSD) and the Pesaran-Yamagata slope homogeneity for the diagnostic test. After confirming the diagnosis test, we employ CIPS and CADF second generation panel unit root test, which confirms that all elements are stationary at first difference. The Pooled Mean Group (PMG), Westerlund cointegration, two-step GMM, panel FMOLS and DOLS model have been used to determine the short term and long-term association among the variables. The cointegration and PMG results confirm that the short-run and long-run association exists among the considered variables. The GMM and DOLS results reveal that developing countries produced environmental pollution at the early stage of development and checked in the long run. The empirical results hold up the EKC hypothesis, which implies that OFDI and energy consumption help expand greener technology to host countries' environmental improvement in the long run and confirm that an inverted U-shaped linkage exists. Hence, the study suggests that developing countries should pay more attention to sustainable development and technological development that encourages more eco-friendly and environment-friendly technology. To frame the profitable strategies, governments of emerging countries should inspire public-private partnerships to circulate the environmental consciousness, guideline for energy efficiency, and generate a pollution-free environment.

scholarly journals The role of EUS in diagnosing early-stage chronic pancreatitis

Suizo ◽  
2011 ◽  
Vol 26 (1) ◽  
pp. 29-36
Author(s):  
Atsushi IRISAWA ◽  
Tadayuki TAKAGI ◽  
Goro SHIBUKAWA ◽  
Ai SATO ◽  
Tsunehiko IKEDA ◽  
...  
Keyword(s):  
Chronic Pancreatitis ◽  
Early Stage

scholarly journals The Potential Role of Direct Air Capture in the German Energy Research Program—Results of a Multi-Dimensional Analysis

Energies ◽  
2019 ◽  
Vol 12 (18) ◽  
pp. 3443 ◽  
Author(s):  
Peter Viebahn ◽  
Alexander Scholz ◽  
Ole Zelt
Keyword(s):  
Dimensional Analysis ◽  
Research Program ◽  
Large Scale ◽  
Potential Role ◽  
Early Stage ◽  
Energy Research ◽  
Stage Of Development ◽  
Direct Air Capture ◽  
Air Capture

A significant reduction in greenhouse gas emissions will be necessary in the coming decades to enable the global community to avoid the most dangerous consequences of man-made global warming. This fact is reflected in Germany’s 7th Federal Energy Research Program (EFP), which was adopted in 2018. Direct Air Capture (DAC) technologies used to absorb carbon dioxide (CO2) from the atmosphere comprise one way to achieve these reductions in greenhouse gases. DAC has been identified as a technology (group) for which there are still major technology gaps. The intention of this article is to explore the potential role of DAC for the EFP by using a multi-dimensional analysis showing the technology’s possible contributions to the German government’s energy and climate policy goals and to German industry’s global reputation in the field of modern energy technologies, as well as the possibilities of integrating DAC into the existing energy system. The results show that the future role of DAC is affected by a variety of uncertainty factors. The technology is still in an early stage of development and has yet to prove its large-scale technical feasibility, as well as its economic viability. The results of the multi-dimensional evaluation, as well as the need for further technological development, integrated assessment, and systems-level analyses, justify the inclusion of DAC technology in national energy research programs like the EFP.

scholarly journals To the origins of creation of Beijing Ballet School. Olga Aleksandrovna Ilyina

2020 ◽  
pp. 25-35
Author(s):  
Tianjiao Zhang
Keyword(s):  
Significant Contribution ◽  
Early Stage ◽  
Strong Basis ◽  
Ballet Dancers ◽  
Stage Of Development ◽  
The Subject ◽  
Classical Ballet ◽  
Education In China ◽  
Chinese Teaching

The subject of this research is the first stage of creation of Beijing Ballet School, while the object is the pedagogue of the Moscow State Academy of Choreography O. A. Ilyina. The author underlines her contribution to the creation of the first professional system of education in China. The role of Soviet ballet masters and pedagogues, who carefully examines the peculiarities of Chinese teaching technique is highlighted. The Russian system of choreographic education with its accumulated valuable theoretical and pedagogical experience laid the foundation for establishment of the system of preparing ballet dancers in China, creating a strong basis for the development of Chinese professional classical ballet. The novelty of this work consist in the analysis of Olga Ilyina’s impact upon the early stage of development of Chinese ballet. The author explores and assesses her versatile activity in China – initially, in creation of Beijing Ballet School, and later, as a pedagogy who made a significant contribution to preparation of national ballet dancers. The scientific novelty is substantiated by the fact that the activity of Olga Ilyina in China has not been previously a subject of a separate research, although she played a significant role, along with other pedagogues of the Moscow State Academy of Choreography under the Bolshoi Theatre, in creation of the first professional ballet school in Beijing.

scholarly journals Early Health Economic Modelling – Optimizing Development for Medical Device Developers? Comment on "Problems and Promises of Health Technologies: The Role of Early Health Economic Modeling"

2019 ◽  
Author(s):  
Conor Teljeur ◽  
Máirín Ryan
Keyword(s):  
Health Economic ◽  
Early Stage ◽  
Data Gathering ◽  
Economic Modeling ◽  
Economic Modelling ◽  
Negative Consequences ◽  
Health Technologies ◽  
Stage Of Development ◽  
Early Health

Abstract This commentary considers the positive and negative consequences of early economic modelling and explores potential future directions. Early economic modelling offers device manufacturers an opportunity to assess the potential value of an innovation at an early stage of development. Early modelling can direct resources into potentially viable technologies and reduce investment in technologies with limited prospect of value. However, it is unclear whether early modelling is sufficiently specific to identify innovations with low value. It may be that early modelling is more useful for directing data gathering to reduce decision uncertainty. Early modelling is of primary benefit to the manufacturer and may have both positive and negative consequences for reimbursement processes that should be considered

scholarly journals The role of Data-Independent Acquisition for Glycoproteomics

2020 ◽  
pp. mcp.R120.002204
Author(s):  
Zilu Ye ◽  
Sergey Y Vakhrushev
Keyword(s):  
Early Stage ◽  
Label Free ◽  
Basic Principles ◽  
Post Translational Modifications ◽  
Full Characterization ◽  
Data Independent Acquisition ◽  
Stage Of Development ◽  
Free Quantification

Data independent acquisition (DIA) is now an emerging method in bottom-up proteomics and capable of achieving deep proteome coverage and accurate label-free quantification. However, for post-translational modifications (PTM), such as glycosylation, DIA methodology is still in the early stage of development. The full characterization of glycoproteins requires site specific glycan identification as well as subsequent quantification of glycan structures at each site. The tremendous complexity of glycosylation represents a significant analytical challenge in glycoproteomics. This review focuses on the development and perspectives of DIA methodology for N- and O- glycoproteomics and posits that DIA-based glycoproteomics could be a method of choice to address some of the challenging aspects of glycoproteomics. First, the current challenges in glycoproteomics and the basic principles of DIA is briefly introduced. DIA based glycoproteomics is then summarized and described into four aspects based on the actual samples. Lastly, we discussed the important challenges and future perspectives in the field. We believe that DIA can significantly facilitate glycoproteomic studies and contribute to the development of future advanced tools and approaches in the field of glycoproteomics.

Do The Charecteristics Of Technology Lead To University Patents Being Unexploited?

2012 ◽  
Author(s):  
Kamariah Ismail ◽  
Wan Zaidi Wan Omar ◽  
Izaidin Abdul Majid
Keyword(s):  
Decision Making ◽  
Early Stage ◽  
Decision Making Process ◽  
Economic Potential ◽  
Stage Of Development ◽  
University Patents ◽  
The University ◽  
University Patent

Fungsi universiti dalam mengkomersilisasikan patent telah banyak dikaji oleh penulis. Setengah universiti telah berjaya mengkomersilisasikan paten mereka terutamanya dengan melesenkan kepada syarikat gergasi atau pun dengan menubuhkan kompeni spin–off. Walau bagaimanapun masih terdapat sebahagian paten universiti yang tidak dieksploitasikan. Kajian ini membincangkan apakah karekteristik paten yang tidak dikomersilisasikan. Sebuah universiti di Scotland telah digunakan sebagai kajian kes. Sepuluh jenis patent yang tidak diekploitasikan oleh universiti berkenaan telah dipilih untuk kajian. Penyelidik daripada paten tersebut telah ditemuduga dengan mendalam menggunakan soalan semi berstruktur. Temuduga telah direkod, ditranskrib, dan data telah dianalisis berdasarkan kepada setiap kes dan silang kes berbantukan Nvivo software. Dapatan menunjukkan sebab yang paling penting kenapa paten tidak dieksploitasikan adalah berkait rapat dengan teknologi itu sendiri. Teknologi didapati berada pada tahap pembangunan yang terlalu awal. Ini menyebabkan syarikat yang telah kukuh lebih berhati–hati untuk membangun dan memasarkan teknologi tersebut. Walau bagaimanapun terdapat teknologi yang mempunyai potensi untuk dieksploitasikan jika peruntukan disediakan untuk penyelidikan lanjut. Dalam kes yang lain pula setengah teknologi telah dipintas oleh teknologi yang lebih ke hadapan dan teknologi tersebut telah mendahului pasaran. Kurangnya motivasi di kalangan penyelidik–penyelidik untuk melihat inovasi mereka ke pasaran, kurangnya jaringan dan pemasaran produk oleh penyelidik dan pihak TTO, adalah juga menyebabkan ia tidak diekploitasikan. Mengkaji kenapa universiti paten tidak dieksploitasikan akan meningkatkan pemahaman tentang proses pengkomersilan bagi paten di universiti. Hasil kajian dapat membantu dalam proses membuat keputusan untuk mengkomersilisasikan hasil penyelidikan universiti. Pemahamam mengenai karekteristik atau ciri universiti paten yang mempunyai potensi nilai ekonomi yang tinggi hanya patut dipatenkan, dan ini akan mengurangi bilangan paten yang tidak dieksploitasikan. Kata kunci: Paten yang tidak diekploitasikan, pengkomersilisasi; universiti paten The role of universities in commercialising their patents has been studied extensively. Some universities have succeeded in commercialising their patents especially through the route of licensing to established companies or forming new spin–off companies. However, there are some university patents remained unexploited, which represent wastage to the universities. This paper discusses what are the features of some patented technologies that are not commercialised. A case study of a university in Scotland was used in this study. Ten patents which are not being exploited by the University were selected. The inventors of these technologies were interviewed in depth, using semistructured questionnaires. The interviews were recorded, transcribed and the data was analysed based on a case and cross case aided by Nvivo software. The findings show that the most significant reason why patents are not exploited is associated with the technologies themselves. The technologies were found to be at very early stage of development, thus established companies were wary of taking them to market. Lack of motivation among the inventors to see their inventions being exploited, lack of industry networking and marketing of the TTO and inventor are another important reason that led to the inventions unexploited. Studying why some university patents were not exploited will enhance the understanding of the process of commercialisation of university patents, which would help refine the decision making process of patenting. Understanding the characteristics of the university inventions that have high economic potential thus should seek patent protections would reduce the number of unexploited patents. Key words: Unexploited patents; commercialisation and university patent

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