scholarly journals Morphological changes in the bone tissue around dental implants after low-frequency low-intensity ultrasound applications

2020 ◽  
Vol 17 (1) ◽  
pp. 20-27 ◽  
Author(s):  
S. P. Rubnikovich ◽  
I. S. Khomich ◽  
Yu. L. Denisova
Keyword(s):  
Bone Tissue ◽  
Dental Implants ◽  
Morphological Changes ◽  
Histological Study ◽  
Low Frequency ◽  
Laboratory Animals ◽  
Pulsed Ultrasound ◽  
Bone Maturation ◽  
Low Intensity ◽  
Dental Implantation

The article presents the results of a histological study of morphological changes in bone tissue around established dental implants after exposure to low-intensity, low-frequency ultrasound during dental implantation. Histological studies of tibia bone blocks were conducted in three groups of laboratory animals around installed dental implants, which were subjected to different modes of ultrasonic exposure. In the course of studies, it was found that the processes of osseointegration of dental implants in animals of all groups occurred without staging. In the early stages, granulation tissue was formed, which was subsequently replaced by reticulofibrotic bone tissue, and then by more mature lamellar tissue. The timing and degree of bone maturation, as well as the indicators of osseointegration in groups using low-intensity pulsed ultrasound and without it, were significantly different. It was shown that the ultrasound effect on peri-implant tissues induces osteoreparative processes, stimulating neoangiogenesis in granulation and newly formed bone tissue. It has been established that ultrasonic exposure of implants, and then peri-implant tissues during dental implantation, promotes the formation of bone tissue, the histostructure of which is similar to the histostructure of the maternal bone at earlier stages.

scholarly journals Evaluation of histological changes in peri-implant bone tissue after ultrasound application at early healing stages

2018 ◽  
pp. 38-42 ◽  
Author(s):  
S.P. Rubnikovich ◽  
I.S. Khomich
Keyword(s):  
Bone Tissue ◽  
Dental Implants ◽  
Morphological Changes ◽  
Experimental Studies ◽  
Low Frequency ◽  
Control Group ◽  
Pulsed Ultrasound ◽  
Low Intensity Pulsed Ultrasound ◽  
Low Intensity ◽  
Dental Implantation

The aim was to study the nature of the morphological changes over time in the bone tissue around the implants under the influence of low-intensity pulsed ultrasound in the experiment. Materials and methods. Experimental studies were carried out on rabbits of the chinchilla breed, with dental implants installed in the tibia – two experimental groups with ultrasound and one control group. The animals were withdrawn from the experiment at 1, 2, 4 and 8 weeks and histological examination of the sections of peri-implant tissues was carried out. Results. The processes of osseointegration of dental implants in all groups of animals occurred without disrupting the normal process sequence. In the early stages granulation tissue is formed, later it is replaced by fibrous-reticular and coarse-fibrous bone tissue, and at the end – by a more mature lamellar bone tissue. However, the timing and degree of maturation of bone tissue, as well as osseointegration of implants in groups using low-frequency low-intensity pulsed ultrasound and without it differed significantly. The study showed that ultrasound exposure to implants and surrounding tissues induces osteoreparation processes, stimulating neoangiogenesis in granulation and newly formed bone tissue. Conclusion. Application of ultrasound to implants and subsequent application to the peri-implant tissues during and after dental implantation promotes the formation of bone tissue, identical by the histostructure to the maternal bone.

scholarly journals THE EXPERIMENTAL SUBSTANTIATION OF THE METHOD OF DENTAL IMPLANTATION USING LOW-INTENSITY PULSED ULTRASOUND IN PATIENTS WITH PARTIAL SECONDARY ADENTIA

2015 ◽  
pp. 75-80
Author(s):  
S. P. Rubnikovich ◽  
I. S. Khomich ◽  
T. E. Vladimirskaya
Keyword(s):  
Experimental Study ◽  
Bone Tissue ◽  
Morphological Changes ◽  
Combined Effect ◽  
Pulsed Ultrasound ◽  
Low Intensity Pulsed Ultrasound ◽  
Low Intensity ◽  
Dental Implantation ◽  
Contact Exposure ◽  
Experimental Substantiation

The work presents the experimental study of the method of dental implantation using low-intensity pulsed ultrasound in animals. The nature of morphological changes in the peri-implant bone tissue after the contact exposure of low intensity pulsed ultrasound to the implant and the peri-implant tissue has been studied. The obtained results are indicative of the efficiency of the method of dental implantation using the combined effect of low-intensity pulsed ultrasound.

Vitamin D Effects on Guided Bone Regeneration and Osseointegration of Dental Implants (Literature Review)

2020 ◽  
Vol 75 (5) ◽  
pp. 552-560
Author(s):  
Sergey Yu. Ivanov ◽  
Svetlana Yu. Kalinchenko ◽  
Nidjat A. Guseynov ◽  
Aleksander A. Muraev ◽  
Aigul Т. Safi ◽  
...  
Keyword(s):  
Vitamin D ◽  
Bone Tissue ◽  
Dental Implants ◽  
Scientific Data ◽  
Reparative Regeneration ◽  
Jaw Bone ◽  
Dental Implantation ◽  
Oral Reconstruction ◽  
Phosphate Exchange ◽  
Regeneration Of Bone

Background.Due to the prevalence of Vitamin D deficiency as well as the frequency of reconstructive surgical interventions followed by dental implantation, the issue arises concerning the effect of Vitamin D on reparative regeneration of bone and osseointegration of dental implants.The purpose using literature data we are conducting an impact assessment of vitamin D on reparative regeneration of bone tissue, in particular, after oral reconstruction surgeries and dental implantation.Methods.Retrieval, systematization and analysis of scientific data on application of vitamin D supplementation and its effect on reparative regeneration of jaw bone tissue.The conclusions.For the most part, the positive effect exerted on reparative regeneration of jaw bone tissue and osseointegration of dental implants is due to the role of vitamin D in physiological processes evolving in bone tissue, namely maintenance of calcium and phosphate exchange through intestinal absorption and TNF, RANKL (Receptor activator of nuclear factor kappa-B ligand) and consequently differentiation of precursors to osteoclasts into osteoclasts through VDR stimulation (VitaminD Receptor) receptors for further osteogenesis. Also, according to literature data, FGF23 (Fibroblast Growth Factor) protein is a marker of osteoblasts differentiation into osteocytes, it is also known that FGF23 and 1,25(ОН)2D3 are genetically related. FGF23 is the main regulator of both phosphate exchange in bones and metabolism of vitamin D and its metabolites. Besides, indirect anti-inflammatory effect has been observed thanks to inhibition of pro-inflammatory cytokine secretion. Taking into account the abovementioned data, of particular relevance is the definition of serum concentration 25(ОН)D and development of schemes of vitamin D level pre-surgery correction in patients, who have to undergo oral reconstruction surgeries and dental implantation. Mass spectrometry is a promising diagnostic method for determining the level of vitamin D in a body, as it allows to identify the actual amount of vitamin D free from admixture of other steroid hormones. The introduction of this method into clinical practice will allow to monitor the level of vitamin D in patients, receiving reconstructive and rehabilitative treatment.

Microbial contamination dynamics in surgical treatment of patients using dental implants in a limited bone tissue volume

2019 ◽  
pp. 52-58
Author(s):  
A.M. Tsitsiashvili ◽  
A.M. Panin ◽  
Ye.N. Nikolayeva ◽  
A.A. Arutyunyan ◽  
M.S. Podporin ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Dental Implants ◽  
Bacteriological Study ◽  
Number Of Species ◽  
Dental Implantation ◽  
Multi Stage ◽  
Short Implants ◽  
Amoxicillin Clavulanate ◽  
Pure Cultures ◽  
Step Therapy

The aim of the study was to evaluate the effectiveness of antibiotic chemotherapy regimens and the dynamics of the nature of microbial associations of the operating area at the surgical stages of treatment of patients using dental implants in conditions of limited bone tissue. The study involved 37 patients (17 m and 20 w, from 32 to 68 years). According to the tactics of the treatment and the type of antibacterial effect, the patients were divided into 3 groups. Per os was prescribed antibiotics as a step therapy: amoxicillin (flemoxin 500 mg 1 tablet 2 per day for 7 days) and amoxicillin / clavulanate (flemoclav 625 mg 1 table 2 per day 7 days), doxycycline (unidox 100 mg 1 table 1 per day 5 days). The 1st group of patients (n1=12; 31.9%) — a multi-stage approach (MA), where the 1st operation is bone grafting (BG) (Flemoxin 500 mg), after 6—9 months, the 2nd dental implantation (DI) (flemoklav 625 mg), after 3—6 months the 3rd — installation of gingival formers (GF) (unidox 100 mg). The 2nd group of patients (n2=14; 36.2%) — a one-stage approach (OA), where the 1st operation is BG with simultaneous DI (flemoxin 500 mg), after 6—9 months — the 2nd — installation of GF (flemoklav 625 mg). 3rd group — narrow/short implants (N/S) without BG were installed (n3=11; 31.9%). The 1st operation — DI (Flemoxin 500 mg), the 2nd — installation of GF (Flemoklav 625 mg). A bacteriological study with the identification of pure cultures of bacteria and determination of sensitivity to antibacterial drugs was performed for all patients before treatment and in dynamics. In MA, there was a suppression of the growth of certain types of bacteria and an increase in the number of species resistant to this antibiotic. In the framework of the OA, when prescribing antibiotics, the results were comparable. With N/S implants, growth inhibition of a number of species present at the beginning of treatment was noted. In multi-stage operations, we consider it reasonable to use beta-lactamase-protected drugs, or drugs of another group that include representatives of parodontopathogenic species and potential carriers of multiple resistance genes in their spectrum of action.

Main Approaches to the Use of Biomaterials in Oral and Maxillofacial Surgery: A Brief Systematic Review

2021 ◽  
pp. 42-48
Author(s):  
Henrique Esteves Magalhães ◽  
Priscilla Janaína de Lima Borelli Bovo ◽  
Luciano Rodrigues Neves ◽  
Marcelo Henrique Batista Santos ◽  
Rogério Luiz de Araújo Vian ◽  
...  
Keyword(s):  
Systematic Review ◽  
Bone Tissue ◽  
Dental Implants ◽  
Bone Growth ◽  
Maxillofacial Surgery ◽  
Oral And Maxillofacial Surgery ◽  
Success Rates ◽  
Dental Implantation ◽  
Regeneration Of Bone Tissue ◽  
Regeneration Of Bone

Introduction: In recent years, procedures with the use of dental implants have increased worldwide, reaching approximately one million dental implants per year. In recent years, a platelet concentrate called FRP (fibrin-rich plasma) has been the subject of clinical studies. Associated with this, the biomaterial Bio-Oss® (Geistlich), as it is biodegradable, biocompatible, non-toxic, and has low immunogenicity, and bio stimulators can act in the regeneration of bone tissue, as it establishes with the cells the appropriate biological niche (favorable microenvironment) for bone growth. Objective: Therefore, the present study aimed to evaluate, through a brief systematic review, the results that involve bone formation for dental implantation, with the use of biomaterials such as fibrin-rich plasma and Bio-Oss®. Methods: The model used for the review was PRISMA. Was used databases such as Scopus, Scielo, Lilacs, Google Scholar, PubMed. Results: Fibrin-rich plasma (FRP) as an autologous biomaterial for use in oral and maxillofacial surgery presents most leukocytes, platelets, and growth factors, forming a fibrin matrix, with three-dimensional architecture. The Bio-Oss® biomaterial (Geistlich), as it is biodegradable, biocompatible, non-toxic, and has low immunogenicity and bio stimulators can act in the regeneration of bone tissue, since it establishes with the adenomatous mesenchymal stem cells the appropriate biological niche for bone growth and, thus, allowing the dental implant to be as effective as possible. Conclusion: The use of FRP associated with Bio-Oss® seems to illustrate high success rates with minimal costs, which may reduce the amount of bone graft needed to fill the sinus cavity, reducing the costs of the procedure.

scholarly journals Low-intensity Pulsed Ultrasound Stimulation Significantly Enhances the Promotion of Bone Formation Around Dental Implants

2011 ◽  
Vol 20 (2) ◽  
pp. 139-146 ◽  
Author(s):  
Yasuhiro Nakanishi ◽  
Pao-Li Wang ◽  
Morio Ochi ◽  
Kazuyo Nakanishi ◽  
Hideki Matsubara
Keyword(s):  
Bone Formation ◽  
Dental Implants ◽  
Pulsed Ultrasound ◽  
Low Intensity Pulsed Ultrasound ◽  
Low Intensity ◽  
Ultrasound Stimulation

scholarly journals Features of trophism of bone tissue after the installation of dental implants

2021 ◽  
Author(s):  
A. V. Ivaschenko ◽  
A. E. Yablokov ◽  
I. I. Markov ◽  
V. A. Monakov ◽  
A. M. Nesterov
Keyword(s):  
Alkaline Phosphatase ◽  
Bone Tissue ◽  
Dental Implants ◽  
Oral Hygiene ◽  
Biological Fluid ◽  
Negative Influence ◽  
Maximum Activity ◽  
Ministry Of Health ◽  
Dental Implantation ◽  
Medical University

Relevance. The most important condition for a successful result of dental implantation is high-quality osseointegration of dental implants. In the literature, the issue of the quality of osseointegration is widely covered, which directly depends on the primary stability of dental implants. In the area of bone tissue remodeling, surrounding the installed dental implants, there are permanent processes of bone resorption and its restoration [1][2].The aim is to reveal the reactivity of alkaline phosphatase and osteocalcin in the biological fluid (saliva) in patients after dental implants.Materials and methods. The collection and analysis of clinical material was carried out on the basis of the Clinics of the Samara State Medical University of the Ministry of Health of Russia. Dental implantation surgery was performed in 184 patients aged 32 to 65 years. The gender ratio was 2:3 (40 men and 60 women). The teeth were lost due to poor oral hygiene and caries complications.Results and discussion. At the time of admission of patients to the department of the Department of Prosthetic Dentistry of the Clinics of the Samara State Medical University of the Ministry of Health of Russia, the bulk of the patients had a low hygienic status. The OHI-S index averaged 2.74 ± 0.33 conventional units. (control – 0.50 ± 0.07 c.u.). In order to reduce the negative influence of microorganisms in the supra- and subgingival dental deposits, all patients underwent professional oral hygiene, as well as antimicrobial therapy. At the time of installation of dental implants, the average OHI-S and Müllemann-Cowell index was 0.72 ± 0.06 and 0.57 ± 0.06 conventional units, respectively.Conclusions. 1. The increase in the titer of alkaline phosphatase and osteocalcin during dental implantation is not statistically significant. 2. TCRF in the oral fluid (saliva) exhibits maximum activity by the 14th day, exceeding the initial three times. This indicator remains at an increased level in the period up to six months from the beginning of the operation. 3. Revealing the values of the TRKF titer after the operation of dental implantation is advisable to use as an assessment of the state of trophic processes occurring in the bone tissue.

scholarly journals The use of polyetheretherketone for the manufacture of removable implant dentures

2021 ◽  
Vol 9 (4) ◽  
pp. 583-588
Author(s):  
Igor’ A. Moldovanov ◽  
◽  
Anna V. Podoprigora ◽  
Generik G. Adamyan ◽  
Mikhail A. Kryuchkov ◽  
...  
Keyword(s):  
Service Life ◽  
Bone Tissue ◽  
Dental Implants ◽  
Mucous Membrane ◽  
Postoperative Period ◽  
Present Stage ◽  
Mechanical Pressure ◽  
Dental Implantation ◽  
Upper Jaw

INTRODUCTION: The industry of temporary prosthetics for dental implantation in the postoperative period at the present stage of the development of dentistry has achieved significant results. However, up to now, there are still cases of insufficient effectiveness of temporary prosthetics, which is expressed in a reduced service life and a violation of the retention of temporary structures, the need for a relatively large number of corrections of their basis, as well as inflammatory and atrophic changes in the mucous membrane of the prosthetic bed and loss of bone tissue in the jaws in the projection of the mechanical pressure of the prosthesis. AIM: To determine the effectiveness of the use of polyetheretherketone for the manufacture of immediate prostheses based on temporary dental implants. MATERIALS AND METHODS: Dental implants in the upper jaw were installed in 76 patients with a diagnosis of full absence of teeth. For temporary rehabilitation for the period of osteointegration, temporary implants were installed in the amount of 2 pieces and temporary removable dentures were made. RESULTS: The use of polyetheretherketone revealed a 25% decrease in dentures breakdowns, an increase in the number of temporary implants viability by 37.5%, and a decrease in bone tissue atrophy by 19% to 22%. CONCLUSIONS: It is advisable to use polyetheretherketone for the manufacture of removable implant dentures.

scholarly journals Low Intensity Pulsed Ultrasound for Bone Tissue Engineering

Micromachines ◽  
2021 ◽  
Vol 12 (12) ◽  
pp. 1488
Author(s):  
Colleen McCarthy ◽  
Gulden Camci-Unal
Keyword(s):  
Bone Formation ◽  
Bone Tissue ◽  
Mechanical Stimulation ◽  
Synergistic Effects ◽  
In Vivo Studies ◽  
Pulsed Ultrasound ◽  
Low Intensity Pulsed Ultrasound ◽  
Low Intensity

As explained by Wolff’s law and the mechanostat hypothesis, mechanical stimulation can be used to promote bone formation. Low intensity pulsed ultrasound (LIPUS) is a source of mechanical stimulation that can activate the integrin/phosphatidylinositol 3-OH kinase/Akt pathway and upregulate osteogenic proteins through the production of cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2). This paper analyzes the results of in vitro and in vivo studies that have evaluated the effects of LIPUS on cell behavior within three-dimensional (3D) titanium, ceramic, and hydrogel scaffolds. We focus specifically on cell morphology and attachment, cell proliferation and viability, osteogenic differentiation, mineralization, bone volume, and osseointegration. As shown by upregulated levels of alkaline phosphatase and osteocalcin, increased mineral deposition, improved cell ingrowth, greater scaffold pore occupancy by bone tissue, and superior vascularization, LIPUS generally has a positive effect and promotes bone formation within engineered scaffolds. Additionally, LIPUS can have synergistic effects by producing the piezoelectric effect and enhancing the benefits of 3D hydrogel encapsulation, growth factor delivery, and scaffold modification. Additional research should be conducted to optimize the ultrasound parameters and evaluate the effects of LIPUS with other types of scaffold materials and cell types.

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