scholarly journals Diagnosis and epidemiology of Coronavirus (COVID-19) outbreak in Indonesia

2020 ◽  
Vol 9 (1) ◽  
pp. 49-57
Author(s):  
Sutaryono Sutaryono ◽  
Sholikhah Deti Andasari ◽  
Heru Subaris Kasjono
Keyword(s):  
Internal Medicine ◽  
Cardiac Disease ◽  
Large Scale ◽  
Signs And Symptoms ◽  
Shortness Of Breath ◽  
Rapid Testing ◽  
Chain Reaction ◽  
History Of ◽  
Polymerase Chain ◽  
The Government

COVID-19 has experienced an increase in 2,995,758 positive cases and 204,987 deaths, in distribution areas of more than 213 countries. This research using a systematic literature review, policy brief, and internet-based questionnaire with the aim of finding out the diagnosis and epidemiology of Coronavirus (COVID-19) outbreak in Indonesia. The cases in Indonesia have reached 9,771 and killed 784 people, possibly as many as 19 cases are asymptomatic but can be carriers of the virus. The diagnosis is carried out by rapid testing and using a polymerase chain reaction (PCR). Most of the patients diagnosed were aged 30-49 years (38.91%), the highest accompanying diseases were hypertension (34.85%), diabetes mellitus (25.76%), and cardiac disease (17.05%). The most signs and symptoms are that the patient has a cough, shortness of breath, and has a history of internal medicine and fever. Based on sex mostly experienced by men (58.94%) compared to women (41.06%), 60.4% of the community is still active outside the home. The Government of Indonesia is making efforts to reduce the COVID 19 outbreak by implementing a health protocol and a Large-scale Social Restrictions or “Pembatasan Sosial Berskala Besar (PSBB)” policy.

scholarly journals Gastrointestinal symptoms as antecedent signs of severe acute respiratory syndrome coronavirus 2 infection

2021 ◽  
Vol 18 (4) ◽  
pp. 323-325
Author(s):  
Aleksandra Młodożeniec ◽  
◽  
Paulina Szul ◽  
Agnieszka Gala-Błądzińska ◽  
◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Respiratory Symptoms ◽  
Gastrointestinal Symptoms ◽  
Final Diagnosis ◽  
Shortness Of Breath ◽  
Chain Reaction ◽  
Acute Infectious Disease ◽  
History Of ◽  
Polymerase Chain ◽  
Loss Of Appetite

Introduction. The coronavirus disease 2019 (COVID‑19) is an acute infectious disease of the respiratory system caused by severe acute respiratory syndrome coronavirus (SARS‑CoV‑2). Most patients present with typical, respiratory symptoms. Common signs include cough, fever, dyspnea and shortness of breath. In this case we provide atypical indications of COVID-19, which may occur earlier than respiratory symptoms. Aim. This case is an example of an unusual course of SARS-CoV-2 infection. Description of the case. This article describes a case of a 63-year-old man and his wife, a 60-year old woman who were admitted to the emergency department with a few days’ history of gastrointestinal symptoms. Both patients presented with the digestive symptoms of nausea, diarrhea and loss of appetite. They denied abdominal pain and the loss of smell or taste. Due to suspicion of SARS-CoV-2 infection a nasopharyngeal swabs of both patients was taken. The results of real- time reverse transcriptase-polymerase chain reaction were positive. When the final diagnosis of COVID-19 was established they were transported to another hospital. Conclusion. COVID-19 may manifest with atypical indications such a nausea and diarrhea. An atypical indications of COVID-19 may occur earlier than respiratory symptoms. It is important for clinicians to remain alert.

scholarly journals COVID-19 pneumonia in a patient with granulomatosis with polyangiitis on rituximab: case-based review

2021 ◽  
Author(s):  
Alicia Rodriguez-Pla ◽  
Holenarasipur R. Vikram ◽  
Vanood Khalid ◽  
Lewis J. Wesselius
Keyword(s):  
Nasal Swab ◽  
Granulomatosis With Polyangiitis ◽  
Atypical Presentation ◽  
Shortness Of Breath ◽  
Past Medical History ◽  
Chain Reaction ◽  
Quick Recovery ◽  
History Of ◽  
Polymerase Chain ◽  
Case Based

AbstractA 77-year-old man with past medical history of granulomatosis with polyangiitis (GPA) on rituximab and prednisone, presented to the hospital with worsening cough and shortness of breath. He had tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection by nasal swab polymerase chain reaction (PCR) while asymptomatic, 6 weeks earlier. He started with cough and shortness of breath 2 weeks after his initial positive test. After developing symptoms, he tested negative twice by nasal swab PCR, but the PCR of his bronchioloalveolar lavage was positive for SARS-CoV-2. He did not develop antibodies against coronavirus. Prednisone 15 mg daily was continued, and he received remdesivir, and convalescent plasma with quick recovery. We reviewed the literature to search for similar cases. Our case suggests that SARS-CoV-2 infection in patients on rituximab may have an atypical presentation and the diagnosis may be delayed due to negative PCR testing in the nasal swab. Patients may benefit from treatment with convalescent plasma.

scholarly journals Seroprevalence of SARS-CoV-2 Antibodies Among Health Care Personnel at a Health Care System in Pakistan

2021 ◽  
pp. 101053952110110
Author(s):  
Salma Abbas ◽  
Aun Raza ◽  
Ayesha Iftikhar ◽  
Aamir Khan ◽  
Shahzaib Khan ◽  
...  
Keyword(s):  
Health Care ◽  
Control Measures ◽  
Health Care Personnel ◽  
Test Results ◽  
Antibody Testing ◽  
Chain Reaction ◽  
Past Infection ◽  
Infection Control Measures ◽  
History Of ◽  
Polymerase Chain

Health care personnel (HCP) are at high risk for coronavirus disease-2019 acquisition. Serum antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) indicate past infection. Our institution offered SARS-CoV-2 antibody testing to HCP. We surveyed HCP with positive test results to explore past exposure to SARS-CoV-2, details of symptoms during the preceding 6 months, and a history of SARS-CoV-2 polymerase chain reaction testing. A total of 2162 HCP underwent antibody testing. Eight hundred fifty-seven (39.6%) employees tested positive and, of these, 820 (95.7%) participated in the survey. When adjusted for age, males had higher odds of testing positive for SARS-CoV-2 antibodies compared with females (OR = 1.68; 95% CI = 1.37-2.05; P = .00) and clinical staff had higher odds of SARS-CoV-2 seropositivity compared with nonclinical staff (OR = 1.273; 95% CI = 1.06-1.53; P = .01). Implementation of effective infection control measures is essential to protect HCP from coronavirus disease-2019.

scholarly journals Adolescent COVID-19-Associated Fatal Rhabdomyolysis

2020 ◽  
Vol 11 ◽  
pp. 215013272098564
Author(s):  
Huda Anwar ◽  
Anwaar Al Lawati
Keyword(s):  
Polymerase Chain Reaction ◽  
Global Health ◽  
Respiratory Tract ◽  
Sore Throat ◽  
Shortness Of Breath ◽  
Past Medical History ◽  
Chain Reaction ◽  
Viral Illness ◽  
Polymerase Chain ◽  
High Index Of Suspicion

Coronavirus disease 2019 (COVID-19) has become an urgent global health priority. Although most patients with COVID-19 manifest with fever and respiratory tract symptoms, COVID-19 infections may also involve other organs and extrarespiratory manifestations, including cardiac, gastrointestinal, hepatic, renal, and neurological symptoms. This case describes a 16-year-old boy who presented with fever, sore throat, myalgia, and subsequently with shortness of breath. A diagnosis of COVID-19 was confirmed by polymerase chain reaction. His condition deteriorated and he died within 3 days of admission. An evaluation of his past medical history confirmed an episode of viral illness which had progressed to myositis and rhabdomyolysis 1 year prior. Clinicians should be aware of this complication and maintain a high index of suspicion in cases of COVID-19 presenting with extrapulmonary symptoms.

scholarly journals Application of a Polymerase Chain Reaction Assay for Detection of Proliferative Enteritis-Affected Swine Herds

1996 ◽  
Vol 8 (2) ◽  
pp. 181-185 ◽  
Author(s):  
Patricia K. Holyoake ◽  
Gary F. Jones ◽  
Peter R. Davies ◽  
Dennis L. Foss ◽  
Michael P. Murtaugh
Keyword(s):  
Polymerase Chain Reaction ◽  
Chain Reaction ◽  
Pcr Assay ◽  
Nursery Pigs ◽  
Clinically Normal ◽  
Source Of Infection ◽  
History Of ◽  
Polymerase Chain ◽  
Swine Herds ◽  
Age Range

A polymerase chain reaction (PCR) assay was used to confirm the presence of ileal symbiont (IS) intracellularis in 3 swine herds with a history of proliferative enteritis (PE). Two pooled fecal specimens, each comprising 5 individual stool samples, were collected from pen floors to screen for the presence of IS intracellularis and determine the age range of pigs shedding the organism. IS intracellularis was detected in the feces of clinically normal 10–25week-old grower/finisher pigs, indicating that this age range of pigs was the main source of infection for younger nursery pigs. Shedding continued without clinical disease when 10–100 g/ton of tylosin or 10 g/ton of chlortetracycline was added to the feed. PCR testing of pooled fecal samples can be used to identify groups of pigs affected with PE. The results of this study indicate that this PCR assay has the potential to accurately assess the IS intracellularis infection status of swine herds and the association of IS intracellular-is with PE and growth performance.

scholarly journals Hoarseness of Voice as a Rare Presentation of Tuberculosis: A Case Report Study

2019 ◽  
Vol 7 (19) ◽  
pp. 3262-3264
Author(s):  
Taher Felemban ◽  
Abdullah Ashi ◽  
Abdullah Sindi ◽  
Mohannad Rajab ◽  
Zuhair Al Jehani
Keyword(s):  
Laryngeal Carcinoma ◽  
Incidental Finding ◽  
Chain Reaction ◽  
Rare Presentation ◽  
Case Presentation ◽  
X Ray ◽  
History Of ◽  
Chest X Ray ◽  
Polymerase Chain ◽  
Laryngeal Tuberculosis

BACKGROUND: Having hoarseness of voice as the first clinical manifestation of tuberculosis is rare. This atypical presentation causes some confusion since other more common conditions, such as laryngeal carcinoma, present similarly and might require more invasive tests to confirm the diagnosis. CASE PRESENTATION: A 38-year-old male presented to the otorhinolaryngology clinic with a four-month history of change in voice. Laryngoscopy demonstrated a right glottic mass, raising suspicion of laryngeal cancer. The computed tomography showed a mass and incidental finding of opacities in lung apices. Chest x-ray demonstrated findings suggestive of tuberculosis. Polymerase chain reaction and culture of sputum samples confirmed the diagnosis and the patient was started on anti-tuberculosis treatment. CONCLUSION: Despite accounting for only 1% of pulmonary tuberculosis cases and having a similar presentation to laryngeal carcinoma, we recommend considering laryngeal tuberculosis when evaluating hoarseness of voice in endemic areas.

scholarly journals Thrombotic, inflammatory, and HIF-regulated genes and thrombosis risk in polycythemia vera and essential thrombocythemia

2020 ◽  
Vol 4 (6) ◽  
pp. 1115-1130 ◽  
Author(s):  
Radhika Gangaraju ◽  
Jihyun Song ◽  
Soo Jin Kim ◽  
Tsewang Tashi ◽  
Brandi N. Reeves ◽  
...  
Keyword(s):  
Polycythemia Vera ◽  
Essential Thrombocythemia ◽  
Quantitative Polymerase Chain Reaction ◽  
Hypoxia Inducible Factor ◽  
Chain Reaction ◽  
Thrombosis Risk ◽  
Inflammatory State ◽  
History Of ◽  
Gene Transcripts ◽  
Polymerase Chain

Abstract Thrombosis is a major cause of morbidity and mortality in polycythemia vera (PV) and essential thrombocythemia (ET). The pathophysiology of thrombosis in these disorders remains unclear, and we hypothesized that upregulation of thrombotic, inflammatory, and hypoxia-inducible factor (HIF)–regulated genes may play a role in it. We performed unbiased RNA sequencing in granulocytes and platelets of PV patients and found differential expression of several thrombotic, inflammatory, and HIF-regulated genes. The expression of many of these genes positively correlated with JAK2 expression and JAK2V617F allelic burden. We then validated these findings by quantitative polymerase chain reaction analyses of selected gene transcripts in a larger number of PV and ET granulocytes and platelets (58 patients) and in 28 controls, and we compared these findings in patients with and without thrombosis. The study included 29 females and 29 males; of these, 28 had a history of thrombosis. We found that transcripts of several selected genes were upregulated in patients with PV or ET compared with controls. In granulocytes, the expression levels of F3, SELP, VEGFA, and SLC2A1 were significantly higher in patients with a history of thrombosis compared with those who did not have thrombosis. Patients with a history of thrombosis have significantly higher expression of IL1RAP (P < .05) in platelets compared with those without thrombosis. Our study confirms the presence of a thrombo-inflammatory state and augmented HIF activity in PV and ET and its role in thrombosis. These data may provide the background for targeted therapies in PV and ET.

scholarly journals SARS–CoV-2 isolation from an appendix

2020 ◽  
Vol 2020 (8) ◽  
Author(s):  
Shahzaib Ahmad ◽  
Rahim Nadeem Ahmed ◽  
Poonam Jani ◽  
Mattee Ullah ◽  
Hossam Aboulgheit
Keyword(s):  
Polymerase Chain Reaction ◽  
Abdominal Pain ◽  
Respiratory Symptoms ◽  
Tissue Sample ◽  
Gastrointestinal Symptoms ◽  
Shortness Of Breath ◽  
Chain Reaction ◽  
Histological Features ◽  
First Case ◽  
Polymerase Chain

Abstract Efforts to recognize SARS–CoV-2 infection have focused on respiratory symptoms such as cough and shortness of breath. Although it is also well known that SARS–CoV-2 infection can cause gastrointestinal symptoms such as abdominal pain, nausea, vomiting and diarrhoea, there are emerging reports of SARS–CoV-2 infection causing surgical pathology. We present the first case report of SARS–CoV-2 infection directly causing acute appendicitis, first suspected due to highly atypical histological features and later confirmed as polymerase chain reaction positive appendicular tissue sample.

Sign in / Sign up

Export Citation Format

Share Document