scholarly journals Efek anti radang ekstrak torbangun (Coleus amboinicus) pada induksi cisplatin tikus putih wistar

2021 ◽  
Vol 4 (4) ◽  
pp. 79-80
Author(s):  
Rondius Solfaine ◽  
Iwan Sahrial Hamid
Keyword(s):  
Blood Urea Nitrogen ◽  
Rattus Norvegicus ◽  
Urea Nitrogen ◽  
Coleus Amboinicus

Penelitian ini bertujuan menganalisis aktivitas ekstrak torbangun (Coleus amboinicus) terhadap biokimia darah dan gambaran histopatologi ginjal pada induksi cisplatin pada tikus putih Wistar (Rattus norvegicus). Penelitian ini menggunakan 24 tikus putih galur Wistar yang terbagi menjadi 3 kelompok yaitu kelompok kontrol negatif dengan pemberian plasebo (P0), kelompok kontrol positif berupa induksi cisplatin dengan pemberian CMC-Na 0.1 % (P1), dan kelompok induksi cisplatin dengan pemberian ekstrak torbangun 500 mg/ kg bb (P2). Pembuatan nefropati pada kelompok perlakuan dengan injeksi intra peritoneal hari ke-4 dosis tunggal cisplatin 5 mg/kg bb. Seluruh kelompok tikus dikorbankan dan diambil sampel darah untuk diukur kadar blood urea nitrogen (BUN), serum kreatinin (SK) dan alkalin phospatase (ALP) sebagai tes fungsi ginjal. Sampel organ fiksasi dengan BNF 10 % untuk histopatologi. Hasil menunjukkan bahwa pemberian ekstrak Coleus amboinicus menurunkan konsentrasi BUN, serum kreatinin, dan alkalin phospatase pada kelompok dengan ekstrak torbangun (P2) dibandingkan dengan kelompok kontrol positif (p<0,05). Analisis histopatologi terlihat perdarahan multifokal, infiltrasi interstisial, adanya adesi membrane capsula glomerulus dan nekrotik tubular secara difus pada kelompok kontrol positif dengan induksi cisplatin (P1). Kerusakan pada glomerulus dan tubulus ginjal lebih ringan pada kelompok yang diberi eksrak torbangun (P2). Berdasarkan hasil penelitian dapat disimpulkan pemberian ekstrak torbangun dapat menormalkan gambaran biokimia darah dan menghambat kerusakan ginjal dengan cara menghambat keradangan pada induksi cisplatin pada tikus putih.

622 Blood urea nitrogen — an important prognostic marker in patients with chronic heart failure

2006 ◽  
Vol 5 (1) ◽  
pp. 145-146
Author(s):  
M ROIK ◽  
M STARCZEWSKA ◽  
S STAWICKI ◽  
Z HUCZEK ◽  
J KOCHANOWSKI ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Prognostic Marker ◽  
Blood Urea Nitrogen ◽  
Urea Nitrogen

Association between Blood Urea Nitrogen-to-creatinine Ratio and Three-Month Outcome in Patients with Acute Ischemic Stroke

2019 ◽  
Vol 16 (2) ◽  
pp. 166-172 ◽  
Author(s):  
Linghui Deng ◽  
Changyi Wang ◽  
Shi Qiu ◽  
Haiyang Bian ◽  
Lu Wang ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Ischemic Stroke ◽  
Clinical Outcome ◽  
Acute Ischemic Stroke ◽  
Blood Urea Nitrogen ◽  
Univariate Analysis ◽  
Density Lipoprotein ◽  
Hydration Status ◽  
Creatinine Ratio ◽  
Urea Nitrogen

Background: Hydration status significantly affects the clinical outcome of acute ischemic stroke (AIS) patients. Blood urea nitrogen-to-creatinine ratio (BUN/Cr) is a biomarker of hydration status. However, it is not known whether there is a relationship between BUN/Cr and three-month outcome as assessed by the modified Rankin Scale (mRS) score in AIS patients. Methods: AIS patients admitted to West China Hospital from 2012 to 2016 were prospectively and consecutively enrolled and baseline data were collected. Poor clinical outcome was defined as three-month mRS > 2. Univariate and multivariate logistic regression analyses were performed to determine the relationship between BUN/Cr and three-month outcome. Confounding factors were identified by univariate analysis. Stratified logistic regression analysis was performed to identify effect modifiers. Results: A total of 1738 patients were included in the study. BUN/Cr showed a positive correlation with the three-month outcome (OR 1.02, 95% CI 1.00-1.03, p=0.04). However, after adjusting for potential confounders, the correlation was no longer significant (p=0.95). An interaction between BUN/Cr and high-density lipoprotein (HDL) was discovered (p=0.03), with a significant correlation between BUN/Cr and three-month outcome in patients with higher HDL (OR 1.03, 95% CI 1.00-1.07, p=0.04). Conclusion: Elevated BUN/Cr is associated with poor three-month outcome in AIS patients with high HDL levels.

Theaflavin Enriched Black Tea Extract Alleviates Diabetic Nephropathy by Suppressing Hyperglycaemia-Mediated Oxidative Stress and Inflammation in Streptozotocin-Induced Rats

2020 ◽  
Vol 10 ◽  
Author(s):  
Dhrubajyoti Sarkar ◽  
Sekhar Kumar Bose ◽  
Tania Chakraborty ◽  
Souvik Roy
Keyword(s):  
Oxidative Stress ◽  
Diabetic Nephropathy ◽  
Blood Glucose ◽  
Blood Urea Nitrogen ◽  
Phenolic Content ◽  
Black Tea ◽  
Total Phenolic ◽  
Urea Nitrogen ◽  
Black Tea Extract ◽  
Tea Extract

Background: Diabetic nephropathy (DN), a microvascular complication of diabetes has been a significant health issue globally. However, theaflavin enriched black tea extract (BTE-TF) could restrain DN. Objective: The main objective of this exploration was to elucidate the effect of BTE-TF on DN, though the underlying mechanism remains unclear and requires further investigation. Method: The tea leaves were fermented to get black tea extract. Total phenolic content and HPLC were carried out to determine the phenolic content and theaflavin in the extract. Streptozotocin induced diabetic rats were treated with 100, 200, and 400 mg/kg/day BTE-TF extract for 12 weeks. Biochemical parameters like blood glucose, creatinine, blood urea nitrogen (BUN), triglyceride and antioxidant parameters of kidney tissue were measured. Histology, immunohistochemistry and TUNEL assay were performed to observe the effect of the extract with comparison to the standard drug (Metformin 200mg/kg/day). Result: Treated animals exhibited reduced blood glucose levels, blood urea nitrogen (BUN), creatinine, and serum triglycerides. Further, BTE-TF restored the histological alterations in the kidney. Chronic hyperglycaemia resulted in a significant increase in oxidative stress and pro-inflammatory cytokines of NF-kβ pathway. BTE-TF attenuated oxidative stress (p<0.01), inflammation (p<0.05) and apoptosis (p<0.05). Conclusion: This study suggests that BTE-TF exerts a protective role against diabetes-induced renal injury by ameliorating oxidative stress, inflammation, and apoptosis.

scholarly journals A High Level of Blood Urea Nitrogen Is a Significant Predictor for In-hospital Mortality in Patients with Acute Myocardial Infarction

2018 ◽  
Vol 59 (2) ◽  
pp. 263-271 ◽  
Author(s):  
Yu Horiuchi ◽  
Jiro Aoki ◽  
Kengo Tanabe ◽  
Koichi Nakao ◽  
Yukio Ozaki ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Hospital Mortality ◽  
Blood Urea Nitrogen ◽  
Urea Nitrogen ◽  
High Level
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