scholarly journals GABAPENTIN

2018 ◽  
Vol 25 (12) ◽  
pp. 1892-1898
Author(s):  
Brig (Retd) Muhammad Boota ◽  
Sohail Nasir ◽  
Imran Hyder
Keyword(s):  
Heart Rate ◽  
Nasotracheal Intubation ◽  
Hemodynamic Response ◽  
Controlled Clinical Trial ◽  
P Value ◽  
Base Line ◽  
Time Intervals ◽  
Treatment Groups ◽  
Group A ◽  
Group B

Introduction: There have been several methods used to prevent or attenuate the adverse hemodynamic changes following endotracheal intubation, but not many studies have been done for the same purpose in patients undergoing nasotracheal intubation. Deepening of anaesthesia, omitting cholinergic premedication, pre-treatment with vasodilators such as nitroglycerine, beta blockers, calcium channel blockers and opioids are few of the different techniques used when trachea is intubated orally or nasally, to blunt significant swings in hemodynamic parameters. We assessed the effectiveness of oral gabapentin to determine changes in hemodynamic response in normotensive patients following nasotracheal intubationwith or without laryngoscopy for elective maxillofacial surgeries. Study Design: Randomized double blind, placebo-controlled clinical trial. Setting: Department of Anesthesia & Intensive Care, Fauji Foundation Hospital Rawalpindi. Period: 18 months after approval from the ethical committee. Material & Methods: Total 130 patients were included in the study. These patients were randomly divided into 2 groups. In Group-A patients were given 800 mg gabapentin and in Group-B patients were given placebo. Heart rate and mean arterial pressures were recorded just before intubation as base line values, and then average readings were taken at 1 minute, 3 minutes, 5 minutes and 10 minutes after intubation. Bradycardia and hypotension were adequately treated with intravenous atropine and vasopressors. Data entry and analysis was done by using SPSS 17. Results: Total 130 patients who underwent elective surgeries were included in the study and divided into 2 groups each group containing 65 patients each. At 1st minute MAP in Group-A (oral gabapentin) and in Group-B (Placebo) was 86.89±4.36 and 98.70±4.39. At 3rd minute MAP in Group-A, in Group-B was 83.40±4.05 and 92.93±4.79. At 5th minute MAP was 82.50±5.00 and 88.03±4.22 and lastly at 10th minute MAP was 79.81±5.37 in Group-A and 83.18±4.77 in Group-B respectively. P-value at 1st, 3rd, 5th and at 10th minutes showed that statistically MAP was different in both treatment groups at the above mentioned time intervals. 1st minute: p-value=0.042, 3rd minute: p-value=0.000, 5th minute: p-value=0.000 and at 10th minute: p-value=0.000. At 1st minute heart rate in Group-A and Group-B was 87.89±1.39 and 93.47±6.88 respectively. At 3rd minute heart rate in Group-A and Group-B was 83.47±5.47 and 89.70±6.76. At 5th minute heart rate was 82.10±5.01 and 84.60±5.91 and lastly at 10th minute heart rate was 78.09±6.79 in Group-A and 77.27±5.34 in Group-B respectively. P -value at 1st, 3rd and 5th minutes showed that statistically heart rate was different in both treatment groups at the above mentioned time intervals. But at 10th minute heart rate was statistically same in both treatment groups. 1st minute: p-value=0.144, 3rd minute: p-value=0.000, 5th minute: p-value=0.011 and at 10th minute: p-value=0.448. Conclusion: According to the results of this study it was observed that oral gabapentin is effective in modifying hemodynamic response to nasotracheal intubation in normotensive patients undergoing elective maxillofacial surgeries. MAP (10th Minute: Group-A vs. Group-B: 0.000) & Heart Rate (10th Minute: Group-A vs. Group-B:0.448)

scholarly journals Comparative Evaluation of Triphala and Ela Decoction With 0.2% Chlorhexidine as Mouthwash in the Treatment of Plaque-Induced Gingivitis and Halitosis: A Randomized Controlled Clinical Trial

2016 ◽  
Vol 22 (3) ◽  
pp. 468-472 ◽  
Author(s):  
Pratibha Mamgain ◽  
Abhishek Kandwal ◽  
Ravindra K. Mamgain
Keyword(s):  
Group Analysis ◽  
T Test ◽  
Plaque Index ◽  
Controlled Clinical Trial ◽  
Base Line ◽  
Time Intervals ◽  
Intergroup Comparison ◽  
Significant Difference ◽  
Group A ◽  
Group B

Present study evaluates efficacy of Trifala and Ela as plaque controlling agent and compares it with chlorhexidine. Aim. To evaluate Antigingivitis, Antiplaque and Antihalitosis effect of Triphala and Ela decoction. A randomized sample of 60 patients with plaque induced gingivitis was enrolled and equally divided into two groups group A and group B. Group A was given Trifala and Ela decoction and Group B Chlorehexidine mouthwash for 21 days twice daily. Gingival inflammation index, plaque index and Organoleptic scoring scale was recorded at baseline, 14th day and 21st day. Comparing the plaque index for Group A with group B the reduction in from baseline to 14 day was 42.59 % and 38.62% respectively while from baseline to 21 day was 56.20% and 68.57% respectively. On comparing Gingival index for group A with group B the reduction from baseline to 14 day was 31.95% and 38.62 % respectively while from baseline to 21 day was 69.95 % and 68.57% respectively. Halitosis Percentage reduction at 14th day from base line was 33.33% and 38.18%; at 21 day from baseline 66.66% and 72.72% respectively for group A and group B. No statistical significant difference for intergroup comparison was found using paired t test. Intra group analysis using unpaired t test was significant for all the indices at different time intervals. Triphala and Ela decoction is organic, easy to prepare economical and equally effective as compared to chlorhexidine mouthwash.

scholarly journals A prospective randomized single blind study to compare the safety and efficacy of propronolol and topiramate in migraine prophylaxis

2021 ◽  
Vol 10 (4) ◽  
pp. 425
Author(s):  
Keelu Rajkumar ◽  
Pothuru Anil Kumar
Keyword(s):  
Blind Study ◽  
P Value ◽  
Base Line ◽  
Safety And Efficacy ◽  
Treatment Groups ◽  
Migraine Headaches ◽  
Group A ◽  
The Mean ◽  
Group B ◽  
Single Blind

Background: The aim of the study was to compare the Safety and efficacy of propranolol and topiramate in migraine prophylaxis.Methods: This was a prospective, randomized, single blind study which was conducted for six months in 100 patients of outpatient department of Neurology Government General Hospital, Guntur.Results: Among the hundred patients fifty were allotted to group A – propranolol 40 mg bd and fifty were allotted to group B- topiramate 25 mg bd. statistically there is no significant differences were found between the treatment groups of Propranolol and topiramate for the reduction in mean duration and severity of migraine headaches. Both Propranolol and topiramate have p value<0.001. This shows that both propranolol and topiramate have significantly decreased in the mean duration and severity of migraine attacks. However, in the present study topiramate is slightly more efficacious in reducing the symptoms of migraine frequency per month (days), duration and severity (visual analogue scale- VAS score) from baseline at the end of six months. The decrease in frequency of migraine attacks from 10.44±4.38 to 3.18±4.48 i.e., 70.2% from baseline is seen with topiramate.Conclusions: This study demonstrated that both propranolol and topiramate could significantly reduce migraine headache frequency, duration and intensity. However, compared with propranolol topiramate showed better results. topiramate 25 mg reduced the symptoms like frequency, duration and severity of migraine attacks from base line at the end of six months but more number of adverse effects were seen in topiramate group.

scholarly journals Comparison of 4% Topical Hydroquinone versus Combination of Oral Tranexamic Acid and 4% Topical Hydroquinone in the Treatment of Epidermal Melasma

2021 ◽  
Vol 15 (10) ◽  
pp. 3406-3409
Author(s):  
Sarah Riaz ◽  
Najia Ahmed ◽  
Ayesha Anwar ◽  
Moizza Tahir ◽  
Farrah Yousaf ◽  
...  
Keyword(s):  
Tranexamic Acid ◽  
Topical Therapy ◽  
Military Hospital ◽  
Ethical Review ◽  
P Value ◽  
Treatment Groups ◽  
Quasi Experimental ◽  
Group A ◽  
Group B ◽  
Better Than

Objective: comparison of efficacy of topical 4% hydroquinone monotherapy with combination of oral tranexamic acid and topical 4% hydroquinone in the treatment of epidermal melasma Study design: Quasi experimental study Study period and place: Dermatology OPD, Pak Emirates Military Hospital Rawalpindi from July 2018 to January 2019. Methodology: Total 80 patients presenting with epidermal melasma were selected from outdoor patient department after applying the inclusion criteria and consent was taken from selected patients. Study was started after getting permission from hospital ethical review board. Two treatment groups were made after dividing patients by using alternate method. Treatment with topical 4% hydroquinone alone was started for group A patients and combination of capsule tranexamic acid (250 mg two times a day) along with topical 4% hydroquinone were started for group B patients for the next 6 months. Evaluation of patients through detailed history, clinical and wood’s light examination before starting therapy and after of 24 weeks of treatment was done for both groups. Efficacy of treatment was assessed via Modified MASI score. Results: Hydroquinone monotherapy was effective in 21 (52.5%) patients among group A while in group B patients, combination treatment i.e. oral tranexamic acid and topical hydroquinone, was effective in 31 (77.5%) patients (p value= 0.01). Conclusion: Effectiveness of Hydroquinone 4% topical therapy combined with oral tranexamic acid for epidermal melasma is better than topical 4% hydroquinone alone. Key words: Epidermal melasma, oral tranexamic acid, topical 4% hydroquinone.

Cardiopulmonary Functions in Dogs under Propofol, Ketamine and Isoflurane Anaesthesia Premedicated with Glycopyrrolate, Dexmedetomidine and Butorphanol

2021 ◽  
Author(s):  
Hitesh Bayan ◽  
Kushal Konwar Sarma ◽  
Gutti Dhananjaya Rao ◽  
Dwijen Kalita ◽  
Devojyoti Dutta ◽  
...  
Keyword(s):  
Heart Rate ◽  
Mean Arterial Pressure ◽  
Diastolic Pressure ◽  
Systolic Pressure ◽  
Slight Variation ◽  
Base Line ◽  
Isoflurane Anaesthesia ◽  
Group A ◽  
Group B ◽  
Group D

Background: The study was conducted to evaluate the cardiopulmonary functions in dog under propofol, ketamine and isoflurane anaesthesia premedicated with dexmedetomidine and butorphanol.Methods: Four groups of dogs (A,B,C and D) comprising of six animals in each groups were premedicated with glycopyrrolate @ 0.01 mg/kg, dexmedetomidine @5ìg/kg IV and Butorphanol @ 0.1mg/kg IV. Induction was done with propofol (A and B) and with ketamine (C and D). The anaesthesia was maintained with isoflurane (A and C), propofol (B) and ketamine (D). The cardiopulmonary functions were recorded at 0 minute (before premedication) and 20 minutes, 40 minutes and 60 minutes. Result: The heart rate decreased significantly in Group B while there was a significant gradual increase in heart rate in Group D. A significant decrease in respiratory rate was observed in all the groups with a lowest value in group D. The systolic pressure decreased significantly in Group A, B and C but in Group D, the systolic pressure decreased initially at 20 minute. The diastolic pressure decreased significantly in Group A and Group B and but in group D, the diastolic pressure decreased at 20 minute. A significant decrease in mean arterial pressure was recorded in Group A, B and C. In Group D, a decrease in the mean arterial pressure was noticed at 20 minute. The SpO2 level remained near the base line values with slight variation in Group A and C where as the values remained at lower level from the base line value in Group B and D. The EtCO2 level showed non-significant changes in Group A and C. In Group B and D, the EtCO2 levels increased non-significantly with the highest value recorded in Group D. The ECG parameters remained within the normal limit with slight variation according to the heart rate.

scholarly journals A RANDOMIZED COMPARATIVE CLINICAL EVALUATION OF HARIDRADI LEHA AND VASADI KASHAYA IN THE MANAGEMENT OF TAMAKA SHWASA (BRONCHIAL ASTHMA)

2021 ◽  
Vol 12 (3) ◽  
pp. 3-12
Author(s):  
Rashmi Mutha ◽  
Ajay Kumar Sahu ◽  
Jai Prakash Singh ◽  
Ram Kishor Joshi ◽  
Shankar Gautam
Keyword(s):  
Heart Rate ◽  
Bronchial Asthma ◽  
Body Position ◽  
Forced Expiratory Volume ◽  
P Value ◽  
Precipitating Factors ◽  
Accessory Muscle ◽  
Group A ◽  
Group B ◽  
Lukewarm Water

Tamaka Shwasa in Ayurveda is analogous to Bronchial Asthma due to similarity in causative and precipitating factors, onset, pathogenesis and symptoms. An estimated 300 million people worldwide suffer from asthma, with 250,000 annual deaths attributed to the disease. The Objective is to evaluate and compare the efficacy of Haridradi Leha with and without Vasadi Kashaya in the management of Tamaka Shwasa. Total 30 patients were registered for the present study. The patients of group A were administered Haridradi Leha in a dose of 20 grams BD (Bis in die i.e., twice daily) in empty stomach orally with lukewarm water for 21 days. The patients of group B were administered Haridradi Leha (20 grams BD) and Vasadi Kashaya (50 ml BD) with Anupana (co-administers with medicine) of honey orally for 21 days. There are highly significant results (p value: p<0.01, p<0.001) in breathlessness, cough, body position, wheezing in a day, wheezing in night, heart rate in both group but quantity of sputum, respiratory rate, use of accessory muscle and mental status shows highly significant result only in Group B. Both groups have highly significant result in peak expiratory flow rate (PEFR) and forced expiratory volume in one second (FEV1). Both the Haridradi Leha and Vasadi Kashaya are highly effective in the management of Tamaka Shwasa. Haridradi Leha along with Vasadi Kashaya provided better relief than Haridradi Leha alone in most of the sign and symptom of the disease at significant level.

scholarly journals Efficacy and tolerability of 0.1% tazarotene cream and 0.05% tretinoin cream in the treatment of acne vulgaris

2016 ◽  
Vol 8 (1) ◽  
pp. 24
Author(s):  
Mohammad Habibur Rahman ◽  
Md. Shahidullah Sikder ◽  
Lubna Khondker
Keyword(s):  
Treated Patient ◽  
Acne Vulgaris ◽  
Chronic Inflammatory Disease ◽  
Controlled Clinical Trial ◽  
Base Line ◽  
Excellent Response ◽  
Group A ◽  
Group B ◽  
Medical University

<p><strong>Background:</strong> Acne vulgaris is a chronic inflammatory disease of the pilosebaceous follicles that is seen primarily in adolescents.</p><p><strong>Objective:</strong> To compare the efficacy of 0.1 % tazarotene cream and 0.05% tretinoin cream in the treatment of mild to moderate acne vulgaris.</p><p><strong>Methods:</strong> A randomized controlled clinical trial was done in the department of Dermatol­ogy and Venereology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.</p><p><strong>Results:</strong> At base line mean number of comedones in group A and group B was 12.77 ± 4.01 and 11.80 ± 3.93 respectively (p=0.350) and at final follow up 4.17 ± 4.02 and 3.47 ± 4.00(p=0.501). At base line mean number ofpapules in group A and group B was 17.30 ± 10.29 and 18.57 ± 13.88 respectively (p=0.690) and at final follow up 7.63 ± 8.08 and 7.73 ± 9.98 (p=0.966). At base line mean number of pustules in group A and group B was 0.50 ± 1.33 and 0.53 ± 1.28 respectively (p=0. 922) and at final follow up 0.07 ± 0.37 and 0.00 (p=0.326). At baseline mean of total acne score was 30.57 ± 13.62 and 30.90 ± 17.17 in group A and B(p=0.934) and at final follow up it was 11.87 ± 12.04 and 11.20 ± 13.85 respectively in group A and B(p=0.846). At 1st follow up 3.3% of both group got excellent response, at 2nd follow up 13.3% of group A and 30.0% of group B got excellent response, and at final follow up 56.7% of group A and 63.3% of group B achieved excel­lent response. About 73.33% oftretinoin treated patient and 60% oftazarotene treated did not experience any side effects.</p><p><strong>Conclusion:</strong> It can be concluded that 0.1 % tazarotene cream and 0.05% tretinoin cream is individually effective and tolerability of 0.1 % tazarotene is comparable to 0.05% tretinoin in the treatment of mild to moderate acne vulgaris.</p>

scholarly journals EVALUATION OF DEXMEDETOMIDINE ON HEMODYNAMIC STRESS RESPONSE DURING LARYNGOSCOPY AND INTUBATION

2021 ◽  
Vol 71 (6) ◽  
pp. 2126-30
Author(s):  
Abdul Raafeh Jamal ◽  
Bilal Yaseen ◽  
Mohammad Saeed ◽  
Rao Ali Shan Khan ◽  
Syed Hamid Ali Shah ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Stress Response ◽  
Systolic Blood Pressure ◽  
Military Hospital ◽  
P Value ◽  
Hemodynamic Stress ◽  
Group A ◽  
The Mean ◽  
Group B

Objective: To compare the efficacy of Dexmedetomidine (Precedex) in addressing the mean haemodynamic stress response to laryngoscopy and endotracheal intubation (L&I). Study Design: Quasi-experimental study. Place and Duration of Study: Anesthesiology Department, Combined Military Hospital, Rawalpindi, from Jun 2019 Jun 2020. Methodology: The patients were divided into two groups. Group A was given Inj. Dexmedetomidine and group B (placebo). Operation theatre assistant randomly assigned the patients to either group A or group B each day. The second person administered the drug or placebo. The third person (researcher) recorded all the parameters mentioned in the proforma. Results: There were 100 patients with an age range of 18-60 years. The majority of the patients were ASA-I physical status. The main surgical procedure was laparoscopic cholecystectomy. Recording of heart rate and systolic blood pressure during laryngoscopy and intubation, after administration of drug or placebo, showed mean heart rate less than mean basal value in group-A and 22% above mean basal value in group-B, and it was statistically highly significant (p-value <0.001). Whereas mean systolic blood pressure in group-A was 122.42 ± 14.91 (less than the mean basal value) as compared to group B, 155.00 ± 18.32/min (20% above mean basal value). This change was also statistically highly significant (p-value <0.001). Conclusion: It is concluded that dexmedetomidine showed statistically significant stabilizing effects on the expected changes of the hemodynamic stress response.

scholarly journals HEPATITIS ‘C’;

2012 ◽  
Vol 19 (02) ◽  
pp. 193-196
Author(s):  
MUZAFFAR MEHMOOD KHAN ◽  
Muhammad TAHIR ◽  
Mohsin RAZA ◽  
Muhammad Ali BHATTI ◽  
Muhammad Riaz Khokar
Keyword(s):  
Hearing Loss ◽  
Hepatitis C ◽  
Pure Tone ◽  
Bone Conduction ◽  
P Value ◽  
Base Line ◽  
Quasi Experimental ◽  
Group A ◽  
Group B ◽  
Base Line Data

Objective: The objective of this study was to determine association of Interferon-Ribavarin therapy with hearing loss in patientssuffering from Hepatitis ‘C’. Study Design: Quasi-experimental study. Place and Duration: Otolaryngology Department Combined MilitaryHospital Rawalpindi from 09 June 2006 to 08 June 2007. Patients and Methods: Consenting sixty patients of Hepatitis C divided into two equalgroups of 30 each, (group A receiving Interferon-Ribavarin therapy and group B, not receiving it) during the study period fitting the inclusioncriteria were selected. Pure Tone Audiometery including both air and bone conduction performed as base line data at commencement oftherapy and then at the end of therapy (after six months) . Patients were sampled by Convenience (non-probability) technique. Results: Thenumber of patients who were found to have defined hearing loss was 06 (20%) in Group A (n=30) and 05(16.67%) in Group B (n=30). Chi Squaretest was applied which showed a p-value of 0.739 which is highly insignificant. Conclusions: Interferon-Ribavarin Therapy does not have asignificant association with hearing loss in patients of Hepatitis ‘C’.

scholarly journals Epidural tramadol improves the quality of pain relief during labor

2017 ◽  
Vol 6 (3) ◽  
pp. 14-19
Author(s):  
I N Shrestha ◽  
G P Deo ◽  
S K Shrestha ◽  
S Neupane ◽  
B S Regmi
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Side Effects ◽  
Pain Relief ◽  
Total Dose ◽  
Analgesic Efficacy ◽  
Time Intervals ◽  
Group A ◽  
Group B

 To study the analgesic efficacy and side effects of Tramadol for painless labor in combination with Bupivacaine. Randomized, controlled, double blind, open prospective study conducted at Department of Obstetrics and Gynaecology, Chitwan Medical College from July 1st 2015 to June 30th 2016. 100 patients of ASA Grade I and II, aged between 20-35 years willing for epidural analgesia for labor pain were included in the study. They were divided into two groups: Group A- Control group and Group B- Study group. Subjects of Group A received 10 ml of 0.25% Bupivacaine and that of Group B received 10ml of 0.25% Bupivacaine with 1mg/kg body weight of tramadol. Analgesic efficacy was assessed by Visual Analogue Scale (VAS) and other vital parameters (Blood Pressure, Heart Rate and Respiratory Rate) before the administration of the drug and at different time intervals of 0, 5 min, 10 min, 15 min, 30 min, 45 min, 60 min and every hourly up to maximum of 5 hrs. Neonatal out comes were assessed by the use of APGAR scores and the side effects of the drugs in two groups were also evaluated. Total number of patients was 100, of ASA Grade I and II, aged between 20-35 years. The mean age of patients in Group A was 23.54 ± 3.74 years and 24.22 ± 3.64 years in Group B. Mode of delivery was spontaneous vaginal in 42 patients (84%) in group A and 45 patients (90%) in group B. Instrumental vaginal delivery was done in 1 patient (2%) of group A and none of group B. Cesarean section was done in 7 patients (14%) of group A and 5 patients (10%) of group B. There was no significant difference in heart rate, blood pressure and respiratory rate at various time intervals. Pain score of Group B was significantly less at 60th min and had lower values than Group A at various time intervals. Time for first top up was significantly delayed and the total dose of bupivacaine was significantly lower in Group B patients but the incidence of nausea and vomiting was significantly high among Group B patients. At one minute majority of the babies of group A had mean APGAR score 6.98 ± 0.55 versus 7.18 ± 0.60 in group B. At 5 minute, Group A had mean score of 8.02 ± 0.47 versus 8.22 ± 0.58 in Group B. There were no significant differences in 2 groups. In both the groups there was no significant effect on duration of second stage of labor and it wasn’t prolonged in any of the patients. Epidural anesthesia with bupivacaine and tramadol provided better pain relief and reduced the total dose of bupivacaine in majority of the patients with no adverse effects on mother and fetus. As tramadol is cheap, safe and effective, it can be considered as a better option to improve quality of pain relief during labor.

scholarly journals The Effect of Metformin When Combined With Neoadjuvant Chemotherapy in Breast Cancer Patients

2021 ◽  
Author(s):  
Shaimaa El-Khayat ◽  
Mohamed Abouegylah ◽  
Dina Abdallah ◽  
Ahmed Gaber Geweil ◽  
A.M. Elenbaby ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Cancer Patients ◽  
Pathological Response ◽  
Phase Iii ◽  
P Value ◽  
Base Line ◽  
Breast Cancer Patients ◽  
Group A ◽  
Group B

Abstract BackgroundMetformin has been used to treat type 2 Diabetes Mellitus since long time. It has two proposed anti-neoplastic mechanisms, direct (insulin-independent) and indirect (insulin-dependent) actions. PurposeTo assess the effect of Metformin on pathological response when combined with neoadjuvant chemotherapy in breast cancer. Material and MethodsA prospective study included stage II, III non-diabetic breast cancer patients who received neoadjuvant chemotherapy in our center during the period from May 2017 to March 2019. 59 patients met our inclusion criteria and completed the study, 27 patients received 850mg Metformin every 12 hrs with chemotherapy (group A), 32 patients received chemotherapy without Metformin (group B). Pathological response was assessed by Chevallier classification and residual cancer burden score (RCB). ResultsBoth groups were well balanced regarding base line characteristics. The results of our study showed that the rate of pathological complete response (pCR) was 14.8% in group (A) vs. 6.3% in group (B) with a P-value of 0.39. RCB class 3 was 40.7% in group (A) Vs. 68.8% in group (B) which was statistically significant with a (P-value of 0.031). Patients with triple-positive histology who had RCB class 3 were only (14.3%) in group (A) versus (60%) in group B. Patients with body mass index (BMI) ≥25 who had RCB 3 were 40% and 66.7% in group (A) and (B) respectively. ConclusionMetformin may increase the pCR especially in patients with BMI≥25 and patients with triple-positive histology, a larger phase III study is needed to confirm this finding.

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